2q7z - Revision history

OCA at 09:14, 21 February 2024

OCA — Wed, 21 Feb 2024 09:14:36 GMT

←Older revision		Revision as of 09:14, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='2q7z' size='340' side='right'caption='[[2q7z]]' scene=''>		<StructureSection load='2q7z' size='340' side='right'caption='[[2q7z]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q7z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q7Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q7z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q7Z FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1gkn\|1gkn]], [[1gkg\|1gkg]], [[1ppq\|1ppq]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CR1, C3BR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7z OCA], [https://pdbe.org/2q7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q7z RCSB], [https://www.ebi.ac.uk/pdbsum/2q7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q7z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7z OCA], [https://pdbe.org/2q7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q7z RCSB], [https://www.ebi.ac.uk/pdbsum/2q7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CR1_HUMAN CR1_HUMAN]] Mediates cellular binding of particles and immune complexes that have activated complement.	+	[https://www.uniprot.org/uniprot/CR1_HUMAN CR1_HUMAN] Mediates cellular binding of particles and immune complexes that have activated complement.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q7z ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q7z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Human complement receptor type 1 (CR1, CD35) is a type I membrane-bound glycoprotein that belongs to the regulators of complement activity (RCA) family. The extra-cellular component of CR1 is comprised of 30 short complement regulator (SCR) domains, whereas complement receptor type 2 (CR2) has 15 SCR domains and factor H (FH) has 20 SCR domains. The domain arrangement of a soluble form of CR1 (sCR1) was studied by X-ray scattering and analytical ultracentrifugation. The radius of gyration R(G) of sCR1 of 13.4(+/-1.1) nm is not much greater than those for CR2 and FH, and its R(G)/R(0) anisotropy ratio is 3.76, compared to ratios of 3.67 for FH and 4.1 for CR2. Unlike CR2, but similar to FH, two cross-sectional R(G) ranges were identified that gave R(XS) values of 4.7(+/-0.2) nm and 1.2(+/-0.7) nm, respectively, showing that the SCR domains adopt a range of conformations including folded-back ones. The distance distribution function P(r) showed that the most commonly occurring distance in sCR1 is at 11.5 nm. Its maximum length of 55 nm is less than double those for CR2 or FH, even though sCR1 has twice the number of SCR domains compared to CR2 Sedimentation equilibrium experiments gave a mean molecular weight of 235 kDa for sCR1. This is consistent with the value of 245 kDa calculated from its composition including 14 N-linked oligosaccharide sites, and confirmed that sCR1 is a monomer in solution. Sedimentation velocity experiments gave a sedimentation coefficient of 5.8 S. From this, the frictional ratio (f/f(0)) of sCR1 was calculated to be 2.29, which is greater than those of 1.96 for CR2 and 1.77 for FH. The constrained scattering modelling of the sCR1 solution structure starting from homologous SCR domain structures generated 5000 trial conformationally randomised models, 43 of which gave good scattering fits to show that sCR1 has a partly folded-back structure. We conclude that the inter-SCR linkers show structural features in common with those in FH, but differ from those in CR2, and the SCR arrangement in CR1 will permit C3b or C4b to access all three ligand sites.
-
-	The partly folded back solution structure arrangement of the 30 SCR domains in human complement receptor type 1 (CR1) permits access to its C3b and C4b ligands.,Furtado PB, Huang CY, Ihyembe D, Hammond RA, Marsh HC, Perkins SJ J Mol Biol. 2008 Jan 4;375(1):102-18. Epub 2007 Oct 3. PMID:18028942<ref>PMID:18028942</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2q7z" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Furtado~~, P B~~]]	+	[[Category: Furtado PB]]
-	[[Category: Hammond~~, R A~~]]	+	[[Category: Hammond RA]]
-	[[Category: Huang~~, C Y~~]]	+	[[Category: Huang CY]]
-	[[Category: Ihyembe, D]]	+	[[Category: Ihyembe D]]
-	[[Category: Marsh~~, H C~~]]	+	[[Category: Marsh HC]]
-	[[Category: Perkins~~, S J]]~~	+	[[Category: Perkins SJ]]
-	~~[[Category: Blood group antigen]]~~	+
-	~~[[Category: Complement]]~~	+
-	~~[[Category: Complement pathway]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Innate immunity]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Pyrrolidone carboxylic acid]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Scr domain]]~~	+
-	~~[[Category: Sushi]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 08:11, 25 June 2021

