2rjr - Revision history

OCA at 11:58, 30 August 2023

OCA — Wed, 30 Aug 2023 11:58:24 GMT

←Older revision		Revision as of 11:58, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2rjr' size='340' side='right'caption='[[2rjr]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2rjr' size='340' side='right'caption='[[2rjr]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rjr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"actinomyces_globisporus"_krasil'nikov_1941 "actinomyces~~ globisporus~~" krasil'nikov 1941~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rjr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=295:(2S~~,~~3S)-3-(4-FLUOROPHENYL)-~~2~~,3-DIHYDROXYPROPANOIC+ACID'>295</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=295:(2S,3S)-3-(4-FLUOROPHENYL)-2,3-DIHYDROXYPROPANOIC+ACID'>295</scene>, <scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ohy\|2ohy]], [[2qve\|2qve]], [[2rjs\|2rjs]]</div></td></tr>	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SgcC4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1908 "Actinomyces globisporus" Krasil'nikov 1941])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tyrosine_2,3-aminomutase Tyrosine 2,3-aminomutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.6 5.4.3.6] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjr OCA], [https://pdbe.org/2rjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rjr RCSB], [https://www.ebi.ac.uk/pdbsum/2rjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjr OCA], [https://pdbe.org/2rjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rjr RCSB], [https://www.ebi.ac.uk/pdbsum/2rjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TAM_STRGL TAM_STRGL] Involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. Catalyzes the MIO-dependent deamination of L-tyrosine generating the corresponding alpha,beta-unsaturated acid, (S)-beta-tyrosine.<ref>PMID:12183628</ref> <ref>PMID:17516659</ref> <ref>PMID:20577998</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Actinomyces globisporus krasil'nikov 1941]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Tyrosine 2,3-aminomutase~~]]	+	[[Category: Streptomyces globisporus]]
-	[[Category: Bruner~~, S D~~]]	+	[[Category: Bruner SD]]
-	[[Category: Christianson~~, C V~~]]	+	[[Category: Christianson CV]]
-	[[Category: Montavon~~, T J]]~~	+	[[Category: Montavon TJ]]
-	~~[[Category: 4-methylidene imidizole]]~~	+
-	~~[[Category: Aminomutase]]~~	+
-	~~[[Category: C-1027]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Mio~~]]	+

OCA at 04:28, 2 July 2021

OCA — Fri, 02 Jul 2021 04:28:00 GMT

←Older revision		Revision as of 04:28, 2 July 2021
Line 1:		Line 1:

	==Substrate mimic bound to SgTAM==		==Substrate mimic bound to SgTAM==
-	<StructureSection load='2rjr' size='340' side='right' caption='[[2rjr]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2rjr' size='340' side='right'caption='[[2rjr]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rjr]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"actinomyces_globisporus"_krasil'nikov_1941 "actinomyces globisporus" krasil'nikov 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rjr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_globisporus"_krasil'nikov_1941 "actinomyces globisporus" krasil'nikov 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=295:(2S,3S)-3-(4-FLUOROPHENYL)-2,3-DIHYDROXYPROPANOIC+ACID'>295</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=295:(2S,3S)-3-(4-FLUOROPHENYL)-2,3-DIHYDROXYPROPANOIC+ACID'>295</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ohy\|2ohy]], [[2qve\|2qve]], [[2rjs\|2rjs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ohy\|2ohy]], [[2qve\|2qve]], [[2rjs\|2rjs]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SgcC4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1908 "Actinomyces globisporus" Krasil'nikov 1941])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SgcC4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1908 "Actinomyces globisporus" Krasil'nikov 1941])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Tyrosine_2,3-aminomutase Tyrosine 2,3-aminomutase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.6 5.4.3.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tyrosine_2,3-aminomutase Tyrosine 2,3-aminomutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.6 5.4.3.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjr OCA], [~~http~~://pdbe.org/2rjr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rjr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rjr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjr OCA], [https://pdbe.org/2rjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rjr RCSB], [https://www.ebi.ac.uk/pdbsum/2rjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rjr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rjr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2rjr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2rjr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminomutase 3D structures\|Aminomutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Actinomyces globisporus krasil'nikov 1941]]		[[Category: Actinomyces globisporus krasil'nikov 1941]]
		+	[[Category: Large Structures]]
	[[Category: Tyrosine 2,3-aminomutase]]		[[Category: Tyrosine 2,3-aminomutase]]
	[[Category: Bruner, S D]]		[[Category: Bruner, S D]]

