2p5v - Revision history

OCA at 15:16, 17 June 2021

OCA — Thu, 17 Jun 2021 15:16:52 GMT

←Older revision		Revision as of 15:16, 17 June 2021
Line 1:		Line 1:

	==Crystal Structure of Transcriptional Regulator NMB0573 from Neisseria Meningitidis==		==Crystal Structure of Transcriptional Regulator NMB0573 from Neisseria Meningitidis==
-	<StructureSection load='2p5v' size='340' side='right' caption='[[2p5v]], [[Resolution\|resolution]] 1.99Å' scene=''>	+	<StructureSection load='2p5v' size='340' side='right'caption='[[2p5v]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p5v]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Neimb Neimb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2P5V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p5v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Neimb Neimb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P5V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NMB0573 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=122586 NEIMB])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NMB0573 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=122586 NEIMB])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2p5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p5v OCA], [~~http~~://pdbe.org/2p5v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2p5v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2p5v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2p5v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p5v OCA], [https://pdbe.org/2p5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p5v RCSB], [https://www.ebi.ac.uk/pdbsum/2p5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p5v ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Neimb]]		[[Category: Neimb]]
	[[Category: OPPF, Oxford Protein Production Facility]]		[[Category: OPPF, Oxford Protein Production Facility]]

OCA at 07:23, 22 August 2018

OCA — Wed, 22 Aug 2018 07:23:47 GMT

←Older revision		Revision as of 07:23, 22 August 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Transcriptional Regulator NMB0573 from Neisseria Meningitidis==		==Crystal Structure of Transcriptional Regulator NMB0573 from Neisseria Meningitidis==
	<StructureSection load='2p5v' size='340' side='right' caption='[[2p5v]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='2p5v' size='340' side='right' caption='[[2p5v]], [[Resolution\|resolution]] 1.99Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NMB0573 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=122586 NEIMB])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NMB0573 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=122586 NEIMB])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p5v OCA], [http://pdbe.org/2p5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p5v RCSB], [http://www.ebi.ac.uk/pdbsum/2p5v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p5v OCA], [http://pdbe.org/2p5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p5v RCSB], [http://www.ebi.ac.uk/pdbsum/2p5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p5v ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p5/2p5v_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p5/2p5v_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p5v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:02, 11 September 2015

OCA — Fri, 11 Sep 2015 14:02:29 GMT

←Older revision		Revision as of 14:02, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2p5v' size='340' side='right' caption='[[2p5v]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='2p5v' size='340' side='right' caption='[[2p5v]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p5v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Neisseria_meningitidis Neisseria meningitidis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P5V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p5v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Neimb Neimb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P5V FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NMB0573 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~487 Neisseria meningitidis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NMB0573 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=122586 NEIMB])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p5v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p5v RCSB], [http://www.ebi.ac.uk/pdbsum/2p5v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p5v OCA], [http://pdbe.org/2p5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p5v RCSB], [http://www.ebi.ac.uk/pdbsum/2p5v PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2p5v" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Neisseria meningitidis~~]]	+	[[Category: Neimb]]
	[[Category: OPPF, Oxford Protein Production Facility]]		[[Category: OPPF, Oxford Protein Production Facility]]
	[[Category: Owens, R J]]		[[Category: Owens, R J]]

OCA at 14:13, 19 January 2015

OCA — Mon, 19 Jan 2015 14:13:45 GMT

←Older revision		Revision as of 14:13, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2p5v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P5V FirstGlance]. <br>		<table><tr><td colspan='2'>[[2p5v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P5V FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NMB0573 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 Neisseria meningitidis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NMB0573 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 Neisseria meningitidis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p5v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p5v RCSB], [http://www.ebi.ac.uk/pdbsum/2p5v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p5v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p5v RCSB], [http://www.ebi.ac.uk/pdbsum/2p5v PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Neisseria meningitidis]]		[[Category: Neisseria meningitidis]]
-	[[Category: OPPF, Oxford Protein Production Facility.]]	+	[[Category: OPPF, Oxford Protein Production Facility]]
-	[[Category: Owens, R J.]]	+	[[Category: Owens, R J]]
-	[[Category: Ren, J.]]	+	[[Category: Ren, J]]
-	[[Category: Sainsbury, S.]]	+	[[Category: Sainsbury, S]]
	[[Category: Lrp/asnc-family]]		[[Category: Lrp/asnc-family]]
	[[Category: Nmb0573]]		[[Category: Nmb0573]]

