2poq - Revision history

OCA at 11:06, 30 August 2023

OCA — Wed, 30 Aug 2023 11:06:04 GMT

←Older revision		Revision as of 11:06, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2poq' size='340' side='right'caption='[[2poq]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='2poq' size='340' side='right'caption='[[2poq]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2poq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Crab-eating_macaque Crab-eating macaque~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2POQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2poq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2POQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ISD:(5R)-5-[(1R)-1,2-DIHYDROXYETHYL]-3,4-DIHYDROXYFURAN-2(5H)-ONE'>ISD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.59Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2o48\|2o48]], [[2o4u\|2o4u]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ISD:(5R)-5-[(1R)-1,2-DIHYDROXYETHYL]-3,4-DIHYDROXYFURAN-2(5H)-ONE'>ISD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CMO2DD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9541 Crab-eating macaque])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trans-1,2-dihydrobenzene-1,2-diol_dehydrogenase Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.20 1.3.1.20] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2poq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2poq OCA], [https://pdbe.org/2poq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2poq RCSB], [https://www.ebi.ac.uk/pdbsum/2poq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2poq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2poq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2poq OCA], [https://pdbe.org/2poq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2poq RCSB], [https://www.ebi.ac.uk/pdbsum/2poq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2poq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DHDH_MACFA DHDH_MACFA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Crab-eating macaque]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase~~]]	+	[[Category: Macaca fascicularis]]
-	[[Category: Carbone, V]]	+	[[Category: Carbone V]]
-	[[Category: El-Kabbani, O]]	+	[[Category: El-Kabbani O]]
-	~~[[Category: Nadp-binding rossmann-fold domain]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Predominantly anti-parallel beta sheet~~]]	+

OCA at 15:29, 17 June 2021

OCA — Thu, 17 Jun 2021 15:29:16 GMT

←Older revision		Revision as of 15:29, 17 June 2021
Line 1:		Line 1:

	==Dimeric Dihydrodiol Dehydrogenase complexed with inhibitor, Isoascorbic acid==		==Dimeric Dihydrodiol Dehydrogenase complexed with inhibitor, Isoascorbic acid==
-	<StructureSection load='2poq' size='340' side='right' caption='[[2poq]], [[Resolution\|resolution]] 2.59Å' scene=''>	+	<StructureSection load='2poq' size='340' side='right'caption='[[2poq]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2poq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Crab-eating_macaque Crab-eating macaque]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2POQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2poq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Crab-eating_macaque Crab-eating macaque]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2POQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ISD:(5R)-5-[(1R)-1,2-DIHYDROXYETHYL]-3,4-DIHYDROXYFURAN-2(5H)-ONE'>ISD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ISD:(5R)-5-[(1R)-1,2-DIHYDROXYETHYL]-3,4-DIHYDROXYFURAN-2(5H)-ONE'>ISD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o48\|2o48]], [[2o4u\|2o4u]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2o48\|2o48]], [[2o4u\|2o4u]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CMO2DD ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9541 Crab-eating macaque])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CMO2DD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9541 Crab-eating macaque])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Trans-1,2-dihydrobenzene-1,2-diol_dehydrogenase Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.20 1.3.1.20] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trans-1,2-dihydrobenzene-1,2-diol_dehydrogenase Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.20 1.3.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2poq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2poq OCA], [~~http~~://pdbe.org/2poq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2poq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2poq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2poq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2poq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2poq OCA], [https://pdbe.org/2poq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2poq RCSB], [https://www.ebi.ac.uk/pdbsum/2poq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2poq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Crab-eating macaque]]		[[Category: Crab-eating macaque]]
		+	[[Category: Large Structures]]
	[[Category: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase]]		[[Category: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase]]
	[[Category: Carbone, V]]		[[Category: Carbone, V]]

OCA at 08:55, 29 August 2018

OCA — Wed, 29 Aug 2018 08:55:42 GMT

←Older revision		Revision as of 08:55, 29 August 2018
Line 1:		Line 1:
		+
	==Dimeric Dihydrodiol Dehydrogenase complexed with inhibitor, Isoascorbic acid==		==Dimeric Dihydrodiol Dehydrogenase complexed with inhibitor, Isoascorbic acid==
	<StructureSection load='2poq' size='340' side='right' caption='[[2poq]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='2poq' size='340' side='right' caption='[[2poq]], [[Resolution\|resolution]] 2.59Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CMO2DD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9541 Crab-eating macaque])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CMO2DD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9541 Crab-eating macaque])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trans-1,2-dihydrobenzene-1,2-diol_dehydrogenase Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.20 1.3.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trans-1,2-dihydrobenzene-1,2-diol_dehydrogenase Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.20 1.3.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2poq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2poq OCA], [http://pdbe.org/2poq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2poq RCSB], [http://www.ebi.ac.uk/pdbsum/2poq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2poq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2poq OCA], [http://pdbe.org/2poq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2poq RCSB], [http://www.ebi.ac.uk/pdbsum/2poq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2poq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/po/2poq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/po/2poq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:35, 7 February 2016

