2qeh - Revision history

OCA at 08:17, 25 June 2021

OCA — Fri, 25 Jun 2021 08:17:27 GMT

←Older revision		Revision as of 08:17, 25 June 2021
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	==Crystal Structure of Anopheles gambiae D7r4-serotonin complex==		==Crystal Structure of Anopheles gambiae D7r4-serotonin complex==
-	<StructureSection load='2qeh' size='340' side='right' caption='[[2qeh]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2qeh' size='340' side='right'caption='[[2qeh]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qeh]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Anoga Anoga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QEH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QEH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qeh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anoga Anoga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QEH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qeb\|2qeb]], [[2qeo\|2qeo]], [[2qev\|2qev]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2qeb\|2qeb]], [[2qeo\|2qeo]], [[2qev\|2qev]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D7r4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D7r4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qeh OCA], [~~http~~://pdbe.org/2qeh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qeh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qeh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qeh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qeh OCA], [https://pdbe.org/2qeh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qeh RCSB], [https://www.ebi.ac.uk/pdbsum/2qeh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qeh ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qe/2qeh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qe/2qeh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Anoga]]		[[Category: Anoga]]
		+	[[Category: Large Structures]]
	[[Category: Andersen, J F]]		[[Category: Andersen, J F]]
	[[Category: Calvo, E]]		[[Category: Calvo, E]]

OCA at 09:44, 18 October 2017

OCA — Wed, 18 Oct 2017 09:44:45 GMT

←Older revision		Revision as of 09:44, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Anopheles gambiae D7r4-serotonin complex==		==Crystal Structure of Anopheles gambiae D7r4-serotonin complex==
	<StructureSection load='2qeh' size='340' side='right' caption='[[2qeh]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2qeh' size='340' side='right' caption='[[2qeh]], [[Resolution\|resolution]] 2.10Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qeb\|2qeb]], [[2qeo\|2qeo]], [[2qev\|2qev]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qeb\|2qeb]], [[2qeo\|2qeo]], [[2qev\|2qev]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D7r4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D7r4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qeh OCA], [http://pdbe.org/2qeh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qeh RCSB], [http://www.ebi.ac.uk/pdbsum/2qeh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qeh OCA], [http://pdbe.org/2qeh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qeh RCSB], [http://www.ebi.ac.uk/pdbsum/2qeh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qeh ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qeh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:02, 11 September 2015

OCA — Fri, 11 Sep 2015 14:02:08 GMT

←Older revision		Revision as of 14:02, 11 September 2015
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	<StructureSection load='2qeh' size='340' side='right' caption='[[2qeh]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2qeh' size='340' side='right' caption='[[2qeh]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qeh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Anopheles_gambiae Anopheles gambiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QEH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qeh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anoga Anoga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QEH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qeb\|2qeb]], [[2qeo\|2qeo]], [[2qev\|2qev]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qeb\|2qeb]], [[2qeo\|2qeo]], [[2qev\|2qev]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D7r4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ~~Anopheles gambiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D7r4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qeh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qeh RCSB], [http://www.ebi.ac.uk/pdbsum/2qeh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qeh OCA], [http://pdbe.org/2qeh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qeh RCSB], [http://www.ebi.ac.uk/pdbsum/2qeh PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qeh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Anopheles gambiae~~]]	+	[[Category: Anoga]]
	[[Category: Andersen, J F]]		[[Category: Andersen, J F]]
	[[Category: Calvo, E]]		[[Category: Calvo, E]]

OCA at 14:13, 19 January 2015

OCA — Mon, 19 Jan 2015 14:13:05 GMT

←Older revision		Revision as of 14:13, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qeh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QEH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qeh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QEH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRO:SEROTONIN'>SRO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qeb\|2qeb]], [[2qeo\|2qeo]], [[2qev\|2qev]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qeb\|2qeb]], [[2qeo\|2qeo]], [[2qev\|2qev]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D7r4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 Anopheles gambiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D7r4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 Anopheles gambiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qeh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qeh RCSB], [http://www.ebi.ac.uk/pdbsum/2qeh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qeh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qeh RCSB], [http://www.ebi.ac.uk/pdbsum/2qeh PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Anopheles gambiae]]		[[Category: Anopheles gambiae]]
-	[[Category: Andersen, J F.]]	+	[[Category: Andersen, J F]]
-	[[Category: Calvo, E.]]	+	[[Category: Calvo, E]]
-	[[Category: Mans, B J.]]	+	[[Category: Mans, B J]]
-	[[Category: Ribeiro, J M.]]	+	[[Category: Ribeiro, J M]]
	[[Category: All-helical]]		[[Category: All-helical]]
	[[Category: Ligand binding protein]]		[[Category: Ligand binding protein]]
	[[Category: Odorant-binding protein]]		[[Category: Odorant-binding protein]]

