2rne - Revision history

OCA at 19:14, 29 May 2024

OCA — Wed, 29 May 2024 19:14:35 GMT

←Older revision		Revision as of 19:14, 29 May 2024
Line 1:		Line 1:

	==Solution structure of the second RNA recognition motif (RRM) of TIA-1==		==Solution structure of the second RNA recognition motif (RRM) of TIA-1==
-	<StructureSection load='2rne' size='340' side='right'caption='[[2rne~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2rne' size='340' side='right'caption='[[2rne]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rne]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RNE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rne]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RNE FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Tia1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rne OCA], [https://pdbe.org/2rne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rne RCSB], [https://www.ebi.ac.uk/pdbsum/2rne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rne ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rne OCA], [https://pdbe.org/2rne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rne RCSB], [https://www.ebi.ac.uk/pdbsum/2rne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rne ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TIA1_MOUSE TIA1_MOUSE] Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Abe, C]]	+	[[Category: Abe C]]
-	[[Category: Guntert, P]]	+	[[Category: Guntert P]]
-	[[Category: Hayashizaki, Y]]	+	[[Category: Hayashizaki Y]]
-	[[Category: Inoue, M]]	+	[[Category: Inoue M]]
-	[[Category: Kigawa, T]]	+	[[Category: Kigawa T]]
-	[[Category: Kobayashi, N]]	+	[[Category: Kobayashi N]]
-	[[Category: Kuwasako, K]]	+	[[Category: Kuwasako K]]
-	[[Category: Muto, Y]]	+	[[Category: Muto Y]]
-	[[Category: Shirouzu, M]]	+	[[Category: Shirouzu M]]
-	[[Category: Taguchi, S]]	+	[[Category: Taguchi S]]
-	[[Category: Takahashi, M]]	+	[[Category: Takahashi M]]
-	[[Category: Tanaka, A]]	+	[[Category: Tanaka A]]
-	[[Category: Terada, T]]	+	[[Category: Terada T]]
-	[[Category: Tsuda, K]]	+	[[Category: Tsuda K]]
-	[[Category: Yokoyama, S]]	+	[[Category: Yokoyama S]]
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rrm domain~~]]	+

OCA at 10:34, 7 July 2021

OCA — Wed, 07 Jul 2021 10:34:00 GMT

←Older revision		Revision as of 10:34, 7 July 2021
Line 1:		Line 1:

	==Solution structure of the second RNA recognition motif (RRM) of TIA-1==		==Solution structure of the second RNA recognition motif (RRM) of TIA-1==
-	<StructureSection load='2rne' size='340' side='right' caption='[[2rne]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2rne' size='340' side='right'caption='[[2rne]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rne]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RNE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rne]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RNE FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tia1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tia1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rne OCA], [~~http~~://pdbe.org/2rne PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rne RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rne PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rne ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rne OCA], [https://pdbe.org/2rne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rne RCSB], [https://www.ebi.ac.uk/pdbsum/2rne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rne ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Abe, C]]		[[Category: Abe, C]]

OCA at 11:10, 5 September 2018

OCA — Wed, 05 Sep 2018 11:10:53 GMT

←Older revision		Revision as of 11:10, 5 September 2018
Line 1:		Line 1:
		+
	==Solution structure of the second RNA recognition motif (RRM) of TIA-1==		==Solution structure of the second RNA recognition motif (RRM) of TIA-1==
	<StructureSection load='2rne' size='340' side='right' caption='[[2rne]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rne' size='340' side='right' caption='[[2rne]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2rne]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rne]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNE FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tia1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tia1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rne OCA], [http://pdbe.org/2rne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rne RCSB], [http://www.ebi.ac.uk/pdbsum/2rne PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rne OCA], [http://pdbe.org/2rne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rne RCSB], [http://www.ebi.ac.uk/pdbsum/2rne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rne ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/2rne_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/2rne_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:39, 9 February 2016

OCA — Tue, 09 Feb 2016 20:39:27 GMT

←Older revision		Revision as of 20:39, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2rne' size='340' side='right' caption='[[2rne]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rne' size='340' side='right' caption='[[2rne]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rne]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rne]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNE FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tia1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tia1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rne RCSB], [http://www.ebi.ac.uk/pdbsum/2rne PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rne OCA], [http://pdbe.org/2rne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rne RCSB], [http://www.ebi.ac.uk/pdbsum/2rne PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rne ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2rne" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Abe, C]]		[[Category: Abe, C]]
	[[Category: Guntert, P]]		[[Category: Guntert, P]]

