2pj9 - Revision history

OCA at 11:03, 30 August 2023

OCA — Wed, 30 Aug 2023 11:03:03 GMT

←Older revision		Revision as of 11:03, 30 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PJ9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PJ9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=281:(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(S)-{(1R)-1-[(2,1,3-BENZOTHIADIAZOL-4-YLSULFONYL)AMINO]-2-METHYLPROPYL}(HYDROXY)PHOSPHORYL]PROPANOIC+ACID'>281</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.56Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]], [[2piy\|2piy]], [[2piz\|2piz]], [[2pj0\|2pj0]], [[2pj1\|2pj1]], [[2pj2\|2pj2]], [[2pj3\|2pj3]], [[2pj4\|2pj4]], [[2pj5\|2pj5]], [[2pj6\|2pj6]], [[2pj7\|2pj7]], [[2pj8\|2pj8]], [[2pja\|2pja]], [[2pjb\|2pjb]], [[2pjc\|2pjc]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=281:(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(S)-{(1R)-1-[(2,1,3-BENZOTHIADIAZOL-4-YLSULFONYL)AMINO]-2-METHYLPROPYL}(HYDROXY)PHOSPHORYL]PROPANOIC+ACID'>281</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pj9 OCA], [https://pdbe.org/2pj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pj9 RCSB], [https://www.ebi.ac.uk/pdbsum/2pj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pj9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pj9 OCA], [https://pdbe.org/2pj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pj9 RCSB], [https://www.ebi.ac.uk/pdbsum/2pj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pj9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CBPB1_PIG CBPB1_PIG]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Carboxypeptidase B]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Adler, M]]	+	[[Category: Adler M]]
-	[[Category: Whitlow, M]]	+	[[Category: Whitlow M]]
-	~~[[Category: Carboxypeptidase b]]~~	+
-	~~[[Category: Exopeptidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Phosphinate based inhibitor~~]]	+

OCA at 07:45, 9 March 2022

OCA — Wed, 09 Mar 2022 07:45:57 GMT

←Older revision		Revision as of 07:45, 9 March 2022
Line 3:		Line 3:
	<StructureSection load='2pj9' size='340' side='right'caption='[[2pj9]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='2pj9' size='340' side='right'caption='[[2pj9]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2pj9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJ9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2PJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2pj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PJ9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=281:(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(S)-{(1R)-1-[(2,1,3-BENZOTHIADIAZOL-4-YLSULFONYL)AMINO]-2-METHYLPROPYL}(HYDROXY)PHOSPHORYL]PROPANOIC+ACID'>281</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=281:(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(S)-{(1R)-1-[(2,1,3-BENZOTHIADIAZOL-4-YLSULFONYL)AMINO]-2-METHYLPROPYL}(HYDROXY)PHOSPHORYL]PROPANOIC+ACID'>281</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]], [[2piy\|2piy]], [[2piz\|2piz]], [[2pj0\|2pj0]], [[2pj1\|2pj1]], [[2pj2\|2pj2]], [[2pj3\|2pj3]], [[2pj4\|2pj4]], [[2pj5\|2pj5]], [[2pj6\|2pj6]], [[2pj7\|2pj7]], [[2pj8\|2pj8]], [[2pja\|2pja]], [[2pjb\|2pjb]], [[2pjc\|2pjc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]], [[2piy\|2piy]], [[2piz\|2piz]], [[2pj0\|2pj0]], [[2pj1\|2pj1]], [[2pj2\|2pj2]], [[2pj3\|2pj3]], [[2pj4\|2pj4]], [[2pj5\|2pj5]], [[2pj6\|2pj6]], [[2pj7\|2pj7]], [[2pj8\|2pj8]], [[2pja\|2pja]], [[2pjb\|2pjb]], [[2pjc\|2pjc]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2pj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pj9 OCA], [~~http~~://pdbe.org/2pj9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2pj9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2pj9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2pj9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pj9 OCA], [https://pdbe.org/2pj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pj9 RCSB], [https://www.ebi.ac.uk/pdbsum/2pj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pj9 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 06:55, 3 June 2020