OCA — Sun, 07 Feb 2016 17:35:28 GMT

←Older revision		Revision as of 17:35, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2poq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:41, 10 September 2015

OCA — Thu, 10 Sep 2015 03:41:10 GMT

←Older revision		Revision as of 03:41, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2poq' size='340' side='right' caption='[[2poq]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='2poq' size='340' side='right' caption='[[2poq]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2poq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Macaca_fascicularis Macaca fascicularis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2POQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2poq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Crab-eating_macaque Crab-eating macaque]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2POQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ISD:(5R)-5-[(1R)-1,2-DIHYDROXYETHYL]-3,4-DIHYDROXYFURAN-2(5H)-ONE'>ISD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ISD:(5R)-5-[(1R)-1,2-DIHYDROXYETHYL]-3,4-DIHYDROXYFURAN-2(5H)-ONE'>ISD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o48\|2o48]], [[2o4u\|2o4u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o48\|2o48]], [[2o4u\|2o4u]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CMO2DD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9541 ~~Macaca fascicularis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CMO2DD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9541 Crab-eating macaque])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trans-1,2-dihydrobenzene-1,2-diol_dehydrogenase Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.20 1.3.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trans-1,2-dihydrobenzene-1,2-diol_dehydrogenase Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.20 1.3.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2poq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2poq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2poq RCSB], [http://www.ebi.ac.uk/pdbsum/2poq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2poq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2poq OCA], [http://pdbe.org/2poq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2poq RCSB], [http://www.ebi.ac.uk/pdbsum/2poq PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2poq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Macaca fascicularis~~]]	+	[[Category: Crab-eating macaque]]
	[[Category: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase]]		[[Category: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase]]
	[[Category: Carbone, V]]		[[Category: Carbone, V]]

OCA at 18:34, 19 January 2015

OCA — Mon, 19 Jan 2015 18:34:08 GMT

OCA at 20:17, 30 September 2014

OCA — Tue, 30 Sep 2014 20:17:21 GMT

←Older revision		Revision as of 20:17, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2poq.~~png~~\|~~left~~\|200px]]	+	==Dimeric Dihydrodiol Dehydrogenase complexed with inhibitor, Isoascorbic acid==
		+	<StructureSection load='2poq' size='340' side='right' caption='[[2poq]], [[Resolution\|resolution]] 2.59Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2poq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2POQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ISD:(5R)-5-[(1R)-1,2-DIHYDROXYETHYL]-3,4-DIHYDROXYFURAN-2(5H)-ONE'>ISD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o48\|2o48]], [[2o4u\|2o4u]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CMO2DD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9541 Macaca fascicularis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trans-1,2-dihydrobenzene-1,2-diol_dehydrogenase Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.20 1.3.1.20] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2poq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2poq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2poq RCSB], [http://www.ebi.ac.uk/pdbsum/2poq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/po/2poq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mammalian dimeric dihydrodiol dehydrogenase (DD) is identical to NADP+-dependent D-xylose dehydrogenase. A recent investigation showed that the three-dimensional structure of monkey DD is similar to those of prokaryotic NADP(H)-dependent glucose-fructose oxidoreductase (GFO) and 1,5-anhydro-D-fructose reductase (AFR); however, it differs in coenzyme-binding and catalytic residues. Dimeric DD has a high affinity for NADP(H) when compared with AFR and differs from both GFO and AFR in its specificity for sugars and hydrophobic xenobiotic compounds as substrates. The crystal structure of monkey dimeric DD complexed with the inhibitor isoascorbic acid has been determined at 2.59 angstroms resolution. Molecular modelling of coenzyme binding complemented with site-directed mutagenesis has been utilized to propose a binding mode for the coenzyme molecule and to gain insights into the roles of the residues comprising the active site and coenzyme-binding domain of DD. Several key residues have been identified within the coenzyme-binding domain, including Arg37, Arg41, His76 and His79, that contribute to the high affinity for coenzyme. The interaction of Arg37 and Arg41 with the 2'-phosphate and adenine-ring moiety of the coenzyme has been established from the large increases (29-fold to 438-fold) in the Kd values for NADP(H) for the R37D and R41D mutant enzymes. The mutation of several residues lining the inhibitor-binding site of DD suggested the involvement of Trp125, Phe154, Trp254 and Phe279 in determining the broad substrate specificity and inhibitor potency of the enzyme. In addition, mutants of Lys97, which is present near the catalytic residue Tyr180, greatly reduced the kcat value without changing the Kd values for coenzyme, suggesting the importance of Lys97 in the catalytic mechanism of DD.

