2qbe - Revision history

OCA: Redirecting to 4v54

OCA — Wed, 10 Dec 2014 15:12:47 GMT

Redirecting to 4v54

←Older revision		Revision as of 15:12, 10 December 2014
Line 1:		Line 1:
-	==Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF). This file contains the 50S subunit of the first 70S ribosome, with RRF bound. The entire crystal structure contains two 70S ribosomes and is described in remark 400.==	+	#REDIRECT [[4v54]] This PDB entry is obsolete and replaced by 4v54
-	~~<StructureSection load='2qbe' size='340' side='right' caption='~~[[~~2qbe]], [[Resolution\|resolution]] 3.30Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[2qbe~~]] is ~~a 31 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]~~ and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QBE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QBE FirstGlance]. <br>	+
-	~~</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>~~	+
-	~~<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qbd\|2qbd]], [[2qbf\|2qbf]], [[2qbg\|2qbg]]</td></tr>~~	+
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qbe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qbe RCSB], [http://www.ebi.ac.uk/pdbsum/2qbe PDBsum]</span></td></tr>	+
-	~~<table>~~	+
-	~~== Evolutionary Conservation ==~~	+
-	~~[[Image:Consurf_key_small.gif\|200px\|right]]~~	+
-	~~Check<jmol>~~	+
-	~~<jmolCheckbox>~~	+
-	~~<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qb/2qbe_consurf.spt"</scriptWhenChecked>~~	+
-	~~<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>~~	+
-	~~<text>to colour the structure~~ by ~~Evolutionary Conservation</text>~~	+
-	~~</jmolCheckbox>~~	+
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].	+
-	~~<div style="clear:both"></div>~~	+
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Aminoglycosides are widely used antibiotics that cause messenger RNA decoding errors, block mRNA and transfer RNA translocation, and inhibit ribosome recycling. Ribosome recycling follows the termination of protein synthesis and is aided by ribosome recycling factor (RRF) in bacteria. The molecular mechanism by which aminoglycosides inhibit ribosome recycling is unknown. Here we show in X-ray crystal structures of the Escherichia coli 70S ribosome that RRF binding causes RNA helix H69 of the large ribosomal subunit, which is crucial for subunit association, to swing away from the subunit interface. Aminoglycosides bind to H69 and completely restore the contacts between ribosomal subunits that are disrupted by RRF. These results provide a structural explanation for aminoglycoside inhibition of ribosome recycling.	+
-		+
-	Structural basis for aminoglycoside inhibition of bacterial ribosome recycling.,Borovinskaya MA, Pai RD, Zhang W, Schuwirth BS, Holton JM, Hirokawa G, Kaji H, Kaji A, Cate JH Nat Struct Mol Biol. 2007 Aug;14(8):727-32. Epub 2007 Jul 29. PMID:17660832<ref>PMID:17660832</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-		+
-	~~==See Also==~~	+
-	*[[Ribosome 3D structures\|Ribosome 3D structures]]	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Escherichia coli]]~~	+
-	~~[[Category: Thermus thermophilus]]~~	+
-	~~[[Category: Borovinskaya, M A.]]~~	+
-	~~[[Category: Cate, J H.D.]]~~	+
-	~~[[Category: Hirokawa, G.]]~~	+
-	~~[[Category: Holton, J M.]]~~	+
-	~~[[Category: Kaji, A.]]~~	+
-	~~[[Category: Kaji, H.]]~~	+
-	~~[[Category: Pai, R D.]]~~	+
-	~~[[Category: Schuwirth, B S.]]~~	+
-	~~[[Category: Zhang, W.]]~~	+
-	~~[[Category: Ribosome]]~~	+
-	~~[[Category: Rna-protein complex]]~~	+

