2p8v - Revision history

OCA at 10:57, 30 August 2023

OCA — Wed, 30 Aug 2023 10:57:49 GMT

←Older revision		Revision as of 10:57, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2p8v' size='340' side='right'caption='[[2p8v]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2p8v' size='340' side='right'caption='[[2p8v]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p8v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P8V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p8v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P8V FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HOMER3 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8v OCA], [https://pdbe.org/2p8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p8v RCSB], [https://www.ebi.ac.uk/pdbsum/2p8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8v OCA], [https://pdbe.org/2p8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p8v RCSB], [https://www.ebi.ac.uk/pdbsum/2p8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HOME3_HUMAN HOME3_HUMAN]] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.	+	[https://www.uniprot.org/uniprot/HOME3_HUMAN HOME3_HUMAN] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bouyain, S]]	+	[[Category: Bouyain S]]
-	[[Category: Huang~~, G N~~]]	+	[[Category: Huang GN]]
-	[[Category: Leahy, D]]	+	[[Category: Leahy D]]
-	[[Category: Tu, J]]	+	[[Category: Tu J]]
-	[[Category: Worley~~, P F]]~~	+	[[Category: Worley PF]]
-	~~[[Category: Evh1 domain]]~~	+
-	~~[[Category: Homer3]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 15:18, 17 June 2021

OCA — Thu, 17 Jun 2021 15:18:48 GMT

←Older revision		Revision as of 15:18, 17 June 2021
Line 1:		Line 1:

	==Crystal structure of human Homer3 EVH1 domain==		==Crystal structure of human Homer3 EVH1 domain==
-	<StructureSection load='2p8v' size='340' side='right' caption='[[2p8v]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='2p8v' size='340' side='right'caption='[[2p8v]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p8v]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2P8V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p8v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P8V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2p8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8v OCA], [~~http~~://pdbe.org/2p8v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2p8v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2p8v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8v OCA], [https://pdbe.org/2p8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p8v RCSB], [https://www.ebi.ac.uk/pdbsum/2p8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HOME3_HUMAN HOME3_HUMAN]] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.	+	[[https://www.uniprot.org/uniprot/HOME3_HUMAN HOME3_HUMAN]] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/2p8v_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/2p8v_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bouyain, S]]		[[Category: Bouyain, S]]
	[[Category: Huang, G N]]		[[Category: Huang, G N]]

OCA at 09:20, 18 October 2017

OCA — Wed, 18 Oct 2017 09:20:17 GMT

←Older revision		Revision as of 09:20, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of human Homer3 EVH1 domain==		==Crystal structure of human Homer3 EVH1 domain==
	<StructureSection load='2p8v' size='340' side='right' caption='[[2p8v]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2p8v' size='340' side='right' caption='[[2p8v]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8v OCA], [http://pdbe.org/2p8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p8v RCSB], [http://www.ebi.ac.uk/pdbsum/2p8v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8v OCA], [http://pdbe.org/2p8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p8v RCSB], [http://www.ebi.ac.uk/pdbsum/2p8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p8v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:20, 11 September 2015

OCA — Fri, 11 Sep 2015 15:20:22 GMT

←Older revision		Revision as of 15:20, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2p8v' size='340' side='right' caption='[[2p8v]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2p8v' size='340' side='right' caption='[[2p8v]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p8v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p8v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8V FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p8v RCSB], [http://www.ebi.ac.uk/pdbsum/2p8v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8v OCA], [http://pdbe.org/2p8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p8v RCSB], [http://www.ebi.ac.uk/pdbsum/2p8v PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2p8v" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bouyain, S]]		[[Category: Bouyain, S]]
	[[Category: Huang, G N]]		[[Category: Huang, G N]]

OCA at 18:18, 25 December 2014

OCA — Thu, 25 Dec 2014 18:18:35 GMT

←Older revision		Revision as of 18:18, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2p8v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8V FirstGlance]. <br>		<table><tr><td colspan='2'>[[2p8v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8V FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p8v RCSB], [http://www.ebi.ac.uk/pdbsum/2p8v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p8v RCSB], [http://www.ebi.ac.uk/pdbsum/2p8v PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HOME3_HUMAN HOME3_HUMAN]] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bouyain, S.]]	+	[[Category: Bouyain, S]]
-	[[Category: Huang, G N.]]	+	[[Category: Huang, G N]]
-	[[Category: Leahy, D.]]	+	[[Category: Leahy, D]]
-	[[Category: Tu, J.]]	+	[[Category: Tu, J]]
-	[[Category: Worley, P F.]]	+	[[Category: Worley, P F]]
	[[Category: Evh1 domain]]		[[Category: Evh1 domain]]
	[[Category: Homer3]]		[[Category: Homer3]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 19:26, 30 September 2014

