2qy0 - Revision history

OCA at 11:42, 30 August 2023

OCA — Wed, 30 Aug 2023 11:42:53 GMT

←Older revision		Revision as of 11:42, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2qy0' size='340' side='right'caption='[[2qy0]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2qy0' size='340' side='right'caption='[[2qy0]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qy0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QY0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qy0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QY0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>C1R ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Complement_subcomponent_C1r Complement subcomponent C1r], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.41 3.4.21.41]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy0 OCA], [https://pdbe.org/2qy0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qy0 RCSB], [https://www.ebi.ac.uk/pdbsum/2qy0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qy0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy0 OCA], [https://pdbe.org/2qy0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qy0 RCSB], [https://www.ebi.ac.uk/pdbsum/2qy0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qy0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/C1R_HUMAN C1R_HUMAN]] C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.	+	[https://www.uniprot.org/uniprot/C1R_HUMAN C1R_HUMAN] C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Complement subcomponent C1r]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barabas, O]]	+	[[Category: Barabas O]]
-	[[Category: Gal, P]]	+	[[Category: Gal P]]
-	[[Category: Goto, Y]]	+	[[Category: Goto Y]]
-	[[Category: Graf, L]]	+	[[Category: Graf L]]
-	[[Category: Harmat, V]]	+	[[Category: Harmat V]]
-	[[Category: Kardos, J]]	+	[[Category: Kardos J]]
-	[[Category: Naray-Szabo, G]]	+	[[Category: Naray-Szabo G]]
-	[[Category: Pallo, A]]	+	[[Category: Pallo A]]
-	[[Category: Szilagyi, K]]	+	[[Category: Szilagyi K]]
-	[[Category: Zavodszky, P]]	+	[[Category: Zavodszky P]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Complement]]~~	+
-	~~[[Category: Complement pathway]]~~	+
-	~~[[Category: Egf-like domain]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydroxylation]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Innate immunity]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Serine protease]]~~	+
-	~~[[Category: Sushi~~]]	+

OCA at 04:08, 2 July 2021

OCA — Fri, 02 Jul 2021 04:08:55 GMT

←Older revision		Revision as of 04:08, 2 July 2021
Line 1:		Line 1:

	==Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts==		==Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts==
-	<StructureSection load='2qy0' size='340' side='right' caption='[[2qy0]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='2qy0' size='340' side='right'caption='[[2qy0]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qy0]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QY0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qy0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QY0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1R ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1R ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Complement_subcomponent_C1r Complement subcomponent C1r], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.41 3.4.21.41] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Complement_subcomponent_C1r Complement subcomponent C1r], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.41 3.4.21.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy0 OCA], [~~http~~://pdbe.org/2qy0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qy0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qy0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qy0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy0 OCA], [https://pdbe.org/2qy0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qy0 RCSB], [https://www.ebi.ac.uk/pdbsum/2qy0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qy0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/C1R_HUMAN C1R_HUMAN]] C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.	+	[[https://www.uniprot.org/uniprot/C1R_HUMAN C1R_HUMAN]] C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Complement subcomponent C1r]]		[[Category: Complement subcomponent C1r]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Barabas, O]]		[[Category: Barabas, O]]
	[[Category: Gal, P]]		[[Category: Gal, P]]

OCA at 11:35, 5 September 2018

OCA — Wed, 05 Sep 2018 11:35:32 GMT

←Older revision		Revision as of 11:35, 5 September 2018
Line 1:		Line 1:
		+
	==Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts==		==Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts==
	<StructureSection load='2qy0' size='340' side='right' caption='[[2qy0]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2qy0' size='340' side='right' caption='[[2qy0]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1r Complement subcomponent C1r], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.41 3.4.21.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1r Complement subcomponent C1r], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.41 3.4.21.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy0 OCA], [http://pdbe.org/2qy0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qy0 RCSB], [http://www.ebi.ac.uk/pdbsum/2qy0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy0 OCA], [http://pdbe.org/2qy0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qy0 RCSB], [http://www.ebi.ac.uk/pdbsum/2qy0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qy0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qy/2qy0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qy/2qy0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qy0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:42, 11 September 2015

