2p8w - Revision history

OCA at 10:35, 12 January 2022

OCA — Wed, 12 Jan 2022 10:35:36 GMT

←Older revision		Revision as of 10:35, 12 January 2022
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	<SX load='2p8w' size='340' side='right' viewer='molstar' caption='[[2p8w]], [[Resolution\|resolution]] 11.30Å' scene=''>		<SX load='2p8w' size='340' side='right' viewer='molstar' caption='[[2p8w]], [[Resolution\|resolution]] 11.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p8w]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [~~http~~://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2P8W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p8w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P8W FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[2p8x\|2p8x]], [[2p8y\|2p8y]], [[2p8z\|2p8z]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[2p8x\|2p8x]], [[2p8y\|2p8y]], [[2p8z\|2p8z]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8w OCA], [~~http~~://pdbe.org/2p8w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2p8w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2p8w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8w ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8w OCA], [https://pdbe.org/2p8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p8w RCSB], [https://www.ebi.ac.uk/pdbsum/2p8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/EFTU2_THET8 EFTU2_THET8]] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.	+	[[https://www.uniprot.org/uniprot/EFTU2_THET8 EFTU2_THET8]] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:57, 10 April 2020

OCA — Fri, 10 Apr 2020 16:57:34 GMT

←Older revision		Revision as of 16:57, 10 April 2020
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	<SX load='2p8w' size='340' side='right' viewer='molstar' caption='[[2p8w]], [[Resolution\|resolution]] 11.30Å' scene=''>		<SX load='2p8w' size='340' side='right' viewer='molstar' caption='[[2p8w]], [[Resolution\|resolution]] 11.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p8w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2P8W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p8w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2P8W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[2p8x\|2p8x]], [[2p8y\|2p8y]], [[2p8z\|2p8z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[2p8x\|2p8x]], [[2p8y\|2p8y]], [[2p8z\|2p8z]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8w OCA], [http://pdbe.org/2p8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p8w RCSB], [http://www.ebi.ac.uk/pdbsum/2p8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8w ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8w OCA], [http://pdbe.org/2p8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p8w RCSB], [http://www.ebi.ac.uk/pdbsum/2p8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 16:56, 6 March 2020

OCA — Fri, 06 Mar 2020 16:56:48 GMT

←Older revision		Revision as of 16:56, 6 March 2020
Line 1:		Line 1:

	==Fitted structure of eEF2 in the 80S:eEF2:GDPNP cryo-EM reconstruction==		==Fitted structure of eEF2 in the 80S:eEF2:GDPNP cryo-EM reconstruction==
-	<~~StructureSection~~ load='2p8w' size='340' side='right'caption='[[2p8w]], [[Resolution\|resolution]] 11.30Å' scene=''>	+	<SX load='2p8w' size='340' side='right' viewer='molstar' caption='[[2p8w]], [[Resolution\|resolution]] 11.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2p8w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8W FirstGlance]. <br>		<table><tr><td colspan='2'>[[2p8w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8W FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]

OCA at 08:06, 18 December 2019

OCA — Wed, 18 Dec 2019 08:06:33 GMT

←Older revision		Revision as of 08:06, 18 December 2019
Line 1:		Line 1:

	==Fitted structure of eEF2 in the 80S:eEF2:GDPNP cryo-EM reconstruction==		==Fitted structure of eEF2 in the 80S:eEF2:GDPNP cryo-EM reconstruction==
-	<StructureSection load='2p8w' size='340' side='right' caption='[[2p8w]], [[Resolution\|resolution]] 11.30Å' scene=''>	+	<StructureSection load='2p8w' size='340' side='right'caption='[[2p8w]], [[Resolution\|resolution]] 11.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2p8w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8W FirstGlance]. <br>		<table><tr><td colspan='2'>[[2p8w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8W FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Elongation factor\|Elongation factor]]	+	*[[Elongation factor 3D structures\|Elongation factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]

OCA at 07:53, 18 July 2018

OCA — Wed, 18 Jul 2018 07:53:42 GMT

←Older revision		Revision as of 07:53, 18 July 2018
Line 1:		Line 1:
		+
	==Fitted structure of eEF2 in the 80S:eEF2:GDPNP cryo-EM reconstruction==		==Fitted structure of eEF2 in the 80S:eEF2:GDPNP cryo-EM reconstruction==
	<StructureSection load='2p8w' size='340' side='right' caption='[[2p8w]], [[Resolution\|resolution]] 11.30Å' scene=''>		<StructureSection load='2p8w' size='340' side='right' caption='[[2p8w]], [[Resolution\|resolution]] 11.30Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[2p8x\|2p8x]], [[2p8y\|2p8y]], [[2p8z\|2p8z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[2p8x\|2p8x]], [[2p8y\|2p8y]], [[2p8z\|2p8z]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8w OCA], [http://pdbe.org/2p8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p8w RCSB], [http://www.ebi.ac.uk/pdbsum/2p8w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8w OCA], [http://pdbe.org/2p8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p8w RCSB], [http://www.ebi.ac.uk/pdbsum/2p8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/2p8w_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/2p8w_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p8w ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:44, 11 September 2015

OCA — Fri, 11 Sep 2015 09:44:03 GMT

←Older revision		Revision as of 09:44, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[2p8x\|2p8x]], [[2p8y\|2p8y]], [[2p8z\|2p8z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[2p8x\|2p8x]], [[2p8y\|2p8y]], [[2p8z\|2p8z]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p8w RCSB], [http://www.ebi.ac.uk/pdbsum/2p8w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8w OCA], [http://pdbe.org/2p8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p8w RCSB], [http://www.ebi.ac.uk/pdbsum/2p8w PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2p8w" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:40, 25 December 2014

