2qkh - Revision history

OCA at 08:23, 25 June 2021

OCA — Fri, 25 Jun 2021 08:23:11 GMT

←Older revision		Revision as of 08:23, 25 June 2021
Line 1:		Line 1:

	==Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP==		==Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP==
-	<StructureSection load='2qkh' size='340' side='right' caption='[[2qkh]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2qkh' size='340' side='right'caption='[[2qkh]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qkh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QKH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QKH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qkh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QKH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~QKH~~:~~METHYL~~-~~CYCLO-HEPTA~~-~~AMYLOSE~~'>~~QKH~~</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GIPR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZB0:'>ZB0</scene>, <scene name='pdbligand=ZB1:'>ZB1</scene>, <scene name='pdbligand=ZB2:'>ZB2</scene>, <scene name='pdbligand=ZB3:'>ZB3</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qkh OCA], [~~http~~://pdbe.org/2qkh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qkh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qkh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qkh ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GIPR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qkh OCA], [https://pdbe.org/2qkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qkh RCSB], [https://www.ebi.ac.uk/pdbsum/2qkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qkh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GIP_HUMAN GIP_HUMAN]] Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. [[~~http~~://www.uniprot.org/uniprot/GIPR_HUMAN GIPR_HUMAN]] This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.	+	[[https://www.uniprot.org/uniprot/GIP_HUMAN GIP_HUMAN]] Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. [[https://www.uniprot.org/uniprot/GIPR_HUMAN GIPR_HUMAN]] This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/2qkh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/2qkh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2qkh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2qkh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glucose-dependent Insulinotropic Polypeptide Receptor\|Glucose-dependent Insulinotropic Polypeptide Receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Demuth, H U]]		[[Category: Demuth, H U]]
	[[Category: Fanghanel, J]]		[[Category: Fanghanel, J]]

OCA at 09:51, 18 October 2017

OCA — Wed, 18 Oct 2017 09:51:32 GMT

←Older revision		Revision as of 09:51, 18 October 2017
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		+
	==Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP==		==Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP==
	<StructureSection load='2qkh' size='340' side='right' caption='[[2qkh]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2qkh' size='340' side='right' caption='[[2qkh]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QKH:METHYL-CYCLO-HEPTA-AMYLOSE'>QKH</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QKH:METHYL-CYCLO-HEPTA-AMYLOSE'>QKH</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GIPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GIPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qkh OCA], [http://pdbe.org/2qkh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qkh RCSB], [http://www.ebi.ac.uk/pdbsum/2qkh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qkh OCA], [http://pdbe.org/2qkh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qkh RCSB], [http://www.ebi.ac.uk/pdbsum/2qkh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qkh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qkh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2qkh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2qkh" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Glucose-dependent Insulinotropic Polypeptide Receptor\|Glucose-dependent Insulinotropic Polypeptide Receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 46:		Line 44:
	[[Category: Schlenzig, D]]		[[Category: Schlenzig, D]]
	[[Category: Stubbs, M T]]		[[Category: Stubbs, M T]]
		+	[[Category: Alternative splicing]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]
	[[Category: Diabetes]]		[[Category: Diabetes]]
Line 60:		Line 59:
	[[Category: Ligand binding domain]]		[[Category: Ligand binding domain]]
	[[Category: Membrane]]		[[Category: Membrane]]
		+	[[Category: Polymorphism]]
	[[Category: Signaling protein-hormone complex]]		[[Category: Signaling protein-hormone complex]]
	[[Category: Transducer]]		[[Category: Transducer]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

OCA at 02:21, 12 September 2015

OCA — Sat, 12 Sep 2015 02:21:23 GMT

←Older revision		Revision as of 02:21, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2qkh' size='340' side='right' caption='[[2qkh]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2qkh' size='340' side='right' caption='[[2qkh]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qkh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QKH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QKH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qkh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QKH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QKH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QKH:METHYL-CYCLO-HEPTA-AMYLOSE'>QKH</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QKH:METHYL-CYCLO-HEPTA-AMYLOSE'>QKH</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GIPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GIPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qkh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qkh RCSB], [http://www.ebi.ac.uk/pdbsum/2qkh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qkh OCA], [http://pdbe.org/2qkh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qkh RCSB], [http://www.ebi.ac.uk/pdbsum/2qkh PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qkh" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Demuth, H U]]		[[Category: Demuth, H U]]
	[[Category: Fanghanel, J]]		[[Category: Fanghanel, J]]