OCA at 18:24, 30 September 2014

OCA — Tue, 30 Sep 2014 18:24:58 GMT

←Older revision		Revision as of 18:24, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2qeh.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Anopheles gambiae D7r4-serotonin complex==
		+	<StructureSection load='2qeh' size='340' side='right' caption='[[2qeh]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2qeh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QEH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SRO:SEROTONIN'>SRO</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qeb\|2qeb]], [[2qeo\|2qeo]], [[2qev\|2qev]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">D7r4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 Anopheles gambiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qeh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qeh RCSB], [http://www.ebi.ac.uk/pdbsum/2qeh PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qe/2qeh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The D7-related (D7r) proteins of the malaria vector Anopheles gambiae have been shown to bind the biogenic amines serotonin, norepinephrine, and histamine with high affinity. One member of the group (D7r1 or hamadarin) has also been shown to have an anticoagulant/antikinin activity. To understand the mechanistic details of its antihemostatic/anti-inflammatory effects, we have determined the crystal structure of one member of this group, D7r4, along with the structures of ligand complexes with serotonin, tryptamine, histamine, and norepinephrine. The D7 fold consists of an arrangement of eight alpha-helices stabilized by three disulfide bonds. The structure is similar to those of the arthropod odorant-binding proteins, a relationship that had been predicted based on sequence comparisons. Although odorant-binding proteins commonly have six alpha-helices, D7r4 has eight, resulting in significantly different positioning and structure of the ligand binding pocket. The pocket itself is lined by hydrophobic side chains along with polar and charged groups oriented to form hydrogen bonds with the aliphatic amino group and with groups on the aromatic portions of the ligands. These structures, along with accompanying mutagenesis studies, have allowed us to identify critical residues for biogenic amine binding and to predict which members of the large D7 protein family found in blood-feeding nematocerous Diptera will function as biogenic amine-binding proteins.

-	~~{{STRUCTURE_2qeh\| PDB=2qeh \| SCENE= }}~~	+	The crystal structure of D7r4, a salivary biogenic amine-binding protein from the malaria mosquito Anopheles gambiae.,Mans BJ, Calvo E, Ribeiro JM, Andersen JF J Biol Chem. 2007 Dec 14;282(50):36626-33. Epub 2007 Oct 9. PMID:17928288<ref>PMID:17928288</ref>

-	~~===Crystal Structure~~ of ~~Anopheles gambiae D7r4-serotonin complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17928288}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2qeh]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Anopheles_gambiae Anopheles gambiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2QEH OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017928288<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Anopheles gambiae]]		[[Category: Anopheles gambiae]]
	[[Category: Andersen, J F.]]		[[Category: Andersen, J F.]]

OCA: Protected "2qeh" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 21:02:17 GMT

Protected "2qeh" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:02, 7 January 2013

OCA at 21:02, 7 January 2013

OCA — Mon, 07 Jan 2013 21:02:15 GMT

←Older revision		Revision as of 21:02, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2qeh.png\|left\|200px]]		[[Image:2qeh.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2qeh", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2qeh\| PDB=2qeh \| SCENE= }}		{{STRUCTURE_2qeh\| PDB=2qeh \| SCENE= }}

	===Crystal Structure of Anopheles gambiae D7r4-serotonin complex===		===Crystal Structure of Anopheles gambiae D7r4-serotonin complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17928288}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17928288 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17928288}}		{{ABSTRACT_PUBMED_17928288}}

	==About this Structure==		==About this Structure==
-	~~2QEH~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QEH OCA].	+	[[2qeh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QEH OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17928288~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017928288</ref><references group="xtra"/>
	[[Category: Anopheles gambiae]]		[[Category: Anopheles gambiae]]
	[[Category: Andersen, J F.]]		[[Category: Andersen, J F.]]
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	[[Category: Ligand binding protein]]		[[Category: Ligand binding protein]]
	[[Category: Odorant-binding protein]]		[[Category: Odorant-binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:10:25 2009''

OCA at 22:10, 17 February 2009

OCA — Tue, 17 Feb 2009 22:10:27 GMT

←Older revision		Revision as of 22:10, 17 February 2009
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	==About this Structure==		==About this Structure==
-	2QEH is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QEH OCA].	+	2QEH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QEH OCA].

