2qk4 - Revision history

OCA at 11:34, 30 August 2023

OCA — Wed, 30 Aug 2023 11:34:27 GMT

←Older revision		Revision as of 11:34, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2qk4' size='340' side='right'caption='[[2qk4]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='2qk4' size='340' side='right'caption='[[2qk4]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qk4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QK4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qk4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QK4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GART, PGFT, PRGS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoribosylamine--glycine_ligase Phosphoribosylamine--glycine ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.13 6.3.4.13] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qk4 OCA], [https://pdbe.org/2qk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qk4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qk4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qk4 OCA], [https://pdbe.org/2qk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qk4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qk4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PUR2_HUMAN PUR2_HUMAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phosphoribosylamine--glycine ligase]]~~	+	[[Category: Arrowsmith CH]]
-	[[Category: Arrowsmith~~, C H]]~~	+	[[Category: Berglund H]]
-	~~[[Category: Berg, S van den~~]]	+	[[Category: Busam R]]
-	[[Category: Berglund, H]]	+	[[Category: Collins R]]
-	[[Category: Busam, R]]	+	[[Category: Dahlgren LG]]
-	[[Category: Collins, R]]	+	[[Category: Edwards A]]
-	[[Category: Dahlgren~~, L G~~]]	+	[[Category: Flodin S]]
-	[[Category: Edwards, A]]	+	[[Category: Flores A]]
-	[[Category: Flodin, S]]	+	[[Category: Graslund S]]
-	[[Category: Flores, A]]	+	[[Category: Hallberg BM]]
-	[[Category: Graslund, S]]	+	[[Category: Hammarstrom M]]
-	[[Category: Hallberg~~, B M~~]]	+	[[Category: Herman MD]]
-	[[Category: Hammarstrom, M]]	+	[[Category: Holmberg-Schiavone L]]
-	[[Category: Herman~~, M D~~]]	+	[[Category: Johansson I]]
-	[[Category: Holmberg-Schiavone, L]]	+	[[Category: Kallas A]]
-	[[Category: Johansson, I]]	+	[[Category: Karlberg T]]
-	[[Category: Kallas, A]]	+	[[Category: Kotenyova T]]
-	[[Category: Karlberg, T]]	+	[[Category: Lehtio L]]
-	[[Category: Kotenyova, T]]	+	[[Category: Moche M]]
-	[[Category: Lehtio, L]]	+	[[Category: Nordlund P]]
-	[[Category: Moche, M]]	+	[[Category: Nyman T]]
-	[[Category: Nordlund, P]]	+	[[Category: Persson C]]
-	[[Category: Nyman, T]]	+	[[Category: Sagemark J]]
-	[[Category: Persson, C]]	+	[[Category: Stenmark P]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Sundstrom M]]
-	[[Category: Sagemark, J]]	+	[[Category: Thorsell AG]]
-	[[Category: Stenmark, P]]	+	[[Category: Tresaugues L]]
-	[[Category: Sundstrom, M]]	+	[[Category: Weigelt J]]
-	[[Category: Thorsell~~, A G~~]]	+	[[Category: Welin M]]
-	[[Category: Tresaugues, L]]	+	[[Category: Van den Berg S]]
-	[[Category: Weigelt, J]]	+
-	[[Category: Welin, M]]	+
-	[[Category: ~~Enzyme]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Protein-atp complex]]~~	+
-	~~[[Category: Purine synthesis]]~~	+
-	~~[[Category: Sgc~~]]	+

OCA at 08:22, 25 June 2021

OCA — Fri, 25 Jun 2021 08:22:45 GMT

←Older revision		Revision as of 08:22, 25 June 2021
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	==Human glycinamide ribonucleotide synthetase==		==Human glycinamide ribonucleotide synthetase==
-	<StructureSection load='2qk4' size='340' side='right' caption='[[2qk4]], [[Resolution\|resolution]] 2.45Å' scene=''>	+	<StructureSection load='2qk4' size='340' side='right'caption='[[2qk4]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qk4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QK4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qk4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QK4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GART, PGFT, PRGS ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GART, PGFT, PRGS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphoribosylamine--glycine_ligase Phosphoribosylamine--glycine ligase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.13 6.3.4.13] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoribosylamine--glycine_ligase Phosphoribosylamine--glycine ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.13 6.3.4.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qk4 OCA], [~~http~~://pdbe.org/2qk4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qk4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qk4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qk4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qk4 OCA], [https://pdbe.org/2qk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qk4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qk4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Phosphoribosylamine--glycine ligase]]		[[Category: Phosphoribosylamine--glycine ligase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 11:30, 5 September 2018

