2p7p - Revision history

OCA at 10:56, 30 August 2023

OCA — Wed, 30 Aug 2023 10:56:48 GMT

←Older revision		Revision as of 10:56, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2p7p' size='340' side='right'caption='[[2p7p]], [[Resolution\|resolution]] 2.17Å' scene=''>		<StructureSection load='2p7p' size='340' side='right'caption='[[2p7p]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p7p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lismo Lismo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P7P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p7p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P7P FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.17Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2p7k\|2p7k]]~~, ~~[[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7q\|2p7q]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7p OCA], [https://pdbe.org/2p7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p7p RCSB], [https://www.ebi.ac.uk/pdbsum/2p7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7p OCA], [https://pdbe.org/2p7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p7p RCSB], [https://www.ebi.ac.uk/pdbsum/2p7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7p ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FOSX_LISMO FOSX_LISMO] Catalyzes the hydration of fosfomycin.<ref>PMID:14677948</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lismo~~]]	+	[[Category: Listeria monocytogenes EGD-e]]
-	[[Category: Armstrong~~, R N~~]]	+	[[Category: Armstrong RN]]
-	[[Category: Fillgrove~~, K L~~]]	+	[[Category: Fillgrove KL]]
-	[[Category: Newcomer~~, M E~~]]	+	[[Category: Newcomer ME]]
-	[[Category: Pakhomova, S]]	+	[[Category: Pakhomova S]]
-	[[Category: Schaab, M]]	+	[[Category: Schaab M]]
-	~~[[Category: Antibiotic resistance]]~~	+
-	~~[[Category: Fosfomycin resistance protein]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Mn binding~~]]	+

OCA at 07:54, 2 March 2022

OCA — Wed, 02 Mar 2022 07:54:55 GMT

←Older revision		Revision as of 07:54, 2 March 2022
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	<StructureSection load='2p7p' size='340' side='right'caption='[[2p7p]], [[Resolution\|resolution]] 2.17Å' scene=''>		<StructureSection load='2p7p' size='340' side='right'caption='[[2p7p]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p7p]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2P7P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p7p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P7P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7q\|2p7q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7q\|2p7q]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7p OCA], [~~http~~://pdbe.org/2p7p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2p7p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2p7p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7p OCA], [https://pdbe.org/2p7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p7p RCSB], [https://www.ebi.ac.uk/pdbsum/2p7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7p ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:09, 27 May 2020

OCA — Wed, 27 May 2020 08:09:41 GMT

←Older revision		Revision as of 08:09, 27 May 2020
Line 1:		Line 1:

	==Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and sulfate ion==		==Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and sulfate ion==
-	<StructureSection load='2p7p' size='340' side='right' caption='[[2p7p]], [[Resolution\|resolution]] 2.17Å' scene=''>	+	<StructureSection load='2p7p' size='340' side='right'caption='[[2p7p]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p7p]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2P7P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p7p]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2P7P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7q\|2p7q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7q\|2p7q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7p OCA], [http://pdbe.org/2p7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p7p RCSB], [http://www.ebi.ac.uk/pdbsum/2p7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7p OCA], [http://pdbe.org/2p7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p7p RCSB], [http://www.ebi.ac.uk/pdbsum/2p7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7p ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lismo]]		[[Category: Lismo]]
	[[Category: Armstrong, R N]]		[[Category: Armstrong, R N]]

OCA at 07:01, 22 August 2018

OCA — Wed, 22 Aug 2018 07:01:57 GMT

←Older revision		Revision as of 07:01, 22 August 2018
Line 1:		Line 1:
		+
	==Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and sulfate ion==		==Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and sulfate ion==
	<StructureSection load='2p7p' size='340' side='right' caption='[[2p7p]], [[Resolution\|resolution]] 2.17Å' scene=''>		<StructureSection load='2p7p' size='340' side='right' caption='[[2p7p]], [[Resolution\|resolution]] 2.17Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7q\|2p7q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7q\|2p7q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7p OCA], [http://pdbe.org/2p7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p7p RCSB], [http://www.ebi.ac.uk/pdbsum/2p7p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7p OCA], [http://pdbe.org/2p7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p7p RCSB], [http://www.ebi.ac.uk/pdbsum/2p7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7p ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/2p7p_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/2p7p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:17, 8 February 2016

OCA — Mon, 08 Feb 2016 23:17:41 GMT

←Older revision		Revision as of 23:17, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p7p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:18, 10 September 2015

OCA — Thu, 10 Sep 2015 16:18:34 GMT

←Older revision		Revision as of 16:18, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2p7p' size='340' side='right' caption='[[2p7p]], [[Resolution\|resolution]] 2.17Å' scene=''>		<StructureSection load='2p7p' size='340' side='right' caption='[[2p7p]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p7p]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Listeria_monocytogenes Listeria monocytogenes~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P7P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p7p]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P7P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7q\|2p7q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7q\|2p7q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p7p RCSB], [http://www.ebi.ac.uk/pdbsum/2p7p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7p OCA], [http://pdbe.org/2p7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p7p RCSB], [http://www.ebi.ac.uk/pdbsum/2p7p PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2p7p" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Listeria monocytogenes~~]]	+	[[Category: Lismo]]
	[[Category: Armstrong, R N]]		[[Category: Armstrong, R N]]
	[[Category: Fillgrove, K L]]		[[Category: Fillgrove, K L]]

