2r3z - Revision history

OCA at 11:45, 30 August 2023

OCA — Wed, 30 Aug 2023 11:45:19 GMT

←Older revision		Revision as of 11:45, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2r3z' size='340' side='right'caption='[[2r3z]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2r3z' size='340' side='right'caption='[[2r3z]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r3z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R3Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r3z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R3Z FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1o7y\|1o7y]], [[1o7z\|1o7z]], [[1o80\|1o80]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">Cxcl10, Crg2, Ifi10, Inp10, Scyb10 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5&~~id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [https://pdbe.org/2r3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [https://www.ebi.ac.uk/pdbsum/2r3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r3z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [https://pdbe.org/2r3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [https://www.ebi.ac.uk/pdbsum/2r3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r3z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CXL10_MOUSE CXL10_MOUSE]] In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.	+	[https://www.uniprot.org/uniprot/CXL10_MOUSE CXL10_MOUSE] In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Acharya~~, K R~~]]	+	[[Category: Acharya KR]]
-	[[Category: Jabeen, T]]	+	[[Category: Jabeen T]]
-	[[Category: Jamaluddin, H]]	+	[[Category: Jamaluddin H]]
-	[[Category: Leonard, P]]	+	[[Category: Leonard P]]
-	~~[[Category: Attractant]]~~	+
-	~~[[Category: Chemokine]]~~	+
-	~~[[Category: Chemotaxis]]~~	+
-	~~[[Category: Inflammatory response]]~~	+
-	~~[[Category: Ip-10/cxcl10~~]]	+

OCA at 04:13, 2 July 2021

OCA — Fri, 02 Jul 2021 04:13:36 GMT

←Older revision		Revision as of 04:13, 2 July 2021
Line 1:		Line 1:

	==Crystal structure of mouse IP-10==		==Crystal structure of mouse IP-10==
-	<StructureSection load='2r3z' size='340' side='right' caption='[[2r3z]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2r3z' size='340' side='right'caption='[[2r3z]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r3z]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2R3Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r3z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R3Z FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o7y\|1o7y]], [[1o7z\|1o7z]], [[1o80\|1o80]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1o7y\|1o7y]], [[1o7z\|1o7z]], [[1o80\|1o80]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cxcl10, Crg2, Ifi10, Inp10, Scyb10 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cxcl10, Crg2, Ifi10, Inp10, Scyb10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [~~http~~://pdbe.org/2r3z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2r3z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2r3z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [https://pdbe.org/2r3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [https://www.ebi.ac.uk/pdbsum/2r3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r3z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CXL10_MOUSE CXL10_MOUSE]] In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.	+	[[https://www.uniprot.org/uniprot/CXL10_MOUSE CXL10_MOUSE]] In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[C-X-C motif chemokine\|C-X-C motif chemokine]]	+	*[[C-X-C motif chemokine 3D structures\|C-X-C motif chemokine 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]

OCA at 11:17, 5 September 2018

OCA — Wed, 05 Sep 2018 11:17:28 GMT

←Older revision		Revision as of 11:17, 5 September 2018
Line 1:		Line 1:
		+
	==Crystal structure of mouse IP-10==		==Crystal structure of mouse IP-10==
	<StructureSection load='2r3z' size='340' side='right' caption='[[2r3z]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2r3z' size='340' side='right' caption='[[2r3z]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o7y\|1o7y]], [[1o7z\|1o7z]], [[1o80\|1o80]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o7y\|1o7y]], [[1o7z\|1o7z]], [[1o80\|1o80]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cxcl10, Crg2, Ifi10, Inp10, Scyb10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cxcl10, Crg2, Ifi10, Inp10, Scyb10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [http://pdbe.org/2r3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [http://www.ebi.ac.uk/pdbsum/2r3z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [http://pdbe.org/2r3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [http://www.ebi.ac.uk/pdbsum/2r3z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r3z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r3/2r3z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r3/2r3z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r3z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:58, 11 September 2015