OCA at 22:38, 25 December 2014

OCA — Thu, 25 Dec 2014 22:38:09 GMT

←Older revision		Revision as of 22:38, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qkh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QKH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QKH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qkh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QKH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QKH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QKH:METHYL-CYCLO-HEPTA-AMYLOSE'>QKH</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QKH:METHYL-CYCLO-HEPTA-AMYLOSE'>QKH</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GIPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GIPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qkh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qkh RCSB], [http://www.ebi.ac.uk/pdbsum/2qkh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qkh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qkh RCSB], [http://www.ebi.ac.uk/pdbsum/2qkh PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GIP_HUMAN GIP_HUMAN]] Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. [[http://www.uniprot.org/uniprot/GIPR_HUMAN GIPR_HUMAN]] This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Demuth, H U.]]	+	[[Category: Demuth, H U]]
-	[[Category: Fanghanel, J.]]	+	[[Category: Fanghanel, J]]
-	[[Category: Kleinschmidt, M.]]	+	[[Category: Kleinschmidt, M]]
-	[[Category: Manhart, S.]]	+	[[Category: Manhart, S]]
-	[[Category: Neumann, P.]]	+	[[Category: Neumann, P]]
-	[[Category: Parthier, C.]]	+	[[Category: Parthier, C]]
-	[[Category: Rahfeld, J U.]]	+	[[Category: Rahfeld, J U]]
-	[[Category: Rudolph, R.]]	+	[[Category: Rudolph, R]]
-	[[Category: Schlenzig, D.]]	+	[[Category: Schlenzig, D]]
-	[[Category: Stubbs, M T.]]	+	[[Category: Stubbs, M T]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]
	[[Category: Diabetes]]		[[Category: Diabetes]]

OCA at 20:07, 30 September 2014

OCA — Tue, 30 Sep 2014 20:07:01 GMT

←Older revision		Revision as of 20:07, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2qkh\| PDB=2qkh \| SCENE= }}~~	+	==Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP==
-	===Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP===	+	<StructureSection load='2qkh' size='340' side='right' caption='[[2qkh]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17715056}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2qkh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QKH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QKH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QKH:METHYL-CYCLO-HEPTA-AMYLOSE'>QKH</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GIPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qkh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qkh RCSB], [http://www.ebi.ac.uk/pdbsum/2qkh PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/2qkh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Incretins, endogenous polypeptide hormones released in response to food intake, potentiate insulin secretion from pancreatic beta cells after oral glucose ingestion (the incretin effect). This response is signaled by the two peptide hormones glucose-dependent insulinotropic polypeptide (GIP) (also known as gastric inhibitory polypeptide) and glucagon-like peptide 1 through binding and activation of their cognate class 2 G protein-coupled receptors (GPCRs). Because the incretin effect is lost or significantly reduced in patients with type 2 diabetes mellitus, glucagon-like peptide 1 and GIP have attracted considerable attention for their potential in antidiabetic therapy. A paucity of structural information precludes a detailed understanding of the processes of hormone binding and receptor activation, hampering efforts to develop novel pharmaceuticals. Here we report the crystal structure of the complex of human GIP receptor extracellular domain (ECD) with its agonist, the incretin GIP(1-42). The hormone binds in an alpha-helical conformation in a surface groove of the ECD largely through hydrophobic interactions. The N-terminal ligand residues would remain free to interact with other parts of the receptor. Thermodynamic data suggest that binding is concomitant with structural organization of the hormone, resulting in a complex mode of receptor-ligand recognition. The presentation of a well structured, alpha-helical ligand by the ECD is expected to be conserved among other hormone receptors of this class.

-	~~==About this Structure==~~	+	Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.,Parthier C, Kleinschmidt M, Neumann P, Rudolph R, Manhart S, Schlenzig D, Fanghanel J, Rahfeld JU, Demuth HU, Stubbs MT Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13942-7. Epub 2007 Aug 21. PMID:17715056<ref>PMID:17715056</ref>
-	~~[[2qkh]] is a 2 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2QKH OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Glucose-dependent Insulinotropic Polypeptide Receptor\|Glucose-dependent Insulinotropic Polypeptide Receptor]]		*[[Glucose-dependent Insulinotropic Polypeptide Receptor\|Glucose-dependent Insulinotropic Polypeptide Receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017715056<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Demuth, H U.]]		[[Category: Demuth, H U.]]

