2r9k - Revision history

OCA at 11:50, 30 August 2023

OCA — Wed, 30 Aug 2023 11:50:16 GMT

←Older revision		Revision as of 11:50, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2r9k' size='340' side='right'caption='[[2r9k]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2r9k' size='340' side='right'caption='[[2r9k]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r9k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~European_mistletoe European mistletoe~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r9k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m2t\|1m2t]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [https://pdbe.org/2r9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [https://www.ebi.ac.uk/pdbsum/2r9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [https://pdbe.org/2r9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [https://www.ebi.ac.uk/pdbsum/2r9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL]] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>	+	[https://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: European mistletoe]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Betzel, C]]
-	[[Category: Celewicz, L]]
-	[[Category: Erdmann, V A]]
-	[[Category: Meyer, A]]
-	[[Category: Rypniewski, W]]
-	[[Category: Voelter, W]]
-	[[Category: Glycoprotein]]
-	[[Category: Hydrolase]]
-	[[Category: Lectin]]
-	[[Category: Ml-i]]
-	[[Category: Phloretamide]]
-	[[Category: Plant defense]]
-	[[Category: Protein synthesis inhibitor]]
-	[[Category: Toxin]]
	[[Category: Viscum album]]		[[Category: Viscum album]]
		+	[[Category: Betzel C]]
		+	[[Category: Celewicz L]]
		+	[[Category: Erdmann VA]]
		+	[[Category: Meyer A]]
		+	[[Category: Rypniewski W]]
		+	[[Category: Voelter W]]

OCA at 07:46, 16 March 2022

OCA — Wed, 16 Mar 2022 07:46:53 GMT

←Older revision		Revision as of 07:46, 16 March 2022
Line 3:		Line 3:
	<StructureSection load='2r9k' size='340' side='right'caption='[[2r9k]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2r9k' size='340' side='right'caption='[[2r9k]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r9k]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/European_mistletoe European mistletoe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2R9K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r9k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/European_mistletoe European mistletoe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2t\|1m2t]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m2t\|1m2t]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [~~http~~://pdbe.org/2r9k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2r9k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [https://pdbe.org/2r9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [https://www.ebi.ac.uk/pdbsum/2r9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL]] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>	+	[[https://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL]] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:10, 10 June 2020

OCA — Wed, 10 Jun 2020 07:10:46 GMT

←Older revision		Revision as of 07:10, 10 June 2020
Line 1:		Line 1:

	==Crystal Structure of Misteltoe Lectin I in Complex with Phloretamide==		==Crystal Structure of Misteltoe Lectin I in Complex with Phloretamide==
-	<StructureSection load='2r9k' size='340' side='right' caption='[[2r9k]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='2r9k' size='340' side='right'caption='[[2r9k]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/European_mistletoe European mistletoe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2R9K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/European_mistletoe European mistletoe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2R9K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2t\|1m2t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2t\|1m2t]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [http://pdbe.org/2r9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [http://www.ebi.ac.uk/pdbsum/2r9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [http://pdbe.org/2r9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [http://www.ebi.ac.uk/pdbsum/2r9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: European mistletoe]]		[[Category: European mistletoe]]
		+	[[Category: Large Structures]]
	[[Category: Betzel, C]]		[[Category: Betzel, C]]
	[[Category: Celewicz, L]]		[[Category: Celewicz, L]]

OCA at 10:59, 5 September 2018

OCA — Wed, 05 Sep 2018 10:59:08 GMT

←Older revision		Revision as of 10:59, 5 September 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Misteltoe Lectin I in Complex with Phloretamide==		==Crystal Structure of Misteltoe Lectin I in Complex with Phloretamide==
	<StructureSection load='2r9k' size='340' side='right' caption='[[2r9k]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2r9k' size='340' side='right' caption='[[2r9k]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2t\|1m2t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2t\|1m2t]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [http://pdbe.org/2r9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [http://www.ebi.ac.uk/pdbsum/2r9k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [http://pdbe.org/2r9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [http://www.ebi.ac.uk/pdbsum/2r9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9k_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9k_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r9k ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:09, 11 September 2015

OCA — Fri, 11 Sep 2015 15:09:10 GMT

←Older revision		Revision as of 15:09, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2r9k' size='340' side='right' caption='[[2r9k]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2r9k' size='340' side='right' caption='[[2r9k]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Viscum_album Viscum album~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/European_mistletoe European mistletoe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2t\|1m2t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2t\|1m2t]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [http://www.ebi.ac.uk/pdbsum/2r9k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [http://pdbe.org/2r9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [http://www.ebi.ac.uk/pdbsum/2r9k PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2r9k" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Viscum album~~]]	+	[[Category: European mistletoe]]
	[[Category: Betzel, C]]		[[Category: Betzel, C]]
	[[Category: Celewicz, L]]		[[Category: Celewicz, L]]
Line 46:		Line 47:
	[[Category: Protein synthesis inhibitor]]		[[Category: Protein synthesis inhibitor]]
	[[Category: Toxin]]		[[Category: Toxin]]
		+	[[Category: Viscum album]]

