2r5h - Revision history

OCA at 09:19, 21 February 2024

OCA — Wed, 21 Feb 2024 09:19:53 GMT

←Older revision		Revision as of 09:19, 21 February 2024
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	<StructureSection load='2r5h' size='340' side='right'caption='[[2r5h]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='2r5h' size='340' side='right'caption='[[2r5h]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r5h]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human_papilloma_virus~~ Human ~~papilloma virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r5h]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5H FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1dzl\|1dzl]]~~, [[~~2r5i~~\|~~2r5i~~]]~~, [[2r5j\|2r5j]], [[2r5k\|2r5k]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.7Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5h OCA], [https://pdbe.org/2r5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5h RCSB], [https://www.ebi.ac.uk/pdbsum/2r5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5h OCA], [https://pdbe.org/2r5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5h RCSB], [https://www.ebi.ac.uk/pdbsum/2r5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5h ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1U9YFU1_9PAPI A0A1U9YFU1_9PAPI] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r5h ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r5h ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Human papillomaviruses (HPVs) are known etiologic agents of cervical cancer. Vaccines that contain virus-like particles (VLPs) made of L1 capsid protein from several high risk HPV types have proven to be effective against HPV infections. Raising high levels of neutralizing antibodies against each HPV type is believed to be the primary mechanism of protection, gained by vaccination. Antibodies elicited by a particular HPV type are highly specific to that particular HPV type and show little or no cross-reactivity between HPV types. With an intention to understand the interplay between the L1 structure of different HPV types and the type specificity of neutralizing antibodies, we have prepared the L1 pentamers of four different HPV types, HPV11, HPV16, HPV18, and HPV35. The pentamers only bind the type-specific neutralizing monoclonal antibodies (NmAbs) that are raised against the VLP of the corresponding HPV type, implying that the surface loop structures of the pentamers from each type are distinctive and functionally active as VLPs in terms of antibody binding. We have determined the crystal structures of all four L1 pentamers, and their comparisons revealed characteristic conformational differences of the surface loops that contain the known epitopes for the NmAbs. On the basis of these distinct surface loop structures, we have provided a molecular explanation for the type specificity of NmAbs against HPV infection.
-
-	Crystal structures of four types of human papillomavirus L1 capsid proteins: understanding the specificity of neutralizing monoclonal antibodies.,Bishop B, Dasgupta J, Klein M, Garcea RL, Christensen ND, Zhao R, Chen XS J Biol Chem. 2007 Oct 26;282(43):31803-11. Epub 2007 Sep 4. PMID:17804402<ref>PMID:17804402</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2r5h" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]		*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human ~~papilloma virus~~]]	+	[[Category: Human papillomavirus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bishop, B]]	+	[[Category: Bishop B]]
-	[[Category: Chen~~, X S~~]]	+	[[Category: Chen XS]]
-	[[Category: Dasgupta, J]]	+	[[Category: Dasgupta J]]
-	~~[[Category: Capsid]]~~	+
-	~~[[Category: Capsid protein]]~~	+
-	~~[[Category: Pentamer]]~~	+
-	~~[[Category: Protein]]~~	+
-	~~[[Category: Type specific epitope]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Virion~~]]	+

OCA at 04:15, 2 July 2021

OCA — Fri, 02 Jul 2021 04:15:02 GMT

←Older revision		Revision as of 04:15, 2 July 2021
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	<StructureSection load='2r5h' size='340' side='right'caption='[[2r5h]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='2r5h' size='340' side='right'caption='[[2r5h]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r5h]] is a 15 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human_papilloma_virus Human papilloma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2R5H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r5h]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papilloma_virus Human papilloma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5H FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzl\|1dzl]], [[2r5i\|2r5i]], [[2r5j\|2r5j]], [[2r5k\|2r5k]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dzl\|1dzl]], [[2r5i\|2r5i]], [[2r5j\|2r5j]], [[2r5k\|2r5k]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2r5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5h OCA], [~~http~~://pdbe.org/2r5h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2r5h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2r5h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5h OCA], [https://pdbe.org/2r5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5h RCSB], [https://www.ebi.ac.uk/pdbsum/2r5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5h ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
-	*[[Major capsid protein L1\|Major capsid protein L1]]	+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
-	*[[Virus coat ~~protein~~\|Virus coat ~~protein~~]]	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:28, 21 August 2019

OCA — Wed, 21 Aug 2019 07:28:32 GMT

←Older revision		Revision as of 07:28, 21 August 2019
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	==Pentamer structure of Major Capsid Protein L1 of Human Papilloma Virus type 16==		==Pentamer structure of Major Capsid Protein L1 of Human Papilloma Virus type 16==
-	<StructureSection load='2r5h' size='340' side='right' caption='[[2r5h]], [[Resolution\|resolution]] 3.70Å' scene=''>	+	<StructureSection load='2r5h' size='340' side='right'caption='[[2r5h]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2r5h]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papilloma_virus Human papilloma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5H FirstGlance]. <br>		<table><tr><td colspan='2'>[[2r5h]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papilloma_virus Human papilloma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5H FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5h_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5h_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2r5h" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2r5h" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Major capsid protein L1\|Major capsid protein L1]]
		+	*[[Virus coat protein\|Virus coat protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human papilloma virus]]		[[Category: Human papilloma virus]]
		+	[[Category: Large Structures]]
	[[Category: Bishop, B]]		[[Category: Bishop, B]]
	[[Category: Chen, X S]]		[[Category: Chen, X S]]