OCA at 19:43, 30 September 2014

OCA — Tue, 30 Sep 2014 19:43:48 GMT

←Older revision		Revision as of 19:43, 30 September 2014
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-	~~{{Large structure}}~~	+	==Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF). This file contains the 50S subunit of the first 70S ribosome, with RRF bound. The entire crystal structure contains two 70S ribosomes and is described in remark 400.==
-	~~{{STRUCTURE_2qbe\| PDB=2qbe \| SCENE= }}~~	+	<StructureSection load='2qbe' size='340' side='right' caption='[[2qbe]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	===Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF). This file contains the 50S subunit of the first 70S ribosome, with RRF bound. The entire crystal structure contains two 70S ribosomes and is described in remark 400.===	+	== Structural highlights ==
-	~~{{ABSTRACT_PUBMED_17660832}}~~	+	<table><tr><td colspan='2'>[[2qbe]] is a 31 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QBE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QBE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qbd\|2qbd]], [[2qbf\|2qbf]], [[2qbg\|2qbg]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qbe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qbe RCSB], [http://www.ebi.ac.uk/pdbsum/2qbe PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qb/2qbe_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aminoglycosides are widely used antibiotics that cause messenger RNA decoding errors, block mRNA and transfer RNA translocation, and inhibit ribosome recycling. Ribosome recycling follows the termination of protein synthesis and is aided by ribosome recycling factor (RRF) in bacteria. The molecular mechanism by which aminoglycosides inhibit ribosome recycling is unknown. Here we show in X-ray crystal structures of the Escherichia coli 70S ribosome that RRF binding causes RNA helix H69 of the large ribosomal subunit, which is crucial for subunit association, to swing away from the subunit interface. Aminoglycosides bind to H69 and completely restore the contacts between ribosomal subunits that are disrupted by RRF. These results provide a structural explanation for aminoglycoside inhibition of ribosome recycling.

-	~~==About this Structure==~~	+	Structural basis for aminoglycoside inhibition of bacterial ribosome recycling.,Borovinskaya MA, Pai RD, Zhang W, Schuwirth BS, Holton JM, Hirokawa G, Kaji H, Kaji A, Cate JH Nat Struct Mol Biol. 2007 Aug;14(8):727-32. Epub 2007 Jul 29. PMID:17660832<ref>PMID:17660832</ref>
-	~~[[2qbe]] is a 31 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli] and [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2QBE OCA].~~	+

-	~~==See Also==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	*[[Ribosomal protein L11\|Ribosomal protein L11]]	+	</div>
-	*[[Ribosomal protein L13\|Ribosomal protein L13]]	+
-	*[[Ribosomal protein L14\|Ribosomal protein L14]]	+
-	*[[Ribosomal protein L15\|Ribosomal protein L15]]	+
-	*[[Ribosomal protein L16\|Ribosomal protein L16]]	+
-	*[[Ribosomal protein L17\|Ribosomal protein L17]]	+
-	*[[Ribosomal protein L18\|Ribosomal protein L18]]	+
-	*[[Ribosomal protein L19\|Ribosomal protein L19]]	+
-	*[[Ribosomal protein L2\|Ribosomal protein L2]]	+
-	*[[Ribosomal protein L20\|Ribosomal protein L20]]	+
-	*[[Ribosomal protein L21\|Ribosomal protein L21]]	+
-	*[[Ribosomal protein L22\|Ribosomal protein L22]]	+
-	*[[Ribosomal protein L23\|Ribosomal protein L23]]	+
-	*[[Ribosomal protein L24\|Ribosomal protein L24]]	+
-	*[[Ribosomal protein L25\|Ribosomal protein L25]]	+
-	*[[Ribosomal protein L27\|Ribosomal protein L27]]	+
-	*[[Ribosomal protein L28\|Ribosomal protein L28]]	+
-	*[[Ribosomal protein L29\|Ribosomal protein L29]]	+
-	*[[Ribosomal protein L3\|Ribosomal protein L3]]	+
-	*[[Ribosomal protein L30\|Ribosomal protein L30]]	+
-	*[[Ribosomal protein L32\|Ribosomal protein L32]]	+
-	*[[Ribosomal protein L33\|Ribosomal protein L33]]	+
-	*[[Ribosomal protein L34\|Ribosomal protein L34]]	+
-	*[[Ribosomal protein L35\|Ribosomal protein L35]]	+
-	*[[Ribosomal protein L36\|Ribosomal protein L36]]	+
-	*[[Ribosomal protein L4\|Ribosomal protein L4]]	+
-	*[[Ribosomal protein L5\|Ribosomal protein L5]]	+
-	*[[Ribosomal protein L6\|Ribosomal protein L6]]	+
-	*[[Ribosomal protein L9\|Ribosomal protein L9]]	+
-	*[[Ribosome\|Ribosome]]	+

