2qvq - Revision history

OCA: Redirecting to 4lof

OCA — Thu, 01 Aug 2013 04:52:35 GMT

Redirecting to 4lof

←Older revision		Revision as of 04:52, 1 August 2013
Line 1:		Line 1:
-	~~{{STRUCTURE_2qvq\| PDB=2qvq \| SCENE= }}~~	+	#REDIRECT [[4lof]] This PDB entry is obsolete and replaced by 4lof
-	~~===Human p53 Core Domain Mutant V157F/N235K/N239Y===~~	+
-		+
-	~~==Disease==~~	+
-	[[~~http://www.uniprot.org/uniprot/P53_HUMAN P53_HUMAN~~]] Note=TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium. The condition develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease and predisposes to the development of esophageal adenocarcinoma. Defects in TP53 are a cause of esophageal cancer (ESCR) [MIM:[http://omim.org/entry~~/133239 133239]]. Defects in TP53 are a cause of Li-Fraumeni syndrome (LFS) [MIM:[http://omim.org/entry/151623 151623]]. LFS~~ is an autosomal dominant familial cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed (PubMed:8118819 and PubMed:8718514) and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15, rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers.<ref>PMID:10570149</ref><ref>PMID:1933902</ref><ref>PMID:1978757</ref><ref>PMID:2259385</ref><ref>PMID:1737852</ref><ref>PMID:1565144</ref><ref>PMID:7887414</ref><ref>PMID:8825920</ref><ref>PMID:9452042</ref><ref>PMID:10484981</ref> Defects in TP53 are involved in head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck. Defects in TP53 are a cause of lung cancer (LNCR) [MIM:[http://omim.org/entry/211980 211980]]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Defects in TP53 are a cause of choroid plexus papilloma (CPLPA) [MIM:[http://omim.org/entry/260500 260500]]. Choroid plexus papilloma is a slow-growing benign tumor of the choroid plexus that often invades the leptomeninges. In children it is usually in a lateral ventricle but in adults it is more often in the fourth ventricle. Hydrocephalus is common, either from obstruction or from tumor secretion of cerebrospinal fluid. If it undergoes malignant transformation it is called a choroid plexus carcinoma. Primary choroid plexus tumors are rare and usually occur in early childhood.<ref>PMID:12085209</ref> Defects in TP53 are a cause of adrenocortical carcinoma (ADCC) [MIM:[http://omim.org/entry/202300 202300]]. ADCC is a rare childhood tumor of the adrenal cortex. It occurs with increased frequency in patients with the Beckwith-Wiedemann syndrome and is a component tumor in Li-Fraumeni syndrome.<ref>PMID:11481490</ref> Defects in TP53 are the cause of susceptibility to basal cell carcinoma 7 (BCC7) [MIM:[http://omim.org/entry/614740 614740]]. A common malignant skin neoplasm that typically appears on hair-bearing skin, most commonly on sun-exposed areas. It is slow growing and rarely metastasizes, but has potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small, raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can vary from a few millimeters to several centimeters in diameter.<ref>PMID:21946351</ref>	+
-		+
-	~~==Function==~~	+
-	[[http://www.uniprot.org/uniprot/P53_HUMAN P53_HUMAN]] Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; te function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.<ref>PMID:9840937</ref><ref>PMID:11025664</ref><ref>PMID:12810724</ref><ref>PMID:15186775</ref><ref>PMID:15340061</ref><ref>PMID:17317671</ref><ref>PMID:17349958</ref><ref>PMID:19556538</ref><ref>PMID:20673990</ref><ref>PMID:20959462</ref><ref>PMID:22726440</ref>	+
-		+
-	~~==About this Structure==~~	+
-	[[2qvq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QVQ OCA].	+
-		+
-	~~==See Also==~~	+
-	*[[P53\|P53]]	+
-		+
-	~~==Reference==~~	+
-	~~<references group="xtra"/><references/>~~	+
-	~~[[Category: Homo sapiens]]~~	+
-	~~[[Category: Luecke, H.]]~~	+
-	~~[[Category: Wang, Y.]]~~	+
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Anti-oncogene]]~~	+
-	~~[[Category: Antitumor protein]]~~	+
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Cancer]]~~	+
-	~~[[Category: Cancer mutation]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Endoplasmic reticulum]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Host-virus interaction]]~~	+
-	~~[[Category: Li-fraumeni syndrome]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: P53]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Suppressor mutation]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Tumor suppressor]]~~	+