OCA at 02:13, 16 November 2017

OCA — Thu, 16 Nov 2017 02:13:22 GMT

←Older revision		Revision as of 02:13, 16 November 2017
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		+
	==Pentamer structure of Major Capsid Protein L1 of Human Papilloma Virus type 16==		==Pentamer structure of Major Capsid Protein L1 of Human Papilloma Virus type 16==
	<StructureSection load='2r5h' size='340' side='right' caption='[[2r5h]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='2r5h' size='340' side='right' caption='[[2r5h]], [[Resolution\|resolution]] 3.70Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2r5h]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papilloma_virus Human papilloma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5H FirstGlance]. <br>		<table><tr><td colspan='2'>[[2r5h]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papilloma_virus Human papilloma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5H FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzl\|1dzl]], [[2r5i\|2r5i]], [[2r5j\|2r5j]], [[2r5k\|2r5k]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzl\|1dzl]], [[2r5i\|2r5i]], [[2r5j\|2r5j]], [[2r5k\|2r5k]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5h OCA], [http://pdbe.org/2r5h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r5h RCSB], [http://www.ebi.ac.uk/pdbsum/2r5h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5h OCA], [http://pdbe.org/2r5h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r5h RCSB], [http://www.ebi.ac.uk/pdbsum/2r5h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5h ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r5h ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 2r5h" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2r5h" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Virus coat protein\|Virus coat protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:38, 12 September 2015

OCA — Sat, 12 Sep 2015 01:38:39 GMT

←Older revision		Revision as of 01:38, 12 September 2015
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	<StructureSection load='2r5h' size='340' side='right' caption='[[2r5h]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='2r5h' size='340' side='right' caption='[[2r5h]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r5h]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_papillomavirus~~ Human ~~papillomavirus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r5h]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papilloma_virus Human papilloma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5H FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzl\|1dzl]], [[2r5i\|2r5i]], [[2r5j\|2r5j]], [[2r5k\|2r5k]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzl\|1dzl]], [[2r5i\|2r5i]], [[2r5j\|2r5j]], [[2r5k\|2r5k]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r5h RCSB], [http://www.ebi.ac.uk/pdbsum/2r5h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5h OCA], [http://pdbe.org/2r5h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r5h RCSB], [http://www.ebi.ac.uk/pdbsum/2r5h PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2r5h" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human ~~papillomavirus~~]]	+	[[Category: Human papilloma virus]]
	[[Category: Bishop, B]]		[[Category: Bishop, B]]
	[[Category: Chen, X S]]		[[Category: Chen, X S]]

OCA at 22:06, 25 December 2014

OCA — Thu, 25 Dec 2014 22:06:28 GMT

←Older revision		Revision as of 22:06, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2r5h]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5H FirstGlance]. <br>		<table><tr><td colspan='2'>[[2r5h]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5H FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzl\|1dzl]], [[2r5i\|2r5i]], [[2r5j\|2r5j]], [[2r5k\|2r5k]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzl\|1dzl]], [[2r5i\|2r5i]], [[2r5j\|2r5j]], [[2r5k\|2r5k]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r5h RCSB], [http://www.ebi.ac.uk/pdbsum/2r5h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r5h RCSB], [http://www.ebi.ac.uk/pdbsum/2r5h PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Human papillomavirus]]		[[Category: Human papillomavirus]]
-	[[Category: Bishop, B.]]	+	[[Category: Bishop, B]]
-	[[Category: Chen, X S.]]	+	[[Category: Chen, X S]]
-	[[Category: Dasgupta, J.]]	+	[[Category: Dasgupta, J]]
	[[Category: Capsid]]		[[Category: Capsid]]
	[[Category: Capsid protein]]		[[Category: Capsid protein]]