OCA at 13:46, 19 January 2015

OCA — Mon, 19 Jan 2015 13:46:01 GMT

←Older revision		Revision as of 13:46, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rne]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rne]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tia1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tia1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rne RCSB], [http://www.ebi.ac.uk/pdbsum/2rne PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rne RCSB], [http://www.ebi.ac.uk/pdbsum/2rne PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Abe, C.]]	+	[[Category: Abe, C]]
-	[[Category: Guntert, P.]]	+	[[Category: Guntert, P]]
-	[[Category: Hayashizaki, Y.]]	+	[[Category: Hayashizaki, Y]]
-	[[Category: Inoue, M.]]	+	[[Category: Inoue, M]]
-	[[Category: Kigawa, T.]]	+	[[Category: Kigawa, T]]
-	[[Category: Kobayashi, N.]]	+	[[Category: Kobayashi, N]]
-	[[Category: Kuwasako, K.]]	+	[[Category: Kuwasako, K]]
-	[[Category: Muto, Y.]]	+	[[Category: Muto, Y]]
-	[[Category: Shirouzu, M.]]	+	[[Category: Shirouzu, M]]
-	[[Category: Taguchi, S.]]	+	[[Category: Taguchi, S]]
-	[[Category: Takahashi, M.]]	+	[[Category: Takahashi, M]]
-	[[Category: Tanaka, A.]]	+	[[Category: Tanaka, A]]
-	[[Category: Terada, T.]]	+	[[Category: Terada, T]]
-	[[Category: Tsuda, K.]]	+	[[Category: Tsuda, K]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
	[[Category: Rrm domain]]		[[Category: Rrm domain]]

OCA at 01:30, 1 October 2014

OCA — Wed, 01 Oct 2014 01:30:49 GMT

←Older revision		Revision as of 01:30, 1 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2rne.~~png\|left~~\|200px]]	+	==Solution structure of the second RNA recognition motif (RRM) of TIA-1==
		+	<StructureSection load='2rne' size='340' side='right' caption='[[2rne]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2rne]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tia1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rne RCSB], [http://www.ebi.ac.uk/pdbsum/2rne PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/2rne_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	T cell intracellular antigen-1 (TIA-1), an apoptosis promoting factor, functions as a splicing regulator for the Fas pre-mRNA. TIA-1 possesses three RNA recognition motifs (RRMs) and a glutamine-rich domain. The second RRM (RRM2) is necessary and sufficient for tight, sequence-specific binding to the uridine-rich sequences buried around the 5' splice sites. In the present study, we solved the solution structure of the murine TIA-1 RRM2 by heteronuclear-nuclear magnetic resonance spectroscopy. The TIA-1 RRM2 adopts the RRM fold (betaalphabetabetaalphabeta) and possesses an extra beta-strand between beta2 and beta3, which forms an additional beta-sheet with the C-terminal part of beta2. We refer to this structure as the beta2-beta2' beta-loop. Interestingly, this characteristic beta-loop structure is conserved among a number of RRMs, including the U2AF65 RRM2 and the Sex-lethal RRM1 and RRM2, which also bind to uridine-rich RNAs. Furthermore, we identified a new sequence motif in the beta2-beta2' beta-loop, the DxxT motif. Chemical shift perturbation analyses of both the main and side chains upon binding to the uridine pentamer RNA revealed that most of the beta-sheet surface, including the beta2-beta2' beta-loop, is involved in the RNA binding. An investigation of the chemical shift perturbation revealed similarity in the RNA recognition modes between the TIA-1 and U2AF65 RRMs.

-	~~{{STRUCTURE_2rne\| PDB=2rne \| SCENE= }}~~	+	Solution structure of the second RNA recognition motif (RRM) domain of murine T cell intracellular antigen-1 (TIA-1) and its RNA recognition mode.,Kuwasako K, Takahashi M, Tochio N, Abe C, Tsuda K, Inoue M, Terada T, Shirouzu M, Kobayashi N, Kigawa T, Taguchi S, Tanaka A, Hayashizaki Y, Guntert P, Muto Y, Yokoyama S Biochemistry. 2008 Jun 17;47(24):6437-50. Epub 2008 May 24. PMID:18500819<ref>PMID:18500819</ref>

-	~~===Solution structure~~ of the ~~second RNA recognition motif (RRM) of TIA-1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18500819}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2rne]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018500819<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Abe, C.]]		[[Category: Abe, C.]]

