2qir - Revision history

OCA at 08:21, 25 June 2021

OCA — Fri, 25 Jun 2021 08:21:24 GMT

←Older revision		Revision as of 08:21, 25 June 2021
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	<StructureSection load='2qir' size='340' side='right'caption='[[2qir]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2qir' size='340' side='right'caption='[[2qir]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qir]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QIR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qir]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QIR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9CS:(1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL+2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE'>9CS</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9CS:(1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL+2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE'>9CS</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2prb\|2prb]], [[2pr8\|2pr8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2prb\|2prb]], [[2pr8\|2pr8]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qir OCA], [~~http~~://pdbe.org/2qir PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qir RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qir PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qir ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qir OCA], [https://pdbe.org/2qir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qir RCSB], [https://www.ebi.ac.uk/pdbsum/2qir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qir ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:35, 31 July 2019

OCA — Wed, 31 Jul 2019 07:35:22 GMT

←Older revision		Revision as of 07:35, 31 July 2019
Line 1:		Line 1:

	==Crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A and kanamycin==		==Crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A and kanamycin==
-	<StructureSection load='2qir' size='340' side='right' caption='[[2qir]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2qir' size='340' side='right'caption='[[2qir]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qir]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qir]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIR FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qi/2qir_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qi/2qir_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Benas, P]]		[[Category: Benas, P]]
	[[Category: Broutin, I]]		[[Category: Broutin, I]]

OCA at 02:21, 11 December 2016

OCA — Sun, 11 Dec 2016 02:21:44 GMT

←Older revision		Revision as of 02:21, 11 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A and kanamycin==		==Crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A and kanamycin==
	<StructureSection load='2qir' size='340' side='right' caption='[[2qir]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2qir' size='340' side='right' caption='[[2qir]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2prb\|2prb]], [[2pr8\|2pr8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2prb\|2prb]], [[2pr8\|2pr8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qir OCA], [http://pdbe.org/2qir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qir RCSB], [http://www.ebi.ac.uk/pdbsum/2qir PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qir OCA], [http://pdbe.org/2qir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qir RCSB], [http://www.ebi.ac.uk/pdbsum/2qir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qir ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 20:31, 9 February 2016

OCA — Tue, 09 Feb 2016 20:31:52 GMT

←Older revision		Revision as of 20:31, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qir ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:47, 11 September 2015

OCA — Fri, 11 Sep 2015 01:47:19 GMT

←Older revision		Revision as of 01:47, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2qir' size='340' side='right' caption='[[2qir]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2qir' size='340' side='right' caption='[[2qir]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qir]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qir]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9CS:(1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL+2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE'>9CS</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9CS:(1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL+2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE'>9CS</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2prb\|2prb]], [[2pr8\|2pr8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2prb\|2prb]], [[2pr8\|2pr8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aac(6')-Ib ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qir OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qir RCSB], [http://www.ebi.ac.uk/pdbsum/2qir PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qir OCA], [http://pdbe.org/2qir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qir RCSB], [http://www.ebi.ac.uk/pdbsum/2qir PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qir" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Benas, P]]		[[Category: Benas, P]]
	[[Category: Broutin, I]]		[[Category: Broutin, I]]

OCA at 13:40, 19 January 2015

OCA — Mon, 19 Jan 2015 13:40:44 GMT

←Older revision		Revision as of 13:40, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qir]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qir]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9CS:(1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL+2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE'>9CS</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9CS:(1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL+2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE'>9CS</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2prb\|2prb]], [[2pr8\|2pr8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2prb\|2prb]], [[2pr8\|2pr8]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aac(6')-Ib ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aac(6')-Ib ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qir OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qir RCSB], [http://www.ebi.ac.uk/pdbsum/2qir PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qir OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qir RCSB], [http://www.ebi.ac.uk/pdbsum/2qir PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
-	[[Category: Benas, P.]]	+	[[Category: Benas, P]]
-	[[Category: Broutin, I.]]	+	[[Category: Broutin, I]]
-	[[Category: Collatz, E.]]	+	[[Category: Collatz, E]]
-	[[Category: Dardel, F.]]	+	[[Category: Dardel, F]]
-	[[Category: Maurice, F.]]	+	[[Category: Maurice, F]]
-	[[Category: Podglajen, I.]]	+	[[Category: Podglajen, I]]
	[[Category: Acetyltransferase]]		[[Category: Acetyltransferase]]
	[[Category: Aminoglycoside resistance]]		[[Category: Aminoglycoside resistance]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA: Protected "2qir" [edit=sysop:move=sysop]

OCA — Tue, 30 Sep 2014 18:13:00 GMT

Protected "2qir" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:13, 30 September 2014