OCA at 09:00, 29 September 2014

OCA — Mon, 29 Sep 2014 09:00:32 GMT

←Older revision		Revision as of 09:00, 29 September 2014
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-	[[~~Image:~~2r5h.~~png~~\|~~left~~\|200px]]	+	==Pentamer structure of Major Capsid Protein L1 of Human Papilloma Virus type 16==
		+	<StructureSection load='2r5h' size='340' side='right' caption='[[2r5h]], [[Resolution\|resolution]] 3.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2r5h]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5H FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dzl\|1dzl]], [[2r5i\|2r5i]], [[2r5j\|2r5j]], [[2r5k\|2r5k]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r5h RCSB], [http://www.ebi.ac.uk/pdbsum/2r5h PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5h_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human papillomaviruses (HPVs) are known etiologic agents of cervical cancer. Vaccines that contain virus-like particles (VLPs) made of L1 capsid protein from several high risk HPV types have proven to be effective against HPV infections. Raising high levels of neutralizing antibodies against each HPV type is believed to be the primary mechanism of protection, gained by vaccination. Antibodies elicited by a particular HPV type are highly specific to that particular HPV type and show little or no cross-reactivity between HPV types. With an intention to understand the interplay between the L1 structure of different HPV types and the type specificity of neutralizing antibodies, we have prepared the L1 pentamers of four different HPV types, HPV11, HPV16, HPV18, and HPV35. The pentamers only bind the type-specific neutralizing monoclonal antibodies (NmAbs) that are raised against the VLP of the corresponding HPV type, implying that the surface loop structures of the pentamers from each type are distinctive and functionally active as VLPs in terms of antibody binding. We have determined the crystal structures of all four L1 pentamers, and their comparisons revealed characteristic conformational differences of the surface loops that contain the known epitopes for the NmAbs. On the basis of these distinct surface loop structures, we have provided a molecular explanation for the type specificity of NmAbs against HPV infection.

-	~~{{STRUCTURE_2r5h\| PDB=2r5h \| SCENE= }}~~	+	Crystal structures of four types of human papillomavirus L1 capsid proteins: understanding the specificity of neutralizing monoclonal antibodies.,Bishop B, Dasgupta J, Klein M, Garcea RL, Christensen ND, Zhao R, Chen XS J Biol Chem. 2007 Oct 26;282(43):31803-11. Epub 2007 Sep 4. PMID:17804402<ref>PMID:17804402</ref>

-	~~===Pentamer structure~~ of ~~Major Capsid Protein L1 of Human Papilloma Virus type 16===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17804402}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2r5h]] is a 15 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human_papillomavirus Human papillomavirus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA].~~	+

	==See Also==		==See Also==
	*[[Virus coat protein\|Virus coat protein]]		*[[Virus coat protein\|Virus coat protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017804402<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Human papillomavirus]]		[[Category: Human papillomavirus]]
	[[Category: Bishop, B.]]		[[Category: Bishop, B.]]

OCA: Protected "2r5h" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 22:12:31 GMT

Protected "2r5h" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:12, 20 October 2012

OCA at 22:12, 20 October 2012

OCA — Sat, 20 Oct 2012 22:12:29 GMT

←Older revision		Revision as of 22:12, 20 October 2012
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-	{{Seed}}
	[[Image:2r5h.png\|left\|200px]]		[[Image:2r5h.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2r5h", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2r5h\| PDB=2r5h \| SCENE= }}		{{STRUCTURE_2r5h\| PDB=2r5h \| SCENE= }}

	===Pentamer structure of Major Capsid Protein L1 of Human Papilloma Virus type 16===		===Pentamer structure of Major Capsid Protein L1 of Human Papilloma Virus type 16===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17804402}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17804402 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17804402}}		{{ABSTRACT_PUBMED_17804402}}

	==About this Structure==		==About this Structure==
-	~~2R5H~~ is a 15 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA].	+	[[2r5h]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA].
		+
		+	==See Also==
		+	*[[Virus coat protein\|Virus coat protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17804402~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017804402</ref><references group="xtra"/>
	[[Category: Human papillomavirus]]		[[Category: Human papillomavirus]]
	[[Category: Bishop, B.]]		[[Category: Bishop, B.]]
Line 32:		Line 23:
	[[Category: Pentamer]]		[[Category: Pentamer]]
	[[Category: Protein]]		[[Category: Protein]]
-	[[Category: Structure]]
	[[Category: Type specific epitope]]		[[Category: Type specific epitope]]
	[[Category: Viral protein]]		[[Category: Viral protein]]
	[[Category: Virion]]		[[Category: Virion]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:19:25 2009''

OCA at 07:19, 18 February 2009

OCA — Wed, 18 Feb 2009 07:19:26 GMT

←Older revision		Revision as of 07:19, 18 February 2009
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	==About this Structure==		==About this Structure==
-	2R5H is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA].	+	2R5H is a 15 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5H OCA].

	==Reference==		==Reference==
-	Crystal structures of four types of human papillomavirus L1 capsid proteins: understanding the specificity of neutralizing monoclonal antibodies., Bishop B, Dasgupta J, Klein M, Garcea RL, Christensen ND, Zhao R, Chen XS, J Biol Chem. 2007 Oct 26;282(43):31803-11. Epub 2007 Sep 4. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17804402 17804402]~~	+	<ref group="xtra">PMID:17804402</ref><references group="xtra"/>
	[[Category: Human papillomavirus]]		[[Category: Human papillomavirus]]
-	[[Category: Single protein]]
	[[Category: Bishop, B.]]		[[Category: Bishop, B.]]
	[[Category: Chen, X S.]]		[[Category: Chen, X S.]]
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	[[Category: Virion]]		[[Category: Virion]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 15~~:34:~~05 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:19:25 2009''