2q7c - Revision history

OCA at 07:18, 29 March 2023

OCA — Wed, 29 Mar 2023 07:18:42 GMT

←Older revision		Revision as of 07:18, 29 March 2023
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	<StructureSection load='2q7c' size='340' side='right'caption='[[2q7c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2q7c' size='340' side='right'caption='[[2q7c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q7c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q7C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q7c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q7C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:~~CHLORIDE~~+~~ION~~'>CL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~ACE~~:~~ACETYL~~+~~GROUP~~'>~~ACE~~</scene~~></td></tr>~~	+
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2q5u\|2q5u]]</div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7c OCA], [https://pdbe.org/2q7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q7c RCSB], [https://www.ebi.ac.uk/pdbsum/2q7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q7c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7c OCA], [https://pdbe.org/2q7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q7c RCSB], [https://www.ebi.ac.uk/pdbsum/2q7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q7c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/A3F986_9HIV1 A3F986_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.[RuleBase:RU004292]	+	[https://www.uniprot.org/uniprot/A3F986_9HIV1 A3F986_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.[RuleBase:RU004292]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
		+	*[[Gcn4 3D Structures\|Gcn4 3D Structures]]
	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]		*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eckert~~, D M~~]]	+	[[Category: Eckert DM]]
-	[[Category: Hong~~, L H~~]]	+	[[Category: Hong LH]]
-	[[Category: Kim~~, P S~~]]	+	[[Category: Kim PS]]
-	[[Category: Malashkevich~~, V N]]~~	+	[[Category: Malashkevich VN]]
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Envelope glycoprotein]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Viral protein/viral protein inhibitor~~]]	+

OCA at 08:10, 25 June 2021

OCA — Fri, 25 Jun 2021 08:10:53 GMT

←Older revision		Revision as of 08:10, 25 June 2021
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	<StructureSection load='2q7c' size='340' side='right'caption='[[2q7c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2q7c' size='340' side='right'caption='[[2q7c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q7c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Q7C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q7c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q7C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q5u\|2q5u]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2q5u\|2q5u]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2q7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7c OCA], [~~http~~://pdbe.org/2q7c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2q7c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2q7c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2q7c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7c OCA], [https://pdbe.org/2q7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q7c RCSB], [https://www.ebi.ac.uk/pdbsum/2q7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q7c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/A3F986_9HIV1 A3F986_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.[RuleBase:RU004292]	+	[[https://www.uniprot.org/uniprot/A3F986_9HIV1 A3F986_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.[RuleBase:RU004292]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:21, 31 July 2019

OCA — Wed, 31 Jul 2019 07:21:45 GMT

←Older revision		Revision as of 07:21, 31 July 2019
Line 1:		Line 1:

	==Crystal structure of IQN17==		==Crystal structure of IQN17==
-	<StructureSection load='2q7c' size='340' side='right' caption='[[2q7c]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2q7c' size='340' side='right'caption='[[2q7c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2q7c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q7C FirstGlance]. <br>		<table><tr><td colspan='2'>[[2q7c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q7C FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 2q7c" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2q7c" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Eckert, D M]]		[[Category: Eckert, D M]]
	[[Category: Hong, L H]]		[[Category: Hong, L H]]

OCA at 09:40, 18 October 2017

OCA — Wed, 18 Oct 2017 09:40:30 GMT

←Older revision		Revision as of 09:40, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of IQN17==		==Crystal structure of IQN17==
	<StructureSection load='2q7c' size='340' side='right' caption='[[2q7c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2q7c' size='340' side='right' caption='[[2q7c]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q5u\|2q5u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q5u\|2q5u]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7c OCA], [http://pdbe.org/2q7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q7c RCSB], [http://www.ebi.ac.uk/pdbsum/2q7c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7c OCA], [http://pdbe.org/2q7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q7c RCSB], [http://www.ebi.ac.uk/pdbsum/2q7c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2q7c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 2q7c" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2q7c" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Gcn4\|Gcn4]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 28:
	[[Category: Kim, P S]]		[[Category: Kim, P S]]
	[[Category: Malashkevich, V N]]		[[Category: Malashkevich, V N]]
		+	[[Category: Coiled coil]]
	[[Category: Envelope glycoprotein]]		[[Category: Envelope glycoprotein]]
	[[Category: Viral protein]]		[[Category: Viral protein]]
	[[Category: Viral protein/viral protein inhibitor]]		[[Category: Viral protein/viral protein inhibitor]]

OCA at 23:36, 9 September 2015

OCA — Wed, 09 Sep 2015 23:36:32 GMT

←Older revision		Revision as of 23:36, 9 September 2015
Line 6:		Line 6:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q5u\|2q5u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q5u\|2q5u]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q7c RCSB], [http://www.ebi.ac.uk/pdbsum/2q7c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7c OCA], [http://pdbe.org/2q7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q7c RCSB], [http://www.ebi.ac.uk/pdbsum/2q7c PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A3F986_9HIV1 A3F986_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.[RuleBase:RU004292]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2q7c" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:33, 22 January 2015

OCA — Thu, 22 Jan 2015 06:33:40 GMT

←Older revision		Revision as of 06:33, 22 January 2015
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Gcn4\|Gcn4]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Eckert, D M.]]	+	[[Category: Eckert, D M]]
-	[[Category: Hong, L H.]]	+	[[Category: Hong, L H]]
-	[[Category: Kim, P S.]]	+	[[Category: Kim, P S]]
-	[[Category: Malashkevich, V N.]]	+	[[Category: Malashkevich, V N]]
	[[Category: Envelope glycoprotein]]		[[Category: Envelope glycoprotein]]
	[[Category: Viral protein]]		[[Category: Viral protein]]
	[[Category: Viral protein/viral protein inhibitor]]		[[Category: Viral protein/viral protein inhibitor]]

