2p34 - Revision history

OCA at 09:07, 21 February 2024

OCA — Wed, 21 Feb 2024 09:07:37 GMT

←Older revision		Revision as of 09:07, 21 February 2024
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	<StructureSection load='2p34' size='340' side='right'caption='[[2p34]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2p34' size='340' side='right'caption='[[2p34]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p34]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Canavalia_maritima~~ Canavalia ~~maritima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p34]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P34 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-MANNOSE'>~~MAN~~</scene>, <scene name='pdbligand=~~MMA~~:~~O1-METHYL-MANNOSE~~'>~~MMA~~</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p34 OCA], [https://pdbe.org/2p34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p34 RCSB], [https://www.ebi.ac.uk/pdbsum/2p34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p34 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p34 OCA], [https://pdbe.org/2p34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p34 RCSB], [https://www.ebi.ac.uk/pdbsum/2p34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p34 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CONA_CANRO CONA_CANRO]] Glucose/D-mannose specific lectin.	+	[https://www.uniprot.org/uniprot/CONA_CANRO CONA_CANRO] Glucose/D-mannose specific lectin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p34 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p34 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Plant lectins, especially those purified from species of the Leguminosae family, represent the best studied group of carbohydrate-binding proteins. The legume lectins from Diocleinae subtribe are highly similar proteins that present significant differences in the potency/efficacy of their biological activities. The structural studies of the interactions between lectins and sugars may clarify the origin of the distinct biological activities observed in this high similar class of proteins. In this way, this work presents a crystallographic study of the ConM and CGL (agglutinins from Canavalia maritima and Canavalia gladiata, respectively) in the following complexes: ConM/CGL:Man(alpha1-2)Man(alpha1-O)Me, ConM/CGL:Man(alpha1-3)Man(alpha1-O)Me and ConM/CGL:Man(alpha1-4)Man(alpha1-O)Me, which crystallized in different conditions and space group from the native proteins. The structures were solved by molecular replacement, presenting satisfactory values for R(factor) and R(free). Comparisons between ConM, CGL and ConA (Canavalia ensiformis lectin) binding mode with the dimannosides in subject, presented different interactions patterns, which may account for a structural explanation of the distincts biological properties observed in the lectins of Diocleinae subtribe.
-
-	Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: new insights into the understanding of the structure-biological activity relationship in legume lectins.,Bezerra GA, Oliveira TM, Moreno FB, de Souza EP, da Rocha BA, Benevides RG, Delatorre P, de Azevedo WF Jr, Cavada BS J Struct Biol. 2007 Nov;160(2):168-76. Epub 2007 Aug 16. PMID:17881248<ref>PMID:17881248</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2p34" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Concanavalin 3D structures\|Concanavalin 3D structures]]		*[[Concanavalin 3D structures\|Concanavalin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Canavalia ~~maritima~~]]	+	[[Category: Canavalia rosea]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Azevedo, W de]]~~	+	[[Category: Benevides RG]]
-	[[Category: Benevides~~, R G~~]]	+	[[Category: Bezerra GA]]
-	[[Category: Bezerra~~, G A~~]]	+	[[Category: Cavada BS]]
-	[[Category: Cavada~~, B S~~]]	+	[[Category: Delatorre P]]
-	[[Category: Delatorre, P]]	+	[[Category: Moreno FBMB]]
-	[[Category: Moreno~~, F B.M B~~]]	+	[[Category: Oliveira TM]]
-	[[Category: Oliveira~~, T M~~]]	+	[[Category: Rocha BAM]]
-	[[Category: Rocha~~, B A.M~~]]	+	[[Category: Souza EP]]
-	[[Category: Souza~~, E P~~]]	+	[[Category: De Azevedo Jr W]]
-	[[Category: ~~Canavalia maritima lectin]]~~	+
-	~~[[Category: Dimannoside]]~~	+
-	~~[[Category: Plant protein~~]]	+

