2qo2 - Revision history

OCA at 11:37, 30 August 2023

OCA — Wed, 30 Aug 2023 11:37:08 GMT

←Older revision		Revision as of 11:37, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2qo2' size='340' side='right'caption='[[2qo2]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2qo2' size='340' side='right'caption='[[2qo2]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qo2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QO2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qo2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QO2 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BME:BETA~~-~~MERCAPTOETHANOL'>BME</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; max-height: 3em;'>[[2gsf\|2gsf]], [[2qo7\|2qo7]], [[2qo9\|2qo9]], [[2qob\|2qob]], [[2qoc\|2qoc]], [[2qod\|2qod]], [[2qof\|2qof]], [[2qoi\|2qoi]], [[2qok\|2qok]], [[2qol\|2qol]], [[2qon\|2qon]], [[2qoo\|2qoo]], [[2qoq\|2qoq]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>EPHA3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qo2 OCA], [https://pdbe.org/2qo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qo2 RCSB], [https://www.ebi.ac.uk/pdbsum/2qo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qo2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qo2 OCA], [https://pdbe.org/2qo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qo2 RCSB], [https://www.ebi.ac.uk/pdbsum/2qo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qo2 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN] Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:[https://omim.org/entry/114500 114500].
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.<ref>PMID:11870224</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Receptor protein-tyrosine kinase]]~~	+	[[Category: Arrowsmith CH]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Bochkarev A]]
-	[[Category: Bochkarev, A]]	+	[[Category: Butler-Cole C]]
-	[[Category: Butler-Cole, C]]	+	[[Category: Davis T]]
-	[[Category: Davis, T]]	+	[[Category: Dhe-Paganon S]]
-	[[Category: Dhe-Paganon, S]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Mackenzie F]]
-	[[Category: Mackenzie, F]]	+	[[Category: Newman EM]]
-	[[Category: Newman~~, E M]]~~	+	[[Category: Sundstrom M]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Walker JR]]
-	[[Category: Sundstrom, M]]	+	[[Category: Weigelt J]]
-	[[Category: Walker~~, J R~~]]	+
-	[[Category: Weigelt, J]]	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Juxtamembrane segment]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Receptor tyrosine kinase]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Tyrosine-protein kinase~~]]	+

OCA at 08:26, 25 June 2021

OCA — Fri, 25 Jun 2021 08:26:51 GMT

←Older revision		Revision as of 08:26, 25 June 2021
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	==Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure==		==Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure==
-	<StructureSection load='2qo2' size='340' side='right' caption='[[2qo2]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='2qo2' size='340' side='right'caption='[[2qo2]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qo2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QO2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QO2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qo2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QO2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gsf\|2gsf]], [[2qo7\|2qo7]], [[2qo9\|2qo9]], [[2qob\|2qob]], [[2qoc\|2qoc]], [[2qod\|2qod]], [[2qof\|2qof]], [[2qoi\|2qoi]], [[2qok\|2qok]], [[2qol\|2qol]], [[2qon\|2qon]], [[2qoo\|2qoo]], [[2qoq\|2qoq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gsf\|2gsf]], [[2qo7\|2qo7]], [[2qo9\|2qo9]], [[2qob\|2qob]], [[2qoc\|2qoc]], [[2qod\|2qod]], [[2qof\|2qof]], [[2qoi\|2qoi]], [[2qok\|2qok]], [[2qol\|2qol]], [[2qon\|2qon]], [[2qoo\|2qoo]], [[2qoq\|2qoq]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qo2 OCA], [~~http~~://pdbe.org/2qo2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qo2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qo2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qo2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qo2 OCA], [https://pdbe.org/2qo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qo2 RCSB], [https://www.ebi.ac.uk/pdbsum/2qo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qo2 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qo/2qo2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qo/2qo2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2qo2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2qo2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ephrin receptor 3D structures\|Ephrin receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 07:30, 25 October 2017