OCA at 07:53, 25 October 2017

OCA — Wed, 25 Oct 2017 07:53:01 GMT

←Older revision		Revision as of 07:53, 25 October 2017
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2rjr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2rjr" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Aminomutase\|Aminomutase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:05, 11 August 2016

OCA — Thu, 11 Aug 2016 08:05:38 GMT

←Older revision		Revision as of 08:05, 11 August 2016
Line 1:		Line 1:
		+
	==Substrate mimic bound to SgTAM==		==Substrate mimic bound to SgTAM==
	<StructureSection load='2rjr' size='340' side='right' caption='[[2rjr]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2rjr' size='340' side='right' caption='[[2rjr]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rjr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptomyces_globisporus Streptomyces~~ globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rjr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_globisporus"_krasil'nikov_1941 "actinomyces globisporus" krasil'nikov 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RJR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=295:(2S,3S)-3-(4-FLUOROPHENYL)-2,3-DIHYDROXYPROPANOIC+ACID'>295</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=295:(2S,3S)-3-(4-FLUOROPHENYL)-2,3-DIHYDROXYPROPANOIC+ACID'>295</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ohy\|2ohy]], [[2qve\|2qve]], [[2rjs\|2rjs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ohy\|2ohy]], [[2qve\|2qve]], [[2rjs\|2rjs]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SgcC4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1908 ~~Streptomyces~~ globisporus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SgcC4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1908 "Actinomyces globisporus" Krasil'nikov 1941])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine_2,3-aminomutase Tyrosine 2,3-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.6 5.4.3.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine_2,3-aminomutase Tyrosine 2,3-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.6 5.4.3.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rjr RCSB], [http://www.ebi.ac.uk/pdbsum/2rjr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjr OCA], [http://pdbe.org/2rjr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rjr RCSB], [http://www.ebi.ac.uk/pdbsum/2rjr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rjr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2rjr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminomutase\|Aminomutase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptomyces~~ globisporus]]	+	[[Category: Actinomyces globisporus krasil'nikov 1941]]
	[[Category: Tyrosine 2,3-aminomutase]]		[[Category: Tyrosine 2,3-aminomutase]]
	[[Category: Bruner, S D]]		[[Category: Bruner, S D]]

OCA at 14:39, 19 January 2015

OCA — Mon, 19 Jan 2015 14:39:38 GMT

←Older revision		Revision as of 14:39, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rjr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RJR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rjr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RJR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=295:(2S,3S)-3-(4-FLUOROPHENYL)-2,3-DIHYDROXYPROPANOIC+ACID'>295</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=295:(2S,3S)-3-(4-FLUOROPHENYL)-2,3-DIHYDROXYPROPANOIC+ACID'>295</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ohy\|2ohy]], [[2qve\|2qve]], [[2rjs\|2rjs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ohy\|2ohy]], [[2qve\|2qve]], [[2rjs\|2rjs]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SgcC4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1908 Streptomyces globisporus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SgcC4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1908 Streptomyces globisporus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine_2,3-aminomutase Tyrosine 2,3-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.6 5.4.3.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine_2,3-aminomutase Tyrosine 2,3-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.6 5.4.3.6] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rjr RCSB], [http://www.ebi.ac.uk/pdbsum/2rjr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rjr RCSB], [http://www.ebi.ac.uk/pdbsum/2rjr PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Streptomyces globisporus]]		[[Category: Streptomyces globisporus]]
	[[Category: Tyrosine 2,3-aminomutase]]		[[Category: Tyrosine 2,3-aminomutase]]
-	[[Category: Bruner, S D.]]	+	[[Category: Bruner, S D]]
-	[[Category: Christianson, C V.]]	+	[[Category: Christianson, C V]]
-	[[Category: Montavon, T J.]]	+	[[Category: Montavon, T J]]
	[[Category: 4-methylidene imidizole]]		[[Category: 4-methylidene imidizole]]
	[[Category: Aminomutase]]		[[Category: Aminomutase]]