OCA at 03:47, 25 March 2013

OCA — Mon, 25 Mar 2013 03:47:07 GMT

←Older revision		Revision as of 03:47, 25 March 2013
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-	[[Image:2qvq.png\|left\|200px]]
-
	{{STRUCTURE_2qvq\| PDB=2qvq \| SCENE= }}		{{STRUCTURE_2qvq\| PDB=2qvq \| SCENE= }}
-
	===Human p53 Core Domain Mutant V157F/N235K/N239Y===		===Human p53 Core Domain Mutant V157F/N235K/N239Y===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/P53_HUMAN P53_HUMAN]] Note=TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium. The condition develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease and predisposes to the development of esophageal adenocarcinoma. Defects in TP53 are a cause of esophageal cancer (ESCR) [MIM:[http://omim.org/entry/133239 133239]]. Defects in TP53 are a cause of Li-Fraumeni syndrome (LFS) [MIM:[http://omim.org/entry/151623 151623]]. LFS is an autosomal dominant familial cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed (PubMed:8118819 and PubMed:8718514) and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15, rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers.<ref>PMID:10570149</ref><ref>PMID:1933902</ref><ref>PMID:1978757</ref><ref>PMID:2259385</ref><ref>PMID:1737852</ref><ref>PMID:1565144</ref><ref>PMID:7887414</ref><ref>PMID:8825920</ref><ref>PMID:9452042</ref><ref>PMID:10484981</ref> Defects in TP53 are involved in head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck. Defects in TP53 are a cause of lung cancer (LNCR) [MIM:[http://omim.org/entry/211980 211980]]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Defects in TP53 are a cause of choroid plexus papilloma (CPLPA) [MIM:[http://omim.org/entry/260500 260500]]. Choroid plexus papilloma is a slow-growing benign tumor of the choroid plexus that often invades the leptomeninges. In children it is usually in a lateral ventricle but in adults it is more often in the fourth ventricle. Hydrocephalus is common, either from obstruction or from tumor secretion of cerebrospinal fluid. If it undergoes malignant transformation it is called a choroid plexus carcinoma. Primary choroid plexus tumors are rare and usually occur in early childhood.<ref>PMID:12085209</ref> Defects in TP53 are a cause of adrenocortical carcinoma (ADCC) [MIM:[http://omim.org/entry/202300 202300]]. ADCC is a rare childhood tumor of the adrenal cortex. It occurs with increased frequency in patients with the Beckwith-Wiedemann syndrome and is a component tumor in Li-Fraumeni syndrome.<ref>PMID:11481490</ref> Defects in TP53 are the cause of susceptibility to basal cell carcinoma 7 (BCC7) [MIM:[http://omim.org/entry/614740 614740]]. A common malignant skin neoplasm that typically appears on hair-bearing skin, most commonly on sun-exposed areas. It is slow growing and rarely metastasizes, but has potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small, raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can vary from a few millimeters to several centimeters in diameter.<ref>PMID:21946351</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/P53_HUMAN P53_HUMAN]] Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; te function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.<ref>PMID:9840937</ref><ref>PMID:11025664</ref><ref>PMID:12810724</ref><ref>PMID:15186775</ref><ref>PMID:15340061</ref><ref>PMID:17317671</ref><ref>PMID:17349958</ref><ref>PMID:19556538</ref><ref>PMID:20673990</ref><ref>PMID:20959462</ref><ref>PMID:22726440</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:
	==See Also==		==See Also==
	*[[P53\|P53]]		*[[P53\|P53]]
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Luecke, H.]]		[[Category: Luecke, H.]]

OCA at 21:40, 20 October 2012

OCA — Sat, 20 Oct 2012 21:40:57 GMT

←Older revision		Revision as of 21:40, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2qvq]] is a 1 chain structure ~~of [[P53]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QVQ OCA].	+	[[2qvq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QVQ OCA].

