2rmb - Revision history

OCA at 10:33, 7 July 2021

OCA — Wed, 07 Jul 2021 10:33:23 GMT

←Older revision		Revision as of 10:33, 7 July 2021
Line 1:		Line 1:

	==Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A==		==Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A==
-	<StructureSection load='2rmb' size='340' side='right' caption='[[2rmb]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2rmb' size='340' side='right'caption='[[2rmb]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rmb]] is a 20 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RMB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rmb]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RMB FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN A ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmb OCA], [~~http~~://pdbe.org/2rmb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rmb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rmb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmb OCA], [https://pdbe.org/2rmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rmb RCSB], [https://www.ebi.ac.uk/pdbsum/2rmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.	+	[[https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rm/2rmb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rm/2rmb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 2rmb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2rmb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Ke, H]]		[[Category: Ke, H]]

OCA at 06:36, 1 November 2017

OCA — Wed, 01 Nov 2017 06:36:51 GMT

←Older revision		Revision as of 06:36, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A==		==Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A==
	<StructureSection load='2rmb' size='340' side='right' caption='[[2rmb]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2rmb' size='340' side='right' caption='[[2rmb]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rmb]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rmb]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMB FirstGlance]. <br>
-	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmb OCA], [http://pdbe.org/2rmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rmb RCSB], [http://www.ebi.ac.uk/pdbsum/2rmb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmb OCA], [http://pdbe.org/2rmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rmb RCSB], [http://www.ebi.ac.uk/pdbsum/2rmb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 2rmb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2rmb" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cyclophilin\|Cyclophilin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:53, 7 February 2016

OCA — Sun, 07 Feb 2016 14:53:33 GMT

←Older revision		Revision as of 14:53, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2rmb' size='340' side='right' caption='[[2rmb]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2rmb' size='340' side='right' caption='[[2rmb]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rmb]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rmb]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMB FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rmb RCSB], [http://www.ebi.ac.uk/pdbsum/2rmb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmb OCA], [http://pdbe.org/2rmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rmb RCSB], [http://www.ebi.ac.uk/pdbsum/2rmb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rmb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2rmb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Ke, H]]		[[Category: Ke, H]]

OCA at 16:02, 24 December 2014

OCA — Wed, 24 Dec 2014 16:02:53 GMT

←Older revision		Revision as of 16:02, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rmb]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rmb]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rmb RCSB], [http://www.ebi.ac.uk/pdbsum/2rmb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rmb RCSB], [http://www.ebi.ac.uk/pdbsum/2rmb PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
-	[[Category: Ke, H.]]	+	[[Category: Ke, H]]
-	[[Category: Mayrose, D.]]	+	[[Category: Mayrose, D]]
	[[Category: Cyclophilin]]		[[Category: Cyclophilin]]
	[[Category: Cyclophilin-cyclosporin complex]]		[[Category: Cyclophilin-cyclosporin complex]]

OCA at 08:41, 29 September 2014

OCA — Mon, 29 Sep 2014 08:41:22 GMT

←Older revision		Revision as of 08:41, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2rmb.~~png~~\|~~left~~\|200px]]	+	==Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A==
		+	<StructureSection load='2rmb' size='340' side='right' caption='[[2rmb]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2rmb]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rmb RCSB], [http://www.ebi.ac.uk/pdbsum/2rmb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rm/2rmb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Cyclophilin (CyP) is a ubiquitious intracellular protein that binds the immunosuppressive drug cyclosporin A (CsA). CyP-CsA forms a ternary complex with calcineurin and thereby inhibits T-cell activation. CyP also has enzymatic activity, catalyzing the cis-trans isomerization of peptidyl-prolyl amide bonds. RESULTS: We have determined the structure of human cyclophilin A (CyPA) complexed with CsA to 2.1 A resolution. We also report here the structure of CyPA complexed with an analog of CsA, CsA (MeBm2t1-CsA), which binds less well to CyPA, but has increased immunosuppressive activity. Comparison of these structures with previously determined structures of unligated CyPA and CyPA complexed with a candidate substrate for the isomerase activity, the dipeptide AlaPro, reveals that subtle conformational changes occur in both CsA and CyPA on complex formation. CONCLUSIONS: MeBm2t1-CsA binds to CyPA in an essentially similar manner to CsA. The 100-fold weaker affinity of its binding may be attributable to the close contact between MeBmt1 and the active site residue Ala103 of CyPA, which causes small conformational changes in both protein and drug. One change, the slight movement of MeLeu6 in CsA relative to MeBm2t1-CsA, may be at least partially responsible for the higher affinity of the CyPA-MeBm2t1-CsA complex for calcineurin. Our comparison between CyPA-CsA and CyPA-AlaPro suggests that CsA is probably not an analog of the natural substrate, confirming that the catalytic activity of CyPA is not related to its role in immunosuppression either structurally or functionally.