OCA — Wed, 25 Oct 2017 07:30:42 GMT

←Older revision		Revision as of 07:30, 25 October 2017
Line 1:		Line 1:
		+
	==Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure==		==Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure==
	<StructureSection load='2qo2' size='340' side='right' caption='[[2qo2]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2qo2' size='340' side='right' caption='[[2qo2]], [[Resolution\|resolution]] 1.60Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qo2 OCA], [http://pdbe.org/2qo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qo2 RCSB], [http://www.ebi.ac.uk/pdbsum/2qo2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qo2 OCA], [http://pdbe.org/2qo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qo2 RCSB], [http://www.ebi.ac.uk/pdbsum/2qo2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qo2 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qo2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 2qo2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2qo2" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ephrin receptor\|Ephrin receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:36, 12 September 2015

OCA — Sat, 12 Sep 2015 01:36:05 GMT

←Older revision		Revision as of 01:36, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2qo2' size='340' side='right' caption='[[2qo2]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2qo2' size='340' side='right' caption='[[2qo2]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qo2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QO2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qo2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QO2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gsf\|2gsf]], [[2qo7\|2qo7]], [[2qo9\|2qo9]], [[2qob\|2qob]], [[2qoc\|2qoc]], [[2qod\|2qod]], [[2qof\|2qof]], [[2qoi\|2qoi]], [[2qok\|2qok]], [[2qol\|2qol]], [[2qon\|2qon]], [[2qoo\|2qoo]], [[2qoq\|2qoq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gsf\|2gsf]], [[2qo7\|2qo7]], [[2qo9\|2qo9]], [[2qob\|2qob]], [[2qoc\|2qoc]], [[2qod\|2qod]], [[2qof\|2qof]], [[2qoi\|2qoi]], [[2qok\|2qok]], [[2qol\|2qol]], [[2qon\|2qon]], [[2qoo\|2qoo]], [[2qoq\|2qoq]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qo2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qo2 RCSB], [http://www.ebi.ac.uk/pdbsum/2qo2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qo2 OCA], [http://pdbe.org/2qo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qo2 RCSB], [http://www.ebi.ac.uk/pdbsum/2qo2 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qo2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 16:43, 19 January 2015

OCA — Mon, 19 Jan 2015 16:43:18 GMT

←Older revision		Revision as of 16:43, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qo2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QO2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qo2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QO2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gsf\|2gsf]], [[2qo7\|2qo7]], [[2qo9\|2qo9]], [[2qob\|2qob]], [[2qoc\|2qoc]], [[2qod\|2qod]], [[2qof\|2qof]], [[2qoi\|2qoi]], [[2qok\|2qok]], [[2qol\|2qol]], [[2qon\|2qon]], [[2qoo\|2qoo]], [[2qoq\|2qoq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gsf\|2gsf]], [[2qo7\|2qo7]], [[2qo9\|2qo9]], [[2qob\|2qob]], [[2qoc\|2qoc]], [[2qod\|2qod]], [[2qof\|2qof]], [[2qoi\|2qoi]], [[2qok\|2qok]], [[2qol\|2qol]], [[2qon\|2qon]], [[2qoo\|2qoo]], [[2qoq\|2qoq]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qo2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qo2 RCSB], [http://www.ebi.ac.uk/pdbsum/2qo2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qo2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qo2 RCSB], [http://www.ebi.ac.uk/pdbsum/2qo2 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bochkarev, A.]]	+	[[Category: Bochkarev, A]]
-	[[Category: Butler-Cole, C.]]	+	[[Category: Butler-Cole, C]]
-	[[Category: Davis, T.]]	+	[[Category: Davis, T]]
-	[[Category: Dhe-Paganon, S.]]	+	[[Category: Dhe-Paganon, S]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Mackenzie, F.]]	+	[[Category: Mackenzie, F]]
-	[[Category: Newman, E M.]]	+	[[Category: Newman, E M]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Walker, J R.]]	+	[[Category: Walker, J R]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Juxtamembrane segment]]		[[Category: Juxtamembrane segment]]
Line 54:		Line 54:
	[[Category: Receptor tyrosine kinase]]		[[Category: Receptor tyrosine kinase]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Tyrosine-protein kinase]]		[[Category: Tyrosine-protein kinase]]

