2owy - Revision history

OCA at 13:53, 13 March 2024

OCA — Wed, 13 Mar 2024 13:53:20 GMT

←Older revision		Revision as of 13:53, 13 March 2024
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	<StructureSection load='2owy' size='340' side='right'caption='[[2owy]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2owy' size='340' side='right'caption='[[2owy]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2owy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OWY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2owy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OWY FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~rdgC (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5&~~id=208964 PSEAE])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2owy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2owy OCA], [https://pdbe.org/2owy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2owy RCSB], [https://www.ebi.ac.uk/pdbsum/2owy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2owy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2owy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2owy OCA], [https://pdbe.org/2owy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2owy RCSB], [https://www.ebi.ac.uk/pdbsum/2owy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2owy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RDGC_PSEAE RDGC_PSEAE]] May be involved in recombination (By similarity).	+	[https://www.uniprot.org/uniprot/RDGC_PSEAE RDGC_PSEAE] May be involved in recombination (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2owy ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2owy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	RecA plays a central role in the nonmutagenic repair of stalled replication forks in bacteria. RdgC, a recombination-associated DNA-binding protein, is a potential negative regulator of RecA function. Here, we have determined the crystal structure of RdgC from Pseudomonas aeruginosa. The J-shaped monomer has a unique fold and can be divided into three structural domains: tip domain, center domain and base domain. Two such monomers dimerize to form a ring-shaped molecule of approximate 2-fold symmetry. Of the two inter-subunit interfaces within the dimer, one interface ('interface A') between tip/center domains is more nonpolar than the other ('interface B') between base domains. The structure allows us to propose that the RdgC dimer binds dsDNA through the central hole of approximately 30 A diameter. The proposed model is supported by our DNA-binding assays coupled with mutagenesis, which indicate that the conserved positively charged residues on the protein surface around the central hole play important roles in DNA binding. The novel ring-shaped architecture of the RdgC dimer has significant implications for its role in homologous recombination.
-
-	The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding.,Ha JY, Kim HK, Kim do J, Kim KH, Oh SJ, Lee HH, Yoon HJ, Song HK, Suh SW Nucleic Acids Res. 2007;35(8):2671-81. Epub 2007 Apr 10. PMID:17426134<ref>PMID:17426134</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2owy" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Pseae]]~~	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	~~[[Category: Suh, S W]]~~	+	[[Category: Suh SW]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Homologous recombination]]~~	+
-	[[Category: Pseudomonas aeruginosa]]	+
-	[[Category: ~~Rdgc]]~~	+
-	~~[[Category: Reca]]~~	+
-	~~[[Category: Ring-shaped dna binding protein~~]]	+

OCA at 13:08, 9 June 2021

OCA — Wed, 09 Jun 2021 13:08:08 GMT

←Older revision		Revision as of 13:08, 9 June 2021
Line 1:		Line 1:

	==The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding==		==The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding==
-	<StructureSection load='2owy' size='340' side='right' caption='[[2owy]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2owy' size='340' side='right'caption='[[2owy]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2owy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OWY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2owy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OWY FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rdgC ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rdgC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2owy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2owy OCA], [~~http~~://pdbe.org/2owy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2owy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2owy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2owy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2owy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2owy OCA], [https://pdbe.org/2owy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2owy RCSB], [https://www.ebi.ac.uk/pdbsum/2owy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2owy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RDGC_PSEAE RDGC_PSEAE]] May be involved in recombination (By similarity).	+	[[https://www.uniprot.org/uniprot/RDGC_PSEAE RDGC_PSEAE]] May be involved in recombination (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ow/2owy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ow/2owy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pseae]]		[[Category: Pseae]]
	[[Category: Suh, S W]]		[[Category: Suh, S W]]

OCA at 09:11, 18 October 2017

OCA — Wed, 18 Oct 2017 09:11:46 GMT

←Older revision		Revision as of 09:11, 18 October 2017
Line 1:		Line 1:
		+
	==The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding==		==The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding==
	<StructureSection load='2owy' size='340' side='right' caption='[[2owy]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2owy' size='340' side='right' caption='[[2owy]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2owy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OWY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2owy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OWY FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rdgC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rdgC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2owy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2owy OCA], [http://pdbe.org/2owy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2owy RCSB], [http://www.ebi.ac.uk/pdbsum/2owy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2owy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2owy OCA], [http://pdbe.org/2owy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2owy RCSB], [http://www.ebi.ac.uk/pdbsum/2owy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2owy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 00:09, 9 February 2016

OCA — Tue, 09 Feb 2016 00:09:51 GMT

←Older revision		Revision as of 00:09, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2owy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:42, 10 September 2015

OCA — Thu, 10 Sep 2015 16:42:04 GMT

←Older revision		Revision as of 16:42, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2owy' size='340' side='right' caption='[[2owy]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2owy' size='340' side='right' caption='[[2owy]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2owy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa Pseudomonas aeruginosa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OWY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2owy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OWY FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rdgC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~287 Pseudomonas aeruginosa~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rdgC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2owy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2owy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2owy RCSB], [http://www.ebi.ac.uk/pdbsum/2owy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2owy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2owy OCA], [http://pdbe.org/2owy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2owy RCSB], [http://www.ebi.ac.uk/pdbsum/2owy PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2owy" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pseudomonas aeruginosa~~]]	+	[[Category: Pseae]]
	[[Category: Suh, S W]]		[[Category: Suh, S W]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Homologous recombination]]		[[Category: Homologous recombination]]
		+	[[Category: Pseudomonas aeruginosa]]
	[[Category: Rdgc]]		[[Category: Rdgc]]
	[[Category: Reca]]		[[Category: Reca]]
	[[Category: Ring-shaped dna binding protein]]		[[Category: Ring-shaped dna binding protein]]