OCA: Protected "2rne" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:53:27 GMT

Protected "2rne" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:53, 7 January 2013

OCA at 20:53, 7 January 2013

OCA — Mon, 07 Jan 2013 20:53:22 GMT

←Older revision		Revision as of 20:53, 7 January 2013
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-	{{Seed}}
	[[Image:2rne.png\|left\|200px]]		[[Image:2rne.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2rne", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2rne\| PDB=2rne \| SCENE= }}		{{STRUCTURE_2rne\| PDB=2rne \| SCENE= }}

	===Solution structure of the second RNA recognition motif (RRM) of TIA-1===		===Solution structure of the second RNA recognition motif (RRM) of TIA-1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18500819}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18500819 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18500819}}		{{ABSTRACT_PUBMED_18500819}}

	==About this Structure==		==About this Structure==
-	~~2RNE~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA].	+	[[2rne]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18500819~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018500819</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Abe, C.]]		[[Category: Abe, C.]]
Line 42:		Line 30:
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
	[[Category: Rrm domain]]		[[Category: Rrm domain]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:35:39 2009''

OCA at 10:35, 17 February 2009

OCA — Tue, 17 Feb 2009 10:35:40 GMT

←Older revision		Revision as of 10:35, 17 February 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2rne.~~jpg~~\|left\|200px]]	+	[[Image:2rne.png\|left\|200px]]

	<!--		<!--
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2RNE is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA].	+	2RNE is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA].

	==Reference==		==Reference==
-	Solution structure of the second RNA recognition motif (RRM) domain of murine T cell intracellular antigen-1 (TIA-1) and its RNA recognition mode., Kuwasako K, Takahashi M, Tochio N, Abe C, Tsuda K, Inoue M, Terada T, Shirouzu M, Kobayashi N, Kigawa T, Taguchi S, Tanaka A, Hayashizaki Y, Guntert P, Muto Y, Yokoyama S, Biochemistry. 2008 Jun 17;47(24):6437-50. Epub 2008 May 24. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18500819 18500819]~~	+	<ref group="xtra">PMID:18500819</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Single protein]]
	[[Category: Abe, C.]]		[[Category: Abe, C.]]
	[[Category: Guntert, P.]]		[[Category: Guntert, P.]]
Line 44:		Line 43:
	[[Category: Rrm domain]]		[[Category: Rrm domain]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Nov 5~~ 12:23:~~30 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:35:39 2009''

OCA at 10:23, 5 November 2008

OCA — Wed, 05 Nov 2008 10:23:31 GMT

←Older revision		Revision as of 10:23, 5 November 2008
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2rne.jpg\|left\|200px]]

-	The ~~entry 2rne~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2rne", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2rne\| PDB=2rne \| SCENE= }}

-	~~Authors: Takahashi, M., Kuwasako, K., Abe, C., Tsuda, K., Inoue, M., Terada, T., Shirouzu, M., Kobayashi, N., Kigawa, T., Taguchi, S., Tanaka, A., Hayashizaki, Y., Yokoyama, S.~~	+	===Solution structure of the second RNA recognition motif (RRM) of TIA-1===

-	Description:

		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18500819}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18500819 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18500819}}

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 11 08~~:49:36 2008''	+	==About this Structure==
		+	2RNE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNE OCA].
		+
		+	==Reference==
		+	Solution structure of the second RNA recognition motif (RRM) domain of murine T cell intracellular antigen-1 (TIA-1) and its RNA recognition mode., Kuwasako K, Takahashi M, Tochio N, Abe C, Tsuda K, Inoue M, Terada T, Shirouzu M, Kobayashi N, Kigawa T, Taguchi S, Tanaka A, Hayashizaki Y, Guntert P, Muto Y, Yokoyama S, Biochemistry. 2008 Jun 17;47(24):6437-50. Epub 2008 May 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18500819 18500819]
		+	[[Category: Mus musculus]]
		+	[[Category: Single protein]]
		+	[[Category: Abe, C.]]
		+	[[Category: Guntert, P.]]
		+	[[Category: Hayashizaki, Y.]]
		+	[[Category: Inoue, M.]]
		+	[[Category: Kigawa, T.]]
		+	[[Category: Kobayashi, N.]]
		+	[[Category: Kuwasako, K.]]
		+	[[Category: Muto, Y.]]
		+	[[Category: Shirouzu, M.]]
		+	[[Category: Taguchi, S.]]
		+	[[Category: Takahashi, M.]]
		+	[[Category: Tanaka, A.]]
		+	[[Category: Terada, T.]]
		+	[[Category: Tsuda, K.]]
		+	[[Category: Yokoyama, S.]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Rrm domain]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 5 12:23:30 2008''