2qjt - Revision history

OCA at 08:22, 25 June 2021

OCA — Fri, 25 Jun 2021 08:22:24 GMT

←Older revision		Revision as of 08:22, 25 June 2021
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	==Crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase complexed with AMP and MN ion from Francisella tularensis==		==Crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase complexed with AMP and MN ion from Francisella tularensis==
-	<StructureSection load='2qjt' size='340' side='right' caption='[[2qjt]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2qjt' size='340' side='right'caption='[[2qjt]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qjt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacterium_tularense"_mccoy_and_chapin_1912 "bacterium tularense" mccoy and chapin 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QJT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qjt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacterium_tularense"_mccoy_and_chapin_1912 "bacterium tularense" mccoy and chapin 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QJT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nadM ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=263 "Bacterium tularense" McCoy and Chapin 1912])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nadM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=263 "Bacterium tularense" McCoy and Chapin 1912])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjt OCA], [~~http~~://pdbe.org/2qjt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qjt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qjt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qjt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjt OCA], [https://pdbe.org/2qjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qjt RCSB], [https://www.ebi.ac.uk/pdbsum/2qjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qjt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qj/2qjt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qj/2qjt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Bacterium tularense mccoy and chapin 1912]]		[[Category: Bacterium tularense mccoy and chapin 1912]]
		+	[[Category: Large Structures]]
	[[Category: Brautigan, C]]		[[Category: Brautigan, C]]
	[[Category: Grishin, N V]]		[[Category: Grishin, N V]]

OCA at 09:50, 18 October 2017

OCA — Wed, 18 Oct 2017 09:50:23 GMT

←Older revision		Revision as of 09:50, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase complexed with AMP and MN ion from Francisella tularensis==		==Crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase complexed with AMP and MN ion from Francisella tularensis==
	<StructureSection load='2qjt' size='340' side='right' caption='[[2qjt]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2qjt' size='340' side='right' caption='[[2qjt]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nadM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=263 "Bacterium tularense" McCoy and Chapin 1912])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nadM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=263 "Bacterium tularense" McCoy and Chapin 1912])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjt OCA], [http://pdbe.org/2qjt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qjt RCSB], [http://www.ebi.ac.uk/pdbsum/2qjt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjt OCA], [http://pdbe.org/2qjt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qjt RCSB], [http://www.ebi.ac.uk/pdbsum/2qjt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qjt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 16:12, 7 February 2016

OCA — Sun, 07 Feb 2016 16:12:29 GMT

←Older revision		Revision as of 16:12, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qjt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:06, 10 September 2015

OCA — Thu, 10 Sep 2015 03:06:58 GMT

←Older revision		Revision as of 03:06, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2qjt' size='340' side='right' caption='[[2qjt]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2qjt' size='340' side='right' caption='[[2qjt]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qjt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Francisella_tularensis Francisella tularensis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QJT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qjt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_tularense"_mccoy_and_chapin_1912 "bacterium tularense" mccoy and chapin 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QJT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nadM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=263 ~~Francisella tularensis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nadM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=263 "Bacterium tularense" McCoy and Chapin 1912])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qjt RCSB], [http://www.ebi.ac.uk/pdbsum/2qjt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjt OCA], [http://pdbe.org/2qjt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qjt RCSB], [http://www.ebi.ac.uk/pdbsum/2qjt PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qjt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Francisella tularensis~~]]	+	[[Category: Bacterium tularense mccoy and chapin 1912]]
	[[Category: Brautigan, C]]		[[Category: Brautigan, C]]
	[[Category: Grishin, N V]]		[[Category: Grishin, N V]]