OCA at 07:53, 2 March 2022

OCA — Wed, 02 Mar 2022 07:53:55 GMT

←Older revision		Revision as of 07:53, 2 March 2022
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	<StructureSection load='2p34' size='340' side='right'caption='[[2p34]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2p34' size='340' side='right'caption='[[2p34]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p34]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Canavalia_maritima Canavalia maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2P34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p34]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_maritima Canavalia maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P34 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~MMA~~:O1-~~METHYL~~-MANNOSE'>~~MMA~~</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2p34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p34 OCA], [~~http~~://pdbe.org/2p34 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2p34 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2p34 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2p34 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p34 OCA], [https://pdbe.org/2p34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p34 RCSB], [https://www.ebi.ac.uk/pdbsum/2p34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p34 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CONA_CANRO CONA_CANRO]] Glucose/D-mannose specific lectin.	+	[[https://www.uniprot.org/uniprot/CONA_CANRO CONA_CANRO]] Glucose/D-mannose specific lectin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:06, 27 May 2020

OCA — Wed, 27 May 2020 08:06:48 GMT

←Older revision		Revision as of 08:06, 27 May 2020
Line 1:		Line 1:

	==Crystal structure of a lectin from Canavalia maritima seeds (CML) in complex with man1-4man-OMe==		==Crystal structure of a lectin from Canavalia maritima seeds (CML) in complex with man1-4man-OMe==
-	<StructureSection load='2p34' size='340' side='right' caption='[[2p34]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2p34' size='340' side='right'caption='[[2p34]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_maritima Canavalia maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2P34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_maritima Canavalia maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2P34 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2p34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p34 OCA], [http://pdbe.org/2p34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p34 RCSB], [http://www.ebi.ac.uk/pdbsum/2p34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p34 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2p34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p34 OCA], [http://pdbe.org/2p34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p34 RCSB], [http://www.ebi.ac.uk/pdbsum/2p34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p34 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Concanavalin A\|Concanavalin A]]	+	*[[Concanavalin 3D structures\|Concanavalin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Canavalia maritima]]		[[Category: Canavalia maritima]]
		+	[[Category: Large Structures]]
	[[Category: Azevedo, W de]]		[[Category: Azevedo, W de]]
	[[Category: Benevides, R G]]		[[Category: Benevides, R G]]

OCA at 07:14, 22 August 2018

OCA — Wed, 22 Aug 2018 07:14:01 GMT

←Older revision		Revision as of 07:14, 22 August 2018
Line 1:		Line 1:
		+
	==Crystal structure of a lectin from Canavalia maritima seeds (CML) in complex with man1-4man-OMe==		==Crystal structure of a lectin from Canavalia maritima seeds (CML) in complex with man1-4man-OMe==
	<StructureSection load='2p34' size='340' side='right' caption='[[2p34]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2p34' size='340' side='right' caption='[[2p34]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Canavalia_rosea~~ Canavalia ~~rosea~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_maritima Canavalia maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P34 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-MANNOSE'>~~MAN~~</scene>, <scene name='pdbligand=~~MMA~~:~~O1-METHYL-MANNOSE~~'>~~MMA~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p34 OCA], [http://pdbe.org/2p34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p34 RCSB], [http://www.ebi.ac.uk/pdbsum/2p34 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p34 OCA], [http://pdbe.org/2p34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p34 RCSB], [http://www.ebi.ac.uk/pdbsum/2p34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p34 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p3/2p34_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p3/2p34_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p34 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Canavalia ~~rosea~~]]	+	[[Category: Canavalia maritima]]
	[[Category: Azevedo, W de]]		[[Category: Azevedo, W de]]
	[[Category: Benevides, R G]]		[[Category: Benevides, R G]]

OCA at 10:48, 11 September 2015

OCA — Fri, 11 Sep 2015 10:48:58 GMT

←Older revision		Revision as of 10:48, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2p34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P34 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2p34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P34 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p34 RCSB], [http://www.ebi.ac.uk/pdbsum/2p34 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p34 OCA], [http://pdbe.org/2p34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p34 RCSB], [http://www.ebi.ac.uk/pdbsum/2p34 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~CONA_CANMR CONA_CANMR~~]] Glucose/D-mannose specific lectin.	+	[[http://www.uniprot.org/uniprot/CONA_CANRO CONA_CANRO]] Glucose/D-mannose specific lectin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2p34" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:26, 25 December 2014

