2r0l - Revision history

OCA at 11:43, 30 August 2023

OCA — Wed, 30 Aug 2023 11:43:47 GMT

←Older revision		Revision as of 11:43, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2r0l' size='340' side='right'caption='[[2r0l]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2r0l' size='340' side='right'caption='[[2r0l]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r0l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R0L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r0l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R0L FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BMA:BETA~~-~~D-MANNOSE'>BMA</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1ybw\|1ybw]], [[1yc0\|1yc0]], [[2r0k\|2r0k]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">HGFAC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0l OCA], [https://pdbe.org/2r0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r0l RCSB], [https://www.ebi.ac.uk/pdbsum/2r0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r0l ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0l OCA], [https://pdbe.org/2r0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r0l RCSB], [https://www.ebi.ac.uk/pdbsum/2r0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r0l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HGFA_HUMAN HGFA_HUMAN]] Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.	+	[https://www.uniprot.org/uniprot/HGFA_HUMAN HGFA_HUMAN] Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Eigenbrot, C~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Shia, S~~]]	+	[[Category: Eigenbrot C]]
-	[[Category: ~~Allosteric inhibitor]]~~	+	[[Category: Shia S]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Egf-like domain]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Kringle]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Serine protease]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 04:10, 2 July 2021

OCA — Fri, 02 Jul 2021 04:10:52 GMT

←Older revision		Revision as of 04:10, 2 July 2021
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	==Short Form HGFA with Inhibitory Fab75==		==Short Form HGFA with Inhibitory Fab75==
-	<StructureSection load='2r0l' size='340' side='right' caption='[[2r0l]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2r0l' size='340' side='right'caption='[[2r0l]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r0l]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2R0L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r0l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R0L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybw\|1ybw]], [[1yc0\|1yc0]], [[2r0k\|2r0k]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ybw\|1ybw]], [[1yc0\|1yc0]], [[2r0k\|2r0k]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HGFAC ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HGFAC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2r0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0l OCA], [~~http~~://pdbe.org/2r0l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2r0l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2r0l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2r0l ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0l OCA], [https://pdbe.org/2r0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r0l RCSB], [https://www.ebi.ac.uk/pdbsum/2r0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r0l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HGFA_HUMAN HGFA_HUMAN]] Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.	+	[[https://www.uniprot.org/uniprot/HGFA_HUMAN HGFA_HUMAN]] Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r0/2r0l_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r0/2r0l_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[3D structures of antibody\|3D structures of antibody]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Hepatocyte growth factor activator\|Hepatocyte growth factor activator]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Eigenbrot, C]]		[[Category: Eigenbrot, C]]
	[[Category: Shia, S]]		[[Category: Shia, S]]

OCA at 07:39, 25 October 2017

OCA — Wed, 25 Oct 2017 07:39:52 GMT

←Older revision		Revision as of 07:39, 25 October 2017
Line 1:		Line 1:
		+
	==Short Form HGFA with Inhibitory Fab75==		==Short Form HGFA with Inhibitory Fab75==
	<StructureSection load='2r0l' size='340' side='right' caption='[[2r0l]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2r0l' size='340' side='right' caption='[[2r0l]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybw\|1ybw]], [[1yc0\|1yc0]], [[2r0k\|2r0k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybw\|1ybw]], [[1yc0\|1yc0]], [[2r0k\|2r0k]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HGFAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HGFAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0l OCA], [http://pdbe.org/2r0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r0l RCSB], [http://www.ebi.ac.uk/pdbsum/2r0l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0l OCA], [http://pdbe.org/2r0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r0l RCSB], [http://www.ebi.ac.uk/pdbsum/2r0l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r0l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 32:

	==See Also==		==See Also==
-	*[[~~Antibody~~\|~~Antibody]]~~	+	*[[3D structures of antibody\|3D structures of antibody]]
-	*[[Hepatocyte growth factor activator\|Hepatocyte growth factor activator]]	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:19, 8 February 2016

OCA — Mon, 08 Feb 2016 08:19:00 GMT

←Older revision		Revision as of 08:19, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r0l ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:38, 10 September 2015

OCA — Thu, 10 Sep 2015 09:38:43 GMT

←Older revision		Revision as of 09:38, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2r0l' size='340' side='right' caption='[[2r0l]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2r0l' size='340' side='right' caption='[[2r0l]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r0l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human~~], [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Ruellia Ruellia~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R0L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r0l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R0L FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybw\|1ybw]], [[1yc0\|1yc0]], [[2r0k\|2r0k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybw\|1ybw]], [[1yc0\|1yc0]], [[2r0k\|2r0k]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HGFAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HGFAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r0l RCSB], [http://www.ebi.ac.uk/pdbsum/2r0l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0l OCA], [http://pdbe.org/2r0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r0l RCSB], [http://www.ebi.ac.uk/pdbsum/2r0l PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2r0l" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
		+	*[[Hepatocyte growth factor activator\|Hepatocyte growth factor activator]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Homo sapiens]]
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Ruellia]]
	[[Category: Eigenbrot, C]]		[[Category: Eigenbrot, C]]
	[[Category: Shia, S]]		[[Category: Shia, S]]

