2rlo - Revision history

OCA at 19:13, 29 May 2024

OCA — Wed, 29 May 2024 19:13:53 GMT

←Older revision		Revision as of 19:13, 29 May 2024
Line 1:		Line 1:

	==Split PH domain of PI3-kinase enhancer==		==Split PH domain of PI3-kinase enhancer==
-	<StructureSection load='2rlo' size='340' side='right'caption='[[2rlo~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2rlo' size='340' side='right'caption='[[2rlo]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rlo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RLO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rlo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RLO FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CENTG1, AGAP2, KIAA0167 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rlo OCA], [https://pdbe.org/2rlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rlo RCSB], [https://www.ebi.ac.uk/pdbsum/2rlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rlo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rlo OCA], [https://pdbe.org/2rlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rlo RCSB], [https://www.ebi.ac.uk/pdbsum/2rlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rlo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AGAP2_HUMAN AGAP2_HUMAN]] GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.<ref>PMID:12640130</ref> <ref>PMID:14761976</ref> <ref>PMID:15118108</ref> <ref>PMID:16079295</ref>	+	[https://www.uniprot.org/uniprot/AGAP2_HUMAN AGAP2_HUMAN] GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.<ref>PMID:12640130</ref> <ref>PMID:14761976</ref> <ref>PMID:15118108</ref> <ref>PMID:16079295</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wen, W]]	+	[[Category: Wen W]]
-	[[Category: Zhang, M]]	+	[[Category: Zhang M]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Ank repeat]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Gtp-binding]]~~	+
-	~~[[Category: Gtpase activation]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Oncogene]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Split ph domain]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 10:33, 7 July 2021

OCA — Wed, 07 Jul 2021 10:33:03 GMT

←Older revision		Revision as of 10:33, 7 July 2021
Line 1:		Line 1:

	==Split PH domain of PI3-kinase enhancer==		==Split PH domain of PI3-kinase enhancer==
-	<StructureSection load='2rlo' size='340' side='right' caption='[[2rlo]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2rlo' size='340' side='right'caption='[[2rlo]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rlo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RLO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rlo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RLO FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CENTG1, AGAP2, KIAA0167 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CENTG1, AGAP2, KIAA0167 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rlo OCA], [~~http~~://pdbe.org/2rlo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rlo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rlo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rlo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rlo OCA], [https://pdbe.org/2rlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rlo RCSB], [https://www.ebi.ac.uk/pdbsum/2rlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rlo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AGAP2_HUMAN AGAP2_HUMAN]] GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.<ref>PMID:12640130</ref> <ref>PMID:14761976</ref> <ref>PMID:15118108</ref> <ref>PMID:16079295</ref>	+	[[https://www.uniprot.org/uniprot/AGAP2_HUMAN AGAP2_HUMAN]] GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.<ref>PMID:12640130</ref> <ref>PMID:14761976</ref> <ref>PMID:15118108</ref> <ref>PMID:16079295</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Wen, W]]		[[Category: Wen, W]]
	[[Category: Zhang, M]]		[[Category: Zhang, M]]

OCA at 11:02, 5 September 2018

OCA — Wed, 05 Sep 2018 11:02:30 GMT

←Older revision		Revision as of 11:02, 5 September 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rl/2rlo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rl/2rlo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	[[Category: Wen, W]]		[[Category: Wen, W]]
	[[Category: Zhang, M]]		[[Category: Zhang, M]]
		+	[[Category: Alternative splicing]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]
		+	[[Category: Cytoplasm]]
	[[Category: Gtp-binding]]		[[Category: Gtp-binding]]
	[[Category: Gtpase activation]]		[[Category: Gtpase activation]]
Line 43:		Line 45:
	[[Category: Oncogene]]		[[Category: Oncogene]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
		+	[[Category: Polymorphism]]
	[[Category: Protein transport]]		[[Category: Protein transport]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Split ph domain]]		[[Category: Split ph domain]]
	[[Category: Transport]]		[[Category: Transport]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 07:05, 5 August 2016