OCA — Thu, 25 Dec 2014 15:26:27 GMT

←Older revision		Revision as of 15:26, 25 December 2014
Line 1:		Line 1:
-	[[~~Image~~:2p34.~~png\|left~~\|200px]]	+	==Crystal structure of a lectin from Canavalia maritima seeds (CML) in complex with man1-4man-OMe==
		+	<StructureSection load='2p34' size='340' side='right' caption='[[2p34]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2p34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P34 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p34 RCSB], [http://www.ebi.ac.uk/pdbsum/2p34 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CONA_CANMR CONA_CANMR]] Glucose/D-mannose specific lectin.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p3/2p34_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plant lectins, especially those purified from species of the Leguminosae family, represent the best studied group of carbohydrate-binding proteins. The legume lectins from Diocleinae subtribe are highly similar proteins that present significant differences in the potency/efficacy of their biological activities. The structural studies of the interactions between lectins and sugars may clarify the origin of the distinct biological activities observed in this high similar class of proteins. In this way, this work presents a crystallographic study of the ConM and CGL (agglutinins from Canavalia maritima and Canavalia gladiata, respectively) in the following complexes: ConM/CGL:Man(alpha1-2)Man(alpha1-O)Me, ConM/CGL:Man(alpha1-3)Man(alpha1-O)Me and ConM/CGL:Man(alpha1-4)Man(alpha1-O)Me, which crystallized in different conditions and space group from the native proteins. The structures were solved by molecular replacement, presenting satisfactory values for R(factor) and R(free). Comparisons between ConM, CGL and ConA (Canavalia ensiformis lectin) binding mode with the dimannosides in subject, presented different interactions patterns, which may account for a structural explanation of the distincts biological properties observed in the lectins of Diocleinae subtribe.

-	~~{{STRUCTURE_2p34\| PDB=2p34 \| SCENE= }}~~	+	Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: new insights into the understanding of the structure-biological activity relationship in legume lectins.,Bezerra GA, Oliveira TM, Moreno FB, de Souza EP, da Rocha BA, Benevides RG, Delatorre P, de Azevedo WF Jr, Cavada BS J Struct Biol. 2007 Nov;160(2):168-76. Epub 2007 Aug 16. PMID:17881248<ref>PMID:17881248</ref>

-	~~===Crystal structure of~~ a ~~lectin from Canavalia maritima seeds (CML) in complex with man1-4man-OMe===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_17881248}}~~	+	==See Also==
-		+	*[[Concanavalin A\|Concanavalin A]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2p34~~]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:017881248<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Canavalia rosea]]		[[Category: Canavalia rosea]]
-	[[Category: Azevedo, W de.]]	+	[[Category: Azevedo, W de]]
-	[[Category: Benevides, R G.]]	+	[[Category: Benevides, R G]]
-	[[Category: Bezerra, G A.]]	+	[[Category: Bezerra, G A]]
-	[[Category: Cavada, B S.]]	+	[[Category: Cavada, B S]]
-	[[Category: Delatorre, P.]]	+	[[Category: Delatorre, P]]
-	[[Category: Moreno, F B.M B.]]	+	[[Category: Moreno, F B.M B]]
-	[[Category: Oliveira, T M.]]	+	[[Category: Oliveira, T M]]
-	[[Category: Rocha, B A.M.]]	+	[[Category: Rocha, B A.M]]
-	[[Category: Souza, E P.]]	+	[[Category: Souza, E P]]
	[[Category: Canavalia maritima lectin]]		[[Category: Canavalia maritima lectin]]
	[[Category: Dimannoside]]		[[Category: Dimannoside]]
	[[Category: Plant protein]]		[[Category: Plant protein]]

OCA: Protected "2p34" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 10:33:13 GMT

Protected "2p34" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:33, 7 January 2013

OCA at 10:33, 7 January 2013

OCA — Mon, 07 Jan 2013 10:33:09 GMT

←Older revision		Revision as of 10:33, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2p34.png\|left\|200px]]		[[Image:2p34.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2p34", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2p34\| PDB=2p34 \| SCENE= }}		{{STRUCTURE_2p34\| PDB=2p34 \| SCENE= }}

	===Crystal structure of a lectin from Canavalia maritima seeds (CML) in complex with man1-4man-OMe===		===Crystal structure of a lectin from Canavalia maritima seeds (CML) in complex with man1-4man-OMe===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17881248}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17881248 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17881248}}		{{ABSTRACT_PUBMED_17881248}}