OCA — Fri, 25 Jun 2021 08:11:29 GMT

←Older revision		Revision as of 08:11, 25 June 2021
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	==Solution Structure of the 30 SCR domains of human Complement Receptor 1==		==Solution Structure of the 30 SCR domains of human Complement Receptor 1==
-	<StructureSection load='2q7z' size='340' side='right' caption='[[2q7z]]' scene=''>	+	<StructureSection load='2q7z' size='340' side='right'caption='[[2q7z]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q7z]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Q7Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q7z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q7Z FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gkn\|1gkn]], [[1gkg\|1gkg]], [[1ppq\|1ppq]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gkn\|1gkn]], [[1gkg\|1gkg]], [[1ppq\|1ppq]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CR1, C3BR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CR1, C3BR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2q7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7z OCA], [~~http~~://pdbe.org/2q7z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2q7z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2q7z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2q7z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7z OCA], [https://pdbe.org/2q7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q7z RCSB], [https://www.ebi.ac.uk/pdbsum/2q7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CR1_HUMAN CR1_HUMAN]] Mediates cellular binding of particles and immune complexes that have activated complement.	+	[[https://www.uniprot.org/uniprot/CR1_HUMAN CR1_HUMAN]] Mediates cellular binding of particles and immune complexes that have activated complement.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/2q7z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/2q7z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Furtado, P B]]		[[Category: Furtado, P B]]
	[[Category: Hammond, R A]]		[[Category: Hammond, R A]]

OCA at 09:40, 18 October 2017

OCA — Wed, 18 Oct 2017 09:40:45 GMT

←Older revision		Revision as of 09:40, 18 October 2017
Line 1:		Line 1:
		+
	==Solution Structure of the 30 SCR domains of human Complement Receptor 1==		==Solution Structure of the 30 SCR domains of human Complement Receptor 1==
	<StructureSection load='2q7z' size='340' side='right' caption='[[2q7z]]' scene=''>		<StructureSection load='2q7z' size='340' side='right' caption='[[2q7z]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gkn\|1gkn]], [[1gkg\|1gkg]], [[1ppq\|1ppq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gkn\|1gkn]], [[1gkg\|1gkg]], [[1ppq\|1ppq]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CR1, C3BR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CR1, C3BR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7z OCA], [http://pdbe.org/2q7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q7z RCSB], [http://www.ebi.ac.uk/pdbsum/2q7z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7z OCA], [http://pdbe.org/2q7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q7z RCSB], [http://www.ebi.ac.uk/pdbsum/2q7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2q7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q7z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:25, 11 September 2015

OCA — Fri, 11 Sep 2015 14:25:47 GMT

←Older revision		Revision as of 14:25, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2q7z' size='340' side='right' caption='[[2q7z]]' scene=''>		<StructureSection load='2q7z' size='340' side='right' caption='[[2q7z]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q7z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q7Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q7z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q7Z FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gkn\|1gkn]], [[1gkg\|1gkg]], [[1ppq\|1ppq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gkn\|1gkn]], [[1gkg\|1gkg]], [[1ppq\|1ppq]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CR1, C3BR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CR1, C3BR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q7z RCSB], [http://www.ebi.ac.uk/pdbsum/2q7z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7z OCA], [http://pdbe.org/2q7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q7z RCSB], [http://www.ebi.ac.uk/pdbsum/2q7z PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2q7z" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Furtado, P B]]		[[Category: Furtado, P B]]
	[[Category: Hammond, R A]]		[[Category: Hammond, R A]]

OCA at 17:41, 25 December 2014

OCA — Thu, 25 Dec 2014 17:41:29 GMT

←Older revision		Revision as of 17:41, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2q7z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q7Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[2q7z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q7Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gkn\|1gkn]], [[1gkg\|1gkg]], [[1ppq\|1ppq]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gkn\|1gkn]], [[1gkg\|1gkg]], [[1ppq\|1ppq]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CR1, C3BR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CR1, C3BR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q7z RCSB], [http://www.ebi.ac.uk/pdbsum/2q7z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q7z RCSB], [http://www.ebi.ac.uk/pdbsum/2q7z PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CR1_HUMAN CR1_HUMAN]] Mediates cellular binding of particles and immune complexes that have activated complement.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Furtado, P B.]]	+	[[Category: Furtado, P B]]
-	[[Category: Hammond, R A.]]	+	[[Category: Hammond, R A]]
-	[[Category: Huang, C Y.]]	+	[[Category: Huang, C Y]]
-	[[Category: Ihyembe, D.]]	+	[[Category: Ihyembe, D]]
-	[[Category: Marsh, H C.]]	+	[[Category: Marsh, H C]]
-	[[Category: Perkins, S J.]]	+	[[Category: Perkins, S J]]
	[[Category: Blood group antigen]]		[[Category: Blood group antigen]]
	[[Category: Complement]]		[[Category: Complement]]