OCA — Fri, 05 Aug 2016 07:05:28 GMT

←Older revision		Revision as of 07:05, 5 August 2016
Line 1:		Line 1:
		+
	==Split PH domain of PI3-kinase enhancer==		==Split PH domain of PI3-kinase enhancer==
	<StructureSection load='2rlo' size='340' side='right' caption='[[2rlo]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rlo' size='340' side='right' caption='[[2rlo]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rlo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RLO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rlo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RLO FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CENTG1, AGAP2, KIAA0167 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CENTG1, AGAP2, KIAA0167 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rlo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rlo RCSB], [http://www.ebi.ac.uk/pdbsum/2rlo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rlo OCA], [http://pdbe.org/2rlo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rlo RCSB], [http://www.ebi.ac.uk/pdbsum/2rlo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rlo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~CENG1_HUMAN CENG1_HUMAN~~]] GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.<ref>PMID:12640130</ref> <ref>PMID:14761976</ref> <ref>PMID:15118108</ref> <ref>PMID:16079295</ref>	+	[[http://www.uniprot.org/uniprot/AGAP2_HUMAN AGAP2_HUMAN]] GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.<ref>PMID:12640130</ref> <ref>PMID:14761976</ref> <ref>PMID:15118108</ref> <ref>PMID:16079295</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rlo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2rlo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Wen, W]]		[[Category: Wen, W]]
	[[Category: Zhang, M]]		[[Category: Zhang, M]]

OCA at 16:43, 25 December 2014

OCA — Thu, 25 Dec 2014 16:43:59 GMT

←Older revision		Revision as of 16:43, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rlo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RLO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rlo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RLO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CENTG1, AGAP2, KIAA0167 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CENTG1, AGAP2, KIAA0167 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rlo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rlo RCSB], [http://www.ebi.ac.uk/pdbsum/2rlo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rlo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rlo RCSB], [http://www.ebi.ac.uk/pdbsum/2rlo PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CENG1_HUMAN CENG1_HUMAN]] GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.<ref>PMID:12640130</ref> <ref>PMID:14761976</ref> <ref>PMID:15118108</ref> <ref>PMID:16079295</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Wen, W.]]	+	[[Category: Wen, W]]
-	[[Category: Zhang, M.]]	+	[[Category: Zhang, M]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]
	[[Category: Gtp-binding]]		[[Category: Gtp-binding]]

OCA at 20:01, 30 September 2014

OCA — Tue, 30 Sep 2014 20:01:02 GMT

←Older revision		Revision as of 20:01, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2rlo.~~png\|left~~\|200px]]	+	==Split PH domain of PI3-kinase enhancer==
		+	<StructureSection load='2rlo' size='340' side='right' caption='[[2rlo]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2rlo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RLO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CENTG1, AGAP2, KIAA0167 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rlo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rlo RCSB], [http://www.ebi.ac.uk/pdbsum/2rlo PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rl/2rlo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytoplasm-nucleus shuttling of phosphoinositol 3-kinase enhancer (PIKE) is known to correlate directly with its cellular functions. However, the molecular mechanism governing this shuttling is not known. In this work, we demonstrate that PIKE is a new member of split pleckstrin homology (PH) domain-containing proteins. The structure solved in this work reveals that the PIKE PH domain is split into halves by a positively charged nuclear localization sequence. The PIKE PH domain binds to the head groups of di- and triphosphoinositides with similar affinities. Lipid membrane binding of the PIKE PH domain is further enhanced by the positively charged nuclear localization sequence, which is juxtaposed to the phosphoinositide head group-binding pocket of the domain. We demonstrate that the cytoplasmic-nuclear shuttling of PIKE is dynamically regulated by the balancing actions of the lipid-binding property of both the split PH domain and the nuclear targeting function of its nuclear localization sequence.

-	~~{{STRUCTURE_2rlo\| PDB=2rlo \| SCENE= }}~~	+	Split pleckstrin homology domain-mediated cytoplasmic-nuclear localization of PI3-kinase enhancer GTPase.,Yan J, Wen W, Chan LN, Zhang M J Mol Biol. 2008 Apr 25;378(2):425-35. Epub 2008 Mar 4. PMID:18371979<ref>PMID:18371979</ref>

-	~~===Split PH domain~~ of ~~PI3-kinase enhancer===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18371979}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2rlo]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018371979<~~/~~ref~~><~~ref group="xtra">PMID:018713862</ref><references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Wen, W.]]		[[Category: Wen, W.]]