OCA at 17:19, 19 January 2015

OCA — Mon, 19 Jan 2015 17:19:45 GMT

←Older revision		Revision as of 17:19, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qjt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis Francisella tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QJT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qjt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis Francisella tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QJT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nadM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=263 Francisella tularensis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nadM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=263 Francisella tularensis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qjt RCSB], [http://www.ebi.ac.uk/pdbsum/2qjt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qjt RCSB], [http://www.ebi.ac.uk/pdbsum/2qjt PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Francisella tularensis]]		[[Category: Francisella tularensis]]
-	[[Category: Brautigan, C.]]	+	[[Category: Brautigan, C]]
-	[[Category: Grishin, N V.]]	+	[[Category: Grishin, N V]]
-	[[Category: Huang, N.]]	+	[[Category: Huang, N]]
-	[[Category: Magni, G.]]	+	[[Category: Magni, G]]
-	[[Category: Osterman, A.]]	+	[[Category: Osterman, A]]
-	[[Category: Raffaelli, N.]]	+	[[Category: Raffaelli, N]]
-	[[Category: Sorci, L.]]	+	[[Category: Sorci, L]]
-	[[Category: Zhang, H.]]	+	[[Category: Zhang, H]]
-	[[Category: Zhang, X.]]	+	[[Category: Zhang, X]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Two individual domain]]		[[Category: Two individual domain]]

OCA at 19:51, 30 September 2014

OCA — Tue, 30 Sep 2014 19:51:41 GMT

←Older revision		Revision as of 19:51, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2qjt.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase complexed with AMP and MN ion from Francisella tularensis==
		+	<StructureSection load='2qjt' size='340' side='right' caption='[[2qjt]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2qjt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis Francisella tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QJT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nadM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=263 Francisella tularensis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qjt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qjt RCSB], [http://www.ebi.ac.uk/pdbsum/2qjt PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qj/2qjt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial NadM-Nudix is a bifunctional enzyme containing a nicotinamide mononucleotide (NMN) adenylyltransferase and an ADP-ribose (ADPR) pyrophosphatase domain. While most members of this enzyme family, such as that from a model cyanobacterium Synechocystis sp., are involved primarily in nicotinamide adenine dinucleotide (NAD) salvage/recycling pathways, its close homolog in a category-A biodefense pathogen, Francisella tularensis, likely plays a central role in a recently discovered novel pathway of NAD de novo synthesis. The crystal structures of NadM-Nudix from both species, including their complexes with various ligands and catalytic metal ions, revealed detailed configurations of the substrate binding and catalytic sites in both domains. The structure of the N-terminal NadM domain may be exploited for designing new antitularemia therapeutics. The ADPR binding site in the C-terminal Nudix domain is substantially different from that of Escherichia coli ADPR pyrophosphatase, and is more similar to human NUDT9. The latter observation provided new insights into the ligand binding mode of ADPR-gated Ca2+ channel TRPM2.

-	~~{{STRUCTURE_2qjt\| PDB=2qjt \| SCENE= }}~~	+	Bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase: structure and function in bacterial NAD metabolism.,Huang N, Sorci L, Zhang X, Brautigam CA, Li X, Raffaelli N, Magni G, Grishin NV, Osterman AL, Zhang H Structure. 2008 Feb;16(2):196-209. PMID:18275811<ref>PMID:18275811</ref>

-	~~===Crystal structure of a bifunctional NMN adenylyltransferase~~/~~ADP ribose pyrophosphatase complexed with AMP and MN ion from Francisella tularensis===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18275811}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2qjt]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Francisella_tularensis Francisella tularensis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2QJT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018275811<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Francisella tularensis]]		[[Category: Francisella tularensis]]
	[[Category: Brautigan, C.]]		[[Category: Brautigan, C.]]