OCA — Wed, 03 Jun 2020 06:55:44 GMT

←Older revision		Revision as of 06:55, 3 June 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B 2-(3-Aminomethyl-phenyl)-3-{[(R)-1-(benzo[1,2,5]thiadiazole-4-sulfonylamino)-2-methyl-propyl]-hydroxy-phosphinoyl}-propionic acid COMPLEX==		==CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B 2-(3-Aminomethyl-phenyl)-3-{[(R)-1-(benzo[1,2,5]thiadiazole-4-sulfonylamino)-2-methyl-propyl]-hydroxy-phosphinoyl}-propionic acid COMPLEX==
-	<StructureSection load='2pj9' size='340' side='right' caption='[[2pj9]], [[Resolution\|resolution]] 1.56Å' scene=''>	+	<StructureSection load='2pj9' size='340' side='right'caption='[[2pj9]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2pj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2PJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2pj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2PJ9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=281:(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(S)-{(1R)-1-[(2,1,3-BENZOTHIADIAZOL-4-YLSULFONYL)AMINO]-2-METHYLPROPYL}(HYDROXY)PHOSPHORYL]PROPANOIC+ACID'>281</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=281:(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(S)-{(1R)-1-[(2,1,3-BENZOTHIADIAZOL-4-YLSULFONYL)AMINO]-2-METHYLPROPYL}(HYDROXY)PHOSPHORYL]PROPANOIC+ACID'>281</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]], [[2piy\|2piy]], [[2piz\|2piz]], [[2pj0\|2pj0]], [[2pj1\|2pj1]], [[2pj2\|2pj2]], [[2pj3\|2pj3]], [[2pj4\|2pj4]], [[2pj5\|2pj5]], [[2pj6\|2pj6]], [[2pj7\|2pj7]], [[2pj8\|2pj8]], [[2pja\|2pja]], [[2pjb\|2pjb]], [[2pjc\|2pjc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]], [[2piy\|2piy]], [[2piz\|2piz]], [[2pj0\|2pj0]], [[2pj1\|2pj1]], [[2pj2\|2pj2]], [[2pj3\|2pj3]], [[2pj4\|2pj4]], [[2pj5\|2pj5]], [[2pj6\|2pj6]], [[2pj7\|2pj7]], [[2pj8\|2pj8]], [[2pja\|2pja]], [[2pjb\|2pjb]], [[2pjc\|2pjc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2pj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pj9 OCA], [http://pdbe.org/2pj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2pj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pj9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2pj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pj9 OCA], [http://pdbe.org/2pj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2pj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pj9 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Carboxypeptidase\|Carboxypeptidase]]	+	*[[Carboxypeptidase 3D structures\|Carboxypeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Carboxypeptidase B]]		[[Category: Carboxypeptidase B]]
		+	[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Adler, M]]		[[Category: Adler, M]]

OCA at 08:40, 29 August 2018

OCA — Wed, 29 Aug 2018 08:40:05 GMT

←Older revision		Revision as of 08:40, 29 August 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B 2-(3-Aminomethyl-phenyl)-3-{[(R)-1-(benzo[1,2,5]thiadiazole-4-sulfonylamino)-2-methyl-propyl]-hydroxy-phosphinoyl}-propionic acid COMPLEX==		==CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B 2-(3-Aminomethyl-phenyl)-3-{[(R)-1-(benzo[1,2,5]thiadiazole-4-sulfonylamino)-2-methyl-propyl]-hydroxy-phosphinoyl}-propionic acid COMPLEX==
	<StructureSection load='2pj9' size='340' side='right' caption='[[2pj9]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='2pj9' size='340' side='right' caption='[[2pj9]], [[Resolution\|resolution]] 1.56Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]], [[2piy\|2piy]], [[2piz\|2piz]], [[2pj0\|2pj0]], [[2pj1\|2pj1]], [[2pj2\|2pj2]], [[2pj3\|2pj3]], [[2pj4\|2pj4]], [[2pj5\|2pj5]], [[2pj6\|2pj6]], [[2pj7\|2pj7]], [[2pj8\|2pj8]], [[2pja\|2pja]], [[2pjb\|2pjb]], [[2pjc\|2pjc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]], [[2piy\|2piy]], [[2piz\|2piz]], [[2pj0\|2pj0]], [[2pj1\|2pj1]], [[2pj2\|2pj2]], [[2pj3\|2pj3]], [[2pj4\|2pj4]], [[2pj5\|2pj5]], [[2pj6\|2pj6]], [[2pj7\|2pj7]], [[2pj8\|2pj8]], [[2pja\|2pja]], [[2pjb\|2pjb]], [[2pjc\|2pjc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pj9 OCA], [http://pdbe.org/2pj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2pj9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pj9 OCA], [http://pdbe.org/2pj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2pj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pj9 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pj/2pj9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pj/2pj9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:26, 8 February 2016