OCA at 18:25, 30 September 2014

OCA — Tue, 30 Sep 2014 18:25:09 GMT

←Older revision		Revision as of 18:25, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2p5v.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Transcriptional Regulator NMB0573 from Neisseria Meningitidis==
		+	<StructureSection load='2p5v' size='340' side='right' caption='[[2p5v]], [[Resolution\|resolution]] 1.99Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2p5v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P5V FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NMB0573 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 Neisseria meningitidis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p5v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p5v RCSB], [http://www.ebi.ac.uk/pdbsum/2p5v PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p5/2p5v_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Neisseria meningitidis, a causative agent of bacterial meningitis, has a relatively small repertoire of transcription factors, including NMB0573 (annotated AsnC), a member of the Lrp-AsnC family of regulators that are widely expressed in both Bacteria and Archaea. In the present study we show that NMB0573 binds to l-leucine and l-methionine and have solved the structure of the protein with and without bound amino acids. This has shown, for the first time that amino acid binding does not induce significant conformational changes in the structure of an AsnC/Lrp regulator although it does appear to stabilize the octameric assembly of the protein. Transcriptional profiling of wild-type and NMB0573 knock-out strains of N. meningitidis has shown that NMB0573 is associated with an adaptive response to nutrient poor conditions reflected in a reduction in major surface protein expression. On the basis of its structure and the transcriptional response, we propose that NMB0573 is a global regulator in Neisseria controlling responses to nutrient availability through indicators of general amino acid abundance: leucine and methionine.

-	~~{{STRUCTURE_2p5v\| PDB=2p5v \| SCENE= }}~~	+	The structure and transcriptional analysis of a global regulator from Neisseria meningitidis.,Ren J, Sainsbury S, Combs SE, Capper RG, Jordan PW, Berrow NS, Stammers DK, Saunders NJ, Owens RJ J Biol Chem. 2007 May 11;282(19):14655-64. Epub 2007 Mar 20. PMID:17374605<ref>PMID:17374605</ref>

-	~~===Crystal Structure~~ of ~~Transcriptional Regulator NMB0573 from Neisseria Meningitidis===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17374605}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2p5v]] is a 8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Neisseria_meningitidis Neisseria meningitidis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017374605<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Neisseria meningitidis]]		[[Category: Neisseria meningitidis]]
	[[Category: OPPF, Oxford Protein Production Facility.]]		[[Category: OPPF, Oxford Protein Production Facility.]]

OCA: Protected "2p5v" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 13:16:17 GMT

Protected "2p5v" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:16, 7 January 2013

OCA at 13:16, 7 January 2013

OCA — Mon, 07 Jan 2013 13:16:15 GMT

←Older revision		Revision as of 13:16, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2p5v.png\|left\|200px]]		[[Image:2p5v.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2p5v", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2p5v\| PDB=2p5v \| SCENE= }}		{{STRUCTURE_2p5v\| PDB=2p5v \| SCENE= }}

	===Crystal Structure of Transcriptional Regulator NMB0573 from Neisseria Meningitidis===		===Crystal Structure of Transcriptional Regulator NMB0573 from Neisseria Meningitidis===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17374605}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_17374605}}		{{ABSTRACT_PUBMED_17374605}}

	==About this Structure==		==About this Structure==
-	~~2P5V~~ is a 8 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Neisseria_meningitidis_mc58~~ Neisseria meningitidis ~~mc58~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA].	+	[[2p5v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17374605~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017374605</ref><references group="xtra"/>
-	[[Category: Neisseria meningitidis ~~mc58~~]]	+	[[Category: Neisseria meningitidis]]
	[[Category: OPPF, Oxford Protein Production Facility.]]		[[Category: OPPF, Oxford Protein Production Facility.]]
	[[Category: Owens, R J.]]		[[Category: Owens, R J.]]
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	[[Category: Structural and functional analysis of n. meninigitidis transcriptional regulator]]		[[Category: Structural and functional analysis of n. meninigitidis transcriptional regulator]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
		+	[[Category: Transcription]]
	[[Category: Transcriptional regulator]]		[[Category: Transcriptional regulator]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 19 08:51:17 2009''

