2r56 - Revision history

OCA at 11:47, 30 August 2023

OCA — Wed, 30 Aug 2023 11:47:06 GMT

←Older revision		Revision as of 11:47, 30 August 2023
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	<StructureSection load='2r56' size='340' side='right'caption='[[2r56]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2r56' size='340' side='right'caption='[[2r56]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r56]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R56 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r56]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R56 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=LMT:DODECYL~~-~~BETA-D-MALTOSIDE'>LMT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~LGB ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r56 OCA], [https://pdbe.org/2r56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r56 RCSB], [https://www.ebi.ac.uk/pdbsum/2r56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r56 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r56 OCA], [https://pdbe.org/2r56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r56 RCSB], [https://www.ebi.ac.uk/pdbsum/2r56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r56 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN]] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.	+	[https://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hakulinen, N]]	+	[[Category: Hakulinen N]]
-	[[Category: Kallio~~, J M~~]]	+	[[Category: Kallio JM]]
-	[[Category: Niemi, M]]	+	[[Category: Niemi M]]
-	[[Category: Rouvinen, J]]	+	[[Category: Rouvinen J]]
-	~~[[Category: Allergen]]~~	+
-	~~[[Category: Epitope]]~~	+
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Ige]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunocomplex]]~~	+
-	~~[[Category: Lipocalin]]~~	+
-	~~[[Category: Milk protein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Retinol-binding]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Transport~~]]	+

OCA at 04:14, 2 July 2021

OCA — Fri, 02 Jul 2021 04:14:44 GMT

←Older revision		Revision as of 04:14, 2 July 2021
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	==Crystal Structure of a Recombinant IgE Fab Fragment in Complex with Bovine Beta-Lactoglobulin Allergen==		==Crystal Structure of a Recombinant IgE Fab Fragment in Complex with Bovine Beta-Lactoglobulin Allergen==
-	<StructureSection load='2r56' size='340' side='right' caption='[[2r56]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2r56' size='340' side='right'caption='[[2r56]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r56]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin] and [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R56 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2R56 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r56]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R56 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2r56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r56 OCA], [~~http~~://pdbe.org/2r56 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2r56 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2r56 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2r56 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r56 OCA], [https://pdbe.org/2r56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r56 RCSB], [https://www.ebi.ac.uk/pdbsum/2r56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r56 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN]] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.	+	[[https://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN]] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
-	*[[Beta-lactoglobulin\|Beta-lactoglobulin]]	+	*[[Beta-lactoglobulin 3D structures\|Beta-lactoglobulin 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 40:
	[[Category: Bovin]]		[[Category: Bovin]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Hakulinen, N]]		[[Category: Hakulinen, N]]
	[[Category: Kallio, J M]]		[[Category: Kallio, J M]]

OCA at 11:30, 5 September 2018

OCA — Wed, 05 Sep 2018 11:30:25 GMT

←Older revision		Revision as of 11:30, 5 September 2018
Line 1:		Line 1:
		+
	==Crystal Structure of a Recombinant IgE Fab Fragment in Complex with Bovine Beta-Lactoglobulin Allergen==		==Crystal Structure of a Recombinant IgE Fab Fragment in Complex with Bovine Beta-Lactoglobulin Allergen==
	<StructureSection load='2r56' size='340' side='right' caption='[[2r56]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2r56' size='340' side='right' caption='[[2r56]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r56 OCA], [http://pdbe.org/2r56 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r56 RCSB], [http://www.ebi.ac.uk/pdbsum/2r56 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r56 OCA], [http://pdbe.org/2r56 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r56 RCSB], [http://www.ebi.ac.uk/pdbsum/2r56 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r56 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r56_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r56_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:

	==See Also==		==See Also==
-	*[[Antibody\|Antibody]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Beta-lactoglobulin\|Beta-lactoglobulin]]		*[[Beta-lactoglobulin\|Beta-lactoglobulin]]
	== References ==		== References ==
Line 50:		Line 51:
	[[Category: Lipocalin]]		[[Category: Lipocalin]]
	[[Category: Milk protein]]		[[Category: Milk protein]]
		+	[[Category: Polymorphism]]
	[[Category: Retinol-binding]]		[[Category: Retinol-binding]]
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Transport]]		[[Category: Transport]]

OCA at 22:59, 9 February 2016

OCA — Tue, 09 Feb 2016 22:59:16 GMT

←Older revision		Revision as of 22:59, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r56 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:54, 11 September 2015

OCA — Fri, 11 Sep 2015 02:54:14 GMT

←Older revision		Revision as of 02:54, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2r56' size='340' side='right' caption='[[2r56]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2r56' size='340' side='right' caption='[[2r56]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r56]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R56 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r56]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R56 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 ~~Bos taurus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r56 RCSB], [http://www.ebi.ac.uk/pdbsum/2r56 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r56 OCA], [http://pdbe.org/2r56 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r56 RCSB], [http://www.ebi.ac.uk/pdbsum/2r56 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2r56" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hakulinen, N]]		[[Category: Hakulinen, N]]

