2q8b - Revision history

OCA at 11:24, 30 August 2023

OCA — Wed, 30 Aug 2023 11:24:55 GMT

←Older revision		Revision as of 11:24, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2q8b' size='340' side='right'caption='[[2q8b]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2q8b' size='340' side='right'caption='[[2q8b]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q8b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q8B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q8b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q8B FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~AMA1 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=36329 PLAF7])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8b OCA], [https://pdbe.org/2q8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q8b RCSB], [https://www.ebi.ac.uk/pdbsum/2q8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8b OCA], [https://pdbe.org/2q8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q8b RCSB], [https://www.ebi.ac.uk/pdbsum/2q8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8b ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7KQK5_PLAF7 Q7KQK5_PLAF7]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: ~~Plaf7~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: Anders~~, R F~~]]	+	[[Category: Anders RF]]
-	[[Category: Batchelor~~, A H~~]]	+	[[Category: Batchelor AH]]
-	[[Category: Gupta, A]]	+	[[Category: Gupta A]]
-	[[Category: Murphy~~, V J]]~~	+	[[Category: Murphy VJ]]
-	~~[[Category: Antigen-antibody complex]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 08:11, 25 June 2021

OCA — Fri, 25 Jun 2021 08:11:51 GMT

←Older revision		Revision as of 08:11, 25 June 2021
Line 1:		Line 1:

	==Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody==		==Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody==
-	<StructureSection load='2q8b' size='340' side='right' caption='[[2q8b]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2q8b' size='340' side='right'caption='[[2q8b]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q8b]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [~~http~~://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Q8B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q8b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q8B FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMA1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMA1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8b OCA], [~~http~~://pdbe.org/2q8b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2q8b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2q8b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8b OCA], [https://pdbe.org/2q8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q8b RCSB], [https://www.ebi.ac.uk/pdbsum/2q8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8b ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Plaf7]]		[[Category: Plaf7]]

OCA at 08:46, 29 August 2018

OCA — Wed, 29 Aug 2018 08:46:19 GMT

←Older revision		Revision as of 08:46, 29 August 2018
Line 1:		Line 1:
		+
	==Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody==		==Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody==
	<StructureSection load='2q8b' size='340' side='right' caption='[[2q8b]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2q8b' size='340' side='right' caption='[[2q8b]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2q8b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q8B FirstGlance]. <br>		<table><tr><td colspan='2'>[[2q8b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q8B FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8b OCA], [http://pdbe.org/2q8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q8b RCSB], [http://www.ebi.ac.uk/pdbsum/2q8b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8b OCA], [http://pdbe.org/2q8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q8b RCSB], [http://www.ebi.ac.uk/pdbsum/2q8b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8b ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/2q8b_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/2q8b_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:11, 8 February 2016

OCA — Mon, 08 Feb 2016 01:11:05 GMT

←Older revision		Revision as of 01:11, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q8b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:29, 10 September 2015

OCA — Thu, 10 Sep 2015 06:29:15 GMT

←Older revision		Revision as of 06:29, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2q8b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q8B FirstGlance]. <br>		<table><tr><td colspan='2'>[[2q8b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q8B FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q8b RCSB], [http://www.ebi.ac.uk/pdbsum/2q8b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8b OCA], [http://pdbe.org/2q8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q8b RCSB], [http://www.ebi.ac.uk/pdbsum/2q8b PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2q8b" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:17, 19 January 2015

OCA — Mon, 19 Jan 2015 18:17:19 GMT

←Older revision		Revision as of 18:17, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2q8b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q8B FirstGlance]. <br>		<table><tr><td colspan='2'>[[2q8b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q8B FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q8b RCSB], [http://www.ebi.ac.uk/pdbsum/2q8b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q8b RCSB], [http://www.ebi.ac.uk/pdbsum/2q8b PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Plaf7]]		[[Category: Plaf7]]
-	[[Category: Anders, R F.]]	+	[[Category: Anders, R F]]
-	[[Category: Batchelor, A H.]]	+	[[Category: Batchelor, A H]]
-	[[Category: Gupta, A.]]	+	[[Category: Gupta, A]]
-	[[Category: Murphy, V J.]]	+	[[Category: Murphy, V J]]
	[[Category: Antigen-antibody complex]]		[[Category: Antigen-antibody complex]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 07:28, 10 September 2014