OCA — Fri, 11 Sep 2015 15:42:04 GMT

←Older revision		Revision as of 15:42, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2qy0' size='340' side='right' caption='[[2qy0]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2qy0' size='340' side='right' caption='[[2qy0]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qy0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QY0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qy0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QY0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1r Complement subcomponent C1r], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.41 3.4.21.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1r Complement subcomponent C1r], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.41 3.4.21.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qy0 RCSB], [http://www.ebi.ac.uk/pdbsum/2qy0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy0 OCA], [http://pdbe.org/2qy0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qy0 RCSB], [http://www.ebi.ac.uk/pdbsum/2qy0 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qy0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Complement subcomponent C1r]]		[[Category: Complement subcomponent C1r]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Barabas, O]]		[[Category: Barabas, O]]
	[[Category: Gal, P]]		[[Category: Gal, P]]

OCA at 18:32, 25 December 2014

OCA — Thu, 25 Dec 2014 18:32:27 GMT

←Older revision		Revision as of 18:32, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qy0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QY0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qy0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QY0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1r Complement subcomponent C1r], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.41 3.4.21.41] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1r Complement subcomponent C1r], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.41 3.4.21.41] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qy0 RCSB], [http://www.ebi.ac.uk/pdbsum/2qy0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qy0 RCSB], [http://www.ebi.ac.uk/pdbsum/2qy0 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/C1R_HUMAN C1R_HUMAN]] C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	[[Category: Complement subcomponent C1r]]		[[Category: Complement subcomponent C1r]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Barabas, O.]]	+	[[Category: Barabas, O]]
-	[[Category: Gal, P.]]	+	[[Category: Gal, P]]
-	[[Category: Goto, Y.]]	+	[[Category: Goto, Y]]
-	[[Category: Graf, L.]]	+	[[Category: Graf, L]]
-	[[Category: Harmat, V.]]	+	[[Category: Harmat, V]]
-	[[Category: Kardos, J.]]	+	[[Category: Kardos, J]]
-	[[Category: Naray-Szabo, G.]]	+	[[Category: Naray-Szabo, G]]
-	[[Category: Pallo, A.]]	+	[[Category: Pallo, A]]
-	[[Category: Szilagyi, K.]]	+	[[Category: Szilagyi, K]]
-	[[Category: Zavodszky, P.]]	+	[[Category: Zavodszky, P]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Complement]]		[[Category: Complement]]

OCA at 19:46, 30 September 2014

OCA — Tue, 30 Sep 2014 19:46:30 GMT

←Older revision		Revision as of 19:46, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2qy0.~~png~~\|~~left~~\|200px]]	+	==Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts==
		+	<StructureSection load='2qy0' size='340' side='right' caption='[[2qy0]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2qy0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QY0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1r Complement subcomponent C1r], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.41 3.4.21.41] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qy0 RCSB], [http://www.ebi.ac.uk/pdbsum/2qy0 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qy/2qy0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	C1r is a modular serine protease which is the autoactivating component of the C1 complex of the classical pathway of the complement system. We have determined the first crystal structure of the entire active catalytic region of human C1r. This fragment contains the C-terminal serine protease (SP) domain and the preceding two complement control protein (CCP) modules. The activated CCP1-CCP2-SP fragment makes up a dimer in a head-to-tail fashion similarly to the previously characterized zymogen. The present structure shows an increased number of stabilizing interactions. Moreover, in the crystal lattice there is an enzyme-product relationship between the C1r molecules of neighboring dimers. This enzyme-product complex exhibits the crucial S1-P1 salt bridge between Asp631 and Arg446 residues, and intermolecular interaction between the CCP2 module and the SP domain. Based on these novel structural information we propose a new split-and-reassembly model for the autoactivation of the C1r. This model is consistent with experimental results that have not been explained adequately by previous models. It allows autoactivation of C1r without large-scale, directed movement of C1q arms. The model is concordant with the stability of the C1 complex during activation of the next complement components.

-	~~{{STRUCTURE_2qy0\| PDB=2qy0 \| SCENE= }}~~	+	Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r.,Kardos J, Harmat V, Pallo A, Barabas O, Szilagyi K, Graf L, Naray-Szabo G, Goto Y, Zavodszky P, Gal P Mol Immunol. 2008 Mar;45(6):1752-60. Epub 2007 Nov 9. PMID:17996945<ref>PMID:17996945</ref>

-	~~===Active dimeric structure~~ of the ~~catalytic domain of C1r reveals enzyme-product like contacts===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17996945}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2qy0]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017996945<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Complement subcomponent C1r]]		[[Category: Complement subcomponent C1r]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA: Protected "2qy0" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:39:35 GMT