OCA — Fri, 11 Sep 2015 16:58:26 GMT

←Older revision		Revision as of 16:58, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2r3z' size='340' side='right' caption='[[2r3z]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2r3z' size='340' side='right' caption='[[2r3z]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r3z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R3Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r3z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R3Z FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o7y\|1o7y]], [[1o7z\|1o7z]], [[1o80\|1o80]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o7y\|1o7y]], [[1o7z\|1o7z]], [[1o80\|1o80]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cxcl10, Crg2, Ifi10, Inp10, Scyb10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cxcl10, Crg2, Ifi10, Inp10, Scyb10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [http://www.ebi.ac.uk/pdbsum/2r3z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [http://pdbe.org/2r3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [http://www.ebi.ac.uk/pdbsum/2r3z PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CXL10_MOUSE CXL10_MOUSE]] In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2r3z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]
	[[Category: Jabeen, T]]		[[Category: Jabeen, T]]

OCA at 13:57, 19 January 2015

OCA — Mon, 19 Jan 2015 13:57:27 GMT

←Older revision		Revision as of 13:57, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2r3z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R3Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[2r3z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R3Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o7y\|1o7y]], [[1o7z\|1o7z]], [[1o80\|1o80]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o7y\|1o7y]], [[1o7z\|1o7z]], [[1o80\|1o80]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cxcl10, Crg2, Ifi10, Inp10, Scyb10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cxcl10, Crg2, Ifi10, Inp10, Scyb10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [http://www.ebi.ac.uk/pdbsum/2r3z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [http://www.ebi.ac.uk/pdbsum/2r3z PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Acharya, K R.]]	+	[[Category: Acharya, K R]]
-	[[Category: Jabeen, T.]]	+	[[Category: Jabeen, T]]
-	[[Category: Jamaluddin, H.]]	+	[[Category: Jamaluddin, H]]
-	[[Category: Leonard, P.]]	+	[[Category: Leonard, P]]
	[[Category: Attractant]]		[[Category: Attractant]]
	[[Category: Chemokine]]		[[Category: Chemokine]]

OCA at 18:20, 30 September 2014

OCA — Tue, 30 Sep 2014 18:20:27 GMT

←Older revision		Revision as of 18:20, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2r3z.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of mouse IP-10==
		+	<StructureSection load='2r3z' size='340' side='right' caption='[[2r3z]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2r3z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R3Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o7y\|1o7y]], [[1o7z\|1o7z]], [[1o80\|1o80]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cxcl10, Crg2, Ifi10, Inp10, Scyb10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [http://www.ebi.ac.uk/pdbsum/2r3z PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r3/2r3z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Interferon-gamma-inducible protein (IP-10) belongs to the CXC class of chemokines and plays a significant role in the pathophysiology of various immune and inflammatory responses. It is also a potent angiostatic factor with antifibrotic properties. The biological activities of IP-10 are exerted by interactions with the G-protein-coupled receptor CXCR3 expressed on Th1 lymphocytes. IP-10 thus forms an attractive target for structure-based rational drug design of anti-inflammatory molecules. The crystal structure of mouse IP-10 has been determined and reveals a novel tetrameric association. In the tetramer, two conventional CXC chemokine dimers are associated through their N-terminal regions to form a 12-stranded elongated beta-sheet of approximately 90 A in length. This association differs significantly from the previously studied tetramers of human IP-10, platelet factor 4 and neutrophil-activating peptide-2. In addition, heparin- and receptor-binding residues were mapped on the surface of IP-10 tetramer. Two heparin-binding sites were observed on the surface and were present at the interface of each of the two beta-sheet dimers. The structure supports the formation of higher order oligomers of IP-10, as observed in recent in vivo studies with mouse IP-10, which will have functional relevance.