-	~~{{STRUCTURE_2rmb\| PDB=2rmb \| SCENE= }}~~	+	Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A.,Ke H, Mayrose D, Belshaw PJ, Alberg DG, Schreiber SL, Chang ZY, Etzkorn FA, Ho S, Walsh CT Structure. 1994 Jan 15;2(1):33-44. PMID:8075981<ref>PMID:8075981</ref>

-	~~===Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4~~,~~4-dimethylthreonine cyclosporin A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8075981}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2rmb]] is~~ a ~~20 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA].~~	+

	==See Also==		==See Also==
	*[[Cyclophilin\|Cyclophilin]]		*[[Cyclophilin\|Cyclophilin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:008075981<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]

OCA at 06:59, 20 October 2012

OCA — Sat, 20 Oct 2012 06:59:04 GMT

←Older revision		Revision as of 06:59, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2rmb]] is a 20 chain structure ~~of [[Cyclophilin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA].	+	[[2rmb]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA].

	==See Also==		==See Also==

OCA at 14:55, 25 July 2012

OCA — Wed, 25 Jul 2012 14:55:38 GMT

←Older revision		Revision as of 14:55, 25 July 2012
Line 1:		Line 1:
	[[Image:2rmb.png\|left\|200px]]		[[Image:2rmb.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2rmb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2rmb\| PDB=2rmb \| SCENE= }}		{{STRUCTURE_2rmb\| PDB=2rmb \| SCENE= }}

	===Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A===		===Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8075981}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8075981 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8075981}}		{{ABSTRACT_PUBMED_8075981}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Cyclophilin]]	+	*[[Cyclophilin\|Cyclophilin]]

	==Reference==		==Reference==

OCA: Protected "2rmb" [edit=sysop:move=sysop]

OCA — Wed, 27 Jul 2011 05:19:44 GMT

Protected "2rmb" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:19, 27 July 2011

OCA at 05:19, 27 July 2011

OCA — Wed, 27 Jul 2011 05:19:42 GMT

←Older revision		Revision as of 05:19, 27 July 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2rmb.png\|left\|200px]]		[[Image:2rmb.png\|left\|200px]]

Line 10:		Line 9:
	{{STRUCTURE_2rmb\| PDB=2rmb \| SCENE= }}		{{STRUCTURE_2rmb\| PDB=2rmb \| SCENE= }}

-	===~~CRYSTAL STRUCTURES OF CYCLOPHILIN~~ A ~~COMPLEXED WITH CYCLOSPORIN~~ A ~~AND~~ N-~~METHYL~~-4-[(E)-2-~~BUTENYL~~]-4,4-~~DIMETHYLTHREONINE CYCLOSPORIN~~ A===	+	===Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A===


Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~2RMB~~ is a 20 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA].	+	[[2rmb]] is a 20 chain structure of [[Cyclophilin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA].
		+
		+	==See Also==
		+	*[[Cyclophilin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8075981~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008075981</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Ke, H.]]		[[Category: Ke, H.]]
	[[Category: Mayrose, D.]]		[[Category: Mayrose, D.]]
-		+	[[Category: Cyclophilin]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 14~~:35:~~46 2009''~~	+	[[Category: Cyclophilin-cyclosporin complex]]
		+	[[Category: Cyclosporin some]]
		+	[[Category: Immunosuppressant]]
		+	[[Category: Isomerase-immunosuppressant complex]]

OCA at 12:35, 16 February 2009

OCA — Mon, 16 Feb 2009 12:35:47 GMT

←Older revision		Revision as of 12:35, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2RMB is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA].	+	2RMB is a 20 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMB OCA].

	==Reference==		==Reference==
-	Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A., Ke H, Mayrose D, Belshaw PJ, Alberg DG, Schreiber SL, Chang ZY, Etzkorn FA, Ho S, Walsh CT, Structure. 1994 Jan 15;2(1):33-44. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/8075981 8075981]~~	+	<ref group="xtra">PMID:8075981</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
-	[[Category: Single protein]]
	[[Category: Ke, H.]]		[[Category: Ke, H.]]
	[[Category: Mayrose, D.]]		[[Category: Mayrose, D.]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 17:~~16:~~50 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:35:46 2009''