OCA at 13:34, 19 January 2015

OCA — Mon, 19 Jan 2015 13:34:08 GMT

←Older revision		Revision as of 13:34, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2p7p]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P7P FirstGlance]. <br>		<table><tr><td colspan='2'>[[2p7p]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P7P FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7q\|2p7q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7q\|2p7q]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p7p RCSB], [http://www.ebi.ac.uk/pdbsum/2p7p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p7p RCSB], [http://www.ebi.ac.uk/pdbsum/2p7p PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Listeria monocytogenes]]		[[Category: Listeria monocytogenes]]
-	[[Category: Armstrong, R N.]]	+	[[Category: Armstrong, R N]]
-	[[Category: Fillgrove, K L.]]	+	[[Category: Fillgrove, K L]]
-	[[Category: Newcomer, M E.]]	+	[[Category: Newcomer, M E]]
-	[[Category: Pakhomova, S.]]	+	[[Category: Pakhomova, S]]
-	[[Category: Schaab, M.]]	+	[[Category: Schaab, M]]
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
	[[Category: Fosfomycin resistance protein]]		[[Category: Fosfomycin resistance protein]]

OCA at 18:09, 30 September 2014

OCA — Tue, 30 Sep 2014 18:09:39 GMT

←Older revision		Revision as of 18:09, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2p7p.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and sulfate ion==
		+	<StructureSection load='2p7p' size='340' side='right' caption='[[2p7p]], [[Resolution\|resolution]] 2.17Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2p7p]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P7P FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7q\|2p7q]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p7p RCSB], [http://www.ebi.ac.uk/pdbsum/2p7p PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/2p7p_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The fosfomycin resistance protein, FosX, catalyzes the hydration of the antibiotic fosfomycin, (1R,2S)-epoxypropylphosphonic acid. Genes encoding the enzyme are found in several pathogenic microorganisms. The structure and mechanism of action of the genomically encoded FosX enzyme from Listeria monocytogenes (FosXLMATCC) obtained from the American Type Culture Collection are reported. The gene harbors 31 point mutations, and as a consequence, the protein differs in 10 amino acid residues from the previously reported FosX encoded in the genome of the EGD strain of L. monocytogenes (FosXLMEGD). The FosXLMATCC enzyme is shown to catalyze the addition of water to the C1 position of the antibiotic with inversion of configuration at C1. The reaction involves Mn(II) activation of the oxirane oxygen and E44 acting as a general base. The structure of the enzyme has been determined from six different crystal forms of the protein. The structures of the enzyme without metal bound are similar but differ in the loop regions. Perhaps the most informative structure is the one with the product bound. This structure shows that the phosphonate group of the product is bound in an orientation that is different than that of fosfomycin bound to the related enzyme, FosA. The implication is that the substrate may also be bound in a different orientation in FosX. A high-resolution structure (1.44 A resolution) of the enzyme reveals a unique conformation in which the C-terminal tail of the protein coordinates to the Mn(II) center via the carboxylate of E126. The kinetic characterization of the E126Q mutant indicates that this conformation of the protein is probably not relevant to the function of the enzyme. Kinetic analysis of mutants of active site residue E44 is consistent with its proposed roll as a general base catalyst in the addition of water to the antibiotic.

-	~~{{STRUCTURE_2p7p\| PDB=2p7p \| SCENE= }}~~	+	Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes.,Fillgrove KL, Pakhomova S, Schaab MR, Newcomer ME, Armstrong RN Biochemistry. 2007 Jul 10;46(27):8110-20. Epub 2007 Jun 13. PMID:17567049<ref>PMID:17567049</ref>

-	~~===Crystal structure of genomically encoded fosfomycin resistance protein~~, ~~FosX, from Listeria monocytogenes complexed with MN(II) and sulfate ion===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17567049}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2p7p]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Listeria_monocytogenes Listeria monocytogenes]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017567049<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Listeria monocytogenes]]		[[Category: Listeria monocytogenes]]
	[[Category: Armstrong, R N.]]		[[Category: Armstrong, R N.]]

OCA: Protected "2p7p" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 10:25:55 GMT

Protected "2p7p" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:25, 7 January 2013

OCA at 10:25, 7 January 2013

OCA — Mon, 07 Jan 2013 10:25:54 GMT

←Older revision		Revision as of 10:25, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2p7p.png\|left\|200px]]		[[Image:2p7p.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2p7p", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2p7p\| PDB=2p7p \| SCENE= }}		{{STRUCTURE_2p7p\| PDB=2p7p \| SCENE= }}

	===Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and sulfate ion===		===Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and sulfate ion===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17567049}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17567049 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17567049}}		{{ABSTRACT_PUBMED_17567049}}

	==About this Structure==		==About this Structure==
-	~~2P7P~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA].	+	[[2p7p]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7P OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17567049~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017567049</ref><references group="xtra"/>
	[[Category: Listeria monocytogenes]]		[[Category: Listeria monocytogenes]]
	[[Category: Armstrong, R N.]]		[[Category: Armstrong, R N.]]
Line 32:		Line 20:
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
	[[Category: Fosfomycin resistance protein]]		[[Category: Fosfomycin resistance protein]]
		+	[[Category: Hydrolase]]
		+	[[Category: Metal binding protein]]
	[[Category: Mn binding]]		[[Category: Mn binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:19:38 2009''