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:017660832</ref><ref group~~=~~"xtra">PMID:018234219~~</~~ref~~><~~references group="xtra"~~/>	+	*[[Ribosome 3D structures\|Ribosome 3D structures]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]

OCA at 08:43, 11 March 2013

OCA — Mon, 11 Mar 2013 08:43:43 GMT

←Older revision		Revision as of 08:43, 11 March 2013
Line 1:		Line 1:
-	~~[[Image:2qbe.png\|left\|200px]]~~	+	{{Large structure}}
-		+
	{{STRUCTURE_2qbe\| PDB=2qbe \| SCENE= }}		{{STRUCTURE_2qbe\| PDB=2qbe \| SCENE= }}
-
	===Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF). This file contains the 50S subunit of the first 70S ribosome, with RRF bound. The entire crystal structure contains two 70S ribosomes and is described in remark 400.===		===Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF). This file contains the 50S subunit of the first 70S ribosome, with RRF bound. The entire crystal structure contains two 70S ribosomes and is described in remark 400.===
-
	{{ABSTRACT_PUBMED_17660832}}		{{ABSTRACT_PUBMED_17660832}}

OCA at 09:18, 20 October 2012

OCA — Sat, 20 Oct 2012 09:18:31 GMT

←Older revision		Revision as of 09:18, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2qbe]] is a 31 chain structure of [[Ribosomal protein L11]], [[Ribosomal protein L13]], [[Ribosomal protein L14]], [[Ribosomal protein L15]], [[Ribosomal protein L16]], [[Ribosomal protein L17]], [[Ribosomal protein L18]], [[Ribosomal protein L19]], [[Ribosomal protein L2]], [[Ribosomal protein L20]], [[Ribosomal protein L21]], [[Ribosomal protein L22]], [[Ribosomal protein L23]], [[Ribosomal protein L24]], [[Ribosomal protein L25]], [[Ribosomal protein L27]], [[Ribosomal protein L28]], [[Ribosomal protein L29]], [[Ribosomal protein L3]], [[Ribosomal protein L30]], [[Ribosomal protein L32]], [[Ribosomal protein L33]], [[Ribosomal protein L34]], [[Ribosomal protein L35]], [[Ribosomal protein L36]], [[Ribosomal protein L4]], [[Ribosomal protein L5]], [[Ribosomal protein L6]], [[Ribosomal protein L9]] and [[Ribosome]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QBE OCA].	+	[[2qbe]] is a 31 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QBE OCA].

	==See Also==		==See Also==

OCA: Protected "2qbe" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 22:27:28 GMT

Protected "2qbe" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:27, 25 July 2012

OCA at 22:27, 25 July 2012

OCA — Wed, 25 Jul 2012 22:27:26 GMT

←Older revision		Revision as of 22:27, 25 July 2012
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-	{{Seed}}
	[[Image:2qbe.png\|left\|200px]]		[[Image:2qbe.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2qbe", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2qbe\| PDB=2qbe \| SCENE= }}		{{STRUCTURE_2qbe\| PDB=2qbe \| SCENE= }}

	===Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF). This file contains the 50S subunit of the first 70S ribosome, with RRF bound. The entire crystal structure contains two 70S ribosomes and is described in remark 400.===		===Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF). This file contains the 50S subunit of the first 70S ribosome, with RRF bound. The entire crystal structure contains two 70S ribosomes and is described in remark 400.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17660832}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17660832 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17660832}}		{{ABSTRACT_PUBMED_17660832}}