OCA at 05:51, 19 April 2009

OCA — Sun, 19 Apr 2009 05:51:17 GMT

←Older revision		Revision as of 05:51, 19 April 2009
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	==About this Structure==		==About this Structure==
-	2P5V is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/~~Neisseria_meningitidis_serogroup_b~~ Neisseria meningitidis ~~serogroup b~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA].	+	2P5V is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_mc58 Neisseria meningitidis mc58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:17374605</ref><references group="xtra"/>		<ref group="xtra">PMID:17374605</ref><references group="xtra"/>
-	[[Category: Neisseria meningitidis ~~serogroup b~~]]	+	[[Category: Neisseria meningitidis mc58]]
	[[Category: OPPF, Oxford Protein Production Facility.]]		[[Category: OPPF, Oxford Protein Production Facility.]]
	[[Category: Owens, R J.]]		[[Category: Owens, R J.]]
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	[[Category: Transcriptional regulator]]		[[Category: Transcriptional regulator]]

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OCA at 22:10, 17 February 2009

OCA — Tue, 17 Feb 2009 22:10:41 GMT

←Older revision		Revision as of 22:10, 17 February 2009
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	==About this Structure==		==About this Structure==
-	2P5V is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_b Neisseria meningitidis serogroup b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA].	+	2P5V is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_b Neisseria meningitidis serogroup b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5V OCA].

	==Reference==		==Reference==
-	The structure and transcriptional analysis of a global regulator from Neisseria meningitidis., Ren J, Sainsbury S, Combs SE, Capper RG, Jordan PW, Berrow NS, Stammers DK, Saunders NJ, Owens RJ, J Biol Chem. 2007 May 11;282(19):14655-64. Epub 2007 Mar 20. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17374605 17374605]~~	+	<ref group="xtra">PMID:17374605</ref><references group="xtra"/>
	[[Category: Neisseria meningitidis serogroup b]]		[[Category: Neisseria meningitidis serogroup b]]
-	[[Category: Single protein]]
	[[Category: OPPF, Oxford Protein Production Facility.]]		[[Category: OPPF, Oxford Protein Production Facility.]]
	[[Category: Owens, R J.]]		[[Category: Owens, R J.]]
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	[[Category: Transcriptional regulator]]		[[Category: Transcriptional regulator]]

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OCA at 04:30, 29 July 2008

OCA — Tue, 29 Jul 2008 04:30:37 GMT

←Older revision		Revision as of 04:30, 29 July 2008
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		+	[[Image:2p5v.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2p5v\| PDB=2p5v \| SCENE= }}		{{STRUCTURE_2p5v\| PDB=2p5v \| SCENE= }}

-	~~'''~~Crystal Structure of Transcriptional Regulator NMB0573 from Neisseria Meningitidis~~'''~~	+	===Crystal Structure of Transcriptional Regulator NMB0573 from Neisseria Meningitidis===


-	~~==Overview==~~	+	<!--
-	~~Neisseria meningitidis~~, ~~a causative agent of bacterial meningitis~~, ~~has a relatively small repertoire of transcription factors, including NMB0573 (annotated AsnC), a member of the Lrp-AsnC family of regulators that are widely expressed in both Bacteria and Archaea. In~~ the ~~present study we show that NMB0573 binds~~ to ~~l-leucine and l-methionine and have solved~~ the ~~structure of the protein with and without bound amino acids~~. ~~This has shown~~, ~~for~~ the first time that amino acid binding does not induce significant conformational changes in the structure of an AsnC/Lrp regulator although it does appear to stabilize the octameric assembly of the protein. ~~Transcriptional profiling of wild~~-~~type and NMB0573 knock~~-out strains of N. meningitidis has shown that NMB0573 is associated with an adaptive response to nutrient poor conditions reflected in a reduction in major surface protein expression. On the basis of its structure and the transcriptional response, we propose that NMB0573 is a global regulator in Neisseria controlling responses to nutrient availability through indicators of general amino acid abundance: leucine and methionine.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17374605}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17374605 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17374605}}

	==About this Structure==		==About this Structure==
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Transcriptional regulator]]		[[Category: Transcriptional regulator]]
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