OCA at 19:25, 30 September 2014

OCA — Tue, 30 Sep 2014 19:25:30 GMT

←Older revision		Revision as of 19:25, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2qo2\| PDB=2qo2 \| SCENE= }}~~	+	==Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure==
-	===Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure===	+	<StructureSection load='2qo2' size='340' side='right' caption='[[2qo2]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18547520}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2qo2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QO2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gsf\|2gsf]], [[2qo7\|2qo7]], [[2qo9\|2qo9]], [[2qob\|2qob]], [[2qoc\|2qoc]], [[2qod\|2qod]], [[2qof\|2qof]], [[2qoi\|2qoi]], [[2qok\|2qok]], [[2qol\|2qol]], [[2qon\|2qon]], [[2qoo\|2qoo]], [[2qoq\|2qoq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qo2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qo2 RCSB], [http://www.ebi.ac.uk/pdbsum/2qo2 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qo/2qo2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ephrin receptors (Eph) affect cell shape and movement, unlike other receptor tyrosine kinases that directly affect proliferative pathways. The kinase domain of EphA3 is activated by ephrin binding and receptor oligomerization. This activation is associated with two tyrosines in the juxtamembrane region; these tyrosines are sites of autophosphorylation and interact with the active site of the kinase to modulate activity. This allosteric event has important implications both in terms of understanding signal transduction pathways mediated by Eph kinases as well as discovering specific therapeutic ligands for receptor kinases. In order to provide further details of the molecular mechanism through which the unphosphorylated juxtamembrane region blocks catalysis, we studied wild-type and site-specific mutants in detail. High-resolution structures of multiple states of EphA3 kinase with and without the juxtamembrane segment allowed us to map the coupled pathway of residues that connect the juxtamembrane segment, the activation loop, and the catalytic residues of the kinase domain. This highly conserved set of residues likely delineates a molecular recognition pathway for most of the Eph RTKs, helping to characterize the dynamic nature of these physiologically important enzymes.

-	~~==About this~~ Structure==	+	Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3).,Davis TL, Walker JR, Loppnau P, Butler-Cole C, Allali-Hassani A, Dhe-Paganon S Structure. 2008 Jun;16(6):873-84. PMID:18547520<ref>PMID:18547520</ref>
-	~~[[2qo2]] is a 1 chain structure with sequence from [http~~:~~//en.wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2QO2 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Ephrin receptor\|Ephrin receptor]]		*[[Ephrin receptor\|Ephrin receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:018547520</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]

OCA at 05:48, 25 March 2013

OCA — Mon, 25 Mar 2013 05:48:26 GMT

←Older revision		Revision as of 05:48, 25 March 2013
Line 1:		Line 1:
-	[[Image:2qo2.png\|left\|200px]]
-
	{{STRUCTURE_2qo2\| PDB=2qo2 \| SCENE= }}		{{STRUCTURE_2qo2\| PDB=2qo2 \| SCENE= }}
-
	===Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure===		===Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure===
-
	{{ABSTRACT_PUBMED_18547520}}		{{ABSTRACT_PUBMED_18547520}}

Line 14:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018547520</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018547520</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]

OCA at 22:11, 20 October 2012

OCA — Sat, 20 Oct 2012 22:11:38 GMT

←Older revision		Revision as of 22:11, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2qo2]] is a 1 chain structure ~~of [[Ephrin receptor]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QO2 OCA].	+	[[2qo2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QO2 OCA].

	==See Also==		==See Also==

OCA: Protected "2qo2" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 15:31:43 GMT

Protected "2qo2" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:31, 27 July 2012

OCA at 15:31, 27 July 2012

OCA — Fri, 27 Jul 2012 15:31:42 GMT

←Older revision		Revision as of 15:31, 27 July 2012
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-	{{Seed}}
	[[Image:2qo2.png\|left\|200px]]		[[Image:2qo2.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2qo2", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2qo2\| PDB=2qo2 \| SCENE= }}		{{STRUCTURE_2qo2\| PDB=2qo2 \| SCENE= }}

	===Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure===		===Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18547520}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18547520 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18547520}}		{{ABSTRACT_PUBMED_18547520}}

	==About this Structure==		==About this Structure==
-	~~2QO2~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QO2 OCA].	+	[[2qo2]] is a 1 chain structure of [[Ephrin receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QO2 OCA].
		+
		+	==See Also==
		+	*[[Ephrin receptor\|Ephrin receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18547520~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018547520</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
Line 49:		Line 40:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Tyrosine-protein kinase]]		[[Category: Tyrosine-protein kinase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:17:18 2009''