	==About this Structure==		==About this Structure==
-	~~2P34~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Canavalia_maritima~~ Canavalia ~~maritima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA].	+	[[2p34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17881248~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017881248</ref><references group="xtra"/>
-	[[Category: Canavalia ~~maritima~~]]	+	[[Category: Canavalia rosea]]
		+	[[Category: Azevedo, W de.]]
	[[Category: Benevides, R G.]]		[[Category: Benevides, R G.]]
	[[Category: Bezerra, G A.]]		[[Category: Bezerra, G A.]]
	[[Category: Cavada, B S.]]		[[Category: Cavada, B S.]]
	[[Category: Delatorre, P.]]		[[Category: Delatorre, P.]]
-	[[Category: Jr., W de Azevedo.]]
	[[Category: Moreno, F B.M B.]]		[[Category: Moreno, F B.M B.]]
	[[Category: Oliveira, T M.]]		[[Category: Oliveira, T M.]]
Line 37:		Line 25:
	[[Category: Dimannoside]]		[[Category: Dimannoside]]
	[[Category: Plant protein]]		[[Category: Plant protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:17:37 2009''

OCA at 18:17, 17 February 2009

OCA — Tue, 17 Feb 2009 18:17:39 GMT

←Older revision		Revision as of 18:17, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA].	+	2P34 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Canavalia_maritima Canavalia maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P34 OCA].

	==Reference==		==Reference==
-	Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: new insights into the understanding of the structure-biological activity relationship in legume lectins., Bezerra GA, Oliveira TM, Moreno FB, de Souza EP, da Rocha BA, Benevides RG, Delatorre P, de Azevedo WF Jr, Cavada BS, J Struct Biol. 2007 Nov;160(2):168-76. Epub 2007 Aug 16. PMID:[~~http~~:~~//www.ncbi.nlm.nih.gov/pubmed/17881248 17881248~~]	+	<ref group="xtra">PMID:17881248</ref><references group="xtra"/>
		+	[[Category: Canavalia maritima]]
	[[Category: Benevides, R G.]]		[[Category: Benevides, R G.]]
	[[Category: Bezerra, G A.]]		[[Category: Bezerra, G A.]]
Line 37:		Line 38:
	[[Category: Plant protein]]		[[Category: Plant protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 04~~:10:~~02 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:17:37 2009''

OCA at 01:10, 29 July 2008

OCA — Tue, 29 Jul 2008 01:10:07 GMT

←Older revision		Revision as of 01:10, 29 July 2008
Line 1:		Line 1:
-	[[Image:2p34.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2p34.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2p34\| PDB=2p34 \| SCENE= }}		{{STRUCTURE_2p34\| PDB=2p34 \| SCENE= }}

-	~~'''~~Crystal structure of a lectin from Canavalia maritima seeds (CML) in complex with man1-4man-OMe~~'''~~	+	===Crystal structure of a lectin from Canavalia maritima seeds (CML) in complex with man1-4man-OMe===


-	~~==Overview==~~	+	<!--
-	~~Plant lectins~~, ~~especially those purified from species of the Leguminosae family~~, ~~represent~~ the ~~best studied group of carbohydrate-binding proteins. The legume lectins from Diocleinae subtribe are highly similar proteins that present significant differences in~~ the potency/efficacy of their biological activities. The structural studies of the interactions between lectins and sugars may clarify the origin of the distinct biological activities observed in this high similar class of proteins. In this way, this work presents a crystallographic study of the ConM and CGL (~~agglutinins from Canavalia maritima and Canavalia gladiata, respectively) in the following complexes~~: ~~ConM~~/~~CGL:Man(alpha1-2)Man(alpha1-O)Me, ConM~~/~~CGL:Man(alpha1-3)Man(alpha1-O)Me and ConM/CGL:Man(alpha1-4)Man(alpha1-O)Me, which crystallized in different conditions and space group from the native proteins~~. ~~The structures were solved by molecular replacement, presenting satisfactory values for R(factor) and R(free)~~. ~~Comparisons between ConM, CGL and ConA (Canavalia ensiformis lectin~~) ~~binding mode with the dimannosides in subject~~, ~~presented different interactions patterns, which may account for a structural explanation of~~ the ~~distincts biological properties observed in the lectins of Diocleinae subtribe~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17881248}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17881248 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17881248}}

	==About this Structure==		==About this Structure==
Line 32:		Line 36:
	[[Category: Dimannoside]]		[[Category: Dimannoside]]
	[[Category: Plant protein]]		[[Category: Plant protein]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 12~~:14:35 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:10:02 2008''