2r4h - Revision history

OCA at 11:45, 30 August 2023

OCA — Wed, 30 Aug 2023 11:45:32 GMT

←Older revision		Revision as of 11:45, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2r4h' size='340' side='right'caption='[[2r4h]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2r4h' size='340' side='right'caption='[[2r4h]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r4h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r4h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4H FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2q9v\|2q9v]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">MAGI1, BAIAP1, BAP1, TNRC19 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [https://pdbe.org/2r4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [https://www.ebi.ac.uk/pdbsum/2r4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [https://pdbe.org/2r4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [https://www.ebi.ac.uk/pdbsum/2r4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MAGI1_HUMAN MAGI1_HUMAN]] May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).	+	[https://www.uniprot.org/uniprot/MAGI1_HUMAN MAGI1_HUMAN] May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Cooper, C]]	+	[[Category: Cooper C]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Doyle DA]]
-	[[Category: Doyle~~, D A~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Elkins JM]]
-	[[Category: Elkins~~, J M~~]]	+	[[Category: Hozjan V]]
-	[[Category: Hozjan, V]]	+	[[Category: Kavanagh KL]]
-	[[Category: Kavanagh~~, K L~~]]	+	[[Category: Oppermann U]]
-	[[Category: Oppermann, U]]	+	[[Category: Pike ACW]]
-	[[Category: Pike~~, A C.W~~]]	+	[[Category: Pilka ES]]
-	[[Category: Pilka~~, E S]]~~	+	[[Category: Sundstrom M]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Ugochukwu E]]
-	[[Category: Sundstrom, M]]	+	[[Category: Weigelt J]]
-	[[Category: Ugochukwu, E]]	+	[[Category: Von Delft F]]
-	[[Category: Weigelt, J]]	+
-	[[Category: ~~Atp-binding]]~~	+
-	~~[[Category: Cell junction]]~~	+
-	~~[[Category: Membrane associated guanylate kinase]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Pdz]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Tight junction]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 04:14, 2 July 2021

OCA — Fri, 02 Jul 2021 04:14:02 GMT

←Older revision		Revision as of 04:14, 2 July 2021
Line 1:		Line 1:

	==Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase==		==Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase==
-	<StructureSection load='2r4h' size='340' side='right' caption='[[2r4h]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='2r4h' size='340' side='right'caption='[[2r4h]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r4h]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2R4H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r4h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9v\|2q9v]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2q9v\|2q9v]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAGI1, BAIAP1, BAP1, TNRC19 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAGI1, BAIAP1, BAP1, TNRC19 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [~~http~~://pdbe.org/2r4h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2r4h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [https://pdbe.org/2r4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [https://www.ebi.ac.uk/pdbsum/2r4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MAGI1_HUMAN MAGI1_HUMAN]] May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).	+	[[https://www.uniprot.org/uniprot/MAGI1_HUMAN MAGI1_HUMAN]] May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4h_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4h_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 21:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4h ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4h ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Guanylate kinase 3D structures\|Guanylate kinase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Cooper, C]]		[[Category: Cooper, C]]

OCA at 07:42, 25 October 2017

OCA — Wed, 25 Oct 2017 07:42:35 GMT

←Older revision		Revision as of 07:42, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase==		==Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase==
	<StructureSection load='2r4h' size='340' side='right' caption='[[2r4h]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2r4h' size='340' side='right' caption='[[2r4h]], [[Resolution\|resolution]] 2.05Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9v\|2q9v]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9v\|2q9v]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAGI1, BAIAP1, BAP1, TNRC19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAGI1, BAIAP1, BAP1, TNRC19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [http://pdbe.org/2r4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [http://www.ebi.ac.uk/pdbsum/2r4h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [http://pdbe.org/2r4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [http://www.ebi.ac.uk/pdbsum/2r4h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4h ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4h ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-
-	==See Also==
-	*[[Guanylate kinase\|Guanylate kinase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 23:52, 9 February 2016

OCA — Tue, 09 Feb 2016 23:52:03 GMT

←Older revision		Revision as of 23:52, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4h ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 03:17, 11 September 2015