OCA — Mon, 08 Feb 2016 04:26:07 GMT

←Older revision		Revision as of 04:26, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pj9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:51, 10 September 2015

OCA — Thu, 10 Sep 2015 07:51:18 GMT

←Older revision		Revision as of 07:51, 10 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]], [[2piy\|2piy]], [[2piz\|2piz]], [[2pj0\|2pj0]], [[2pj1\|2pj1]], [[2pj2\|2pj2]], [[2pj3\|2pj3]], [[2pj4\|2pj4]], [[2pj5\|2pj5]], [[2pj6\|2pj6]], [[2pj7\|2pj7]], [[2pj8\|2pj8]], [[2pja\|2pja]], [[2pjb\|2pjb]], [[2pjc\|2pjc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]], [[2piy\|2piy]], [[2piz\|2piz]], [[2pj0\|2pj0]], [[2pj1\|2pj1]], [[2pj2\|2pj2]], [[2pj3\|2pj3]], [[2pj4\|2pj4]], [[2pj5\|2pj5]], [[2pj6\|2pj6]], [[2pj7\|2pj7]], [[2pj8\|2pj8]], [[2pja\|2pja]], [[2pjb\|2pjb]], [[2pjc\|2pjc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2pj9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pj9 OCA], [http://pdbe.org/2pj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2pj9 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2pj9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:37, 19 January 2015

OCA — Mon, 19 Jan 2015 15:37:27 GMT

←Older revision		Revision as of 15:37, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PJ9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PJ9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=281:(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(S)-{(1R)-1-[(2,1,3-BENZOTHIADIAZOL-4-YLSULFONYL)AMINO]-2-METHYLPROPYL}(HYDROXY)PHOSPHORYL]PROPANOIC+ACID'>281</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=281:(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(S)-{(1R)-1-[(2,1,3-BENZOTHIADIAZOL-4-YLSULFONYL)AMINO]-2-METHYLPROPYL}(HYDROXY)PHOSPHORYL]PROPANOIC+ACID'>281</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]], [[2piy\|2piy]], [[2piz\|2piz]], [[2pj0\|2pj0]], [[2pj1\|2pj1]], [[2pj2\|2pj2]], [[2pj3\|2pj3]], [[2pj4\|2pj4]], [[2pj5\|2pj5]], [[2pj6\|2pj6]], [[2pj7\|2pj7]], [[2pj8\|2pj8]], [[2pja\|2pja]], [[2pjb\|2pjb]], [[2pjc\|2pjc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]], [[2piy\|2piy]], [[2piz\|2piz]], [[2pj0\|2pj0]], [[2pj1\|2pj1]], [[2pj2\|2pj2]], [[2pj3\|2pj3]], [[2pj4\|2pj4]], [[2pj5\|2pj5]], [[2pj6\|2pj6]], [[2pj7\|2pj7]], [[2pj8\|2pj8]], [[2pja\|2pja]], [[2pjb\|2pjb]], [[2pjc\|2pjc]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2pj9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2pj9 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Carboxypeptidase B]]		[[Category: Carboxypeptidase B]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Adler, M.]]	+	[[Category: Adler, M]]
-	[[Category: Whitlow, M.]]	+	[[Category: Whitlow, M]]
	[[Category: Carboxypeptidase b]]		[[Category: Carboxypeptidase b]]
	[[Category: Exopeptidase]]		[[Category: Exopeptidase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Phosphinate based inhibitor]]		[[Category: Phosphinate based inhibitor]]

