2q34 - Revision history

OCA at 11:16, 30 August 2023

OCA — Wed, 30 Aug 2023 11:16:59 GMT

←Older revision		Revision as of 11:16, 30 August 2023
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	<StructureSection load='2q34' size='340' side='right'caption='[[2q34]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2q34' size='340' side='right'caption='[[2q34]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q34]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lyngbya_majuscula_19l Lyngbya majuscula 19l~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q34]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorena_producens_19L Moorena producens 19L]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q34 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[2q2x\|2q2x]]~~, [[~~2q35~~\|~~2q35~~]]~~</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~curF ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=276768 Lyngbya majuscula 19L])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q34 OCA], [https://pdbe.org/2q34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q34 RCSB], [https://www.ebi.ac.uk/pdbsum/2q34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q34 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q34 OCA], [https://pdbe.org/2q34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q34 RCSB], [https://www.ebi.ac.uk/pdbsum/2q34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q34 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6DNE7_9CYAN Q6DNE7_9CYAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lyngbya majuscula 19l~~]]	+	[[Category: Moorena producens 19L]]
-	[[Category: Geders~~, T W~~]]	+	[[Category: Geders TW]]
-	[[Category: Mowers~~, J C~~]]	+	[[Category: Mowers JC]]
-	[[Category: Smith~~, J L]]~~	+	[[Category: Smith JL]]
-	~~[[Category: Crotonase]]~~	+
-	~~[[Category: Lyase~~]]	+

OCA at 08:06, 25 June 2021

OCA — Fri, 25 Jun 2021 08:06:24 GMT

←Older revision		Revision as of 08:06, 25 June 2021
Line 1:		Line 1:

	==Crystal Structure of the ECH2 decarboxylase domain of CurF from Lyngbya majuscula, rhombohedral crystal form==		==Crystal Structure of the ECH2 decarboxylase domain of CurF from Lyngbya majuscula, rhombohedral crystal form==
-	<StructureSection load='2q34' size='340' side='right' caption='[[2q34]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='2q34' size='340' side='right'caption='[[2q34]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q34]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lyngbya_majuscula_19l Lyngbya majuscula 19l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q34 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Q34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q34]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lyngbya_majuscula_19l Lyngbya majuscula 19l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q34 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q2x\|2q2x]], [[2q35\|2q35]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2q2x\|2q2x]], [[2q35\|2q35]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">curF ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=276768 Lyngbya majuscula 19L])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">curF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=276768 Lyngbya majuscula 19L])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2q34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q34 OCA], [~~http~~://pdbe.org/2q34 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2q34 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2q34 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2q34 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q34 OCA], [https://pdbe.org/2q34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q34 RCSB], [https://www.ebi.ac.uk/pdbsum/2q34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q34 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q34_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q34_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lyngbya majuscula 19l]]		[[Category: Lyngbya majuscula 19l]]
	[[Category: Geders, T W]]		[[Category: Geders, T W]]

OCA at 09:38, 18 October 2017

OCA — Wed, 18 Oct 2017 09:38:36 GMT

←Older revision		Revision as of 09:38, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the ECH2 decarboxylase domain of CurF from Lyngbya majuscula, rhombohedral crystal form==		==Crystal Structure of the ECH2 decarboxylase domain of CurF from Lyngbya majuscula, rhombohedral crystal form==
	<StructureSection load='2q34' size='340' side='right' caption='[[2q34]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2q34' size='340' side='right' caption='[[2q34]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q2x\|2q2x]], [[2q35\|2q35]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q2x\|2q2x]], [[2q35\|2q35]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">curF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=276768 Lyngbya majuscula 19L])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">curF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=276768 Lyngbya majuscula 19L])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q34 OCA], [http://pdbe.org/2q34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q34 RCSB], [http://www.ebi.ac.uk/pdbsum/2q34 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q34 OCA], [http://pdbe.org/2q34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q34 RCSB], [http://www.ebi.ac.uk/pdbsum/2q34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2q34 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q34 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:06, 12 September 2015

OCA — Sat, 12 Sep 2015 02:06:21 GMT

←Older revision		Revision as of 02:06, 12 September 2015
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q2x\|2q2x]], [[2q35\|2q35]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q2x\|2q2x]], [[2q35\|2q35]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">curF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=276768 Lyngbya majuscula 19L])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">curF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=276768 Lyngbya majuscula 19L])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q34 RCSB], [http://www.ebi.ac.uk/pdbsum/2q34 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q34 OCA], [http://pdbe.org/2q34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q34 RCSB], [http://www.ebi.ac.uk/pdbsum/2q34 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2q34" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:23, 19 January 2015

