2rny - Revision history

OCA at 08:44, 15 November 2023

OCA — Wed, 15 Nov 2023 08:44:41 GMT

←Older revision		Revision as of 08:44, 15 November 2023
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	==Complex Structures of CBP Bromodomain with H4 ack20 Peptide==		==Complex Structures of CBP Bromodomain with H4 ack20 Peptide==
-	<StructureSection load='2rny' size='340' side='right'caption='[[2rny~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2rny' size='340' side='right'caption='[[2rny]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RNY FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rny OCA], [https://pdbe.org/2rny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rny RCSB], [https://www.ebi.ac.uk/pdbsum/2rny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rny ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rny OCA], [https://pdbe.org/2rny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rny RCSB], [https://www.ebi.ac.uk/pdbsum/2rny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rny ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[https://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>	+	[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[https://omim.org/entry/180849 180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>	+	[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Histone acetyltransferase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gerona-Navarro, G]]	+	[[Category: Gerona-Navarro G]]
-	[[Category: Zeng, L]]	+	[[Category: Zeng L]]
-	[[Category: Zhang, Q]]	+	[[Category: Zhang Q]]
-	[[Category: Zhou~~, M M]]~~	+	[[Category: Zhou MM]]
-	~~[[Category: Acetylation]]~~	+
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Bromodomain]]~~	+
-	~~[[Category: Cbp]]~~	+
-	~~[[Category: Chromosomal protein]]~~	+
-	~~[[Category: Chromosomal rearrangement]]~~	+
-	~~[[Category: Creb]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Histone]]~~	+
-	~~[[Category: Host-virus interaction]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Methylation]]~~	+
-	~~[[Category: Nucleosome core]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: P53]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-nuclear protein complex]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 06:54, 16 March 2022

OCA — Wed, 16 Mar 2022 06:54:02 GMT

OCA at 07:13, 10 June 2020

OCA — Wed, 10 Jun 2020 07:13:53 GMT

←Older revision		Revision as of 07:13, 10 June 2020
Line 1:		Line 1:

	==Complex Structures of CBP Bromodomain with H4 ack20 Peptide==		==Complex Structures of CBP Bromodomain with H4 ack20 Peptide==
-	<StructureSection load='2rny' size='340' side='right' caption='[[2rny]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2rny' size='340' side='right'caption='[[2rny]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2RNY FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rny OCA], [http://pdbe.org/2rny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rny RCSB], [http://www.ebi.ac.uk/pdbsum/2rny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rny ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2rny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rny OCA], [http://pdbe.org/2rny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rny RCSB], [http://www.ebi.ac.uk/pdbsum/2rny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rny ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[CREB-binding protein\|CREB-binding protein]]	+	*[[CREB-binding protein 3D structures\|CREB-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 40:		Line 40:
	[[Category: Histone acetyltransferase]]		[[Category: Histone acetyltransferase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gerona-Navarro, G]]		[[Category: Gerona-Navarro, G]]
	[[Category: Zeng, L]]		[[Category: Zeng, L]]

OCA at 11:02, 5 September 2018

OCA — Wed, 05 Sep 2018 11:02:52 GMT

←Older revision		Revision as of 11:02, 5 September 2018
Line 1:		Line 1:
		+
	==Complex Structures of CBP Bromodomain with H4 ack20 Peptide==		==Complex Structures of CBP Bromodomain with H4 ack20 Peptide==
	<StructureSection load='2rny' size='340' side='right' caption='[[2rny]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rny' size='340' side='right' caption='[[2rny]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rny OCA], [http://pdbe.org/2rny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rny RCSB], [http://www.ebi.ac.uk/pdbsum/2rny PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rny OCA], [http://pdbe.org/2rny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rny RCSB], [http://www.ebi.ac.uk/pdbsum/2rny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rny ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/2rny_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/2rny_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 43:		Line 44:
	[[Category: Zhang, Q]]		[[Category: Zhang, Q]]
	[[Category: Zhou, M M]]		[[Category: Zhou, M M]]
		+	[[Category: Acetylation]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Bromodomain]]		[[Category: Bromodomain]]
	[[Category: Cbp]]		[[Category: Cbp]]
	[[Category: Chromosomal protein]]		[[Category: Chromosomal protein]]
		+	[[Category: Chromosomal rearrangement]]
	[[Category: Creb]]		[[Category: Creb]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
Line 62:		Line 65:
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transferase-nuclear protein complex]]		[[Category: Transferase-nuclear protein complex]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 00:58, 9 February 2016