OCA: Protected "2qjt" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:43:06 GMT

Protected "2qjt" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:43, 7 January 2013

OCA at 22:43, 7 January 2013

OCA — Mon, 07 Jan 2013 22:43:04 GMT

←Older revision		Revision as of 22:43, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2qjt.png\|left\|200px]]		[[Image:2qjt.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2qjt", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2qjt\| PDB=2qjt \| SCENE= }}		{{STRUCTURE_2qjt\| PDB=2qjt \| SCENE= }}

	===Crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase complexed with AMP and MN ion from Francisella tularensis===		===Crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase complexed with AMP and MN ion from Francisella tularensis===

-
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	{{ABSTRACT_PUBMED_18275811}}		{{ABSTRACT_PUBMED_18275811}}

	==About this Structure==		==About this Structure==
-	~~2QJT~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Francisella_tularensis Francisella tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJT OCA].	+	[[2qjt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis Francisella tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18275811~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018275811</ref><references group="xtra"/>
	[[Category: Francisella tularensis]]		[[Category: Francisella tularensis]]
	[[Category: Brautigan, C.]]		[[Category: Brautigan, C.]]
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	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Two individual domain]]		[[Category: Two individual domain]]
-
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OCA at 13:01, 16 February 2009

OCA — Mon, 16 Feb 2009 13:01:19 GMT

←Older revision		Revision as of 13:01, 16 February 2009
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	==About this Structure==		==About this Structure==
-	2QJT is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Francisella_tularensis Francisella tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJT OCA].	+	2QJT is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Francisella_tularensis Francisella tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJT OCA].

	==Reference==		==Reference==
-	Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism., Huang N, Sorci L, Zhang X, Brautigam CA, Li X, Raffaelli N, Magni G, Grishin NV, Osterman AL, Zhang H, Structure. 2008 Feb;16(2):196-209. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18275811 18275811]~~	+	<ref group="xtra">PMID:18275811</ref><references group="xtra"/>
	[[Category: Francisella tularensis]]		[[Category: Francisella tularensis]]
-	[[Category: Single protein]]
	[[Category: Brautigan, C.]]		[[Category: Brautigan, C.]]
	[[Category: Grishin, N V.]]		[[Category: Grishin, N V.]]
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	[[Category: Two individual domain]]		[[Category: Two individual domain]]

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OCA at 14:48, 27 July 2008

OCA — Sun, 27 Jul 2008 14:48:35 GMT

←Older revision		Revision as of 14:48, 27 July 2008
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-	[[Image:2qjt.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2qjt.png\|left\|200px]]

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	{{STRUCTURE_2qjt\| PDB=2qjt \| SCENE= }}		{{STRUCTURE_2qjt\| PDB=2qjt \| SCENE= }}

-	~~'''~~Crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase complexed with AMP and MN ion from Francisella tularensis~~'''~~	+	===Crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase complexed with AMP and MN ion from Francisella tularensis===


-	~~==Overview==~~	+	<!--
-	~~Bacterial NadM~~-~~Nudix is a bifunctional enzyme containing a nicotinamide mononucleotide (NMN) adenylyltransferase and an ADP~~-~~ribose (ADPR) pyrophosphatase domain. While most members of~~ this ~~enzyme family~~, ~~such as that from a model cyanobacterium Synechocystis sp.~~, ~~are involved primarily in nicotinamide adenine dinucleotide~~ (~~NAD) salvage~~/~~recycling pathways, its close homolog in a category-A biodefense pathogen, Francisella tularensis, likely plays a central role in a recently discovered novel pathway of NAD de novo synthesis~~. ~~The crystal structures of NadM-Nudix from both species~~, ~~including their complexes with various ligands and catalytic metal ions, revealed detailed configurations of~~ the ~~substrate binding and catalytic sites in both domains~~. ~~The structure of the N~~-~~terminal NadM domain may be exploited for designing new antitularemia therapeutics. The ADPR binding site in the C~~-terminal Nudix domain is substantially different from that of Escherichia coli ADPR pyrophosphatase, and is more similar to human NUDT9. The latter observation provided new insights into the ligand binding mode of ADPR-gated Ca(2+) channel TRPM2.	+	The line below this paragraph, {{ABSTRACT_PUBMED_18275811}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18275811 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18275811}}

	==About this Structure==		==About this Structure==
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	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Two individual domain]]		[[Category: Two individual domain]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 15~~:04:45 2008''	+
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