OCA at 18:12, 30 September 2014

OCA — Tue, 30 Sep 2014 18:12:59 GMT

←Older revision		Revision as of 18:12, 30 September 2014
Line 1:		Line 1:
-	~~{{Seed}}~~	+	==Crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A and kanamycin==
-	[[~~Image:~~2qir.~~png~~\|~~left~~\|200px]]	+	<StructureSection load='2qir' size='340' side='right' caption='[[2qir]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2qir]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9CS:(1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL+2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE'>9CS</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2prb\|2prb]], [[2pr8\|2pr8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aac(6')-Ib ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qir OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qir RCSB], [http://www.ebi.ac.uk/pdbsum/2qir PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qi/2qir_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The emergence of multi-resistant pathogenic bacteria is a worldwide health issue. Recently, clinical variants of a single antibiotic-modifying acetyltransferase, AAC(6')-Ib-a variant of aminoglycoside 6'-N-acetyltransferase-have been identified that confer extended resistance to most aminoglycosides and, more surprisingly, to structurally unrelated fluoroquinolones. The corresponding gene is carried by mobile genetic elements and is present in most multi-resistant pathogenic strains, hence making it a serious threat to current therapies. Here, we report the crystal structures of both narrow- and broad-spectrum resistance variants of this enzyme, which reveal the structural basis for the emergence of extended resistance. The active site shows an important plasticity and has adapted to new substrates by a large-scale gaping process. We have also obtained co-crystals with both substrates, and with a simple transition state analogue, which provides new clues for the design of inhibitors of this resistance mechanism.

-	<!--	+	Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance.,Maurice F, Broutin I, Podglajen I, Benas P, Collatz E, Dardel F EMBO Rep. 2008 Apr;9(4):344-9. Epub 2008 Feb 22. PMID:18292754<ref>PMID:18292754</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2qir"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2qir\| PDB=2qir \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A and kanamycin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_18292754}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 18292754 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
-	~~{{ABSTRACT_PUBMED_18292754}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~2QIR is a 1 chain structure of sequence from [http:~~/~~/en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIR OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:18292754<~~/~~ref~~><~~references group="xtra"~~/>	+
-	[[Category: Salmonella typhimurium]]	+
	[[Category: Benas, P.]]		[[Category: Benas, P.]]
	[[Category: Broutin, I.]]		[[Category: Broutin, I.]]
Line 33:		Line 40:
	[[Category: Acetyltransferase]]		[[Category: Acetyltransferase]]
	[[Category: Aminoglycoside resistance]]		[[Category: Aminoglycoside resistance]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 12:32:57 2009''~~	+

OCA at 10:33, 17 February 2009

OCA — Tue, 17 Feb 2009 10:33:00 GMT

←Older revision		Revision as of 10:33, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2QIR is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIR OCA].	+	2QIR is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIR OCA].

	==Reference==		==Reference==
-	Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance., Maurice F, Broutin I, Podglajen I, Benas P, Collatz E, Dardel F, EMBO Rep. 2008 Apr;9(4):344-349. Epub 2008 Feb 22. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18292754 18292754]~~	+	<ref group="xtra">PMID:18292754</ref><references group="xtra"/>
	[[Category: Salmonella typhimurium]]		[[Category: Salmonella typhimurium]]
-	[[Category: Single protein]]
	[[Category: Benas, P.]]		[[Category: Benas, P.]]
	[[Category: Broutin, I.]]		[[Category: Broutin, I.]]
Line 35:		Line 34:
	[[Category: Aminoglycoside resistance]]		[[Category: Aminoglycoside resistance]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 2 21~~:26:~~47 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:32:57 2009''

OCA at 18:26, 2 July 2008

OCA — Wed, 02 Jul 2008 18:26:47 GMT

←Older revision		Revision as of 18:26, 2 July 2008
Line 1:		Line 1:
-	[[Image:2qir.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2qir.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2qir\| PDB=2qir \| SCENE= }}		{{STRUCTURE_2qir\| PDB=2qir \| SCENE= }}

-	~~'''~~Crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A and kanamycin~~'''~~	+	===Crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A and kanamycin===


-	~~==Overview==~~	+	<!--
-	The ~~emergence of multi-resistant pathogenic bacteria is a worldwide health issue. Recently~~, ~~clinical variants of a single antibiotic-modifying acetyltransferase~~, ~~AAC~~(6')~~-Ib-a variant of aminoglycoside 6'-N-acetyltransferase-have been identified that confer extended resistance to most aminoglycosides and~~, ~~more surprisingly, to structurally unrelated fluoroquinolones. The corresponding gene~~ is ~~carried by mobile genetic elements and is present in most multi-resistant pathogenic strains, hence making it a serious threat to current therapies. Here, we report~~ the ~~crystal structures of both narrow- and broad-spectrum resistance variants of this enzyme, which reveal the structural basis for the emergence of extended resistance~~. ~~The active site shows an important plasticity and has adapted to new substrates by a large~~-~~scale gaping process. We have also obtained co~~-~~crystals with both substrates, and with a simple transition state analogue, which provides new clues for the design of inhibitors of this resistance mechanism.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_18292754}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18292754 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18292754}}

	==About this Structure==		==About this Structure==
Line 30:		Line 34:
	[[Category: Acetyltransferase]]		[[Category: Acetyltransferase]]
	[[Category: Aminoglycoside resistance]]		[[Category: Aminoglycoside resistance]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:26:47 2008''