	==See Also==		==See Also==

OCA: Protected "2qvq" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 13:58:22 GMT

Protected "2qvq" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:58, 27 July 2012

OCA at 13:58, 27 July 2012

OCA — Fri, 27 Jul 2012 13:58:20 GMT

←Older revision		Revision as of 13:58, 27 July 2012
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-	{{Seed}}
	[[Image:2qvq.png\|left\|200px]]		[[Image:2qvq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2qvq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2qvq\| PDB=2qvq \| SCENE= }}		{{STRUCTURE_2qvq\| PDB=2qvq \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~2QVQ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QVQ OCA].	+	[[2qvq]] is a 1 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QVQ OCA].
		+
		+	==See Also==
		+	*[[P53\|P53]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Luecke, H.]]		[[Category: Luecke, H.]]
	[[Category: Wang, Y.]]		[[Category: Wang, Y.]]
-	[[Category: Acetylation]]
	[[Category: Activator]]		[[Category: Activator]]
-	[[Category: Alternative splicing]]
	[[Category: Anti-oncogene]]		[[Category: Anti-oncogene]]
	[[Category: Antitumor protein]]		[[Category: Antitumor protein]]
Line 27:		Line 21:
	[[Category: Cancer mutation]]		[[Category: Cancer mutation]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
-	[[Category: Cytoplasm]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
Line 38:		Line 31:
	[[Category: P53]]		[[Category: P53]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
-	[[Category: Polymorphism]]
	[[Category: Suppressor mutation]]		[[Category: Suppressor mutation]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Tumor suppressor]]		[[Category: Tumor suppressor]]
-	[[Category: Ubl conjugation]]
-	[[Category: Zinc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:40:54 2009''

OCA at 05:40, 18 February 2009

OCA — Wed, 18 Feb 2009 05:40:55 GMT

←Older revision		Revision as of 05:40, 18 February 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2qvq.~~jpg~~\|left\|200px]]	+	[[Image:2qvq.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	2QVQ is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QVQ OCA].	+	2QVQ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QVQ OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Luecke, H.]]		[[Category: Luecke, H.]]
	[[Category: Wang, Y.]]		[[Category: Wang, Y.]]
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	[[Category: Zinc]]		[[Category: Zinc]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 5 12~~:22:~~37 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:40:54 2009''

OCA at 10:22, 5 November 2008

OCA — Wed, 05 Nov 2008 10:22:39 GMT

←Older revision		Revision as of 10:22, 5 November 2008
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2qvq.jpg\|left\|200px]]

-	The ~~entry 2qvq~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2qvq", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2qvq\| PDB=2qvq \| SCENE= }}

-	~~Authors: Wang, Y., Luecke, H.~~	+	===Human p53 Core Domain Mutant V157F/N235K/N239Y===

-	Description: Human p53 Core Domain Mutant V157F/N235K/N239Y

		+	==About this Structure==
		+	2QVQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QVQ OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Single protein]]
		+	[[Category: Luecke, H.]]
		+	[[Category: Wang, Y.]]
		+	[[Category: Acetylation]]
		+	[[Category: Activator]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Anti-oncogene]]
		+	[[Category: Antitumor protein]]
		+	[[Category: Apoptosis]]
		+	[[Category: Cancer]]
		+	[[Category: Cancer mutation]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Disease mutation]]
		+	[[Category: Dna-binding]]
		+	[[Category: Endoplasmic reticulum]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Host-virus interaction]]
		+	[[Category: Li-fraumeni syndrome]]
		+	[[Category: Metal-binding]]
		+	[[Category: Nucleus]]
		+	[[Category: P53]]
		+	[[Category: Phosphorylation]]
		+	[[Category: Polymorphism]]
		+	[[Category: Suppressor mutation]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
		+	[[Category: Tumor suppressor]]
		+	[[Category: Ubl conjugation]]
		+	[[Category: Zinc]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 11 08~~:39:04 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 5 12:22:37 2008''

OCA: New page: '''Unreleased structure''' The entry 2qvq is ON HOLD Authors: Wang, Y., Luecke, H. Description: Human p53 Core Domain Mutant V157F/N235K/N239Y ''Page seeded by [http://oca.weizmann.a...

OCA — Wed, 11 Jun 2008 05:39:07 GMT

New page: '''Unreleased structure''' The entry 2qvq is ON HOLD Authors: Wang, Y., Luecke, H. Description: Human p53 Core Domain Mutant V157F/N235K/N239Y ''Page seeded by [http://oca.weizmann.a...

New page

'''Unreleased structure'''

The entry 2qvq is ON HOLD

Authors: Wang, Y., Luecke, H.

Description: Human p53 Core Domain Mutant V157F/N235K/N239Y

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 08:39:04 2008''