2qwy - Revision history

OCA at 09:18, 21 February 2024

OCA — Wed, 21 Feb 2024 09:18:30 GMT

←Older revision		Revision as of 09:18, 21 February 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [https://pdbe.org/2qwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [https://www.ebi.ac.uk/pdbsum/2qwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qwy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [https://pdbe.org/2qwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [https://www.ebi.ac.uk/pdbsum/2qwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qwy ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	In bacteria, numerous genes harbor regulatory elements in the 5' untranslated regions of their mRNA, termed riboswitches, which control gene expression by binding small-molecule metabolites. These sequences influence the secondary and tertiary structure of the RNA in a ligand-dependent manner, thereby directing its transcription or translation. The crystal structure of an S-adenosylmethionine-responsive riboswitch found predominantly in proteobacteria, SAM-II, has been solved to reveal a second means by which RNA interacts with this important cellular metabolite. Notably, this is the first structure of a complete riboswitch containing all sequences associated with both the ligand binding aptamer domain and the regulatory expression platform. Chemical probing of this RNA in the absence and presence of ligand shows how the structure changes in response to S-adenosylmethionine to sequester the ribosomal binding site and affect translational gene regulation.
-
-	Structure of the SAM-II riboswitch bound to S-adenosylmethionine.,Gilbert SD, Rambo RP, Van Tyne D, Batey RT Nat Struct Mol Biol. 2008 Feb;15(2):177-82. Epub 2008 Jan 20. PMID:18204466<ref>PMID:18204466</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2qwy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Riboswitch 3D structures\|Riboswitch 3D structures]]		*[[Riboswitch 3D structures\|Riboswitch 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:53, 20 December 2023

OCA — Wed, 20 Dec 2023 12:53:48 GMT

←Older revision		Revision as of 12:53, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QWY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QWY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [https://pdbe.org/2qwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [https://www.ebi.ac.uk/pdbsum/2qwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qwy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [https://pdbe.org/2qwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [https://www.ebi.ac.uk/pdbsum/2qwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qwy ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Batey~~, R T~~]]	+	[[Category: Batey RT]]
-	[[Category: Gilbert~~, S D~~]]	+	[[Category: Gilbert SD]]
-	[[Category: Rambo~~, R P~~]]	+	[[Category: Rambo RP]]
-	[[Category: Tyne, D ~~Van]]~~	+	[[Category: Van Tyne D]]
-	~~[[Category: Adomet]]~~	+
-	~~[[Category: Base triple]]~~	+
-	~~[[Category: Double helix]]~~	+
-	~~[[Category: Mrna]]~~	+
-	~~[[Category: Pseudoknot]]~~	+
-	~~[[Category: Riboswitch]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Rna-ligand complex]]~~	+
-	~~[[Category: S-adenosylmethionine]]~~	+
-	~~[[Category: Sam~~]]	+

OCA at 07:45, 16 March 2022

OCA — Wed, 16 Mar 2022 07:45:44 GMT

←Older revision		Revision as of 07:45, 16 March 2022
Line 3:		Line 3:
	<StructureSection load='2qwy' size='340' side='right'caption='[[2qwy]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2qwy' size='340' side='right'caption='[[2qwy]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2QWY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QWY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [~~http~~://pdbe.org/2qwy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qwy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qwy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [https://pdbe.org/2qwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [https://www.ebi.ac.uk/pdbsum/2qwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qwy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:08, 10 June 2020

OCA — Wed, 10 Jun 2020 07:08:57 GMT

←Older revision		Revision as of 07:08, 10 June 2020
Line 1:		Line 1:

	==SAM-II riboswitch bound to S-adenosylmethionine==		==SAM-II riboswitch bound to S-adenosylmethionine==
-	<StructureSection load='2qwy' size='340' side='right' caption='[[2qwy]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2qwy' size='340' side='right'caption='[[2qwy]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QWY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2QWY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [http://pdbe.org/2qwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [http://www.ebi.ac.uk/pdbsum/2qwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qwy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [http://pdbe.org/2qwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [http://www.ebi.ac.uk/pdbsum/2qwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qwy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[Riboswitch\|Riboswitch]]	+	*[[Riboswitch 3D structures\|Riboswitch 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Batey, R T]]		[[Category: Batey, R T]]
	[[Category: Gilbert, S D]]		[[Category: Gilbert, S D]]

OCA at 11:14, 5 September 2018

OCA — Wed, 05 Sep 2018 11:14:07 GMT

←Older revision		Revision as of 11:14, 5 September 2018
Line 1:		Line 1:
		+
	==SAM-II riboswitch bound to S-adenosylmethionine==		==SAM-II riboswitch bound to S-adenosylmethionine==
	<StructureSection load='2qwy' size='340' side='right' caption='[[2qwy]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2qwy' size='340' side='right' caption='[[2qwy]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QWY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QWY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [http://pdbe.org/2qwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [http://www.ebi.ac.uk/pdbsum/2qwy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [http://pdbe.org/2qwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [http://www.ebi.ac.uk/pdbsum/2qwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qwy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:29, 10 September 2015