OCA at 18:41, 30 September 2014

OCA — Tue, 30 Sep 2014 18:41:37 GMT

←Older revision		Revision as of 18:41, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2q7z.~~png~~\|~~left~~\|200px]]	+	==Solution Structure of the 30 SCR domains of human Complement Receptor 1==
		+	<StructureSection load='2q7z' size='340' side='right' caption='[[2q7z]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2q7z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q7Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gkn\|1gkn]], [[1gkg\|1gkg]], [[1ppq\|1ppq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CR1, C3BR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q7z RCSB], [http://www.ebi.ac.uk/pdbsum/2q7z PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/2q7z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human complement receptor type 1 (CR1, CD35) is a type I membrane-bound glycoprotein that belongs to the regulators of complement activity (RCA) family. The extra-cellular component of CR1 is comprised of 30 short complement regulator (SCR) domains, whereas complement receptor type 2 (CR2) has 15 SCR domains and factor H (FH) has 20 SCR domains. The domain arrangement of a soluble form of CR1 (sCR1) was studied by X-ray scattering and analytical ultracentrifugation. The radius of gyration R(G) of sCR1 of 13.4(+/-1.1) nm is not much greater than those for CR2 and FH, and its R(G)/R(0) anisotropy ratio is 3.76, compared to ratios of 3.67 for FH and 4.1 for CR2. Unlike CR2, but similar to FH, two cross-sectional R(G) ranges were identified that gave R(XS) values of 4.7(+/-0.2) nm and 1.2(+/-0.7) nm, respectively, showing that the SCR domains adopt a range of conformations including folded-back ones. The distance distribution function P(r) showed that the most commonly occurring distance in sCR1 is at 11.5 nm. Its maximum length of 55 nm is less than double those for CR2 or FH, even though sCR1 has twice the number of SCR domains compared to CR2 Sedimentation equilibrium experiments gave a mean molecular weight of 235 kDa for sCR1. This is consistent with the value of 245 kDa calculated from its composition including 14 N-linked oligosaccharide sites, and confirmed that sCR1 is a monomer in solution. Sedimentation velocity experiments gave a sedimentation coefficient of 5.8 S. From this, the frictional ratio (f/f(0)) of sCR1 was calculated to be 2.29, which is greater than those of 1.96 for CR2 and 1.77 for FH. The constrained scattering modelling of the sCR1 solution structure starting from homologous SCR domain structures generated 5000 trial conformationally randomised models, 43 of which gave good scattering fits to show that sCR1 has a partly folded-back structure. We conclude that the inter-SCR linkers show structural features in common with those in FH, but differ from those in CR2, and the SCR arrangement in CR1 will permit C3b or C4b to access all three ligand sites.

-	~~{{STRUCTURE_2q7z\| PDB=2q7z \| SCENE= }}~~	+	The partly folded back solution structure arrangement of the 30 SCR domains in human complement receptor type 1 (CR1) permits access to its C3b and C4b ligands.,Furtado PB, Huang CY, Ihyembe D, Hammond RA, Marsh HC, Perkins SJ J Mol Biol. 2008 Jan 4;375(1):102-18. Epub 2007 Oct 3. PMID:18028942<ref>PMID:18028942</ref>

-	~~===Solution Structure~~ of the ~~30 SCR domains of human Complement Receptor 1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18028942}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2q7z]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018028942<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Furtado, P B.]]		[[Category: Furtado, P B.]]

OCA: Protected "2q7z" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 21:21:18 GMT

Protected "2q7z" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:21, 7 January 2013

OCA at 21:21, 7 January 2013

OCA — Mon, 07 Jan 2013 21:21:15 GMT

←Older revision		Revision as of 21:21, 7 January 2013
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-	{{Seed}}
	[[Image:2q7z.png\|left\|200px]]		[[Image:2q7z.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2q7z", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2q7z\| PDB=2q7z \| SCENE= }}		{{STRUCTURE_2q7z\| PDB=2q7z \| SCENE= }}

	===Solution Structure of the 30 SCR domains of human Complement Receptor 1===		===Solution Structure of the 30 SCR domains of human Complement Receptor 1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18028942}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18028942 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18028942}}		{{ABSTRACT_PUBMED_18028942}}

	==About this Structure==		==About this Structure==
-	~~2Q7Z~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA].	+	[[2q7z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18028942~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018028942</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Furtado, P B.]]		[[Category: Furtado, P B.]]
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	[[Category: Innate immunity]]		[[Category: Innate immunity]]
	[[Category: Membrane]]		[[Category: Membrane]]
-	[[Category: Polymorphism]]
	[[Category: Pyrrolidone carboxylic acid]]		[[Category: Pyrrolidone carboxylic acid]]
	[[Category: Receptor]]		[[Category: Receptor]]
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	[[Category: Sushi]]		[[Category: Sushi]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 09:58:19 2010''

OCA at 06:58, 7 April 2010

OCA — Wed, 07 Apr 2010 06:58:20 GMT

←Older revision		Revision as of 06:58, 7 April 2010
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2Q7Z is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA].	+	2Q7Z is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA].

	==Reference==		==Reference==
Line 46:		Line 46:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb 18 00~~:31:~~03 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 09:58:19 2010''

OCA at 22:31, 17 February 2009

OCA — Tue, 17 Feb 2009 22:31:04 GMT

←Older revision		Revision as of 22:31, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2Q7Z is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA].	+	2Q7Z is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA].

	==Reference==		==Reference==
-	The partly folded back solution structure arrangement of the 30 SCR domains in human complement receptor type 1 (CR1) permits access to its C3b and C4b ligands., Furtado PB, Huang CY, Ihyembe D, Hammond RA, Marsh HC, Perkins SJ, J Mol Biol. 2008 Jan 4;375(1):102-18. Epub 2007 Oct 3. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18028942 18028942]~~	+	<ref group="xtra">PMID:18028942</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Furtado, P B.]]		[[Category: Furtado, P B.]]
	[[Category: Hammond, R A.]]		[[Category: Hammond, R A.]]
Line 47:		Line 46:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 07~~:54:~~18 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:31:03 2009''