OCA — Mon, 19 Jan 2015 17:23:59 GMT

←Older revision		Revision as of 17:23, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2q34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lyngbya_majuscula_19l Lyngbya majuscula 19l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q34 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2q34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lyngbya_majuscula_19l Lyngbya majuscula 19l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q34 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q2x\|2q2x]], [[2q35\|2q35]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q2x\|2q2x]], [[2q35\|2q35]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">curF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=276768 Lyngbya majuscula 19L])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">curF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=276768 Lyngbya majuscula 19L])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q34 RCSB], [http://www.ebi.ac.uk/pdbsum/2q34 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q34 RCSB], [http://www.ebi.ac.uk/pdbsum/2q34 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Lyngbya majuscula 19l]]		[[Category: Lyngbya majuscula 19l]]
-	[[Category: Geders, T W.]]	+	[[Category: Geders, T W]]
-	[[Category: Mowers, J C.]]	+	[[Category: Mowers, J C]]
-	[[Category: Smith, J L.]]	+	[[Category: Smith, J L]]
	[[Category: Crotonase]]		[[Category: Crotonase]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 19:55, 30 September 2014

OCA — Tue, 30 Sep 2014 19:55:37 GMT

←Older revision		Revision as of 19:55, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2q34.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the ECH2 decarboxylase domain of CurF from Lyngbya majuscula, rhombohedral crystal form==
		+	<StructureSection load='2q34' size='340' side='right' caption='[[2q34]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2q34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lyngbya_majuscula_19l Lyngbya majuscula 19l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q34 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q2x\|2q2x]], [[2q35\|2q35]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">curF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=276768 Lyngbya majuscula 19L])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q34 RCSB], [http://www.ebi.ac.uk/pdbsum/2q34 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q34_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Curacin A is a mixed polyketide/nonribosomal peptide possessing anti-mitotic and anti-proliferative activity. In the biosynthesis of curacin A, the N-terminal domain of the CurF multifunctional protein catalyzes decarboxylation of 3-methylglutaconyl-acyl carrier protein (ACP) to 3-methylcrotonyl-ACP, the postulated precursor of the cyclopropane ring of curacin A. This decarboxylase is encoded within an "HCS cassette" that is used by several other polyketide biosynthetic systems to generate chemical diversity by introduction of a beta-branch functional group to the natural product. The crystal structure of the CurF N-terminal ECH(2) domain establishes that the protein is a crotonase superfamily member. Ala(78) and Gly(118) form an oxyanion hole in the active site that includes only three polar side chains as potential catalytic residues. Site-directed mutagenesis and a biochemical assay established critical functions for His(240) and Lys(86), whereas Tyr(82) was nonessential. A decarboxylation mechanism is proposed in which His(240) serves to stabilize the substrate carboxylate and Lys(86) donates a proton to C-4 of the acyl-ACP enolate intermediate to form the Delta(2) unsaturated isopentenoyl-ACP product. The CurF ECH(2) domain showed a 20-fold selectivity for ACP-over CoA-linked substrates. Specificity for ACP-linked substrates has not been reported for any other crotonase superfamily decarboxylase. Tyr(73) may select against CoA-linked substrates by blocking a contact of Arg(38) with the CoA adenosine 5'-phosphate.

-	~~{{STRUCTURE_2q34\| PDB=2q34 \| SCENE= }}~~	+	Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching.,Geders TW, Gu L, Mowers JC, Liu H, Gerwick WH, Hakansson K, Sherman DH, Smith JL J Biol Chem. 2007 Dec 7;282(49):35954-63. Epub 2007 Oct 10. PMID:17928301<ref>PMID:17928301</ref>

-	~~===Crystal Structure~~ of the ~~ECH2 decarboxylase domain of CurF from Lyngbya majuscula, rhombohedral crystal form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17928301}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2q34]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lyngbya_majuscula_19l Lyngbya majuscula 19l]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2Q34 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017928301<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Lyngbya majuscula 19l]]		[[Category: Lyngbya majuscula 19l]]
	[[Category: Geders, T W.]]		[[Category: Geders, T W.]]