OCA at 11:00, 11 March 2013

OCA — Mon, 11 Mar 2013 11:00:41 GMT

←Older revision		Revision as of 11:00, 11 March 2013
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-	[[Image:2qkh.png\|left\|200px]]
-
	{{STRUCTURE_2qkh\| PDB=2qkh \| SCENE= }}		{{STRUCTURE_2qkh\| PDB=2qkh \| SCENE= }}
-
	===Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP===		===Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP===
-
	{{ABSTRACT_PUBMED_17715056}}		{{ABSTRACT_PUBMED_17715056}}

OCA: Protected "2qkh" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 23:00:04 GMT

Protected "2qkh" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:00, 7 January 2013

OCA at 23:00, 7 January 2013

OCA — Mon, 07 Jan 2013 23:00:01 GMT

←Older revision		Revision as of 23:00, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2qkh.png\|left\|200px]]		[[Image:2qkh.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2qkh", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2qkh\| PDB=2qkh \| SCENE= }}		{{STRUCTURE_2qkh\| PDB=2qkh \| SCENE= }}

	===Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP===		===Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17715056}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17715056 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17715056}}		{{ABSTRACT_PUBMED_17715056}}

	==About this Structure==		==About this Structure==
-	~~2QKH~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QKH OCA].	+	[[2qkh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QKH OCA].
		+
		+	==See Also==
		+	*[[Glucose-dependent Insulinotropic Polypeptide Receptor\|Glucose-dependent Insulinotropic Polypeptide Receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17715056~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017715056</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Demuth, H U.]]		[[Category: Demuth, H U.]]
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	[[Category: Schlenzig, D.]]		[[Category: Schlenzig, D.]]
	[[Category: Stubbs, M T.]]		[[Category: Stubbs, M T.]]
-	[[Category: Alternative splicing]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]
	[[Category: Diabetes]]		[[Category: Diabetes]]
Line 50:		Line 40:
	[[Category: Ligand binding domain]]		[[Category: Ligand binding domain]]
	[[Category: Membrane]]		[[Category: Membrane]]
-	~~[[Category: Polymorphism]]~~	+	[[Category: Signaling protein-hormone complex]]
-	[[Category: Signaling protein/hormone complex]]	+
	[[Category: Transducer]]		[[Category: Transducer]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:55:50 2009''

OCA at 07:55, 18 February 2009

OCA — Wed, 18 Feb 2009 07:55:50 GMT

←Older revision		Revision as of 07:55, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2QKH is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QKH OCA].	+	2QKH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QKH OCA].

	==Reference==		==Reference==
-	Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor., Parthier C, Kleinschmidt M, Neumann P, Rudolph R, Manhart S, Schlenzig D, Fanghanel J, Rahfeld JU, Demuth HU, Stubbs MT, Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13942-7. Epub 2007 Aug 21. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17715056 17715056]~~	+	<ref group="xtra">PMID:17715056</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Demuth, H U.]]		[[Category: Demuth, H U.]]
	[[Category: Fanghanel, J.]]		[[Category: Fanghanel, J.]]
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	[[Category: Transmembrane]]		[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 16:16~~:55 ~~2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:55:50 2009''

OCA at 13:16, 29 July 2008

OCA — Tue, 29 Jul 2008 13:16:58 GMT

←Older revision		Revision as of 13:16, 29 July 2008
Line 1:		Line 1:
-	[[Image:2qkh.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2qkh.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2qkh\| PDB=2qkh \| SCENE= }}		{{STRUCTURE_2qkh\| PDB=2qkh \| SCENE= }}

-	~~'''~~Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP~~'''~~	+	===Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP===


-	~~==Overview==~~	+	<!--
-	~~Incretins~~, ~~endogenous polypeptide hormones released in response to food intake~~, ~~potentiate insulin secretion from pancreatic beta cells after oral glucose ingestion (~~the ~~incretin effect). This response is signaled by~~ the ~~two peptide hormones glucose-dependent insulinotropic polypeptide~~ (~~GIP) (also known~~ as ~~gastric inhibitory polypeptide) and glucagon-like peptide 1 through binding and activation of their cognate class 2 G protein-coupled receptors (GPCRs)~~. Because the incretin effect is lost or significantly reduced in patients with type 2 diabetes mellitus, glucagon-like peptide 1 and GIP have attracted considerable attention for their potential in antidiabetic therapy. A paucity of structural information precludes a detailed understanding of the processes of hormone binding and receptor activation, hampering efforts to develop novel pharmaceuticals. Here we report the crystal structure of the complex of human GIP receptor extracellular domain (ECD) ~~with its agonist~~, the ~~incretin GIP(1-42)~~. ~~The hormone binds in an alpha~~-~~helical conformation in a surface groove of the ECD largely through hydrophobic interactions. The N~~-terminal ligand residues would remain free to interact with other parts of the receptor. Thermodynamic data suggest that binding is concomitant with structural organization of the hormone, resulting in a complex mode of receptor-ligand recognition. The presentation of a well structured, alpha-helical ligand by the ECD is expected to be conserved among other hormone receptors of this class.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17715056}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17715056 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17715056}}

	==About this Structure==		==About this Structure==
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	[[Category: Transducer]]		[[Category: Transducer]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 15~~:07:00 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:16:55 2008''