OCA: Protected "2rlo" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:06:18 GMT

Protected "2rlo" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:06, 7 January 2013

OCA at 20:06, 7 January 2013

OCA — Mon, 07 Jan 2013 20:06:15 GMT

←Older revision		Revision as of 20:06, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2rlo.png\|left\|200px]]		[[Image:2rlo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2rlo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2rlo\| PDB=2rlo \| SCENE= }}		{{STRUCTURE_2rlo\| PDB=2rlo \| SCENE= }}

	===Split PH domain of PI3-kinase enhancer===		===Split PH domain of PI3-kinase enhancer===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18371979}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18371979 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18371979}}		{{ABSTRACT_PUBMED_18371979}}

	==About this Structure==		==About this Structure==
-	~~2RLO~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA].	+	[[2rlo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18371979~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018371979</ref><ref group="xtra">PMID:018713862</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Wen, W.]]		[[Category: Wen, W.]]
	[[Category: Zhang, M.]]		[[Category: Zhang, M.]]
-	[[Category: Alternative splicing]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]
-	[[Category: Cytoplasm]]
	[[Category: Gtp-binding]]		[[Category: Gtp-binding]]
	[[Category: Gtpase activation]]		[[Category: Gtpase activation]]
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	[[Category: Oncogene]]		[[Category: Oncogene]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
-	[[Category: Polymorphism]]
	[[Category: Protein transport]]		[[Category: Protein transport]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Split ph domain]]		[[Category: Split ph domain]]
	[[Category: Transport]]		[[Category: Transport]]
-	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:04:49 2009''

OCA at 20:04, 17 February 2009

OCA — Tue, 17 Feb 2009 20:04:50 GMT

←Older revision		Revision as of 20:04, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2RLO is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA].	+	2RLO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA].

	==Reference==		==Reference==
-	~~Split pleckstrin homology domain-mediated cytoplasmic-nuclear localization of PI3-kinase enhancer GTPase., Yan J, Wen W, Chan LN, Zhang M, J Mol Biol. 2008 Apr 25;378(2):425-35. Epub 2008 Mar 4.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18371979 18371979]~~	+	<ref group="xtra">PMID:18371979</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Wen, W.]]		[[Category: Wen, W.]]
	[[Category: Zhang, M.]]		[[Category: Zhang, M.]]
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	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:18:~~59 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:04:49 2009''

OCA at 03:19, 29 July 2008

OCA — Tue, 29 Jul 2008 03:19:03 GMT

←Older revision		Revision as of 03:19, 29 July 2008
Line 1:		Line 1:
-	[[Image:2rlo.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2rlo.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2rlo\| PDB=2rlo \| SCENE= }}		{{STRUCTURE_2rlo\| PDB=2rlo \| SCENE= }}

-	~~'''~~Split PH domain of PI3-kinase enhancer~~'''~~	+	===Split PH domain of PI3-kinase enhancer===


-	~~==Overview==~~	+	<!--
-	~~Cytoplasm~~-~~nucleus shuttling of phosphoinositol 3~~-~~kinase enhancer (PIKE) is known to correlate directly with its cellular functions. However, the molecular mechanism governing this shuttling is not known. In~~ this ~~work~~, ~~we demonstrate that PIKE is a new member of split pleckstrin homology (PH) domain-containing proteins. The structure solved in this work reveals that~~ the ~~PIKE PH domain is split into halves by a positively charged nuclear localization sequence. The PIKE PH domain binds~~ to the ~~head groups of di- and triphosphoinositides with similar affinities~~. ~~Lipid membrane binding of the PIKE PH domain is further enhanced by the positively charged nuclear localization sequence~~, ~~which~~ is ~~juxtaposed to~~ the ~~phosphoinositide head group-binding pocket of the domain~~. ~~We demonstrate that the cytoplasmic~~-~~nuclear shuttling of PIKE is dynamically regulated by the balancing actions of the lipid~~-~~binding property of both the split PH domain and the nuclear targeting function of its nuclear localization sequence.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_18371979}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18371979 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18371979}}

	==About this Structure==		==About this Structure==
-	2RLO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA].	+	2RLO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLO OCA].

	==Reference==		==Reference==
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	[[Category: Zinc]]		[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Apr 30 13~~:23:03 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:18:59 2008''