2qos - Revision history

OCA at 11:37, 30 August 2023

OCA — Wed, 30 Aug 2023 11:37:49 GMT

←Older revision		Revision as of 11:37, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2qos' size='340' side='right'caption='[[2qos]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='2qos' size='340' side='right'caption='[[2qos]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QOS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QOS FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1lf7\|1lf7]], [[1iw2\|1iw2]], [[2ove\|2ove]], [[2ova\|2ova]], [[2ovd\|2ovd]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.81Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">C8G ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qos OCA], [https://pdbe.org/2qos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qos RCSB], [https://www.ebi.ac.uk/pdbsum/2qos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qos OCA], [https://pdbe.org/2qos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qos RCSB], [https://www.ebi.ac.uk/pdbsum/2qos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qos ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[https://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[https://omim.org/entry/613790 613790]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN]] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. [[https://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref> <ref>PMID:17872444</ref>	+	[https://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chiswell, B]]	+	[[Category: Chiswell B]]
-	[[Category: Lebioda, L]]	+	[[Category: Lebioda L]]
-	[[Category: Lovelace~~, L L~~]]	+	[[Category: Lovelace LL]]
-	[[Category: Slade~~, D J~~]]	+	[[Category: Slade DJ]]
-	[[Category: Sodetz~~, J M]]~~	+	[[Category: Sodetz JM]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Cleavage on pair of basic residue]]~~	+
-	~~[[Category: Complement alternate pathway]]~~	+
-	~~[[Category: Complement pathway]]~~	+
-	~~[[Category: Cytolysis]]~~	+
-	~~[[Category: Egf-like domain]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Innate immunity]]~~	+
-	~~[[Category: Lipocalin]]~~	+
-	~~[[Category: Membrane attack complex]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 08:27, 25 June 2021

OCA — Fri, 25 Jun 2021 08:27:55 GMT

←Older revision		Revision as of 08:27, 25 June 2021
Line 1:		Line 1:

	==Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8==		==Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8==
-	<StructureSection load='2qos' size='340' side='right' caption='[[2qos]], [[Resolution\|resolution]] 1.81Å' scene=''>	+	<StructureSection load='2qos' size='340' side='right'caption='[[2qos]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qos]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QOS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QOS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QOS FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lf7\|1lf7]], [[1iw2\|1iw2]], [[2ove\|2ove]], [[2ova\|2ova]], [[2ovd\|2ovd]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lf7\|1lf7]], [[1iw2\|1iw2]], [[2ove\|2ove]], [[2ova\|2ova]], [[2ovd\|2ovd]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C8G ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C8G ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qos OCA], [~~http~~://pdbe.org/2qos PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qos RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qos PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qos ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qos OCA], [https://pdbe.org/2qos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qos RCSB], [https://www.ebi.ac.uk/pdbsum/2qos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qos ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[~~http~~://omim.org/entry/613790 613790]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.	+	[[https://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[https://omim.org/entry/613790 613790]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN]] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. [[~~http~~://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref> <ref>PMID:17872444</ref>	+	[[https://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN]] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. [[https://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref> <ref>PMID:17872444</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qo/2qos_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qo/2qos_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chiswell, B]]		[[Category: Chiswell, B]]
	[[Category: Lebioda, L]]		[[Category: Lebioda, L]]

OCA at 07:31, 25 October 2017

OCA — Wed, 25 Oct 2017 07:31:49 GMT

←Older revision		Revision as of 07:31, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8==		==Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8==
	<StructureSection load='2qos' size='340' side='right' caption='[[2qos]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='2qos' size='340' side='right' caption='[[2qos]], [[Resolution\|resolution]] 1.81Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lf7\|1lf7]], [[1iw2\|1iw2]], [[2ove\|2ove]], [[2ova\|2ova]], [[2ovd\|2ovd]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lf7\|1lf7]], [[1iw2\|1iw2]], [[2ove\|2ove]], [[2ova\|2ova]], [[2ovd\|2ovd]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C8G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C8G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qos OCA], [http://pdbe.org/2qos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qos RCSB], [http://www.ebi.ac.uk/pdbsum/2qos PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qos OCA], [http://pdbe.org/2qos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qos RCSB], [http://www.ebi.ac.uk/pdbsum/2qos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qos ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	[[Category: Lipocalin]]		[[Category: Lipocalin]]
	[[Category: Membrane attack complex]]		[[Category: Membrane attack complex]]
		+	[[Category: Polymorphism]]
	[[Category: Secreted]]		[[Category: Secreted]]

OCA at 11:10, 7 February 2016

OCA — Sun, 07 Feb 2016 11:10:55 GMT

←Older revision		Revision as of 11:10, 7 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qos ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:56, 10 September 2015

OCA — Thu, 10 Sep 2015 00:56:05 GMT

←Older revision		Revision as of 00:56, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2qos' size='340' side='right' caption='[[2qos]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='2qos' size='340' side='right' caption='[[2qos]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QOS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QOS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lf7\|1lf7]], [[1iw2\|1iw2]], [[2ove\|2ove]], [[2ova\|2ova]], [[2ovd\|2ovd]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lf7\|1lf7]], [[1iw2\|1iw2]], [[2ove\|2ove]], [[2ova\|2ova]], [[2ovd\|2ovd]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C8G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C8G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qos RCSB], [http://www.ebi.ac.uk/pdbsum/2qos PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qos OCA], [http://pdbe.org/2qos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qos RCSB], [http://www.ebi.ac.uk/pdbsum/2qos PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qos" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chiswell, B]]		[[Category: Chiswell, B]]
	[[Category: Lebioda, L]]		[[Category: Lebioda, L]]

