2q8q - Revision history

OCA at 11:25, 30 August 2023

OCA — Wed, 30 Aug 2023 11:25:20 GMT

←Older revision		Revision as of 11:25, 30 August 2023
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	<StructureSection load='2q8q' size='340' side='right'caption='[[2q8q]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='2q8q' size='340' side='right'caption='[[2q8q]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q8q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Staan Staan~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q8Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q8q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q8Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2q8p\|2q8p]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">isdA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158879 STAAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8q OCA], [https://pdbe.org/2q8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q8q RCSB], [https://www.ebi.ac.uk/pdbsum/2q8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8q OCA], [https://pdbe.org/2q8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q8q RCSB], [https://www.ebi.ac.uk/pdbsum/2q8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ISDE_STAAN ISDE_STAAN]] Involved in heme (porphyrin) scavenging. Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme. Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors to the probable permease IsdF (By similarity).	+	[https://www.uniprot.org/uniprot/ISDE_STAAN ISDE_STAAN] Involved in heme (porphyrin) scavenging. Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme. Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors to the probable permease IsdF (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Staan~~]]	+	[[Category: Staphylococcus aureus subsp. aureus N315]]
-	[[Category: Grigg~~, J C~~]]	+	[[Category: Grigg JC]]
-	[[Category: Murphy~~, M E]]~~	+	[[Category: Murphy ME]]
-	~~[[Category: Helical backbone metal receptor superfamily]]~~	+
-	~~[[Category: Metal transport~~]]	+

OCA at 08:12, 25 June 2021

OCA — Fri, 25 Jun 2021 08:12:20 GMT

←Older revision		Revision as of 08:12, 25 June 2021
Line 1:		Line 1:

	==Crystal Structure of S. aureus IsdE complexed with heme==		==Crystal Structure of S. aureus IsdE complexed with heme==
-	<StructureSection load='2q8q' size='340' side='right' caption='[[2q8q]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='2q8q' size='340' side='right'caption='[[2q8q]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q8q]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staan Staan]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Q8Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q8q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staan Staan]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q8Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q8p\|2q8p]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2q8p\|2q8p]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">isdA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158879 STAAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">isdA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158879 STAAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2q8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8q OCA], [~~http~~://pdbe.org/2q8q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2q8q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2q8q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8q OCA], [https://pdbe.org/2q8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q8q RCSB], [https://www.ebi.ac.uk/pdbsum/2q8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ISDE_STAAN ISDE_STAAN]] Involved in heme (porphyrin) scavenging. Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme. Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors to the probable permease IsdF (By similarity).	+	[[https://www.uniprot.org/uniprot/ISDE_STAAN ISDE_STAAN]] Involved in heme (porphyrin) scavenging. Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme. Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors to the probable permease IsdF (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/2q8q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/2q8q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Staan]]		[[Category: Staan]]
	[[Category: Grigg, J C]]		[[Category: Grigg, J C]]

OCA at 09:41, 18 October 2017

OCA — Wed, 18 Oct 2017 09:41:24 GMT

←Older revision		Revision as of 09:41, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of S. aureus IsdE complexed with heme==		==Crystal Structure of S. aureus IsdE complexed with heme==
	<StructureSection load='2q8q' size='340' side='right' caption='[[2q8q]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='2q8q' size='340' side='right' caption='[[2q8q]], [[Resolution\|resolution]] 2.15Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q8p\|2q8p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q8p\|2q8p]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">isdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158879 STAAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">isdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158879 STAAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8q OCA], [http://pdbe.org/2q8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q8q RCSB], [http://www.ebi.ac.uk/pdbsum/2q8q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8q OCA], [http://pdbe.org/2q8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q8q RCSB], [http://www.ebi.ac.uk/pdbsum/2q8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 02:45, 9 February 2016

OCA — Tue, 09 Feb 2016 02:45:40 GMT

←Older revision		Revision as of 02:45, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q8q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:50, 10 September 2015

OCA — Thu, 10 Sep 2015 17:50:59 GMT

←Older revision		Revision as of 17:50, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2q8q' size='340' side='right' caption='[[2q8q]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='2q8q' size='340' side='right' caption='[[2q8q]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q8Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staan Staan]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q8Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q8p\|2q8p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q8p\|2q8p]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">isdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~46170 Staphylococcus aureus subsp. aureus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">isdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158879 STAAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q8q RCSB], [http://www.ebi.ac.uk/pdbsum/2q8q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8q OCA], [http://pdbe.org/2q8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q8q RCSB], [http://www.ebi.ac.uk/pdbsum/2q8q PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ISDE_STAAN ISDE_STAAN]] Involved in heme (porphyrin) scavenging. Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme. Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors to the probable permease IsdF (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2q8q" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Staphylococcus aureus subsp. aureus~~]]	+	[[Category: Staan]]
	[[Category: Grigg, J C]]		[[Category: Grigg, J C]]
	[[Category: Murphy, M E]]		[[Category: Murphy, M E]]
	[[Category: Helical backbone metal receptor superfamily]]		[[Category: Helical backbone metal receptor superfamily]]
	[[Category: Metal transport]]		[[Category: Metal transport]]