OCA at 03:06, 25 December 2014

OCA — Thu, 25 Dec 2014 03:06:27 GMT

←Older revision		Revision as of 03:06, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2owy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OWY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2owy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OWY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rdgC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rdgC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2owy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2owy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2owy RCSB], [http://www.ebi.ac.uk/pdbsum/2owy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2owy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2owy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2owy RCSB], [http://www.ebi.ac.uk/pdbsum/2owy PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RDGC_PSEAE RDGC_PSEAE]] May be involved in recombination (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
-	[[Category: Suh, S W.]]	+	[[Category: Suh, S W]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Homologous recombination]]		[[Category: Homologous recombination]]
-	[[Category: Pseudomonas aeruginosa]]
	[[Category: Rdgc]]		[[Category: Rdgc]]
	[[Category: Reca]]		[[Category: Reca]]
	[[Category: Ring-shaped dna binding protein]]		[[Category: Ring-shaped dna binding protein]]

OCA at 18:28, 30 September 2014

OCA — Tue, 30 Sep 2014 18:28:45 GMT

←Older revision		Revision as of 18:28, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2owy.~~png\|left~~\|200px]]	+	==The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding==
		+	<StructureSection load='2owy' size='340' side='right' caption='[[2owy]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2owy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OWY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rdgC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2owy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2owy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2owy RCSB], [http://www.ebi.ac.uk/pdbsum/2owy PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ow/2owy_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RecA plays a central role in the nonmutagenic repair of stalled replication forks in bacteria. RdgC, a recombination-associated DNA-binding protein, is a potential negative regulator of RecA function. Here, we have determined the crystal structure of RdgC from Pseudomonas aeruginosa. The J-shaped monomer has a unique fold and can be divided into three structural domains: tip domain, center domain and base domain. Two such monomers dimerize to form a ring-shaped molecule of approximate 2-fold symmetry. Of the two inter-subunit interfaces within the dimer, one interface ('interface A') between tip/center domains is more nonpolar than the other ('interface B') between base domains. The structure allows us to propose that the RdgC dimer binds dsDNA through the central hole of approximately 30 A diameter. The proposed model is supported by our DNA-binding assays coupled with mutagenesis, which indicate that the conserved positively charged residues on the protein surface around the central hole play important roles in DNA binding. The novel ring-shaped architecture of the RdgC dimer has significant implications for its role in homologous recombination.

-	~~{{STRUCTURE_2owy\| PDB=2owy \| SCENE= }}~~	+	The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding.,Ha JY, Kim HK, Kim do J, Kim KH, Oh SJ, Lee HH, Yoon HJ, Song HK, Suh SW Nucleic Acids Res. 2007;35(8):2671-81. Epub 2007 Apr 10. PMID:17426134<ref>PMID:17426134</ref>

-	~~===The recombination-associated protein RdgC adopts~~ a ~~novel toroidal architecture for DNA binding===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17426134}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2owy]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017426134<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Suh, S W.]]		[[Category: Suh, S W.]]

OCA: Protected "2owy" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 10:43:54 GMT

Protected "2owy" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:43, 7 January 2013

OCA at 10:43, 7 January 2013

OCA — Mon, 07 Jan 2013 10:43:51 GMT

←Older revision		Revision as of 10:43, 7 January 2013
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-	{{Seed}}
	[[Image:2owy.png\|left\|200px]]		[[Image:2owy.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2owy", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2owy\| PDB=2owy \| SCENE= }}		{{STRUCTURE_2owy\| PDB=2owy \| SCENE= }}

	===The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding===		===The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17426134}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17426134 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_17426134}}		{{ABSTRACT_PUBMED_17426134}}

	==About this Structure==		==About this Structure==
-	~~2OWY~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA].	+	[[2owy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17426134~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017426134</ref><references group="xtra"/>
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Suh, S W.]]		[[Category: Suh, S W.]]
		+	[[Category: Dna binding protein]]
	[[Category: Homologous recombination]]		[[Category: Homologous recombination]]
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
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	[[Category: Reca]]		[[Category: Reca]]
	[[Category: Ring-shaped dna binding protein]]		[[Category: Ring-shaped dna binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:45:54 2009''

OCA at 02:45, 17 February 2009

OCA — Tue, 17 Feb 2009 02:45:55 GMT

←Older revision		Revision as of 02:45, 17 February 2009
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	==About this Structure==		==About this Structure==
-	2OWY is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA].	+	2OWY is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OWY OCA].

	==Reference==		==Reference==
-	The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding., Ha JY, Kim HK, Kim do J, Kim KH, Oh SJ, Lee HH, Yoon HJ, Song HK, Suh SW, Nucleic Acids Res. 2007;35(8):2671-81. Epub 2007 Apr 10. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17426134 17426134]~~	+	<ref group="xtra">PMID:17426134</ref><references group="xtra"/>
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
-	[[Category: Single protein]]
	[[Category: Suh, S W.]]		[[Category: Suh, S W.]]
	[[Category: Homologous recombination]]		[[Category: Homologous recombination]]
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	[[Category: Ring-shaped dna binding protein]]		[[Category: Ring-shaped dna binding protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 08~~:07:~~35 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:45:54 2009''