OCA at 21:55, 24 December 2014

OCA — Wed, 24 Dec 2014 21:55:29 GMT

←Older revision		Revision as of 21:55, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2r0l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human], [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Ruellia Ruellia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R0L FirstGlance]. <br>		<table><tr><td colspan='2'>[[2r0l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human], [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Ruellia Ruellia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R0L FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybw\|1ybw]], [[1yc0\|1yc0]], [[2r0k\|2r0k]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybw\|1ybw]], [[1yc0\|1yc0]], [[2r0k\|2r0k]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HGFAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HGFAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r0l RCSB], [http://www.ebi.ac.uk/pdbsum/2r0l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r0l RCSB], [http://www.ebi.ac.uk/pdbsum/2r0l PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HGFA_HUMAN HGFA_HUMAN]] Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Ruellia]]		[[Category: Ruellia]]
-	[[Category: Eigenbrot, C.]]	+	[[Category: Eigenbrot, C]]
-	[[Category: Shia, S.]]	+	[[Category: Shia, S]]
	[[Category: Allosteric inhibitor]]		[[Category: Allosteric inhibitor]]
	[[Category: Antibody]]		[[Category: Antibody]]

OCA at 04:22, 3 October 2014

OCA — Fri, 03 Oct 2014 04:22:39 GMT

←Older revision		Revision as of 04:22, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2r0l\| PDB~~=2r0l \| ~~SCENE~~= }}	+	==Short Form HGFA with Inhibitory Fab75==
-	===~~Short Form HGFA~~ with ~~Inhibitory Fab75~~===	+	<StructureSection load='2r0l' size='340' side='right' caption='[[2r0l]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18077410}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2r0l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human], [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Ruellia Ruellia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R0L FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ybw\|1ybw]], [[1yc0\|1yc0]], [[2r0k\|2r0k]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HGFAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r0l RCSB], [http://www.ebi.ac.uk/pdbsum/2r0l PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r0/2r0l_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To better understand how the relatively flat antigen-combining sites of antibodies interact with the concave shaped substrate-binding clefts of proteases, we determined the structures of two antibodies in complex with the trypsin-like hepatocyte growth-factor activator (HGFA). The two inhibitory antibodies, Ab58 and Ab75, were generated from a human Fab phage display library with synthetic diversity in the three complementarity determining regions (H1, H2, and H3) of the heavy chain, mimicking the natural diversity of the human Ig repertoire. Biochemical studies and the structures of the Fab58:HGFA (3.5-A resolution) and the Fab75:HGFA (2.2-A resolution) complexes revealed that Ab58 obstructed substrate access to the active site, whereas Ab75 allosterically inhibited substrate hydrolysis. In both cases, the antibodies interacted with the same protruding element (99-loop), which forms part of the substrate-binding cleft. Ab58 inserted its H1 and H2 loops in the cleft to occupy important substrate interaction sites (S3 and S2). In contrast, Ab75 bound at the backside of the cleft to a region corresponding to thrombin exosite II, which is known to interact with allosteric effector molecules. In agreement with the structural analysis, binding assays with active site inhibitors and enzymatic assays showed that Ab58 is a competitive inhibitor, and Ab75 is a partial competitive inhibitor. These results provide structural insight into antibody-mediated protease inhibition. They suggest that unlike canonical inhibitors, antibodies may preferentially target protruding loops at the rim of the substrate-binding cleft to interfere with the catalytic machinery of proteases without requiring long insertion loops.

-	~~==Function==~~	+	Structural insight into distinct mechanisms of protease inhibition by antibodies.,Wu Y, Eigenbrot C, Liang WC, Stawicki S, Shia S, Fan B, Ganesan R, Lipari MT, Kirchhofer D Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19784-9. Epub 2007 Dec 5. PMID:18077410<ref>PMID:18077410</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/HGFA_HUMAN HGFA_HUMAN]] Activates hepatocyte growth factor~~ (~~HGF~~) ~~by converting it from a single chain to a heterodimeric form~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2r0l]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/ ]~~, ~~[http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Ruellia Ruellia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0L OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:018077410</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Human]]
	[[Category: Ruellia]]		[[Category: Ruellia]]
	[[Category: Eigenbrot, C.]]		[[Category: Eigenbrot, C.]]

OCA at 07:00, 29 September 2013

OCA — Sun, 29 Sep 2013 07:00:53 GMT

←Older revision		Revision as of 07:00, 29 September 2013
Line 1:		Line 1:
-	[[Image:2r0l.png\|left\|200px]]
-
	{{STRUCTURE_2r0l\| PDB=2r0l \| SCENE= }}		{{STRUCTURE_2r0l\| PDB=2r0l \| SCENE= }}
-
	===Short Form HGFA with Inhibitory Fab75===		===Short Form HGFA with Inhibitory Fab75===
		+	{{ABSTRACT_PUBMED_18077410}}

-	~~{{ABSTRACT_PUBMED_18077410}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/HGFA_HUMAN HGFA_HUMAN]] Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.

	==About this Structure==		==About this Structure==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018077410</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018077410</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ruellia]]		[[Category: Ruellia]]

OCA at 09:31, 20 October 2012

OCA — Sat, 20 Oct 2012 09:31:25 GMT

←Older revision		Revision as of 09:31, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2r0l]] is a 4 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/ ] ~~and~~ [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0L OCA].	+	[[2r0l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Ruellia Ruellia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0L OCA].

	==See Also==		==See Also==
Line 16:		Line 16:
	<ref group="xtra">PMID:018077410</ref><references group="xtra"/>		<ref group="xtra">PMID:018077410</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Ruellia]]
	[[Category: Eigenbrot, C.]]		[[Category: Eigenbrot, C.]]
	[[Category: Shia, S.]]		[[Category: Shia, S.]]

OCA: Protected "2r0l" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 23:08:18 GMT

Protected "2r0l" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:08, 25 July 2012