2qjh - Revision history

OCA at 07:43, 16 March 2022

OCA — Wed, 16 Mar 2022 07:43:50 GMT

←Older revision		Revision as of 07:43, 16 March 2022
Line 3:		Line 3:
	<StructureSection load='2qjh' size='340' side='right'caption='[[2qjh]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2qjh' size='340' side='right'caption='[[2qjh]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qjh]] is a 20 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43067 Atcc 43067]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2QJH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qjh]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43067 Atcc 43067]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QJH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qjg\|2qjg]], [[2qji\|2qji]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2qjg\|2qjg]], [[2qji\|2qji]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2qjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjh OCA], [~~http~~://pdbe.org/2qjh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qjh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qjh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qjh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjh OCA], [https://pdbe.org/2qjh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qjh RCSB], [https://www.ebi.ac.uk/pdbsum/2qjh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qjh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ADHS_METJA ADHS_METJA]] Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. Can also catalyze the cleavage of fructose-1,6-bisphosphate (FBP) to glyceraldehyde-3-phosphate (GAP) and dihydroxyacetone phosphate (DHAP).[HAMAP-Rule:MF_00960]<ref>PMID:15182204</ref> <ref>PMID:18318840</ref>	+	[[https://www.uniprot.org/uniprot/ADHS_METJA ADHS_METJA]] Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. Can also catalyze the cleavage of fructose-1,6-bisphosphate (FBP) to glyceraldehyde-3-phosphate (GAP) and dihydroxyacetone phosphate (DHAP).[HAMAP-Rule:MF_00960]<ref>PMID:15182204</ref> <ref>PMID:18318840</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:06, 10 June 2020

OCA — Wed, 10 Jun 2020 07:06:01 GMT

←Older revision		Revision as of 07:06, 10 June 2020
Line 1:		Line 1:

	==M. jannaschii ADH synthase covalently bound to dihydroxyacetone phosphate==		==M. jannaschii ADH synthase covalently bound to dihydroxyacetone phosphate==
-	<StructureSection load='2qjh' size='340' side='right' caption='[[2qjh]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='2qjh' size='340' side='right'caption='[[2qjh]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qjh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43067 Atcc 43067]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QJH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qjh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43067 Atcc 43067]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2QJH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qjg\|2qjg]], [[2qji\|2qji]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qjg\|2qjg]], [[2qji\|2qji]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjh OCA], [http://pdbe.org/2qjh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qjh RCSB], [http://www.ebi.ac.uk/pdbsum/2qjh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qjh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2qjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjh OCA], [http://pdbe.org/2qjh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qjh RCSB], [http://www.ebi.ac.uk/pdbsum/2qjh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qjh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 43067]]		[[Category: Atcc 43067]]
		+	[[Category: Large Structures]]
	[[Category: Ealick, S E]]		[[Category: Ealick, S E]]
	[[Category: Morar, M]]		[[Category: Morar, M]]
	[[Category: Beta-alpha barrel]]		[[Category: Beta-alpha barrel]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 11:04, 5 September 2018

OCA — Wed, 05 Sep 2018 11:04:52 GMT

←Older revision		Revision as of 11:04, 5 September 2018
Line 1:		Line 1:
		+
	==M. jannaschii ADH synthase covalently bound to dihydroxyacetone phosphate==		==M. jannaschii ADH synthase covalently bound to dihydroxyacetone phosphate==
	<StructureSection load='2qjh' size='340' side='right' caption='[[2qjh]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2qjh' size='340' side='right' caption='[[2qjh]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qjg\|2qjg]], [[2qji\|2qji]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qjg\|2qjg]], [[2qji\|2qji]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjh OCA], [http://pdbe.org/2qjh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qjh RCSB], [http://www.ebi.ac.uk/pdbsum/2qjh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjh OCA], [http://pdbe.org/2qjh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qjh RCSB], [http://www.ebi.ac.uk/pdbsum/2qjh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qjh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qj/2qjh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qj/2qjh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qjh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:31, 11 September 2015