OCA — Tue, 09 Feb 2016 00:58:10 GMT

←Older revision		Revision as of 00:58, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2rny' size='340' side='right' caption='[[2rny]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rny' size='340' side='right' caption='[[2rny]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNY FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rny RCSB], [http://www.ebi.ac.uk/pdbsum/2rny PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rny OCA], [http://pdbe.org/2rny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rny RCSB], [http://www.ebi.ac.uk/pdbsum/2rny PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rny ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2rny" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Histone acetyltransferase]]		[[Category: Histone acetyltransferase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gerona-Navarro, G]]		[[Category: Gerona-Navarro, G]]
	[[Category: Zeng, L]]		[[Category: Zeng, L]]

OCA at 15:19, 19 January 2015

OCA — Mon, 19 Jan 2015 15:19:24 GMT

←Older revision		Revision as of 15:19, 19 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_2rny~~\| ~~PDB~~=2rny \| ~~SCENE~~= }}	+	==Complex Structures of CBP Bromodomain with H4 ack20 Peptide==
-	===~~Complex Structures~~ of ~~CBP Bromodomain with H4 ack20 Peptide~~===	+	<StructureSection load='2rny' size='340' side='right' caption='[[2rny]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_18400184}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2rny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RNY FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rny RCSB], [http://www.ebi.ac.uk/pdbsum/2rny PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/2rny_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Histone lysine acetylation is central to epigenetic control of gene transcription. Bromodomains of chromosomal proteins function as acetyl-lysine (Kac) binding domains. However, how bromodomains recognize site-specific histones remains unanswered. Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4. From structural and biochemical binding analyses, we determine consensus histone recognition by the bromodomains of PCAF and CBP, which represent two different subgroups of the bromodomain family. Through bromodomain residues in the ZA and BC loops, PCAF prefers acetylation sites with a hydrophobic residue at (Kac+2) position and a positively charged or aromatic residue at (Kac+3), whereas CBP favors bulky hydrophobic residues at (Kac+1) and (Kac+2), a positively charged residue at (Kac-1), and an aromatic residue at (Kac-2).

-	~~==Disease==~~	+	Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300.,Zeng L, Zhang Q, Gerona-Navarro G, Moshkina N, Zhou MM Structure. 2008 Apr;16(4):643-52. PMID:18400184<ref>PMID:18400184</ref>
-	~~[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause~~ of ~~acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A~~-~~CREBBP may induce leukemia~~ by ~~inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause~~ of ~~Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http:~~/~~/omim~~.~~org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities~~, ~~broad thumbs~~, ~~broad big toes~~, ~~mental retardation and a propensity for development of malignancies~~.~~<ref>PMID~~:~~11331617</ref><ref>~~PMID:~~12114483</ref><ref>PMID:12566391</ref>~~<ref>PMID:~~15706485~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http://www.uniprot.org/uniprot~~/~~CBP_HUMAN CBP_HUMAN]] Acetylates histones~~, ~~giving~~ a ~~specific tag for transcriptional activation~~. ~~Also acetylates non-histone proteins, like NCOA3 and FOXO1~~. ~~Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator~~ of ~~ALX1 in the presence of EP300~~.<~~ref~~>~~PMID:9707565</ref><ref>PMID:11154691</ref><ref>PMID:12738767</ref><ref>PMID:12929931~~</~~ref~~>	+	</div>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~2rny~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA].	+	*[[CREB-binding protein\|CREB-binding protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:018400184</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Histone acetyltransferase]]		[[Category: Histone acetyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Gerona-Navarro, G.]]	+	[[Category: Gerona-Navarro, G]]
-	[[Category: Zeng, L.]]	+	[[Category: Zeng, L]]
-	[[Category: Zhang, Q.]]	+	[[Category: Zhang, Q]]
-	[[Category: Zhou, M M.]]	+	[[Category: Zhou, M M]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Bromodomain]]		[[Category: Bromodomain]]

OCA: Protected "2rny" [edit=sysop:move=sysop]

OCA — Mon, 25 Mar 2013 00:10:48 GMT

Protected "2rny" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:10, 25 March 2013

OCA at 00:10, 25 March 2013

OCA — Mon, 25 Mar 2013 00:10:46 GMT

←Older revision		Revision as of 00:10, 25 March 2013
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-	{{Seed}}
-	[[Image:2rny.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2rny", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2rny\| PDB=2rny \| SCENE= }}		{{STRUCTURE_2rny\| PDB=2rny \| SCENE= }}
-
	===Complex Structures of CBP Bromodomain with H4 ack20 Peptide===		===Complex Structures of CBP Bromodomain with H4 ack20 Peptide===
		+	{{ABSTRACT_PUBMED_18400184}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref><ref>PMID:12114483</ref><ref>PMID:12566391</ref><ref>PMID:15706485</ref>