OCA at 04:31, 3 October 2014

OCA — Fri, 03 Oct 2014 04:31:05 GMT

←Older revision		Revision as of 04:31, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2rjr~~\| ~~PDB~~=2rjr \| ~~SCENE~~= }}	+	==Substrate mimic bound to SgTAM==
-	===~~Substrate mimic bound~~ to ~~SgTAM~~===	+	<StructureSection load='2rjr' size='340' side='right' caption='[[2rjr]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18078753}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2rjr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RJR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=295:(2S,3S)-3-(4-FLUOROPHENYL)-2,3-DIHYDROXYPROPANOIC+ACID'>295</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ohy\|2ohy]], [[2qve\|2qve]], [[2rjs\|2rjs]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SgcC4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1908 Streptomyces globisporus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine_2,3-aminomutase Tyrosine 2,3-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.6 5.4.3.6] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rjr RCSB], [http://www.ebi.ac.uk/pdbsum/2rjr PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rjr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The synthesis and evaluation of two classes of inhibitors for SgTAM, a 4-methylideneimidazole-5-one (MIO) containing tyrosine aminomutase, are described. A mechanism-based strategy was used to design analogs that mimic the substrate or product of the reaction and form covalent interactions with the enzyme through the MIO prosthetic group. The analogs were characterized by measuring inhibition constants and X-ray crystallographic structural analysis of the co-complexes bound to the aminomutase, SgTAM.

-	~~==About this Structure==~~	+	Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM.,Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD Bioorg Med Chem Lett. 2008 May 15;18(10):3099-102. Epub 2007 Nov 19. PMID:18078753<ref>PMID:18078753</ref>
-	~~[[2rjr]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2RJR OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:018078753</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Streptomyces globisporus]]		[[Category: Streptomyces globisporus]]
	[[Category: Tyrosine 2,3-aminomutase]]		[[Category: Tyrosine 2,3-aminomutase]]

OCA at 08:18, 30 June 2013

OCA — Sun, 30 Jun 2013 08:18:13 GMT

←Older revision		Revision as of 08:18, 30 June 2013
Line 1:		Line 1:
-	[[Image:2rjr.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2rjr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2rjr\| PDB=2rjr \| SCENE= }}		{{STRUCTURE_2rjr\| PDB=2rjr \| SCENE= }}
-
	===Substrate mimic bound to SgTAM===		===Substrate mimic bound to SgTAM===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18078753}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18078753 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18078753}}		{{ABSTRACT_PUBMED_18078753}}

Line 22:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018078753</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018078753</ref><references group="xtra"/><references/>
	[[Category: Streptomyces globisporus]]		[[Category: Streptomyces globisporus]]
	[[Category: Tyrosine 2,3-aminomutase]]		[[Category: Tyrosine 2,3-aminomutase]]

OCA: Protected "2rjr" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2011 11:35:48 GMT

Protected "2rjr" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:35, 16 November 2011

OCA at 11:35, 16 November 2011

OCA — Wed, 16 Nov 2011 11:35:46 GMT

←Older revision		Revision as of 11:35, 16 November 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2rjr.png\|left\|200px]]		[[Image:2rjr.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~2RJR~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA].	+	[[2rjr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18078753~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018078753</ref><references group="xtra"/>
	[[Category: Streptomyces globisporus]]		[[Category: Streptomyces globisporus]]
	[[Category: Tyrosine 2,3-aminomutase]]		[[Category: Tyrosine 2,3-aminomutase]]
Line 34:		Line 33:
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Mio]]		[[Category: Mio]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:37:43 2009''

OCA at 18:37, 17 February 2009

OCA — Tue, 17 Feb 2009 18:37:46 GMT

←Older revision		Revision as of 18:37, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2RJR is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA].	+	2RJR is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA].

	==Reference==		==Reference==
-	~~Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM., Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD, Bioorg Med Chem Lett. 2007 Nov 19;.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18078753 18078753]~~	+	<ref group="xtra">PMID:18078753</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Streptomyces globisporus]]		[[Category: Streptomyces globisporus]]
	[[Category: Tyrosine 2,3-aminomutase]]		[[Category: Tyrosine 2,3-aminomutase]]
Line 36:		Line 35:
	[[Category: Mio]]		[[Category: Mio]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 23 10~~:14:~~50 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:37:43 2009''