OCA — Fri, 11 Sep 2015 14:31:37 GMT

←Older revision		Revision as of 14:31, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2qjh' size='340' side='right' caption='[[2qjh]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2qjh' size='340' side='right' caption='[[2qjh]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qjh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Methanocaldococcus_jannaschii Methanocaldococcus jannaschii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QJH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qjh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43067 Atcc 43067]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QJH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qjg\|2qjg]], [[2qji\|2qji]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qjg\|2qjg]], [[2qji\|2qji]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qjh RCSB], [http://www.ebi.ac.uk/pdbsum/2qjh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjh OCA], [http://pdbe.org/2qjh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qjh RCSB], [http://www.ebi.ac.uk/pdbsum/2qjh PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Y400_METJA Y400_METJA~~]] Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. Can also catalyze the cleavage of fructose-1,6-bisphosphate (FBP) to glyceraldehyde-3-phosphate (GAP) and dihydroxyacetone phosphate (DHAP).<ref>PMID:15182204</ref> <ref>PMID:18318840</ref>	+	[[http://www.uniprot.org/uniprot/ADHS_METJA ADHS_METJA]] Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. Can also catalyze the cleavage of fructose-1,6-bisphosphate (FBP) to glyceraldehyde-3-phosphate (GAP) and dihydroxyacetone phosphate (DHAP).[HAMAP-Rule:MF_00960]<ref>PMID:15182204</ref> <ref>PMID:18318840</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qjh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Methanocaldococcus jannaschii~~]]	+	[[Category: Atcc 43067]]
	[[Category: Ealick, S E]]		[[Category: Ealick, S E]]
	[[Category: Morar, M]]		[[Category: Morar, M]]
	[[Category: Beta-alpha barrel]]		[[Category: Beta-alpha barrel]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 17:45, 25 December 2014

OCA — Thu, 25 Dec 2014 17:45:42 GMT

←Older revision		Revision as of 17:45, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qjh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QJH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qjh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QJH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qjg\|2qjg]], [[2qji\|2qji]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qjg\|2qjg]], [[2qji\|2qji]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qjh RCSB], [http://www.ebi.ac.uk/pdbsum/2qjh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qjh RCSB], [http://www.ebi.ac.uk/pdbsum/2qjh PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Y400_METJA Y400_METJA]] Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. Can also catalyze the cleavage of fructose-1,6-bisphosphate (FBP) to glyceraldehyde-3-phosphate (GAP) and dihydroxyacetone phosphate (DHAP).<ref>PMID:15182204</ref> <ref>PMID:18318840</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Methanocaldococcus jannaschii]]		[[Category: Methanocaldococcus jannaschii]]
-	[[Category: Ealick, S E.]]	+	[[Category: Ealick, S E]]
-	[[Category: Morar, M.]]	+	[[Category: Morar, M]]
	[[Category: Beta-alpha barrel]]		[[Category: Beta-alpha barrel]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 18:46, 30 September 2014

OCA — Tue, 30 Sep 2014 18:46:19 GMT

←Older revision		Revision as of 18:46, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2qjh.~~png~~\|~~left~~\|200px]]	+	==M. jannaschii ADH synthase covalently bound to dihydroxyacetone phosphate==
		+	<StructureSection load='2qjh' size='340' side='right' caption='[[2qjh]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2qjh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QJH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qjg\|2qjg]], [[2qji\|2qji]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qjh RCSB], [http://www.ebi.ac.uk/pdbsum/2qjh PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qj/2qjh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Genes responsible for the generation of 3-dehydroquinate (DHQ), an early metabolite in the established shikimic pathway of aromatic amino acid biosynthesis, are absent in most euryarchaeotes. Alternative gene products, Mj0400 and Mj1249, have been identified in Methanocaldococcus jannaschii as the enzymes involved in the synthesis of DHQ. 2-Amino-3,7-dideoxy-d-threo-hept-6-ulosonic acid (ADH) synthase, the product of the Mj0400 gene, catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate and l-aspartate semialdehyde to yield ADH. Dehydroquinate synthase II, the product of the Mj1249 gene, then catalyzes deamination and cyclization of ADH, resulting in DHQ, which is fed into the canonical pathway. Three crystal structures of ADH synthase were determined in this work: a complex with a substrate analogue, fructose 1,6-bisphosphate, a complex with dihydroxyacetone phosphate (DHAP), thought to be a product of fructose 1-phosphate cleavage, and a native structure containing copurified ligands, modeled as DHAP and glycerol. On the basis of the structural analysis and comparison of the enzyme with related aldolases, ADH synthase is classified as a new member of the class I aldolase superfamily. The description of the active site allows for the identification and characterization of possible catalytic residues, Lys184, which is responsible for formation of the Schiff base intermediate, and Asp33 and Tyr153, which are candidates for the general acid/base catalysis.

-	~~{{STRUCTURE_2qjh\| PDB=2qjh \| SCENE= }}~~	+	Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.,Morar M, White RH, Ealick SE Biochemistry. 2007 Sep 18;46(37):10562-71. Epub 2007 Aug 22. PMID:17713928<ref>PMID:17713928</ref>

-	~~===M. jannaschii ADH synthase covalently bound to dihydroxyacetone phosphate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17713928}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2qjh]] is~~ a ~~20 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017713928<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Methanocaldococcus jannaschii]]		[[Category: Methanocaldococcus jannaschii]]
	[[Category: Ealick, S E.]]		[[Category: Ealick, S E.]]