OCA: Protected "2q34" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:46:53 GMT

Protected "2q34" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:46, 7 January 2013

OCA at 22:46, 7 January 2013

OCA — Mon, 07 Jan 2013 22:46:51 GMT

←Older revision		Revision as of 22:46, 7 January 2013
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-	{{Seed}}
	[[Image:2q34.png\|left\|200px]]		[[Image:2q34.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2q34", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2q34\| PDB=2q34 \| SCENE= }}		{{STRUCTURE_2q34\| PDB=2q34 \| SCENE= }}

	===Crystal Structure of the ECH2 decarboxylase domain of CurF from Lyngbya majuscula, rhombohedral crystal form===		===Crystal Structure of the ECH2 decarboxylase domain of CurF from Lyngbya majuscula, rhombohedral crystal form===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17928301}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17928301 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_17928301}}		{{ABSTRACT_PUBMED_17928301}}

	==About this Structure==		==About this Structure==
-	~~2Q34~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Lyngbya_majuscula~~ Lyngbya majuscula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q34 OCA].	+	[[2q34]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lyngbya_majuscula_19l Lyngbya majuscula 19l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q34 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17928301~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017928301</ref><references group="xtra"/>
-	[[Category: Lyngbya majuscula]]	+	[[Category: Lyngbya majuscula 19l]]
	[[Category: Geders, T W.]]		[[Category: Geders, T W.]]
	[[Category: Mowers, J C.]]		[[Category: Mowers, J C.]]
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	[[Category: Crotonase]]		[[Category: Crotonase]]
	[[Category: Lyase]]		[[Category: Lyase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:43:28 2009''

OCA at 07:43, 18 February 2009

OCA — Wed, 18 Feb 2009 07:43:30 GMT

←Older revision		Revision as of 07:43, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2Q34 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Lyngbya_majuscula Lyngbya majuscula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q34 OCA].	+	2Q34 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Lyngbya_majuscula Lyngbya majuscula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q34 OCA].

	==Reference==		==Reference==
-	Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching., Geders TW, Gu L, Mowers JC, Liu H, Gerwick WH, Hakansson K, Sherman DH, Smith JL, J Biol Chem. 2007 Dec 7;282(49):35954-63. Epub 2007 Oct 10. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17928301 17928301]~~	+	<ref group="xtra">PMID:17928301</ref><references group="xtra"/>
	[[Category: Lyngbya majuscula]]		[[Category: Lyngbya majuscula]]
-	[[Category: Single protein]]
	[[Category: Geders, T W.]]		[[Category: Geders, T W.]]
	[[Category: Mowers, J C.]]		[[Category: Mowers, J C.]]
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	[[Category: Lyase]]		[[Category: Lyase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 16~~:02:~~02 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:43:28 2009''

OCA at 13:02, 29 July 2008

OCA — Tue, 29 Jul 2008 13:02:07 GMT

←Older revision		Revision as of 13:02, 29 July 2008
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-	[[Image:2q34.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2q34.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2q34\| PDB=2q34 \| SCENE= }}		{{STRUCTURE_2q34\| PDB=2q34 \| SCENE= }}

-	~~'''~~Crystal Structure of the ECH2 decarboxylase domain of CurF from Lyngbya majuscula, rhombohedral crystal form~~'''~~	+	===Crystal Structure of the ECH2 decarboxylase domain of CurF from Lyngbya majuscula, rhombohedral crystal form===


-	~~==Overview==~~	+	<!--
-	~~Curacin A is a mixed polyketide/nonribosomal peptide possessing anti~~-~~mitotic and anti~~-~~proliferative activity. In the biosynthesis of curacin A~~, ~~the N-terminal domain of the CurF multifunctional protein catalyzes decarboxylation of 3-methylglutaconyl-acyl carrier protein (ACP) to 3-methylcrotonyl-ACP~~, the postulated precursor of the cyclopropane ring of curacin A. This decarboxylase is encoded within an "HCS cassette" that is used by several other polyketide biosynthetic systems to generate chemical diversity by introduction of a beta-branch functional group to the ~~natural product. The crystal structure of the CurF N-terminal ECH~~(~~2) domain establishes that the protein is a crotonase superfamily member. Ala(78) and Gly(118) form an oxyanion hole in the active site that includes only three polar side chains~~ as ~~potential catalytic residues~~. ~~Site-directed mutagenesis and a biochemical assay established critical functions for His(240) and Lys(86~~), ~~whereas Tyr(82) was nonessential. A decarboxylation mechanism~~ is ~~proposed in which His(240) serves to stabilize~~ the ~~substrate carboxylate and Lys(86) donates a proton to C-4 of the acyl-ACP enolate intermediate to form the Delta(2) unsaturated isopentenoyl-ACP product~~. ~~The CurF ECH(2) domain showed a 20~~-~~fold selectivity for ACP~~-over CoA-linked substrates. Specificity for ACP-linked substrates has not been reported for any other crotonase superfamily decarboxylase. Tyr(73) may select against CoA-linked substrates by blocking a contact of Arg(38) with the CoA adenosine 5'-phosphate.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17928301}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17928301 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17928301}}

	==About this Structure==		==About this Structure==
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	[[Category: Crotonase]]		[[Category: Crotonase]]
	[[Category: Lyase]]		[[Category: Lyase]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 14~~:14:10 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:02:02 2008''