OCA — Thu, 25 Dec 2014 14:40:26 GMT

←Older revision		Revision as of 14:40, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2p8w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8W FirstGlance]. <br>		<table><tr><td colspan='2'>[[2p8w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8W FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[2p8x\|2p8x]], [[2p8y\|2p8y]], [[2p8z\|2p8z]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[2p8x\|2p8x]], [[2p8y\|2p8y]], [[2p8z\|2p8z]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p8w RCSB], [http://www.ebi.ac.uk/pdbsum/2p8w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p8w RCSB], [http://www.ebi.ac.uk/pdbsum/2p8w PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EFTU2_THET8 EFTU2_THET8]] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
-	[[Category: Andersen, G R.]]	+	[[Category: Andersen, G R]]
-	[[Category: Frank, J.]]	+	[[Category: Frank, J]]
-	[[Category: Merrill, A R.]]	+	[[Category: Merrill, A R]]
-	[[Category: Nilsson, J.]]	+	[[Category: Nilsson, J]]
-	[[Category: Nissen, P.]]	+	[[Category: Nissen, P]]
-	[[Category: Taylor, D J.]]	+	[[Category: Taylor, D J]]
	[[Category: 80s ribosome]]		[[Category: 80s ribosome]]
	[[Category: Elongation]]		[[Category: Elongation]]

OCA at 09:33, 29 September 2014

OCA — Mon, 29 Sep 2014 09:33:10 GMT

←Older revision		Revision as of 09:33, 29 September 2014
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-	[[~~Image:~~2p8w.~~png~~\|~~left~~\|200px]]	+	==Fitted structure of eEF2 in the 80S:eEF2:GDPNP cryo-EM reconstruction==
		+	<StructureSection load='2p8w' size='340' side='right' caption='[[2p8w]], [[Resolution\|resolution]] 11.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2p8w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8W FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k5x\|1k5x]], [[1k5y\|1k5y]], [[2p8x\|2p8x]], [[2p8y\|2p8y]], [[2p8z\|2p8z]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p8w RCSB], [http://www.ebi.ac.uk/pdbsum/2p8w PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/2p8w_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	On the basis of kinetic data on ribosome protein synthesis, the mechanical energy for translocation of the mRNA-tRNA complex is thought to be provided by GTP hydrolysis of an elongation factor (eEF2 in eukaryotes, EF-G in bacteria). We have obtained cryo-EM reconstructions of eukaryotic ribosomes complexed with ADP-ribosylated eEF2 (ADPR-eEF2), before and after GTP hydrolysis, providing a structural basis for analyzing the GTPase-coupled mechanism of translocation. Using the ADP-ribosyl group as a distinct marker, we observe conformational changes of ADPR-eEF2 that are due strictly to GTP hydrolysis. These movements are likely representative of native eEF2 motions in a physiological context and are sufficient to uncouple the mRNA-tRNA complex from two universally conserved bases in the ribosomal decoding center (A1492 and A1493 in Escherichia coli) during translocation. Interpretation of these data provides a detailed two-step model of translocation that begins with the eEF2/EF-G binding-induced ratcheting motion of the small ribosomal subunit. GTP hydrolysis then uncouples the mRNA-tRNA complex from the decoding center so translocation of the mRNA-tRNA moiety may be completed by a head rotation of the small subunit.

-	~~{{STRUCTURE_2p8w\| PDB=2p8w \| SCENE= }}~~	+	Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation.,Taylor DJ, Nilsson J, Merrill AR, Andersen GR, Nissen P, Frank J EMBO J. 2007 May 2;26(9):2421-31. Epub 2007 Apr 19. PMID:17446867<ref>PMID:17446867</ref>

-	~~===Fitted structure~~ of ~~eEF2 in~~ the ~~80S:eEF2:GDPNP cryo-EM reconstruction===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17446867}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2p8w]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en~~.~~wikipedia.org~~/~~wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA].~~	+

	==See Also==		==See Also==
	*[[Elongation factor\|Elongation factor]]		*[[Elongation factor\|Elongation factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017446867<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]

OCA: Protected "2p8w" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 17:55:36 GMT

Protected "2p8w" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:55, 20 October 2012

OCA at 17:55, 20 October 2012

OCA — Sat, 20 Oct 2012 17:55:34 GMT

←Older revision		Revision as of 17:55, 20 October 2012
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-	{{Seed}}
	[[Image:2p8w.png\|left\|200px]]		[[Image:2p8w.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2p8w\| PDB=2p8w \| SCENE= }}		{{STRUCTURE_2p8w\| PDB=2p8w \| SCENE= }}

	===Fitted structure of eEF2 in the 80S:eEF2:GDPNP cryo-EM reconstruction===		===Fitted structure of eEF2 in the 80S:eEF2:GDPNP cryo-EM reconstruction===

-
-	<!--
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	{{ABSTRACT_PUBMED_17446867}}		{{ABSTRACT_PUBMED_17446867}}

	==About this Structure==		==About this Structure==
-	~~2P8W~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA].	+	[[2p8w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8W OCA].
		+
		+	==See Also==
		+	*[[Elongation factor\|Elongation factor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17446867~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017446867</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
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	[[Category: Elongation]]		[[Category: Elongation]]
	[[Category: Gtpase]]		[[Category: Gtpase]]
		+	[[Category: Translation]]
	[[Category: Translocation]]		[[Category: Translocation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:56:47 2009''