-	~~{{STRUCTURE_2poq\| PDB=2poq \| SCENE= }}~~	+	Structure of monkey dimeric dihydrodiol dehydrogenase in complex with isoascorbic acid.,Carbone V, Sumii R, Ishikura S, Asada Y, Hara A, El-Kabbani O Acta Crystallogr D Biol Crystallogr. 2008 May;64(Pt 5):532-42. Epub 2008, Apr 19. PMID:18453689<ref>PMID:18453689</ref>

-	~~===Dimeric Dihydrodiol Dehydrogenase complexed with inhibitor~~, ~~Isoascorbic acid===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18453689}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2poq]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Macaca_fascicularis Macaca fascicularis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018453689<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Macaca fascicularis]]		[[Category: Macaca fascicularis]]
	[[Category: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase]]		[[Category: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase]]

OCA: Protected "2poq" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 15:20:33 GMT

Protected "2poq" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:20, 7 January 2013

OCA at 15:20, 7 January 2013

OCA — Mon, 07 Jan 2013 15:20:29 GMT

←Older revision		Revision as of 15:20, 7 January 2013
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-	{{Seed}}
	[[Image:2poq.png\|left\|200px]]		[[Image:2poq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2poq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2poq\| PDB=2poq \| SCENE= }}		{{STRUCTURE_2poq\| PDB=2poq \| SCENE= }}

	===Dimeric Dihydrodiol Dehydrogenase complexed with inhibitor, Isoascorbic acid===		===Dimeric Dihydrodiol Dehydrogenase complexed with inhibitor, Isoascorbic acid===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18453689}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18453689 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18453689}}		{{ABSTRACT_PUBMED_18453689}}

	==About this Structure==		==About this Structure==
-	~~2POQ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA].	+	[[2poq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18453689~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018453689</ref><references group="xtra"/>
	[[Category: Macaca fascicularis]]		[[Category: Macaca fascicularis]]
	[[Category: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase]]		[[Category: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase]]
Line 31:		Line 19:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Predominantly anti-parallel beta sheet]]		[[Category: Predominantly anti-parallel beta sheet]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:28:18 2009''

OCA at 13:28, 16 February 2009

OCA — Mon, 16 Feb 2009 13:28:20 GMT

←Older revision		Revision as of 13:28, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2POQ is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA].	+	2POQ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA].

	==Reference==		==Reference==
-	Structure of monkey dimeric dihydrodiol dehydrogenase in complex with isoascorbic acid., Carbone V, Sumii R, Ishikura S, Asada Y, Hara A, El-Kabbani O, Acta Crystallogr D Biol Crystallogr. 2008 May;64(Pt 5):532-42. Epub 2008, Apr 19. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18453689 18453689]~~	+	<ref group="xtra">PMID:18453689</ref><references group="xtra"/>
	[[Category: Macaca fascicularis]]		[[Category: Macaca fascicularis]]
-	[[Category: Single protein]]
	[[Category: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase]]		[[Category: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase]]
	[[Category: Carbone, V.]]		[[Category: Carbone, V.]]
Line 33:		Line 32:
	[[Category: Predominantly anti-parallel beta sheet]]		[[Category: Predominantly anti-parallel beta sheet]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 18~~:22:~~15 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:28:18 2009''

←Older revision		Revision as of 18:34, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2poq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2POQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2poq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2POQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ISD:(5R)-5-[(1R)-1,2-DIHYDROXYETHYL]-3,4-DIHYDROXYFURAN-2(5H)-ONE'>ISD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ISD:(5R)-5-[(1R)-1,2-DIHYDROXYETHYL]-3,4-DIHYDROXYFURAN-2(5H)-ONE'>ISD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o48\|2o48]], [[2o4u\|2o4u]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2o48\|2o48]], [[2o4u\|2o4u]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CMO2DD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9541 Macaca fascicularis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CMO2DD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9541 Macaca fascicularis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trans-1,2-dihydrobenzene-1,2-diol_dehydrogenase Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.20 1.3.1.20] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trans-1,2-dihydrobenzene-1,2-diol_dehydrogenase Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.20 1.3.1.20] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2poq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2poq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2poq RCSB], [http://www.ebi.ac.uk/pdbsum/2poq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2poq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2poq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2poq RCSB], [http://www.ebi.ac.uk/pdbsum/2poq PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	[[Category: Macaca fascicularis]]		[[Category: Macaca fascicularis]]
	[[Category: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase]]		[[Category: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase]]
-	[[Category: Carbone, V.]]	+	[[Category: Carbone, V]]
-	[[Category: El-Kabbani, O.]]	+	[[Category: El-Kabbani, O]]
	[[Category: Nadp-binding rossmann-fold domain]]		[[Category: Nadp-binding rossmann-fold domain]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Predominantly anti-parallel beta sheet]]		[[Category: Predominantly anti-parallel beta sheet]]