OCA at 07:49, 29 September 2014

OCA — Mon, 29 Sep 2014 07:49:53 GMT

←Older revision		Revision as of 07:49, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2pj9.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B 2-(3-Aminomethyl-phenyl)-3-{[(R)-1-(benzo[1,2,5]thiadiazole-4-sulfonylamino)-2-methyl-propyl]-hydroxy-phosphinoyl}-propionic acid COMPLEX==
		+	<StructureSection load='2pj9' size='340' side='right' caption='[[2pj9]], [[Resolution\|resolution]] 1.56Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2pj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PJ9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=281:(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(S)-{(1R)-1-[(2,1,3-BENZOTHIADIAZOL-4-YLSULFONYL)AMINO]-2-METHYLPROPYL}(HYDROXY)PHOSPHORYL]PROPANOIC+ACID'>281</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z5r\|1z5r]], [[1zg7\|1zg7]], [[1zg8\|1zg8]], [[1zg9\|1zg9]], [[2piy\|2piy]], [[2piz\|2piz]], [[2pj0\|2pj0]], [[2pj1\|2pj1]], [[2pj2\|2pj2]], [[2pj3\|2pj3]], [[2pj4\|2pj4]], [[2pj5\|2pj5]], [[2pj6\|2pj6]], [[2pj7\|2pj7]], [[2pj8\|2pj8]], [[2pja\|2pja]], [[2pjb\|2pjb]], [[2pjc\|2pjc]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2pj9 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pj/2pj9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	This article reports the crystal structures of inhibitors of the functional form of thrombin-activatable fibrinolysis inhibitor (TAFIa). In vivo experiments indicate that selective inhibitors of TAFIa would be useful in the treatment of heart attacks. Since TAFIa rapidly degrades in solution, the homologous protein porcine pancreatic carboxypeptidase B (pp-CpB) was used in these crystallography studies. Both TAFIa and pp-CpB are zinc-based exopeptidases that are specific for basic residues. The final development candidate, BX 528, is a potent inhibitor of TAFIa (2 nM) and has almost no measurable effect on the major selectivity target, carboxypeptidase N. BX 528 was designed to mimic the tripeptide Phe-Val-Lys. A sulfonamide replaces the Phe-Val amide bond and a phosphinate connects the Val and Lys groups. The phosphinate also chelates the active-site zinc. The electrostatic interactions with the protein mimic those of the natural substrate. The primary amine in BX 528 forms a salt bridge to Asp255 at the base of the S1' pocket. The carboxylic acid interacts with Arg145 and the sulfonamide is hydrogen bonded to Arg71. Isopropyl and phenyl groups replace the side chains of Val and Phe, respectively. A series of structures are presented here that illustrate the evolution of BX 528 from thiol-based inhibitors that mimic a free C-terminal arginine. The first step in development was the replacement of the thiol with a phosphinate. This caused a precipitous drop in binding affinity. Potency was reclaimed by extending the inhibitors into the downstream binding sites for the natural substrate.

-	~~{{STRUCTURE_2pj9\| PDB=2pj9 \| SCENE= }}~~	+	Structures of potent selective peptide mimetics bound to carboxypeptidase B.,Adler M, Buckman B, Bryant J, Chang Z, Chu K, Emayan K, Hrvatin P, Islam I, Morser J, Sukovich D, West C, Yuan S, Whitlow M Acta Crystallogr D Biol Crystallogr. 2008 Feb;64(Pt 2):149-57. Epub 2008, Jan 16. PMID:18219114<ref>PMID:18219114</ref>

-	~~===CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B 2-(3-Aminomethyl-phenyl)-3-{[(R)-1-(benzo[1~~,~~2,5]thiadiazole-4-sulfonylamino)-2-methyl-propyl]-hydroxy-phosphinoyl}-propionic acid COMPLEX===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18219114}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2pj9]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sus_scrofa Sus scrofa]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2PJ9 OCA].~~	+

	==See Also==		==See Also==
	*[[Carboxypeptidase\|Carboxypeptidase]]		*[[Carboxypeptidase\|Carboxypeptidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018219114<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Carboxypeptidase B]]		[[Category: Carboxypeptidase B]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA at 08:54, 20 October 2012

OCA — Sat, 20 Oct 2012 08:54:16 GMT

←Older revision		Revision as of 08:54, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2pj9]] is a 1 chain structure ~~of [[Carboxypeptidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJ9 OCA].	+	[[2pj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PJ9 OCA].

	==See Also==		==See Also==

OCA: Protected "2pj9" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 21:08:41 GMT

Protected "2pj9" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:08, 25 July 2012