	==About this Structure==		==About this Structure==
-	~~2QBE~~ is a 31 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QBE OCA].	+	[[2qbe]] is a 31 chain structure of [[Ribosomal protein L11]], [[Ribosomal protein L13]], [[Ribosomal protein L14]], [[Ribosomal protein L15]], [[Ribosomal protein L16]], [[Ribosomal protein L17]], [[Ribosomal protein L18]], [[Ribosomal protein L19]], [[Ribosomal protein L2]], [[Ribosomal protein L20]], [[Ribosomal protein L21]], [[Ribosomal protein L22]], [[Ribosomal protein L23]], [[Ribosomal protein L24]], [[Ribosomal protein L25]], [[Ribosomal protein L27]], [[Ribosomal protein L28]], [[Ribosomal protein L29]], [[Ribosomal protein L3]], [[Ribosomal protein L30]], [[Ribosomal protein L32]], [[Ribosomal protein L33]], [[Ribosomal protein L34]], [[Ribosomal protein L35]], [[Ribosomal protein L36]], [[Ribosomal protein L4]], [[Ribosomal protein L5]], [[Ribosomal protein L6]], [[Ribosomal protein L9]] and [[Ribosome]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QBE OCA].
		+
		+	==See Also==
		+	*[[Ribosomal protein L11\|Ribosomal protein L11]]
		+	*[[Ribosomal protein L13\|Ribosomal protein L13]]
		+	*[[Ribosomal protein L14\|Ribosomal protein L14]]
		+	*[[Ribosomal protein L15\|Ribosomal protein L15]]
		+	*[[Ribosomal protein L16\|Ribosomal protein L16]]
		+	*[[Ribosomal protein L17\|Ribosomal protein L17]]
		+	*[[Ribosomal protein L18\|Ribosomal protein L18]]
		+	*[[Ribosomal protein L19\|Ribosomal protein L19]]
		+	*[[Ribosomal protein L2\|Ribosomal protein L2]]
		+	*[[Ribosomal protein L20\|Ribosomal protein L20]]
		+	*[[Ribosomal protein L21\|Ribosomal protein L21]]
		+	*[[Ribosomal protein L22\|Ribosomal protein L22]]
		+	*[[Ribosomal protein L23\|Ribosomal protein L23]]
		+	*[[Ribosomal protein L24\|Ribosomal protein L24]]
		+	*[[Ribosomal protein L25\|Ribosomal protein L25]]
		+	*[[Ribosomal protein L27\|Ribosomal protein L27]]
		+	*[[Ribosomal protein L28\|Ribosomal protein L28]]
		+	*[[Ribosomal protein L29\|Ribosomal protein L29]]
		+	*[[Ribosomal protein L3\|Ribosomal protein L3]]
		+	*[[Ribosomal protein L30\|Ribosomal protein L30]]
		+	*[[Ribosomal protein L32\|Ribosomal protein L32]]
		+	*[[Ribosomal protein L33\|Ribosomal protein L33]]
		+	*[[Ribosomal protein L34\|Ribosomal protein L34]]
		+	*[[Ribosomal protein L35\|Ribosomal protein L35]]
		+	*[[Ribosomal protein L36\|Ribosomal protein L36]]
		+	*[[Ribosomal protein L4\|Ribosomal protein L4]]
		+	*[[Ribosomal protein L5\|Ribosomal protein L5]]
		+	*[[Ribosomal protein L6\|Ribosomal protein L6]]
		+	*[[Ribosomal protein L9\|Ribosomal protein L9]]
		+	*[[Ribosome\|Ribosome]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17660832~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017660832</ref><ref group="xtra">PMID:018234219</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
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	[[Category: Ribosome]]		[[Category: Ribosome]]
	[[Category: Rna-protein complex]]		[[Category: Rna-protein complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 08:17:47 2009''

OCA at 05:17, 23 September 2009

OCA — Wed, 23 Sep 2009 05:17:48 GMT

←Older revision		Revision as of 05:17, 23 September 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2QBE is a 32 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QBE OCA].	+	2QBE is a 31 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QBE OCA].

	==Reference==		==Reference==
Line 38:		Line 38:
	[[Category: Rna-protein complex]]		[[Category: Rna-protein complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Feb 16 19~~:58:37 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 08:17:47 2009''

OCA at 17:58, 16 February 2009

OCA — Mon, 16 Feb 2009 17:58:38 GMT

←Older revision		Revision as of 17:58, 16 February 2009
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	==About this Structure==		==About this Structure==
-	2QBE is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QBE OCA].	+	2QBE is a 32 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QBE OCA].