OCA — Wed, 05 Sep 2018 11:30:41 GMT

←Older revision		Revision as of 11:30, 5 September 2018
Line 1:		Line 1:
		+
	==Human glycinamide ribonucleotide synthetase==		==Human glycinamide ribonucleotide synthetase==
	<StructureSection load='2qk4' size='340' side='right' caption='[[2qk4]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='2qk4' size='340' side='right' caption='[[2qk4]], [[Resolution\|resolution]] 2.45Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GART, PGFT, PRGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GART, PGFT, PRGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylamine--glycine_ligase Phosphoribosylamine--glycine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.13 6.3.4.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylamine--glycine_ligase Phosphoribosylamine--glycine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.13 6.3.4.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qk4 OCA], [http://pdbe.org/2qk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2qk4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qk4 OCA], [http://pdbe.org/2qk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2qk4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qk4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/2qk4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/2qk4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:51, 8 February 2016

OCA — Mon, 08 Feb 2016 06:51:22 GMT

←Older revision		Revision as of 06:51, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qk4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:59, 10 September 2015

OCA — Thu, 10 Sep 2015 08:59:17 GMT

←Older revision		Revision as of 08:59, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2qk4' size='340' side='right' caption='[[2qk4]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='2qk4' size='340' side='right' caption='[[2qk4]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QK4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QK4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GART, PGFT, PRGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GART, PGFT, PRGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylamine--glycine_ligase Phosphoribosylamine--glycine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.13 6.3.4.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylamine--glycine_ligase Phosphoribosylamine--glycine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.13 6.3.4.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2qk4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qk4 OCA], [http://pdbe.org/2qk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2qk4 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qk4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Phosphoribosylamine--glycine ligase]]		[[Category: Phosphoribosylamine--glycine ligase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 17:09, 19 January 2015

OCA — Mon, 19 Jan 2015 17:09:10 GMT

←Older revision		Revision as of 17:09, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QK4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QK4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GART, PGFT, PRGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GART, PGFT, PRGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylamine--glycine_ligase Phosphoribosylamine--glycine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.13 6.3.4.13] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylamine--glycine_ligase Phosphoribosylamine--glycine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.13 6.3.4.13] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2qk4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2qk4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoribosylamine--glycine ligase]]		[[Category: Phosphoribosylamine--glycine ligase]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Berg, S van den.]]	+	[[Category: Berg, S van den]]
-	[[Category: Berglund, H.]]	+	[[Category: Berglund, H]]
-	[[Category: Busam, R.]]	+	[[Category: Busam, R]]
-	[[Category: Collins, R.]]	+	[[Category: Collins, R]]
-	[[Category: Dahlgren, L G.]]	+	[[Category: Dahlgren, L G]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Flodin, S.]]	+	[[Category: Flodin, S]]
-	[[Category: Flores, A.]]	+	[[Category: Flores, A]]
-	[[Category: Graslund, S.]]	+	[[Category: Graslund, S]]
-	[[Category: Hallberg, B M.]]	+	[[Category: Hallberg, B M]]
-	[[Category: Hammarstrom, M.]]	+	[[Category: Hammarstrom, M]]
-	[[Category: Herman, M D.]]	+	[[Category: Herman, M D]]
-	[[Category: Holmberg-Schiavone, L.]]	+	[[Category: Holmberg-Schiavone, L]]
-	[[Category: Johansson, I.]]	+	[[Category: Johansson, I]]
-	[[Category: Kallas, A.]]	+	[[Category: Kallas, A]]
-	[[Category: Karlberg, T.]]	+	[[Category: Karlberg, T]]
-	[[Category: Kotenyova, T.]]	+	[[Category: Kotenyova, T]]
-	[[Category: Lehtio, L.]]	+	[[Category: Lehtio, L]]
-	[[Category: Moche, M.]]	+	[[Category: Moche, M]]
-	[[Category: Nordlund, P.]]	+	[[Category: Nordlund, P]]
-	[[Category: Nyman, T.]]	+	[[Category: Nyman, T]]
-	[[Category: Persson, C.]]	+	[[Category: Persson, C]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sagemark, J.]]	+	[[Category: Sagemark, J]]
-	[[Category: Stenmark, P.]]	+	[[Category: Stenmark, P]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Thorsell, A G.]]	+	[[Category: Thorsell, A G]]
-	[[Category: Tresaugues, L.]]	+	[[Category: Tresaugues, L]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Welin, M.]]	+	[[Category: Welin, M]]
	[[Category: Enzyme]]		[[Category: Enzyme]]
	[[Category: Ligase]]		[[Category: Ligase]]
Line 68:		Line 68:
	[[Category: Purine synthesis]]		[[Category: Purine synthesis]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]