Protected "2qy0" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:39, 7 January 2013

OCA at 22:39, 7 January 2013

OCA — Mon, 07 Jan 2013 22:39:32 GMT

←Older revision		Revision as of 22:39, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2qy0.png\|left\|200px]]		[[Image:2qy0.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2qy0", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2qy0\| PDB=2qy0 \| SCENE= }}		{{STRUCTURE_2qy0\| PDB=2qy0 \| SCENE= }}

	===Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts===		===Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17996945}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17996945 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17996945}}		{{ABSTRACT_PUBMED_17996945}}
-
-	==Disease==
-	Known disease associated with this structure: C1r/C1s deficiency, combined OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=216950 216950]]

	==About this Structure==		==About this Structure==
-	~~2QY0~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA].	+	[[2qy0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17996945~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017996945</ref><references group="xtra"/>
	[[Category: Complement subcomponent C1r]]		[[Category: Complement subcomponent C1r]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 49:		Line 34:
	[[Category: Innate immunity]]		[[Category: Innate immunity]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
-	[[Category: Polymorphism]]
	[[Category: Serine protease]]		[[Category: Serine protease]]
	[[Category: Sushi]]		[[Category: Sushi]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:34:44 2009''

OCA at 00:34, 18 February 2009

OCA — Wed, 18 Feb 2009 00:34:46 GMT

←Older revision		Revision as of 00:34, 18 February 2009
Line 23:		Line 23:

	==About this Structure==		==About this Structure==
-	2QY0 is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA].	+	2QY0 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY0 OCA].

	==Reference==		==Reference==
-	Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r., Kardos J, Harmat V, Pallo A, Barabas O, Szilagyi K, Graf L, Naray-Szabo G, Goto Y, Zavodszky P, Gal P, Mol Immunol. 2008 Mar;45(6):1752-60. Epub 2007 Nov 9. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17996945 17996945]~~	+	<ref group="xtra">PMID:17996945</ref><references group="xtra"/>
	[[Category: Complement subcomponent C1r]]		[[Category: Complement subcomponent C1r]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Barabas, O.]]		[[Category: Barabas, O.]]
	[[Category: Gal, P.]]		[[Category: Gal, P.]]
Line 54:		Line 53:
	[[Category: Sushi]]		[[Category: Sushi]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 09~~:12:~~14 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:34:44 2009''

OCA at 06:12, 29 July 2008

OCA — Tue, 29 Jul 2008 06:12:19 GMT

←Older revision		Revision as of 06:12, 29 July 2008
Line 1:		Line 1:
-	[[Image:2qy0.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2qy0.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2qy0\| PDB=2qy0 \| SCENE= }}		{{STRUCTURE_2qy0\| PDB=2qy0 \| SCENE= }}

-	~~'''~~Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts~~'''~~	+	===Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts===


-	~~==Overview==~~	+	<!--
-	C1r is a modular serine protease which is the autoactivating component of the C1 complex of the classical pathway of the complement system. We have determined the first crystal structure of the entire active catalytic region of human C1r. This fragment contains the C-~~terminal serine protease (SP) domain and the preceding two complement control protein (CCP) modules. The activated CCP1~~-~~CCP2-SP fragment makes up a dimer in a head-to-tail fashion similarly to the previously characterized zymogen.~~ The ~~present structure shows an increased number of stabilizing interactions. Moreover~~, in the crystal lattice there is an enzyme-product relationship between the C1r molecules of neighboring dimers. This enzyme-product complex exhibits the crucial S1-P1 salt bridge between Asp631 and Arg446 residues, ~~and intermolecular interaction between~~ the ~~CCP2 module and~~ the ~~SP domain. Based~~ on ~~these novel structural information we propose a new split-and-reassembly model for the autoactivation of the C1r~~. ~~This model is consistent with experimental results that have not been explained adequately by previous models~~. ~~It allows autoactivation of C1r without large-scale~~, ~~directed movement of C1q arms. The model~~ is ~~concordant with~~ the ~~stability of the C1 complex during activation of the next complement components~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17996945}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17996945 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17996945}}

	==Disease==		==Disease==
Line 49:		Line 53:
	[[Category: Serine protease]]		[[Category: Serine protease]]
	[[Category: Sushi]]		[[Category: Sushi]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 15~~:53:37 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:12:14 2008''