OCA: Protected "2qjh" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 21:26:32 GMT

Protected "2qjh" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:26, 7 January 2013

OCA at 21:26, 7 January 2013

OCA — Mon, 07 Jan 2013 21:26:30 GMT

←Older revision		Revision as of 21:26, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2qjh.png\|left\|200px]]		[[Image:2qjh.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2qjh", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2qjh\| PDB=2qjh \| SCENE= }}		{{STRUCTURE_2qjh\| PDB=2qjh \| SCENE= }}

	===M. jannaschii ADH synthase covalently bound to dihydroxyacetone phosphate===		===M. jannaschii ADH synthase covalently bound to dihydroxyacetone phosphate===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17713928}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17713928 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17713928}}		{{ABSTRACT_PUBMED_17713928}}

	==About this Structure==		==About this Structure==
-	~~2QJH~~ is a 20 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA].	+	[[2qjh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17713928~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017713928</ref><references group="xtra"/>
	[[Category: Methanocaldococcus jannaschii]]		[[Category: Methanocaldococcus jannaschii]]
	[[Category: Ealick, S E.]]		[[Category: Ealick, S E.]]
Line 29:		Line 17:
	[[Category: Beta-alpha barrel]]		[[Category: Beta-alpha barrel]]
	[[Category: Lyase]]		[[Category: Lyase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:35:48 2009''

OCA at 22:35, 17 February 2009

OCA — Tue, 17 Feb 2009 22:35:49 GMT

←Older revision		Revision as of 22:35, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2QJH is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA].	+	2QJH is a 20 chains structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJH OCA].

	==Reference==		==Reference==
-	Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids., Morar M, White RH, Ealick SE, Biochemistry. 2007 Sep 18;46(37):10562-71. Epub 2007 Aug 22. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17713928 17713928]~~	+	<ref group="xtra">PMID:17713928</ref><references group="xtra"/>
	[[Category: Methanocaldococcus jannaschii]]		[[Category: Methanocaldococcus jannaschii]]
-	[[Category: Single protein]]
	[[Category: Ealick, S E.]]		[[Category: Ealick, S E.]]
	[[Category: Morar, M.]]		[[Category: Morar, M.]]
Line 31:		Line 30:
	[[Category: Lyase]]		[[Category: Lyase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 08:~~00:~~02 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:35:48 2009''

OCA at 05:00, 29 July 2008

OCA — Tue, 29 Jul 2008 05:00:05 GMT

←Older revision		Revision as of 05:00, 29 July 2008
Line 1:		Line 1:
-	[[Image:2qjh.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2qjh.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2qjh\| PDB=2qjh \| SCENE= }}		{{STRUCTURE_2qjh\| PDB=2qjh \| SCENE= }}

-	~~'''~~M. jannaschii ADH synthase covalently bound to dihydroxyacetone phosphate~~'''~~	+	===M. jannaschii ADH synthase covalently bound to dihydroxyacetone phosphate===


-	~~==Overview==~~	+	<!--
-	~~Genes responsible for the generation of 3~~-dehydroquinate (DHQ), an early metabolite in the established shikimic pathway of aromatic amino acid biosynthesis, are absent in most euryarchaeotes. Alternative gene products, Mj0400 and Mj1249, have been identified in Methanocaldococcus jannaschii as the enzymes involved in the synthesis of DHQ. 2-~~Amino-3~~,~~7-dideoxy-d-threo-hept-6-ulosonic acid (ADH) synthase~~, the ~~product of the Mj0400 gene, catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate and l-aspartate semialdehyde~~ to ~~yield ADH. Dehydroquinate synthase II,~~ the product of the Mj1249 gene, then catalyzes deamination and cyclization of ADH, resulting in DHQ, which is fed into the canonical pathway. Three crystal structures of ADH synthase were determined in this work: a complex with a substrate analogue, fructose 1,6-bisphosphate, a complex with dihydroxyacetone phosphate (~~DHAP), thought to be a product of fructose 1-phosphate cleavage, and a native structure containing copurified ligands, modeled~~ as ~~DHAP and glycerol~~. ~~On the basis of the structural analysis and comparison of the enzyme with related aldolases, ADH synthase is classified as a new member of the class I aldolase superfamily~~. ~~The description of the active site allows for the identification and characterization of possible catalytic residues, Lys184~~, ~~which~~ is ~~responsible for formation of~~ the ~~Schiff base intermediate, and Asp33 and Tyr153, which are candidates for the general acid/base catalysis~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17713928}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17713928 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17713928}}

	==About this Structure==		==About this Structure==
Line 26:		Line 30:
	[[Category: Beta-alpha barrel]]		[[Category: Beta-alpha barrel]]
	[[Category: Lyase]]		[[Category: Lyase]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 15~~:03:38 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:00:02 2008''