OCA — Tue, 30 Sep 2014 19:26:22 GMT

←Older revision		Revision as of 19:26, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2p8v.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of human Homer3 EVH1 domain==
		+	<StructureSection load='2p8v' size='340' side='right' caption='[[2p8v]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2p8v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8V FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p8v RCSB], [http://www.ebi.ac.uk/pdbsum/2p8v PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/2p8v_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	T cell receptor (TCR) and costimulatory receptor (CD28) signals cooperate in activating T cells, although understanding of how these pathways are themselves regulated is incomplete. We found that Homer2 and Homer3, members of the Homer family of cytoplasmic scaffolding proteins, are negative regulators of T cell activation. This is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin. Homer-NFAT binding was also antagonized by active serine-threonine kinase AKT, thereby enhancing TCR signaling via calcineurin-dependent dephosphorylation of NFAT. This corresponded with changes in cytokine expression and an increase in effector-memory T cell populations in Homer-deficient mice, which also developed autoimmune-like pathology. These results demonstrate a further means by which costimulatory signals are regulated to control self-reactivity.

-	~~{{STRUCTURE_2p8v\| PDB=2p8v \| SCENE= }}~~	+	NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.,Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF Science. 2008 Jan 25;319(5862):476-81. PMID:18218901<ref>PMID:18218901</ref>

-	~~===Crystal structure~~ of ~~human Homer3 EVH1 domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18218901}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2p8v]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018218901<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bouyain, S.]]		[[Category: Bouyain, S.]]

OCA: Protected "2p8v" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:26:05 GMT

Protected "2p8v" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:26, 7 January 2013

OCA at 14:26, 7 January 2013

OCA — Mon, 07 Jan 2013 14:26:02 GMT

←Older revision		Revision as of 14:26, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2p8v.png\|left\|200px]]		[[Image:2p8v.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2p8v", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2p8v\| PDB=2p8v \| SCENE= }}		{{STRUCTURE_2p8v\| PDB=2p8v \| SCENE= }}

	===Crystal structure of human Homer3 EVH1 domain===		===Crystal structure of human Homer3 EVH1 domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18218901}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18218901 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18218901}}		{{ABSTRACT_PUBMED_18218901}}

	==About this Structure==		==About this Structure==
-	~~2P8V~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA].	+	[[2p8v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18218901~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018218901</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bouyain, S.]]		[[Category: Bouyain, S.]]
Line 33:		Line 21:
	[[Category: Homer3]]		[[Category: Homer3]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:56:49 2009''

OCA at 23:56, 17 February 2009

OCA — Tue, 17 Feb 2009 23:56:50 GMT

←Older revision		Revision as of 23:56, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2P8V is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA].	+	2P8V is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA].

	==Reference==		==Reference==
-	NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins., Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF, Science. 2008 Jan 25;319(5862):476-81. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18218901 18218901]~~	+	<ref group="xtra">PMID:18218901</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Bouyain, S.]]		[[Category: Bouyain, S.]]
	[[Category: Huang, G N.]]		[[Category: Huang, G N.]]
Line 35:		Line 34:
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 08~~:48:~~34 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:56:49 2009''

OCA at 05:48, 29 July 2008

OCA — Tue, 29 Jul 2008 05:48:37 GMT

←Older revision		Revision as of 05:48, 29 July 2008
Line 1:		Line 1:
-	[[Image:2p8v.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2p8v.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2p8v\| PDB=2p8v \| SCENE= }}		{{STRUCTURE_2p8v\| PDB=2p8v \| SCENE= }}

-	~~'''~~Crystal structure of human Homer3 EVH1 domain~~'''~~	+	===Crystal structure of human Homer3 EVH1 domain===


-	~~==Overview==~~	+	<!--
-	~~T cell receptor (TCR) and costimulatory receptor (CD28) signals cooperate in activating T cells~~, ~~although understanding of how these pathways are themselves regulated is incomplete. We found that Homer2 and Homer3~~, ~~members of~~ the ~~Homer family of cytoplasmic scaffolding proteins, are negative regulators of T cell activation~~. ~~This is achieved through binding of nuclear factor of activated T cells (NFAT~~) ~~and by competing with calcineurin. Homer-NFAT binding was also antagonized by active serine-threonine kinase AKT~~, ~~thereby enhancing TCR signaling via calcineurin-dependent dephosphorylation of NFAT~~. ~~This corresponded with changes in cytokine expression and an increase in effector~~-~~memory T cell populations in Homer~~-~~deficient mice, which also developed autoimmune-like pathology. These results demonstrate a further means by which costimulatory signals are regulated to control self-reactivity.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_18218901}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18218901 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18218901}}

	==About this Structure==		==About this Structure==
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	[[Category: Homer3]]		[[Category: Homer3]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 12~~:37:24 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:48:34 2008''