OCA at 16:40, 19 January 2015

OCA — Mon, 19 Jan 2015 16:40:04 GMT

←Older revision		Revision as of 16:40, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2q8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q8Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[2q8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q8Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q8p\|2q8p]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q8p\|2q8p]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">isdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46170 Staphylococcus aureus subsp. aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">isdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46170 Staphylococcus aureus subsp. aureus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q8q RCSB], [http://www.ebi.ac.uk/pdbsum/2q8q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q8q RCSB], [http://www.ebi.ac.uk/pdbsum/2q8q PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus subsp. aureus]]		[[Category: Staphylococcus aureus subsp. aureus]]
-	[[Category: Grigg, J C.]]	+	[[Category: Grigg, J C]]
-	[[Category: Murphy, M E.]]	+	[[Category: Murphy, M E]]
	[[Category: Helical backbone metal receptor superfamily]]		[[Category: Helical backbone metal receptor superfamily]]
	[[Category: Metal transport]]		[[Category: Metal transport]]

OCA at 19:23, 30 September 2014

OCA — Tue, 30 Sep 2014 19:23:32 GMT

←Older revision		Revision as of 19:23, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2q8q.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of S. aureus IsdE complexed with heme==
		+	<StructureSection load='2q8q' size='340' side='right' caption='[[2q8q]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2q8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q8Q FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q8p\|2q8p]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">isdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46170 Staphylococcus aureus subsp. aureus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q8q RCSB], [http://www.ebi.ac.uk/pdbsum/2q8q PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/2q8q_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Staphylococcus aureus is a Gram-positive bacterial pathogen and a leading cause of hospital acquired infections. Because the free iron concentration in the human body is too low to support growth, S. aureus must acquire iron from host sources. Heme iron is the most prevalent iron reservoir in the human body and a predominant source of iron for S. aureus. The iron-regulated surface determinant (Isd) system removes heme from host heme proteins and transfers it to IsdE, the cognate substrate-binding lipoprotein of an ATP-binding cassette transporter, for import and subsequent degradation. Herein, we report the crystal structure of the soluble portion of the IsdE lipoprotein in complex with heme. The structure reveals a bi-lobed topology formed by an N- and C-terminal domain bridged by a single alpha-helix. The structure places IsdE as a member of the helical backbone metal receptor superfamily. A six-coordinate heme molecule is bound in the groove established at the domain interface, and the heme iron is coordinated in a novel fashion for heme transporters by Met(78) and His(229). Both heme propionate groups are secured by H-bonds to IsdE main chain and side chain groups. Of these residues, His(229) is essential for IsdE-mediated heme uptake by S. aureus when growth on heme as a sole iron source is measured. Multiple sequence alignments of homologues from several other Gram-positive bacteria, including the human pathogens pyogenes, Bacillus anthracis, and Listeria monocytogenes, suggest that these other systems function equivalently to S. aureus IsdE with respect to heme binding and transport.

-	~~{{STRUCTURE_2q8q\| PDB=2q8q \| SCENE= }}~~	+	Heme coordination by Staphylococcus aureus IsdE.,Grigg JC, Vermeiren CL, Heinrichs DE, Murphy ME J Biol Chem. 2007 Sep 28;282(39):28815-22. Epub 2007 Jul 31. PMID:17666394<ref>PMID:17666394</ref>

-	~~===Crystal Structure~~ of S. ~~aureus IsdE complexed with heme===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17666394}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2q8q]] is a 1 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA].	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017666394<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Staphylococcus aureus subsp. aureus]]		[[Category: Staphylococcus aureus subsp. aureus]]
	[[Category: Grigg, J C.]]		[[Category: Grigg, J C.]]

OCA: Protected "2q8q" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:27:02 GMT

Protected "2q8q" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:27, 7 January 2013

OCA at 19:27, 7 January 2013

OCA — Mon, 07 Jan 2013 19:27:00 GMT

←Older revision		Revision as of 19:27, 7 January 2013
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-	{{Seed}}
	[[Image:2q8q.png\|left\|200px]]		[[Image:2q8q.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2q8q\| PDB=2q8q \| SCENE= }}		{{STRUCTURE_2q8q\| PDB=2q8q \| SCENE= }}

	===Crystal Structure of S. aureus IsdE complexed with heme===		===Crystal Structure of S. aureus IsdE complexed with heme===

-
-	<!--
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	{{ABSTRACT_PUBMED_17666394}}		{{ABSTRACT_PUBMED_17666394}}

	==About this Structure==		==About this Structure==
-	~~2Q8Q~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus~~ Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA].	+	[[2q8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17666394~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017666394</ref><references group="xtra"/>
-	[[Category: Staphylococcus aureus]]	+	[[Category: Staphylococcus aureus subsp. aureus]]
	[[Category: Grigg, J C.]]		[[Category: Grigg, J C.]]
	[[Category: Murphy, M E.]]		[[Category: Murphy, M E.]]
	[[Category: Helical backbone metal receptor superfamily]]		[[Category: Helical backbone metal receptor superfamily]]
	[[Category: Metal transport]]		[[Category: Metal transport]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:50:19 2009''

OCA at 03:50, 17 February 2009

OCA — Tue, 17 Feb 2009 03:50:21 GMT

←Older revision		Revision as of 03:50, 17 February 2009
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	==About this Structure==		==About this Structure==
-	2Q8Q is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA].	+	2Q8Q is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Q OCA].

	==Reference==		==Reference==
-	~~Heme coordination by Staphylococcus aureus IsdE., Grigg JC, Vermeiren CL, Heinrichs DE, Murphy ME, J Biol Chem. 2007 Sep 28;282(39):28815-22. Epub 2007 Jul 31.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17666394 17666394]~~	+	<ref group="xtra">PMID:17666394</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Grigg, J C.]]		[[Category: Grigg, J C.]]
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	[[Category: Metal transport]]		[[Category: Metal transport]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 09~~:16:~~24 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:50:19 2009''