OCA at 18:11, 25 December 2014

OCA — Thu, 25 Dec 2014 18:11:37 GMT

←Older revision		Revision as of 18:11, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2r9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9K FirstGlance]. <br>		<table><tr><td colspan='2'>[[2r9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9K FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2t\|1m2t]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2t\|1m2t]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [http://www.ebi.ac.uk/pdbsum/2r9k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [http://www.ebi.ac.uk/pdbsum/2r9k PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL]] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Viscum album]]		[[Category: Viscum album]]
-	[[Category: Betzel, C.]]	+	[[Category: Betzel, C]]
-	[[Category: Celewicz, L.]]	+	[[Category: Celewicz, L]]
-	[[Category: Erdmann, V A.]]	+	[[Category: Erdmann, V A]]
-	[[Category: Meyer, A.]]	+	[[Category: Meyer, A]]
-	[[Category: Rypniewski, W.]]	+	[[Category: Rypniewski, W]]
-	[[Category: Voelter, W.]]	+	[[Category: Voelter, W]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
Line 44:		Line 46:
	[[Category: Protein synthesis inhibitor]]		[[Category: Protein synthesis inhibitor]]
	[[Category: Toxin]]		[[Category: Toxin]]
-	[[Category: Viscum album]]

OCA at 19:18, 30 September 2014

OCA — Tue, 30 Sep 2014 19:18:24 GMT

←Older revision		Revision as of 19:18, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2r9k.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Misteltoe Lectin I in Complex with Phloretamide==
		+	<StructureSection load='2r9k' size='340' side='right' caption='[[2r9k]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2r9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9K FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2t\|1m2t]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [http://www.ebi.ac.uk/pdbsum/2r9k PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9k_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The X-ray structure at 2.7A resolution of the complex between the European mistletoe lectin I (Viscum album, ML-I) and the plant growth hormone, 3-(p-hydroxyphenyl)-propionic acid amide (phloretamide, PA) from xylem sap has revealed the binding of PA at the so far undescribed hydrophobic cavity located between the two subunits of this ribosome-inhibiting protein. No such cavity is observed in related lectins. The binding of PA is achieved through interactions with the non-conserved residues Val228A, Leu230A, Arg388B, and the C-terminal Pro510B. It is conceivable that binding of PA to ML-I is part of a defence mechanism of the parasite against the host, whereby the parasite prevents the growth hormone of the host from interfering with its own regulatory system. The specific binding of PA to ML-I indicates that heterodimeric RIPs are multifunctional proteins whose functions in the cell have not yet been fully recognized and analyzed.

-	~~{{STRUCTURE_2r9k\| PDB=2r9k \| SCENE= }}~~	+	The mistletoe lectin I--phloretamide structure reveals a new function of plant lectins.,Meyer A, Rypniewski W, Celewicz L, Erdmann VA, Voelter W, Singh TP, Genov N, Barciszewski J, Betzel Ch Biochem Biophys Res Commun. 2007 Dec 14;364(2):195-200. Epub 2007 Oct 5. PMID:17937929<ref>PMID:17937929</ref>

-	~~===Crystal Structure~~ of ~~Misteltoe Lectin I in Complex with Phloretamide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17937929}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2r9k]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Viscum_album Viscum album]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017937929<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Viscum album]]		[[Category: Viscum album]]
	[[Category: Betzel, C.]]		[[Category: Betzel, C.]]

OCA: Protected "2r9k" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:01:23 GMT

Protected "2r9k" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:01, 7 January 2013

OCA at 22:01, 7 January 2013

OCA — Mon, 07 Jan 2013 22:01:19 GMT

←Older revision		Revision as of 22:01, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2r9k.png\|left\|200px]]		[[Image:2r9k.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2r9k", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2r9k\| PDB=2r9k \| SCENE= }}		{{STRUCTURE_2r9k\| PDB=2r9k \| SCENE= }}

	===Crystal Structure of Misteltoe Lectin I in Complex with Phloretamide===		===Crystal Structure of Misteltoe Lectin I in Complex with Phloretamide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17937929}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17937929 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17937929}}		{{ABSTRACT_PUBMED_17937929}}

	==About this Structure==		==About this Structure==
-	~~2R9K~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA].	+	[[2r9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17937929~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017937929</ref><references group="xtra"/>
	[[Category: Viscum album]]		[[Category: Viscum album]]
	[[Category: Betzel, C.]]		[[Category: Betzel, C.]]
Line 31:		Line 19:
	[[Category: Rypniewski, W.]]		[[Category: Rypniewski, W.]]
	[[Category: Voelter, W.]]		[[Category: Voelter, W.]]
-	[[Category: Crystal structure]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Ml-i]]		[[Category: Ml-i]]
-	[[Category: Pharmaceutical]]
	[[Category: Phloretamide]]		[[Category: Phloretamide]]
	[[Category: Plant defense]]		[[Category: Plant defense]]
-	[[Category: Polymorphism]]
	[[Category: Protein synthesis inhibitor]]		[[Category: Protein synthesis inhibitor]]
	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Viscum album]]		[[Category: Viscum album]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:29:27 2009''

OCA at 23:29, 17 February 2009

OCA — Tue, 17 Feb 2009 23:29:30 GMT

←Older revision		Revision as of 23:29, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2R9K is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA].	+	2R9K is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA].

	==Reference==		==Reference==
-	The mistletoe lectin I--phloretamide structure reveals a new function of plant lectins., Meyer A, Rypniewski W, Celewicz L, Erdmann VA, Voelter W, Singh TP, Genov N, Barciszewski J, Betzel Ch, Biochem Biophys Res Commun. 2007 Dec 14;364(2):195-200. Epub 2007 Oct 5. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17937929 17937929]~~	+	<ref group="xtra">PMID:17937929</ref><references group="xtra"/>
-	~~[[Category: Protein complex]]~~	+
	[[Category: Viscum album]]		[[Category: Viscum album]]
	[[Category: Betzel, C.]]		[[Category: Betzel, C.]]
Line 45:		Line 44:
	[[Category: Viscum album]]		[[Category: Viscum album]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 08~~:37:~~49 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:29:27 2009''