OCA — Fri, 11 Sep 2015 03:17:43 GMT

←Older revision		Revision as of 03:17, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2r4h' size='340' side='right' caption='[[2r4h]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2r4h' size='340' side='right' caption='[[2r4h]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r4h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R4H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r4h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R4H FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9v\|2q9v]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9v\|2q9v]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAGI1, BAIAP1, BAP1, TNRC19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAGI1, BAIAP1, BAP1, TNRC19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [http://www.ebi.ac.uk/pdbsum/2r4h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [http://pdbe.org/2r4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [http://www.ebi.ac.uk/pdbsum/2r4h PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Cooper, C]]		[[Category: Cooper, C]]

OCA at 10:22, 25 December 2014

OCA — Thu, 25 Dec 2014 10:22:48 GMT

←Older revision		Revision as of 10:22, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2r4h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R4H FirstGlance]. <br>		<table><tr><td colspan='2'>[[2r4h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R4H FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9v\|2q9v]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9v\|2q9v]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAGI1, BAIAP1, BAP1, TNRC19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAGI1, BAIAP1, BAP1, TNRC19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [http://www.ebi.ac.uk/pdbsum/2r4h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [http://www.ebi.ac.uk/pdbsum/2r4h PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MAGI1_HUMAN MAGI1_HUMAN]] May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Cooper, C.]]	+	[[Category: Cooper, C]]
-	[[Category: Delft, F von.]]	+	[[Category: Delft, F von]]
-	[[Category: Doyle, D A.]]	+	[[Category: Doyle, D A]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Elkins, J M.]]	+	[[Category: Elkins, J M]]
-	[[Category: Hozjan, V.]]	+	[[Category: Hozjan, V]]
-	[[Category: Kavanagh, K L.]]	+	[[Category: Kavanagh, K L]]
-	[[Category: Oppermann, U.]]	+	[[Category: Oppermann, U]]
-	[[Category: Pike, A C.W.]]	+	[[Category: Pike, A C.W]]
-	[[Category: Pilka, E S.]]	+	[[Category: Pilka, E S]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Ugochukwu, E.]]	+	[[Category: Ugochukwu, E]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
Line 46:		Line 48:
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Tight junction]]		[[Category: Tight junction]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:56, 29 September 2014

OCA — Mon, 29 Sep 2014 08:56:26 GMT

←Older revision		Revision as of 08:56, 29 September 2014
Line 1:		Line 1:
-	~~[[Image:2r4h.png\|left\|200px]]~~	+	==Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase==
-		+	<StructureSection load='2r4h' size='340' side='right' caption='[[2r4h]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~{{STRUCTURE_2r4h\| PDB=2r4h \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2r4h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R4H FirstGlance]. <br>
-	===Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9v\|2q9v]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAGI1, BAIAP1, BAP1, TNRC19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	==~~About this Structure~~==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [http://www.ebi.ac.uk/pdbsum/2r4h PDBsum]</span></td></tr>
-	[[2r4h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA].	+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4h_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Guanylate kinase\|Guanylate kinase]]		*[[Guanylate kinase\|Guanylate kinase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]

OCA at 15:34, 20 October 2012

OCA — Sat, 20 Oct 2012 15:34:55 GMT

←Older revision		Revision as of 15:34, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2r4h]] is a 3 chain structure ~~of [[Guanylate kinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA].	+	[[2r4h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA].

	==See Also==		==See Also==

OCA: Protected "2r4h" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 18:50:16 GMT

Protected "2r4h" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:50, 26 July 2012

OCA at 18:50, 26 July 2012

OCA — Thu, 26 Jul 2012 18:50:14 GMT

←Older revision		Revision as of 18:50, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2r4h.png\|left\|200px]]		[[Image:2r4h.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2r4h", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2r4h\| PDB=2r4h \| SCENE= }}		{{STRUCTURE_2r4h\| PDB=2r4h \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~2R4H~~ is a 3 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA].	+	[[2r4h]] is a 3 chain structure of [[Guanylate kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA].
		+
		+	==See Also==
		+	*[[Guanylate kinase\|Guanylate kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 31:		Line 27:
	[[Category: Ugochukwu, E.]]		[[Category: Ugochukwu, E.]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
-	[[Category: Alternative splicing]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
Line 43:		Line 38:
	[[Category: Tight junction]]		[[Category: Tight junction]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:44:36 2009''