OCA at 10:06, 25 December 2014

OCA — Thu, 25 Dec 2014 10:06:55 GMT

←Older revision		Revision as of 10:06, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2r56]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R56 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2r56]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R56 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r56 RCSB], [http://www.ebi.ac.uk/pdbsum/2r56 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r56 RCSB], [http://www.ebi.ac.uk/pdbsum/2r56 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN]] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hakulinen, N.]]	+	[[Category: Hakulinen, N]]
-	[[Category: Kallio, J M.]]	+	[[Category: Kallio, J M]]
-	[[Category: Niemi, M.]]	+	[[Category: Niemi, M]]
-	[[Category: Rouvinen, J.]]	+	[[Category: Rouvinen, J]]
	[[Category: Allergen]]		[[Category: Allergen]]
	[[Category: Epitope]]		[[Category: Epitope]]

OCA at 19:05, 30 September 2014

OCA — Tue, 30 Sep 2014 19:05:31 GMT

←Older revision		Revision as of 19:05, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2r56\| PDB=2r56 \| SCENE= }}~~	+	==Crystal Structure of a Recombinant IgE Fab Fragment in Complex with Bovine Beta-Lactoglobulin Allergen==
-	===Crystal Structure of a Recombinant IgE Fab Fragment in Complex with Bovine Beta-Lactoglobulin Allergen===	+	<StructureSection load='2r56' size='340' side='right' caption='[[2r56]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17997967}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2r56]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R56 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r56 RCSB], [http://www.ebi.ac.uk/pdbsum/2r56 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r56_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Allergies are caused by the immune reaction to commonly harmless proteins, allergens. This reaction is typified by immunoglobulin E (IgE) antibodies. We report the crystal structure of an IgE Fab fragment in complex with beta-lactoglobulin (BLG), one of the major allergens of bovine milk. The solved structure shows how two IgE/Fab molecules bind the dimeric BLG. The epitope of BLG consists of six different short fragments of the polypeptide chain, which are located especially in the beta strands, covering a flat area on the allergen surface. All six CDR (complementary-determining region) loops of the IgE Fab participate in the binding of BLG. The light chain CDR loops are responsible for the binding of the flat beta sheet region of BLG. The IgE epitope is different from common IgG epitopes that are normally located in the exposed loop regions of antigens and observed also in the two recently determined allergen-IgG complexes.

-	~~==Function==~~	+	Molecular interactions between a recombinant IgE antibody and the beta-lactoglobulin allergen.,Niemi M, Jylha S, Laukkanen ML, Soderlund H, Makinen-Kiljunen S, Kallio JM, Hakulinen N, Haahtela T, Takkinen K, Rouvinen J Structure. 2007 Nov;15(11):1413-21. PMID:17997967<ref>PMID:17997967</ref>
-	~~[[http://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN]] Primary component of whey, it binds retinol~~ and ~~is probably involved in~~ the ~~transport of that molecule~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2r56]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus] and [http://en~~.~~wikipedia.org~~/~~wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R56 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
	*[[Beta-lactoglobulin\|Beta-lactoglobulin]]		*[[Beta-lactoglobulin\|Beta-lactoglobulin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:017997967</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 20:18, 24 March 2013

OCA — Sun, 24 Mar 2013 20:18:22 GMT

←Older revision		Revision as of 20:18, 24 March 2013
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-	[[Image:2r56.png\|left\|200px]]
-
	{{STRUCTURE_2r56\| PDB=2r56 \| SCENE= }}		{{STRUCTURE_2r56\| PDB=2r56 \| SCENE= }}
-
	===Crystal Structure of a Recombinant IgE Fab Fragment in Complex with Bovine Beta-Lactoglobulin Allergen===		===Crystal Structure of a Recombinant IgE Fab Fragment in Complex with Bovine Beta-Lactoglobulin Allergen===
		+	{{ABSTRACT_PUBMED_17997967}}

-	~~{{ABSTRACT_PUBMED_17997967}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN]] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.

	==About this Structure==		==About this Structure==
Line 15:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:017997967</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017997967</ref><references group="xtra"/><references/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 15:26, 20 October 2012

OCA — Sat, 20 Oct 2012 15:26:39 GMT

←Older revision		Revision as of 15:26, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2r56]] is a 6 chain structure ~~of [[Antibody]] and [[Beta-lactoglobulin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R56 OCA].	+	[[2r56]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R56 OCA].

	==See Also==		==See Also==

OCA: Protected "2r56" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 18:23:57 GMT

Protected "2r56" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:23, 26 July 2012