	==Reference==		==Reference==
-	Structural basis for aminoglycoside inhibition of bacterial ribosome recycling., Borovinskaya MA, Pai RD, Zhang W, Schuwirth BS, Holton JM, Hirokawa G, Kaji H, Kaji A, Cate JH, Nat Struct Mol Biol. 2007 Aug;14(8):727-32. Epub 2007 Jul 29. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17660832 17660832]~~	+	<ref group="xtra">PMID:17660832</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Protein complex]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Borovinskaya, M A.]]		[[Category: Borovinskaya, M A.]]
Line 39:		Line 38:
	[[Category: Rna-protein complex]]		[[Category: Rna-protein complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon ~~Jul 28 00~~:05:~~53 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:58:37 2009''

OCA at 21:05, 27 July 2008

OCA — Sun, 27 Jul 2008 21:05:58 GMT

←Older revision		Revision as of 21:05, 27 July 2008
Line 1:		Line 1:
-	[[Image:2qbe.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2qbe.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2qbe\| PDB=2qbe \| SCENE= }}		{{STRUCTURE_2qbe\| PDB=2qbe \| SCENE= }}

-	~~'''~~Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF). This file contains the 50S subunit of the first 70S ribosome, with RRF bound. The entire crystal structure contains two 70S ribosomes and is described in remark 400.~~'''~~	+	===Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF). This file contains the 50S subunit of the first 70S ribosome, with RRF bound. The entire crystal structure contains two 70S ribosomes and is described in remark 400.===


-	~~==Overview==~~	+	<!--
-	~~Aminoglycosides are widely used antibiotics that cause messenger RNA decoding errors~~, ~~block mRNA and transfer RNA translocation~~, ~~and inhibit ribosome recycling. Ribosome recycling follows~~ the ~~termination of protein synthesis and is aided by ribosome recycling factor~~ (~~RRF) in bacteria~~. ~~The molecular mechanism by which aminoglycosides inhibit ribosome recycling is unknown~~. ~~Here we show in X-ray crystal structures of the Escherichia coli 70S ribosome that RRF binding causes RNA helix H69 of the large ribosomal subunit~~, ~~which~~ is ~~crucial for subunit association, to swing away from~~ the subunit interface. Aminoglycosides bind to H69 and completely restore the contacts between ribosomal subunits that are disrupted by RRF. These results provide a structural explanation for aminoglycoside inhibition of ribosome recycling.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17660832}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17660832 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17660832}}

	==About this Structure==		==About this Structure==
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	[[Category: Ribosome]]		[[Category: Ribosome]]
	[[Category: Rna-protein complex]]		[[Category: Rna-protein complex]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 14~~:40:22 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:05:53 2008''

OCA at 11:40, 4 May 2008

OCA — Sun, 04 May 2008 11:40:23 GMT

←Older revision		Revision as of 11:40, 4 May 2008
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	[[Image:2qbe.gif\|left\|200px]]		[[Image:2qbe.gif\|left\|200px]]

-	{{Structure	+	<!--
-	\|PDB~~= 2qbe \|SIZE=350\|CAPTION= <~~scene ~~name='initialview01'>2qbe</scene>~~, ~~resolution 3~~.~~3Å~~	+	The line below this paragraph, containing "STRUCTURE_2qbe", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <scene name='pdbligand=A:ADENOSINE~~-~~5'~~-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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-	\|~~GENE~~=	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_2qbe\| PDB=2qbe \| SCENE= }}
-	~~\|RELATEDENTRY=[[2qbd\|2QBD]], [[2qbf\|2QBF]], [[2qbg\|2QBG]]~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qbe OCA], [http://www.ebi.ac.uk/pdbsum/2qbe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qbe RCSB]</span>	+
-	}}	+

	'''Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF). This file contains the 50S subunit of the first 70S ribosome, with RRF bound. The entire crystal structure contains two 70S ribosomes and is described in remark 400.'''		'''Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF). This file contains the 50S subunit of the first 70S ribosome, with RRF bound. The entire crystal structure contains two 70S ribosomes and is described in remark 400.'''
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	[[Category: Schuwirth, B S.]]		[[Category: Schuwirth, B S.]]
	[[Category: Zhang, W.]]		[[Category: Zhang, W.]]
-	[[Category: ~~ribosome~~]]	+	[[Category: Ribosome]]
-	[[Category: ~~rna~~-protein complex]]	+	[[Category: Rna-protein complex]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:40:22 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 04~~:47:14 2008''	+