2qug - Revision history

OCA at 04:06, 2 July 2021

OCA — Fri, 02 Jul 2021 04:06:34 GMT

←Older revision		Revision as of 04:06, 2 July 2021
Line 1:		Line 1:

	==Crystal structure of alpha-1-antitrypsin, crystal form A==		==Crystal structure of alpha-1-antitrypsin, crystal form A==
-	<StructureSection load='2qug' size='340' side='right' caption='[[2qug]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2qug' size='340' side='right'caption='[[2qug]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qug]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QUG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qug]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QUG FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINA1, AAT, PI ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINA1, AAT, PI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qug OCA], [~~http~~://pdbe.org/2qug PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qug RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qug PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qug ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qug OCA], [https://pdbe.org/2qug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qug RCSB], [https://www.ebi.ac.uk/pdbsum/2qug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qug ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN]] Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD) [MIM:[~~http~~://omim.org/entry/613490 613490]]. A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.<ref>PMID:1905728</ref> <ref>PMID:2390072</ref> <ref>PMID:2227940</ref>	+	[[https://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN]] Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD) [MIM:[https://omim.org/entry/613490 613490]]. A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.<ref>PMID:1905728</ref> <ref>PMID:2390072</ref> <ref>PMID:2227940</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN]] Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref> Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref>	+	[[https://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN]] Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref> Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Alpha-1-antitrypsin\|Alpha-1-antitrypsin]]	+	*[[Alpha-1-antitrypsin 3D structures\|Alpha-1-antitrypsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Adams, J J]]		[[Category: Adams, J J]]
	[[Category: Bottomley, S P]]		[[Category: Bottomley, S P]]

OCA at 11:17, 5 September 2018

OCA — Wed, 05 Sep 2018 11:17:56 GMT

←Older revision		Revision as of 11:17, 5 September 2018
Line 1:		Line 1:
		+
	==Crystal structure of alpha-1-antitrypsin, crystal form A==		==Crystal structure of alpha-1-antitrypsin, crystal form A==
	<StructureSection load='2qug' size='340' side='right' caption='[[2qug]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2qug' size='340' side='right' caption='[[2qug]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINA1, AAT, PI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINA1, AAT, PI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qug OCA], [http://pdbe.org/2qug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qug RCSB], [http://www.ebi.ac.uk/pdbsum/2qug PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qug OCA], [http://pdbe.org/2qug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qug RCSB], [http://www.ebi.ac.uk/pdbsum/2qug PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qug ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/2qug_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/2qug_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:16, 7 February 2016

OCA — Sun, 07 Feb 2016 17:16:22 GMT

←Older revision		Revision as of 17:16, 7 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qug ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:33, 10 September 2015

OCA — Thu, 10 Sep 2015 03:33:43 GMT

←Older revision		Revision as of 03:33, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINA1, AAT, PI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINA1, AAT, PI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qug RCSB], [http://www.ebi.ac.uk/pdbsum/2qug PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qug OCA], [http://pdbe.org/2qug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qug RCSB], [http://www.ebi.ac.uk/pdbsum/2qug PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qug" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:18, 19 January 2015

OCA — Mon, 19 Jan 2015 18:18:38 GMT

←Older revision		Revision as of 18:18, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qug]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qug]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QUG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINA1, AAT, PI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINA1, AAT, PI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qug RCSB], [http://www.ebi.ac.uk/pdbsum/2qug PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qug RCSB], [http://www.ebi.ac.uk/pdbsum/2qug PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN]] Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD) [MIM:[http://omim.org/entry/613490 613490]]. A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.<ref>PMID:1905728</ref> <ref>PMID:2390072</ref> <ref>PMID:2227940</ref>		[[http://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN]] Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD) [MIM:[http://omim.org/entry/613490 613490]]. A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.<ref>PMID:1905728</ref> <ref>PMID:2390072</ref> <ref>PMID:2227940</ref>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Adams, J J.]]	+	[[Category: Adams, J J]]
-	[[Category: Bottomley, S P.]]	+	[[Category: Bottomley, S P]]
-	[[Category: Feil, S C.]]	+	[[Category: Feil, S C]]
-	[[Category: Hansen, G.]]	+	[[Category: Hansen, G]]
-	[[Category: Morton, C J.]]	+	[[Category: Morton, C J]]
-	[[Category: Parker, M W.]]	+	[[Category: Parker, M W]]
-	[[Category: Pearce, M C.]]	+	[[Category: Pearce, M C]]
	[[Category: Acute phase]]		[[Category: Acute phase]]
	[[Category: Antitrypsin]]		[[Category: Antitrypsin]]

OCA at 20:11, 30 September 2014

OCA — Tue, 30 Sep 2014 20:11:52 GMT

←Older revision		Revision as of 20:11, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2qug\| PDB~~=2qug \| ~~SCENE~~= }}	+	==Crystal structure of alpha-1-antitrypsin, crystal form A==
-	===~~Crystal~~ structure of alpha-1-antitrypsin, ~~crystal form~~ A===	+	<StructureSection load='2qug' size='340' side='right' caption='[[2qug]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18780818}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2qug]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QUG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINA1, AAT, PI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qug RCSB], [http://www.ebi.ac.uk/pdbsum/2qug PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN]] Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD) [MIM:[http://omim.org/entry/613490 613490]]. A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.<ref>PMID:1905728</ref> <ref>PMID:2390072</ref> <ref>PMID:2227940</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN]] Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref> Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/2qug_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The aggregation of antitrypsin into polymers is one of the causes of neonatal hepatitis, cirrhosis, and emphysema. A similar reaction resulting in disease can occur in other human serpins, and collectively they are known as the serpinopathies. One possible therapeutic strategy involves inhibiting the conformational changes involved in antitrypsin aggregation. The citrate ion has previously been shown to prevent antitrypsin aggregation and maintain the protein in an active conformation; its mechanism of action, however, is unknown. Here we demonstrate that the citrate ion prevents the initial misfolding of the native state to a polymerogenic intermediate in a concentration-dependent manner. Furthermore, we have solved the crystal structure of citrate bound to antitrypsin and show that a single citrate molecule binds in a pocket between the A and B beta-sheets, a region known to be important in maintaining antitrypsin stability.