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_18400184}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref><ref>PMID:11154691</ref><ref>PMID:12738767</ref><ref>PMID:12929931</ref>
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 18400184 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_18400184}}~~	+

	==About this Structure==		==About this Structure==
-	~~2RNY~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA].	+	[[2rny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18400184~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018400184</ref><references group="xtra"/><references/>
	[[Category: Histone acetyltransferase]]		[[Category: Histone acetyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 30:		Line 20:
	[[Category: Zhang, Q.]]		[[Category: Zhang, Q.]]
	[[Category: Zhou, M M.]]		[[Category: Zhou, M M.]]
-	[[Category: Acetylation]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Bromodomain]]		[[Category: Bromodomain]]
	[[Category: Cbp]]		[[Category: Cbp]]
	[[Category: Chromosomal protein]]		[[Category: Chromosomal protein]]
-	[[Category: Chromosomal rearrangement]]
	[[Category: Creb]]		[[Category: Creb]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
Line 50:		Line 38:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Transferase]]		[[Category: Transferase]]
-	[[Category: Transferase/nuclear protein complex]]	+	[[Category: Transferase-nuclear protein complex]]
-	~~[[Category: Zinc~~]]	+
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:10:07 2009''

OCA at 03:10, 17 February 2009

OCA — Tue, 17 Feb 2009 03:10:08 GMT

←Older revision		Revision as of 03:10, 17 February 2009
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	==About this Structure==		==About this Structure==
-	2RNY is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA].	+	2RNY is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA].

	==Reference==		==Reference==
-	Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300., Zeng L, Zhang Q, Gerona-Navarro G, Moshkina N, Zhou MM, Structure. 2008 Apr;16(4):643-52. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18400184 18400184]~~	+	<ref group="xtra">PMID:18400184</ref><references group="xtra"/>
	[[Category: Histone acetyltransferase]]		[[Category: Histone acetyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Gerona-Navarro, G.]]		[[Category: Gerona-Navarro, G.]]
	[[Category: Zeng, L.]]		[[Category: Zeng, L.]]
Line 55:		Line 54:
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 08~~:29:~~25 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:10:07 2009''

OCA at 05:29, 28 July 2008

OCA — Mon, 28 Jul 2008 05:29:30 GMT

←Older revision		Revision as of 05:29, 28 July 2008
Line 1:		Line 1:
-	[[Image:2rny.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2rny.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2rny\| PDB=2rny \| SCENE= }}		{{STRUCTURE_2rny\| PDB=2rny \| SCENE= }}

-	~~'''~~Complex Structures of CBP Bromodomain with H4 ack20 Peptide~~'''~~	+	===Complex Structures of CBP Bromodomain with H4 ack20 Peptide===


-	~~==Overview==~~	+	<!--
-	~~Histone lysine acetylation is central to epigenetic control of gene transcription. Bromodomains of chromosomal proteins function as acetyl~~-~~lysine (Kac) binding domains. However, how bromodomains recognize site~~-~~specific histones remains unanswered. Here~~, ~~we report three three-dimensional solution structures of~~ the ~~bromodomains of~~ the ~~human transcriptional coactivators CREB-binding protein~~ (~~CBP) and p300~~/~~CBP-associated factor (PCAF~~) ~~bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3~~, ~~and lysine 20 in H4. From structural and biochemical binding analyses, we determine consensus histone recognition by~~ the ~~bromodomains of PCAF and CBP, which represent two different subgroups of the bromodomain family~~. Through bromodomain residues in the ZA and BC loops, PCAF prefers acetylation sites with a hydrophobic residue at (Kac+2) position and a positively charged or aromatic residue at (Kac+3), whereas CBP favors bulky hydrophobic residues at (Kac+1) and (Kac+2), a positively charged residue at (Kac-~~1), and an aromatic residue at (Kac~~-~~2).~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_18400184}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18400184 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18400184}}

	==About this Structure==		==About this Structure==
-	2RNY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA].	+	2RNY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA].

	==Reference==		==Reference==
Line 50:		Line 54:
	[[Category: Zinc]]		[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed May 7~~ 08:43:23 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:29:25 2008''

←Older revision		Revision as of 06:54, 16 March 2022
Line 3:		Line 3:
	<StructureSection load='2rny' size='340' side='right'caption='[[2rny]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rny' size='340' side='right'caption='[[2rny]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rny]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2RNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RNY FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2rny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rny OCA], [~~http~~://pdbe.org/2rny PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rny RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rny PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rny ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rny OCA], [https://pdbe.org/2rny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rny RCSB], [https://www.ebi.ac.uk/pdbsum/2rny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rny ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[~~http~~://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>	+	[[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[https://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>	+	[[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]