OCA at 13:47, 19 January 2015

OCA — Mon, 19 Jan 2015 13:47:37 GMT

←Older revision		Revision as of 13:47, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QOS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lf7\|1lf7]], [[1iw2\|1iw2]], [[2ove\|2ove]], [[2ova\|2ova]], [[2ovd\|2ovd]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lf7\|1lf7]], [[1iw2\|1iw2]], [[2ove\|2ove]], [[2ova\|2ova]], [[2ovd\|2ovd]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C8G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C8G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qos RCSB], [http://www.ebi.ac.uk/pdbsum/2qos PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qos RCSB], [http://www.ebi.ac.uk/pdbsum/2qos PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[http://omim.org/entry/613790 613790]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.		[[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[http://omim.org/entry/613790 613790]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chiswell, B.]]	+	[[Category: Chiswell, B]]
-	[[Category: Lebioda, L.]]	+	[[Category: Lebioda, L]]
-	[[Category: Lovelace, L L.]]	+	[[Category: Lovelace, L L]]
-	[[Category: Slade, D J.]]	+	[[Category: Slade, D J]]
-	[[Category: Sodetz, J M.]]	+	[[Category: Sodetz, J M]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]

OCA at 04:17, 3 October 2014

OCA — Fri, 03 Oct 2014 04:17:35 GMT

←Older revision		Revision as of 04:17, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2qos\| PDB=2qos \| SCENE= }}~~	+	==Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8==
-	===Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8===	+	<StructureSection load='2qos' size='340' side='right' caption='[[2qos]], [[Resolution\|resolution]] 1.81Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17692377}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2qos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QOS FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lf7\|1lf7]], [[1iw2\|1iw2]], [[2ove\|2ove]], [[2ova\|2ova]], [[2ovd\|2ovd]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C8G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qos RCSB], [http://www.ebi.ac.uk/pdbsum/2qos PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[http://omim.org/entry/613790 613790]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.		[[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[http://omim.org/entry/613790 613790]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN]] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. [[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref> <ref>PMID:17872444</ref>		[[http://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN]] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. [[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref> <ref>PMID:17872444</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qo/2qos_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human C8 is one of five complement components (C5b, C6, C7, C8 and C9) that interact to form the cytolytic membrane attack complex. It contains three genetically distinct subunits; C8alpha and C8gamma form a disulfide-linked C8alpha-gamma heterodimer that is noncovalently associated with C8beta. The C8alpha subunit is homologous to C8beta, C6, C7 and C9 and together they form the MAC family of proteins. By contrast, C8gamma is the only lipocalin in the complement system. Like other lipocalins, it has a core beta-barrel structure forming a calyx with a distinct binding pocket for a small and as yet unidentified ligand. The binding site on C8alpha for C8gamma was previously localized to a 19-residue segment which contains an insertion (indel) that is unique to C8alpha. Included in the indel is C8alpha Cys 164 which links to Cys 40 in C8gamma. In the present study, C8gamma containing a C40A substitution was co-crystallized with a synthetic indel peptide containing the equivalent of a C8alpha C164A substitution. The X-ray crystal structure shows that the indel peptide completely fills the upper portion of the putative C8gamma ligand binding pocket and is in contact with all four loops at the calyx entrance. The lower part of the C8gamma cavity is either unoccupied or contains disordered solvent. The validity of the structure is supported by the spatial arrangement of C8alpha Ala 164 in the peptide and C8gamma Ala 40, which are within disulfide-bonding distance of each other. Corresponding studies in solution indicate the C8gamma ligand binding site is also occupied by the indel segment of C8alpha in whole C8. These results suggest a role for C8alpha in regulating access to the putative C8gamma ligand binding site.

-	~~==About this Structure==~~	+	Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding.,Lovelace LL, Chiswell B, Slade DJ, Sodetz JM, Lebioda L Mol Immunol. 2008 Feb;45(3):750-6. Epub 2007 Aug 9. PMID:17692377<ref>PMID:17692377</ref>
-	~~[[2qos]] is a 2 chain~~ structure with ~~sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2QOS OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:017692377</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chiswell, B.]]		[[Category: Chiswell, B.]]

OCA at 07:05, 30 June 2013

OCA — Sun, 30 Jun 2013 07:05:03 GMT

←Older revision		Revision as of 07:05, 30 June 2013
Line 7:		Line 7:

	==Function==		==Function==
-	[[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref><ref>PMID:17872444</ref>	+	[[http://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN]] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. [[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref> <ref>PMID:17872444</ref>

	==About this Structure==		==About this Structure==

OCA at 18:42, 24 March 2013

OCA — Sun, 24 Mar 2013 18:42:28 GMT

←Older revision		Revision as of 18:42, 24 March 2013
Line 1:		Line 1:
-	[[Image:2qos.png\|left\|200px]]
-
	{{STRUCTURE_2qos\| PDB=2qos \| SCENE= }}		{{STRUCTURE_2qos\| PDB=2qos \| SCENE= }}
-
	===Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8===		===Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8===
		+	{{ABSTRACT_PUBMED_17692377}}

-	~~{{ABSTRACT_PUBMED_17692377}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[http://omim.org/entry/613790 613790]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref><ref>PMID:17872444</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:017692377</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017692377</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chiswell, B.]]		[[Category: Chiswell, B.]]

OCA: Protected "2qos" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:54:22 GMT

Protected "2qos" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:54, 7 January 2013