OCA — Thu, 10 Sep 2015 09:29:37 GMT

←Older revision		Revision as of 09:29, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QWY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QWY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [http://www.ebi.ac.uk/pdbsum/2qwy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [http://pdbe.org/2qwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [http://www.ebi.ac.uk/pdbsum/2qwy PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qwy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:49, 17 December 2014

OCA — Wed, 17 Dec 2014 13:49:46 GMT

←Older revision		Revision as of 13:49, 17 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2qwy~~\| ~~PDB~~=2qwy \| ~~SCENE~~= }}	+	==SAM-II riboswitch bound to S-adenosylmethionine==
-	===SAM-II riboswitch ~~bound~~ to S-adenosylmethionine~~===~~	+	<StructureSection load='2qwy' size='340' side='right' caption='[[2qwy]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18204466}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QWY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [http://www.ebi.ac.uk/pdbsum/2qwy PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In bacteria, numerous genes harbor regulatory elements in the 5' untranslated regions of their mRNA, termed riboswitches, which control gene expression by binding small-molecule metabolites. These sequences influence the secondary and tertiary structure of the RNA in a ligand-dependent manner, thereby directing its transcription or translation. The crystal structure of an S-adenosylmethionine-responsive riboswitch found predominantly in proteobacteria, SAM-II, has been solved to reveal a second means by which RNA interacts with this important cellular metabolite. Notably, this is the first structure of a complete riboswitch containing all sequences associated with both the ligand binding aptamer domain and the regulatory expression platform. Chemical probing of this RNA in the absence and presence of ligand shows how the structure changes in response to S-adenosylmethionine to sequester the ribosomal binding site and affect translational gene regulation.

-	~~==About this~~ Structure==	+	Structure of the SAM-II riboswitch bound to S-adenosylmethionine.,Gilbert SD, Rambo RP, Van Tyne D, Batey RT Nat Struct Mol Biol. 2008 Feb;15(2):177-82. Epub 2008 Jan 20. PMID:18204466<ref>PMID:18204466</ref>
-	~~[[2qwy]] is a 3 chain structure~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2QWY OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Riboswitch\|Riboswitch]]		*[[Riboswitch\|Riboswitch]]
-	[[Category: Batey, R T.]]	+	== References ==
-	[[Category: Gilbert, S D.]]	+	<references/>
-	[[Category: Rambo, R P.]]	+	__TOC__
-	[[Category: Tyne, D Van.]]	+	</StructureSection>
		+	[[Category: Batey, R T]]
		+	[[Category: Gilbert, S D]]
		+	[[Category: Rambo, R P]]
		+	[[Category: Tyne, D Van]]
	[[Category: Adomet]]		[[Category: Adomet]]
	[[Category: Base triple]]		[[Category: Base triple]]

OCA at 11:03, 11 March 2013

OCA — Mon, 11 Mar 2013 11:03:05 GMT

←Older revision		Revision as of 11:03, 11 March 2013
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	{{STRUCTURE_2qwy\| PDB=2qwy \| SCENE= }}		{{STRUCTURE_2qwy\| PDB=2qwy \| SCENE= }}
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	===SAM-II riboswitch bound to S-adenosylmethionine===		===SAM-II riboswitch bound to S-adenosylmethionine===
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	{{ABSTRACT_PUBMED_18204466}}		{{ABSTRACT_PUBMED_18204466}}

OCA: Protected "2qwy" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 23:03:36 GMT

Protected "2qwy" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:03, 7 January 2013

OCA at 23:03, 7 January 2013

OCA — Mon, 07 Jan 2013 23:03:32 GMT

←Older revision		Revision as of 23:03, 7 January 2013
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-	{{Seed}}
	[[Image:2qwy.png\|left\|200px]]		[[Image:2qwy.png\|left\|200px]]

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	{{STRUCTURE_2qwy\| PDB=2qwy \| SCENE= }}		{{STRUCTURE_2qwy\| PDB=2qwy \| SCENE= }}

	===SAM-II riboswitch bound to S-adenosylmethionine===		===SAM-II riboswitch bound to S-adenosylmethionine===

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	{{ABSTRACT_PUBMED_18204466}}		{{ABSTRACT_PUBMED_18204466}}

	==About this Structure==		==About this Structure==
-	~~2QWY is a~~ [[~~Single protein~~]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA].	+	[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA].

-	==~~Reference~~==	+	==See Also==
-	Structure of the SAM-II riboswitch bound to S-adenosylmethionine., Gilbert SD, Rambo RP, Van Tyne D, Batey RT, Nat Struct Mol Biol. 2008 Feb;15(2):177-82. Epub 2008 Jan 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18204466 18204466]	+	*[[Riboswitch\|Riboswitch]]
-	[[~~Category: Single protein~~]]	+
	[[Category: Batey, R T.]]		[[Category: Batey, R T.]]
	[[Category: Gilbert, S D.]]		[[Category: Gilbert, S D.]]
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	[[Category: Pseudoknot]]		[[Category: Pseudoknot]]
	[[Category: Riboswitch]]		[[Category: Riboswitch]]
		+	[[Category: Rna]]
	[[Category: Rna-ligand complex]]		[[Category: Rna-ligand complex]]
	[[Category: S-adenosylmethionine]]		[[Category: S-adenosylmethionine]]
	[[Category: Sam]]		[[Category: Sam]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:33:59 2008''