OCA at 19:42, 30 September 2014

OCA — Tue, 30 Sep 2014 19:42:09 GMT

←Older revision		Revision as of 19:42, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2qk4.~~png~~\|~~left~~\|200px]]	+	==Human glycinamide ribonucleotide synthetase==
		+	<StructureSection load='2qk4' size='340' side='right' caption='[[2qk4]], [[Resolution\|resolution]] 2.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2qk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QK4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GART, PGFT, PRGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylamine--glycine_ligase Phosphoribosylamine--glycine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.13 6.3.4.13] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2qk4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/2qk4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human purine de novo synthesis pathway contains several multi-functional enzymes, one of which, tri-functional GART, contains three enzymatic activities in a single polypeptide chain. We have solved structures of two domains bearing separate catalytic functions: glycinamide ribonucleotide synthetase and aminoimidazole ribonucleotide synthetase. Structures are compared with those of homologous enzymes from prokaryotes and analyzed in terms of the catalytic mechanism. We also report small angle X-ray scattering models for the full-length protein. These models are consistent with the enzyme forming a dimer through the middle domain. The protein has an approximate seesaw geometry where terminal enzyme units display high mobility owing to flexible linker segments. This resilient seesaw shape may facilitate internal substrate/product transfer or forwarding to other enzymes in the pathway.

-	~~{{STRUCTURE_2qk4\| PDB=2qk4 \| SCENE= }}~~	+	Structural studies of tri-functional human GART.,Welin M, Grossmann JG, Flodin S, Nyman T, Stenmark P, Tresaugues L, Kotenyova T, Johansson I, Nordlund P, Lehtio L Nucleic Acids Res. 2010 Nov 1;38(20):7308-19. Epub 2010 Jul 14. PMID:20631005<ref>PMID:20631005</ref>

-	~~===Human glycinamide ribonucleotide synthetase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20631005}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2qk4]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:020631005<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoribosylamine--glycine ligase]]		[[Category: Phosphoribosylamine--glycine ligase]]

OCA: Protected "2qk4" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:36:35 GMT

Protected "2qk4" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:36, 7 January 2013

OCA at 22:36, 7 January 2013

OCA — Mon, 07 Jan 2013 22:36:32 GMT

←Older revision		Revision as of 22:36, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2qk4.png\|left\|200px]]		[[Image:2qk4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2qk4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2qk4\| PDB=2qk4 \| SCENE= }}		{{STRUCTURE_2qk4\| PDB=2qk4 \| SCENE= }}

	===Human glycinamide ribonucleotide synthetase===		===Human glycinamide ribonucleotide synthetase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20631005}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20631005 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20631005}}		{{ABSTRACT_PUBMED_20631005}}

	==About this Structure==		==About this Structure==
-	~~2QK4~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA].	+	[[2qk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20631005~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020631005</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoribosylamine--glycine ligase]]		[[Category: Phosphoribosylamine--glycine ligase]]
Line 64:		Line 52:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:19:13 2010''

OCA at 08:07, 8 December 2010

OCA — Wed, 08 Dec 2010 08:07:10 GMT

←Older revision		Revision as of 08:07, 8 December 2010
Line 12:		Line 12:
	===Human glycinamide ribonucleotide synthetase===		===Human glycinamide ribonucleotide synthetase===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20631005}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20631005 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20631005}}

	==About this Structure==		==About this Structure==
-	2QK4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA].	+	2QK4 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20631005</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoribosylamine--glycine ligase]]		[[Category: Phosphoribosylamine--glycine ligase]]
Line 49:		Line 58:
	[[Category: Welin, M.]]		[[Category: Welin, M.]]
	[[Category: Enzyme]]		[[Category: Enzyme]]
		+	[[Category: Ligase]]
	[[Category: Protein-atp complex]]		[[Category: Protein-atp complex]]
	[[Category: Purine synthesis]]		[[Category: Purine synthesis]]
Line 55:		Line 65:
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Feb 16 19~~:57:~~32 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:19:13 2010''