	==Reference==		==Reference==
-	The crystal structure of D7r4, a salivary biogenic amine-binding protein from the malaria mosquito Anopheles gambiae., Mans BJ, Calvo E, Ribeiro JM, Andersen JF, J Biol Chem. 2007 Dec 14;282(50):36626-33. Epub 2007 Oct 9. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17928288 17928288]~~	+	<ref group="xtra">PMID:17928288</ref><references group="xtra"/>
	[[Category: Anopheles gambiae]]		[[Category: Anopheles gambiae]]
-	[[Category: Single protein]]
	[[Category: Andersen, J F.]]		[[Category: Andersen, J F.]]
	[[Category: Calvo, E.]]		[[Category: Calvo, E.]]
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	[[Category: Odorant-binding protein]]		[[Category: Odorant-binding protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 07~~:30:~~11 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:10:25 2009''

OCA at 04:30, 29 July 2008

OCA — Tue, 29 Jul 2008 04:30:15 GMT

←Older revision		Revision as of 04:30, 29 July 2008
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-	[[Image:2qeh.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2qeh.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2qeh\| PDB=2qeh \| SCENE= }}		{{STRUCTURE_2qeh\| PDB=2qeh \| SCENE= }}

-	~~'''~~Crystal Structure of Anopheles gambiae D7r4-serotonin complex~~'''~~	+	===Crystal Structure of Anopheles gambiae D7r4-serotonin complex===


-	~~==Overview==~~	+	<!--
-	The ~~D7-related (D7r) proteins of the malaria vector Anopheles gambiae have been shown to bind the biogenic amines serotonin~~, ~~norepinephrine~~, ~~and histamine with high affinity. One member of~~ the ~~group (D7r1 or hamadarin) has also been shown~~ to ~~have an anticoagulant/antikinin activity. To understand~~ the ~~mechanistic details of its antihemostatic~~/anti-inflammatory effects, we have determined the crystal structure of one member of this group, D7r4, along with the structures of ligand complexes with serotonin, tryptamine, histamine, and norepinephrine. ~~The D7 fold consists of an arrangement of eight alpha-helices stabilized by three disulfide bonds~~. ~~The structure is similar to those of the arthropod odorant-binding proteins~~, a relationship that had been predicted based on sequence comparisons. Although odorant-binding proteins commonly have six alpha-helices, D7r4 has eight, resulting in significantly different positioning and structure of the ligand binding pocket. The pocket itself is ~~lined by hydrophobic side chains along with polar and charged groups oriented to form hydrogen bonds with~~ the ~~aliphatic amino group and with groups on the aromatic portions of the ligands~~. These structures, along with accompanying mutagenesis studies, have allowed us to identify critical residues for biogenic amine binding and to predict which members of the large D7 protein family found in blood-~~feeding nematocerous Diptera will function as biogenic amine~~-~~binding proteins.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17928288}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17928288 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17928288}}

	==About this Structure==		==About this Structure==
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	[[Category: Ligand binding protein]]		[[Category: Ligand binding protein]]
	[[Category: Odorant-binding protein]]		[[Category: Odorant-binding protein]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 14~~:48:58 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:30:11 2008''

OCA at 11:48, 4 May 2008

OCA — Sun, 04 May 2008 11:48:59 GMT

←Older revision		Revision as of 11:48, 4 May 2008
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	[[Image:2qeh.jpg\|left\|200px]]		[[Image:2qeh.jpg\|left\|200px]]

-	~~{{Structure~~	+	<!--
-	~~\|PDB= 2qeh \|SIZE=350\|CAPTION= <scene name='initialview01'>2qeh</scene>~~, ~~resolution 2~~.~~102Å~~	+	The line below this paragraph, containing "STRUCTURE_2qeh", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <~~scene ~~name='pdbligand=SRO:SEROTONIN'>SRO</scene>~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY=~~	+	or leave the SCENE parameter empty for the default display.
-	~~\|GENE= D7r4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 Anopheles gambiae]~~)	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_2qeh\| PDB=2qeh \| SCENE= }}
-	~~\|RELATEDENTRY=[[2qeb\|2QEB]]~~, ~~[[2qeo\|2QEO]], [[2qev\|2QEV]]~~	+
-	~~\|RESOURCES=<span class='plainlinks'>[http://oca~~.~~weizmann.ac.il/oca~~-~~docs/fgij/fg.htm?mol=2qeh FirstGlance], [http://oca.weizmann.ac.il/oca~~-~~bin/ocaids?id~~=2qeh ~~OCA], [http://www.ebi.ac.uk/pdbsum/2qeh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId~~=~~2qeh RCSB]</span>~~	+
-	}}	+

	'''Crystal Structure of Anopheles gambiae D7r4-serotonin complex'''		'''Crystal Structure of Anopheles gambiae D7r4-serotonin complex'''
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	[[Category: Mans, B J.]]		[[Category: Mans, B J.]]
	[[Category: Ribeiro, J M.]]		[[Category: Ribeiro, J M.]]
-	[[Category: ~~all~~-helical]]	+	[[Category: All-helical]]
-	[[Category: ~~ligand~~ binding protein]]	+	[[Category: Ligand binding protein]]
-	[[Category: ~~odorant~~-binding protein]]	+	[[Category: Odorant-binding protein]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:48:58 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 04~~:48:21 2008''	+