OCA — Wed, 10 Sep 2014 07:28:00 GMT

←Older revision		Revision as of 07:28, 10 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2q8b.~~png\|left~~\|200px]]	+	==Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody==
		+	<StructureSection load='2q8b' size='340' side='right' caption='[[2q8b]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2q8b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q8B FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q8b RCSB], [http://www.ebi.ac.uk/pdbsum/2q8b PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/2q8b_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Identifying functionally critical regions of the malaria antigen AMA1 (apical membrane antigen 1) is necessary to understand the significance of the polymorphisms within this antigen for vaccine development. The crystal structure of AMA1 in complex with the Fab fragment of inhibitory monoclonal antibody 1F9 reveals that 1F9 binds to the AMA1 solvent-exposed hydrophobic trough, confirming its importance. 1F9 uses the heavy and light chain complementarity-determining regions (CDRs) to wrap around the polymorphic loops adjacent to the trough, but uses a ridge of framework residues to bind to the hydrophobic trough. The resulting 1F9-AMA1-combined buried surface of 2,470 A(2) is considerably larger than previously reported Fab-antigen interfaces. Mutations of polymorphic AMA1 residues within the 1F9 epitope disrupt 1F9 binding and dramatically reduce the binding of affinity-purified human antibodies. Moreover, 1F9 binding to AMA1 is competed by naturally acquired human antibodies, confirming that the 1F9 epitope is a frequent target of immunological attack.

-	~~{{STRUCTURE_2q8b\| PDB=2q8b \| SCENE= }}~~	+	Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody.,Coley AM, Gupta A, Murphy VJ, Bai T, Kim H, Foley M, Anders RF, Batchelor AH PLoS Pathog. 2007 Sep 7;3(9):1308-19. PMID:17907804<ref>PMID:17907804</ref>

-	~~===Structure~~ of the ~~malaria antigen AMA1 in complex with a growth-inhibitory antibody===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17907804}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2q8b]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus] and [http://en~~.~~wikipedia.org~~/~~wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017907804<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plaf7]]
	[[Category: Anders, R F.]]		[[Category: Anders, R F.]]
	[[Category: Batchelor, A H.]]		[[Category: Batchelor, A H.]]

OCA: Protected "2q8b" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:19:30 GMT

Protected "2q8b" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:19, 7 January 2013

OCA at 20:19, 7 January 2013

OCA — Mon, 07 Jan 2013 20:19:27 GMT

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	[[Image:2q8b.png\|left\|200px]]		[[Image:2q8b.png\|left\|200px]]

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	{{STRUCTURE_2q8b\| PDB=2q8b \| SCENE= }}		{{STRUCTURE_2q8b\| PDB=2q8b \| SCENE= }}

	===Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody===		===Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody===

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	==About this Structure==		==About this Structure==
-	~~2Q8B~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA].	+	[[2q8b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17907804~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017907804</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
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	[[Category: Antigen-antibody complex]]		[[Category: Antigen-antibody complex]]
	[[Category: Immune system]]		[[Category: Immune system]]
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OCA at 15:43, 16 February 2009

OCA — Mon, 16 Feb 2009 15:43:28 GMT

←Older revision		Revision as of 15:43, 16 February 2009
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	==About this Structure==		==About this Structure==
-	2Q8B is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA].	+	2Q8B is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8B OCA].

	==Reference==		==Reference==
-	~~Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody., Coley AM, Gupta A, Murphy VJ, Bai T, Kim H, Anders RF, Foley M, Batchelor AH, PLoS Pathog. 2007 Sep 7;3(9):1308-19.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17907804 17907804]~~	+	<ref group="xtra">PMID:17907804</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Single protein]]
	[[Category: Anders, R F.]]		[[Category: Anders, R F.]]
	[[Category: Batchelor, A H.]]		[[Category: Batchelor, A H.]]
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	[[Category: Immune system]]		[[Category: Immune system]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 21~~:11:~~12 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:43:27 2009''