OCA at 11:22, 20 October 2014

OCA — Mon, 20 Oct 2014 11:22:57 GMT

←Older revision		Revision as of 11:22, 20 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2q7c.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of IQN17==
		+	<StructureSection load='2q7c' size='340' side='right' caption='[[2q7c]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2q7c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q7C FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q5u\|2q5u]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q7c RCSB], [http://www.ebi.ac.uk/pdbsum/2q7c PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The HIV-1 gp41 protein promotes viral entry by mediating the fusion of viral and cellular membranes. A prominent pocket on the surface of a central trimeric coiled coil within gp41 was previously identified as a potential target for drugs that inhibit HIV-1 entry. We designed a peptide, IQN17, which properly presents this pocket. Utilizing IQN17 and mirror-image phage display, we identified cyclic, D-peptide inhibitors of HIV-1 infection that share a sequence motif. A 1.5 A cocrystal structure of IQN17 in complex with a D-peptide, and NMR studies, show that conserved residues of these inhibitors make intimate contact with the gp41 pocket. Our studies validate the pocket per se as a target for drug development. IQN17 and these D-peptide inhibitors are likely to be useful for development and identification of a new class of orally bioavailable anti-HIV drugs.

-	~~{{STRUCTURE_2q7c\| PDB=2q7c \| SCENE= }}~~	+	Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket.,Eckert DM, Malashkevich VN, Hong LH, Carr PA, Kim PS Cell. 1999 Oct 1;99(1):103-15. PMID:10520998<ref>PMID:10520998</ref>

-	~~===Crystal structure~~ of ~~IQN17===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10520998}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2q7c]] is a 3 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2Q7C OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010520998<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Eckert, D M.]]		[[Category: Eckert, D M.]]
	[[Category: Hong, L H.]]		[[Category: Hong, L H.]]

OCA: Protected "2q7c" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:58:59 GMT

Protected "2q7c" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:58, 7 January 2013

OCA at 19:58, 7 January 2013

OCA — Mon, 07 Jan 2013 19:58:55 GMT

←Older revision		Revision as of 19:58, 7 January 2013
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-	{{Seed}}
	[[Image:2q7c.png\|left\|200px]]		[[Image:2q7c.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2q7c", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2q7c\| PDB=2q7c \| SCENE= }}		{{STRUCTURE_2q7c\| PDB=2q7c \| SCENE= }}

	===Crystal structure of IQN17===		===Crystal structure of IQN17===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10520998}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10520998 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_10520998}}		{{ABSTRACT_PUBMED_10520998}}

	==About this Structure==		==About this Structure==
-	~~2Q7C is a~~ [[~~Single protein~~]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7C OCA].	+	[[2q7c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7C OCA].

	==Reference==		==Reference==
-	~~Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket., Eckert DM, Malashkevich VN, Hong LH, Carr PA, Kim PS, Cell. 1999 Oct 1;99(1):103-15.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/10520998 10520998]~~	+	<ref group="xtra">PMID:010520998</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Eckert, D M.]]		[[Category: Eckert, D M.]]
	[[Category: Hong, L H.]]		[[Category: Hong, L H.]]
	[[Category: Kim, P S.]]		[[Category: Kim, P S.]]
	[[Category: Malashkevich, V N.]]		[[Category: Malashkevich, V N.]]
-	[[Category: Coiled coil]]
	[[Category: Envelope glycoprotein]]		[[Category: Envelope glycoprotein]]
		+	[[Category: Viral protein]]
	[[Category: Viral protein/viral protein inhibitor]]		[[Category: Viral protein/viral protein inhibitor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:48:41 2008''

OCA at 11:48, 27 July 2008

OCA — Sun, 27 Jul 2008 11:48:42 GMT

←Older revision		Revision as of 11:48, 27 July 2008
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-	[[Image:2q7c.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2q7c.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2q7c\| PDB=2q7c \| SCENE= }}		{{STRUCTURE_2q7c\| PDB=2q7c \| SCENE= }}

-	~~'''~~Crystal structure of IQN17~~'''~~	+	===Crystal structure of IQN17===


-	~~==Overview==~~	+	<!--
-	The ~~HIV-1 gp41 protein promotes viral entry by mediating~~ the ~~fusion of viral and cellular membranes. A prominent pocket on~~ the ~~surface of a central trimeric coiled coil within gp41 was previously identified~~ as ~~a potential target for drugs that inhibit HIV-1 entry~~. ~~We designed a peptide, IQN17, which properly presents this pocket~~. Utilizing IQN17 and mirror-image phage display, we identified cyclic, D-peptide inhibitors of HIV-1 infection that share a sequence motif. A 1.5 A cocrystal structure of IQN17 in complex with a D-peptide, and NMR studies, ~~show that conserved residues of these inhibitors make intimate contact with~~ the ~~gp41 pocket~~. ~~Our studies validate the pocket per se as a target for drug development. IQN17 and these D~~-~~peptide inhibitors are likely to be useful for development and identification of a new class of orally bioavailable anti~~-~~HIV drugs.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_10520998}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 10520998 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_10520998}}

	==About this Structure==		==About this Structure==
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	[[Category: Envelope glycoprotein]]		[[Category: Envelope glycoprotein]]
	[[Category: Viral protein/viral protein inhibitor]]		[[Category: Viral protein/viral protein inhibitor]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4~~ 14:28:36 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:48:41 2008''