-	~~==Disease==~~	+	Preventing serpin aggregation: the molecular mechanism of citrate action upon antitrypsin unfolding.,Pearce MC, Morton CJ, Feil SC, Hansen G, Adams JJ, Parker MW, Bottomley SP Protein Sci. 2008 Dec;17(12):2127-33. Epub 2008 Sep 9. PMID:18780818<ref>PMID:18780818</ref>
-	~~[[http~~:~~//www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN]] Defects in SERPINA1 are~~ the ~~cause~~ of ~~alpha-1-~~antitrypsin ~~deficiency (A1ATD) [MIM:[http://omim.org/entry/613490 613490]]~~. ~~A disorder whose most common manifestation is emphysema~~, ~~which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease~~, ~~which occurs in children and adults~~, ~~and may result in cirrhosis and liver failure. Environmental factors~~, ~~particularly cigarette smoking~~, ~~greatly increase the risk of emphysema at an earlier age~~.~~<ref>PMID~~:~~1905728</ref><ref>~~PMID:~~2390072</ref>~~<ref>PMID:~~2227940~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN]] Inhibitor of serine proteases. Its primary target is elastase~~, ~~but it also has~~ a ~~moderate affinity for plasmin and thrombin~~. ~~Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator~~. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.[:]<ref>PMID:1906855</ref><ref>PMID:1406456</ref> Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of ~~the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE)~~.~~[:]~~<~~ref~~>~~PMID:1906855~~</~~ref~~>~~<ref>PMID:1406456</ref>~~	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[2qug]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUG OCA].	+

	==See Also==		==See Also==
	*[[Alpha-1-antitrypsin\|Alpha-1-antitrypsin]]		*[[Alpha-1-antitrypsin\|Alpha-1-antitrypsin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:018780818</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Adams, J J.]]		[[Category: Adams, J J.]]

OCA at 22:16, 24 March 2013

OCA — Sun, 24 Mar 2013 22:16:47 GMT

←Older revision		Revision as of 22:16, 24 March 2013
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-	[[Image:2qug.png\|left\|200px]]
-
	{{STRUCTURE_2qug\| PDB=2qug \| SCENE= }}		{{STRUCTURE_2qug\| PDB=2qug \| SCENE= }}
-
	===Crystal structure of alpha-1-antitrypsin, crystal form A===		===Crystal structure of alpha-1-antitrypsin, crystal form A===
		+	{{ABSTRACT_PUBMED_18780818}}

-	~~{{ABSTRACT_PUBMED_18780818}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN]] Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD) [MIM:[http://omim.org/entry/613490 613490]]. A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.<ref>PMID:1905728</ref><ref>PMID:2390072</ref><ref>PMID:2227940</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN]] Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.[:]<ref>PMID:1906855</ref><ref>PMID:1406456</ref> Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).[:]<ref>PMID:1906855</ref><ref>PMID:1406456</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018780818</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018780818</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Adams, J J.]]		[[Category: Adams, J J.]]

OCA at 07:20, 20 October 2012

OCA — Sat, 20 Oct 2012 07:20:47 GMT

←Older revision		Revision as of 07:20, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2qug]] is a 1 chain structure ~~of [[Alpha-1-antitrypsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUG OCA].	+	[[2qug]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUG OCA].

	==See Also==		==See Also==

OCA: Protected "2qug" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 16:01:46 GMT

Protected "2qug" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:01, 25 July 2012

OCA at 16:01, 25 July 2012

OCA — Wed, 25 Jul 2012 16:01:45 GMT

←Older revision		Revision as of 16:01, 25 July 2012
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-	{{Seed}}
	[[Image:2qug.png\|left\|200px]]		[[Image:2qug.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2qug", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2qug\| PDB=2qug \| SCENE= }}		{{STRUCTURE_2qug\| PDB=2qug \| SCENE= }}

	===Crystal structure of alpha-1-antitrypsin, crystal form A===		===Crystal structure of alpha-1-antitrypsin, crystal form A===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18780818}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18780818 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18780818}}		{{ABSTRACT_PUBMED_18780818}}

	==About this Structure==		==About this Structure==
-	~~2QUG~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUG OCA].	+	[[2qug]] is a 1 chain structure of [[Alpha-1-antitrypsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUG OCA].
		+
		+	==See Also==
		+	*[[Alpha-1-antitrypsin\|Alpha-1-antitrypsin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18780818~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018780818</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Adams, J J.]]		[[Category: Adams, J J.]]
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	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Polymerisation]]		[[Category: Polymerisation]]
-	[[Category: Polymorphism]]
	[[Category: Protease inhibitor]]		[[Category: Protease inhibitor]]
	[[Category: Protein aggregation]]		[[Category: Protein aggregation]]
Line 44:		Line 34:
	[[Category: Serine protease inhibitor]]		[[Category: Serine protease inhibitor]]
	[[Category: Serpin]]		[[Category: Serpin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:22:31 2009''