-	~~{{STRUCTURE_2r3z\| PDB=2r3z \| SCENE= }}~~	+	Structure of mouse IP-10, a chemokine.,Jabeen T, Leonard P, Jamaluddin H, Acharya KR Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):611-9. Epub 2008, May 14. PMID:18560148<ref>PMID:18560148</ref>

-	~~===Crystal structure~~ of ~~mouse IP-10===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_18560148}}~~	+	==See Also==
-		+	*[[C-X-C motif chemokine\|C-X-C motif chemokine]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2r3z~~]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:018560148<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]

OCA: Protected "2r3z" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 18:13:35 GMT

Protected "2r3z" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:13, 7 January 2013

OCA at 18:13, 7 January 2013

OCA — Mon, 07 Jan 2013 18:13:34 GMT

←Older revision		Revision as of 18:13, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2r3z.png\|left\|200px]]		[[Image:2r3z.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2r3z", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2r3z\| PDB=2r3z \| SCENE= }}		{{STRUCTURE_2r3z\| PDB=2r3z \| SCENE= }}

	===Crystal structure of mouse IP-10===		===Crystal structure of mouse IP-10===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18560148}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18560148 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18560148}}		{{ABSTRACT_PUBMED_18560148}}

	==About this Structure==		==About this Structure==
-	~~2R3Z~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA].	+	[[2r3z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18560148~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018560148</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]
Line 34:		Line 22:
	[[Category: Inflammatory response]]		[[Category: Inflammatory response]]
	[[Category: Ip-10/cxcl10]]		[[Category: Ip-10/cxcl10]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:16:51 2009''

OCA at 02:16, 18 February 2009

OCA — Wed, 18 Feb 2009 02:16:53 GMT

←Older revision		Revision as of 02:16, 18 February 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2r3z.~~jpg~~\|left\|200px]]	+	[[Image:2r3z.png\|left\|200px]]

	<!--		<!--
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2R3Z is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA].	+	2R3Z is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA].

	==Reference==		==Reference==
-	~~Structure of mouse IP-10, a chemokine., Jabeen T, Leonard P, Jamaluddin H, Acharya KR, Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):611-9. Epub 2008, May 14.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18560148 18560148]~~	+	<ref group="xtra">PMID:18560148</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Single protein]]
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]
	[[Category: Jabeen, T.]]		[[Category: Jabeen, T.]]
Line 36:		Line 35:
	[[Category: Ip-10/cxcl10]]		[[Category: Ip-10/cxcl10]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 13 14~~:07:~~10 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:16:51 2009''

OCA at 11:07, 13 August 2008

OCA — Wed, 13 Aug 2008 11:07:10 GMT

←Older revision		Revision as of 11:07, 13 August 2008
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2r3z.jpg\|left\|200px]]

-	The ~~entry 2r3z~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2r3z", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2r3z\| PDB=2r3z \| SCENE= }}

-	~~Authors: Jabeen, T., Leonard, P., Jamaluddin, H., Acharya, K.R.~~	+	===Crystal structure of mouse IP-10===

-	Description: Crystal structure of mouse IP-10

		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18560148}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18560148 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18560148}}

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 11 08~~:47:19 2008''	+	==About this Structure==
		+	2R3Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA].
		+
		+	==Reference==
		+	Structure of mouse IP-10, a chemokine., Jabeen T, Leonard P, Jamaluddin H, Acharya KR, Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):611-9. Epub 2008, May 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18560148 18560148]
		+	[[Category: Mus musculus]]
		+	[[Category: Single protein]]
		+	[[Category: Acharya, K R.]]
		+	[[Category: Jabeen, T.]]
		+	[[Category: Jamaluddin, H.]]
		+	[[Category: Leonard, P.]]
		+	[[Category: Attractant]]
		+	[[Category: Chemokine]]
		+	[[Category: Chemotaxis]]
		+	[[Category: Inflammatory response]]
		+	[[Category: Ip-10/cxcl10]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 13 14:07:10 2008''