2rp5 - Revision history

OCA at 12:54, 20 December 2023

OCA — Wed, 20 Dec 2023 12:54:28 GMT

←Older revision		Revision as of 12:54, 20 December 2023
Line 1:		Line 1:

	==Solution structure of the oligomerization domain in CEP-1==		==Solution structure of the oligomerization domain in CEP-1==
-	<StructureSection load='2rp5' size='340' side='right'caption='[[2rp5~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2rp5' size='340' side='right'caption='[[2rp5]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rp5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Caeel Caeel~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rp5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RP5 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2rp4\|2rp4]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cep-1, F52B5.5, F52B5.5a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rp5 OCA], [https://pdbe.org/2rp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rp5 RCSB], [https://www.ebi.ac.uk/pdbsum/2rp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rp5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rp5 OCA], [https://pdbe.org/2rp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rp5 RCSB], [https://www.ebi.ac.uk/pdbsum/2rp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rp5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CEP1_CAEEL CEP1_CAEEL]] Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. However, not required for DNA repair in response to UV-C or to regulate cell-cycle progression. Required for induction of ced-13 in response to DNA damage. Regulates germline proliferation by activating phg-1.<ref>PMID:11696333</ref> <ref>PMID:11557844</ref> <ref>PMID:12445383</ref> <ref>PMID:15273685</ref> <ref>PMID:15707894</ref> <ref>PMID:15605074</ref> <ref>PMID:16319925</ref> <ref>PMID:17276923</ref> <ref>PMID:17186023</ref> <ref>PMID:17347667</ref> <ref>PMID:17895432</ref> <ref>PMID:18627611</ref> <ref>PMID:18836529</ref> <ref>PMID:19015549</ref>	+	[https://www.uniprot.org/uniprot/CEP1_CAEEL CEP1_CAEEL] Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. However, not required for DNA repair in response to UV-C or to regulate cell-cycle progression. Required for induction of ced-13 in response to DNA damage. Regulates germline proliferation by activating phg-1.<ref>PMID:11696333</ref> <ref>PMID:11557844</ref> <ref>PMID:12445383</ref> <ref>PMID:15273685</ref> <ref>PMID:15707894</ref> <ref>PMID:15605074</ref> <ref>PMID:16319925</ref> <ref>PMID:17276923</ref> <ref>PMID:17186023</ref> <ref>PMID:17347667</ref> <ref>PMID:17895432</ref> <ref>PMID:18627611</ref> <ref>PMID:18836529</ref> <ref>PMID:19015549</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caeel~~]]	+	[[Category: Caenorhabditis elegans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Doetsch, V]]	+	[[Category: Doetsch V]]
-	[[Category: Ou~~, H D]]~~	+	[[Category: Ou HD]]
-	~~[[Category: Cep-1]]~~	+
-	~~[[Category: Oligomerization domain]]~~	+
-	~~[[Category: P53]]~~	+
-	~~[[Category: Sam domain]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 10:34, 7 July 2021

OCA — Wed, 07 Jul 2021 10:34:44 GMT

←Older revision		Revision as of 10:34, 7 July 2021
Line 1:		Line 1:

	==Solution structure of the oligomerization domain in CEP-1==		==Solution structure of the oligomerization domain in CEP-1==
-	<StructureSection load='2rp5' size='340' side='right' caption='[[2rp5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2rp5' size='340' side='right'caption='[[2rp5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rp5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Caeel Caeel]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rp5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caeel Caeel]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RP5 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rp4\|2rp4]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2rp4\|2rp4]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cep-1, F52B5.5, F52B5.5a ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cep-1, F52B5.5, F52B5.5a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rp5 OCA], [~~http~~://pdbe.org/2rp5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rp5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rp5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rp5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rp5 OCA], [https://pdbe.org/2rp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rp5 RCSB], [https://www.ebi.ac.uk/pdbsum/2rp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rp5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CEP1_CAEEL CEP1_CAEEL]] Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. However, not required for DNA repair in response to UV-C or to regulate cell-cycle progression. Required for induction of ced-13 in response to DNA damage. Regulates germline proliferation by activating phg-1.<ref>PMID:11696333</ref> <ref>PMID:11557844</ref> <ref>PMID:12445383</ref> <ref>PMID:15273685</ref> <ref>PMID:15707894</ref> <ref>PMID:15605074</ref> <ref>PMID:16319925</ref> <ref>PMID:17276923</ref> <ref>PMID:17186023</ref> <ref>PMID:17347667</ref> <ref>PMID:17895432</ref> <ref>PMID:18627611</ref> <ref>PMID:18836529</ref> <ref>PMID:19015549</ref>	+	[[https://www.uniprot.org/uniprot/CEP1_CAEEL CEP1_CAEEL]] Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. However, not required for DNA repair in response to UV-C or to regulate cell-cycle progression. Required for induction of ced-13 in response to DNA damage. Regulates germline proliferation by activating phg-1.<ref>PMID:11696333</ref> <ref>PMID:11557844</ref> <ref>PMID:12445383</ref> <ref>PMID:15273685</ref> <ref>PMID:15707894</ref> <ref>PMID:15605074</ref> <ref>PMID:16319925</ref> <ref>PMID:17276923</ref> <ref>PMID:17186023</ref> <ref>PMID:17347667</ref> <ref>PMID:17895432</ref> <ref>PMID:18627611</ref> <ref>PMID:18836529</ref> <ref>PMID:19015549</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Caeel]]		[[Category: Caeel]]
		+	[[Category: Large Structures]]
	[[Category: Doetsch, V]]		[[Category: Doetsch, V]]
	[[Category: Ou, H D]]		[[Category: Ou, H D]]

OCA at 14:37, 4 August 2016

OCA — Thu, 04 Aug 2016 14:37:34 GMT

←Older revision		Revision as of 14:37, 4 August 2016
Line 1:		Line 1:
		+
	==Solution structure of the oligomerization domain in CEP-1==		==Solution structure of the oligomerization domain in CEP-1==
	<StructureSection load='2rp5' size='340' side='right' caption='[[2rp5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rp5' size='340' side='right' caption='[[2rp5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rp5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Caenorhabditis_elegans Caenorhabditis elegans~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rp5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RP5 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rp4\|2rp4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rp4\|2rp4]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cep-1, F52B5.5, F52B5.5a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 ~~Caenorhabditis elegans~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cep-1, F52B5.5, F52B5.5a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rp5 RCSB], [http://www.ebi.ac.uk/pdbsum/2rp5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rp5 OCA], [http://pdbe.org/2rp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rp5 RCSB], [http://www.ebi.ac.uk/pdbsum/2rp5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rp5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2rp5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caenorhabditis elegans~~]]	+	[[Category: Caeel]]
	[[Category: Doetsch, V]]		[[Category: Doetsch, V]]
	[[Category: Ou, H D]]		[[Category: Ou, H D]]

OCA at 10:11, 25 December 2014

OCA — Thu, 25 Dec 2014 10:11:25 GMT

←Older revision		Revision as of 10:11, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rp5 RCSB], [http://www.ebi.ac.uk/pdbsum/2rp5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rp5 RCSB], [http://www.ebi.ac.uk/pdbsum/2rp5 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CEP1_CAEEL CEP1_CAEEL]] Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. However, not required for DNA repair in response to UV-C or to regulate cell-cycle progression. Required for induction of ced-13 in response to DNA damage. Regulates germline proliferation by activating phg-1.<ref>PMID:11696333</ref> <ref>PMID:11557844</ref> <ref>PMID:12445383</ref> <ref>PMID:15273685</ref> <ref>PMID:15707894</ref> <ref>PMID:15605074</ref> <ref>PMID:16319925</ref> <ref>PMID:17276923</ref> <ref>PMID:17186023</ref> <ref>PMID:17347667</ref> <ref>PMID:17895432</ref> <ref>PMID:18627611</ref> <ref>PMID:18836529</ref> <ref>PMID:19015549</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
-	[[Category: Doetsch, V.]]	+	[[Category: Doetsch, V]]
-	[[Category: Ou, H D.]]	+	[[Category: Ou, H D]]
	[[Category: Cep-1]]		[[Category: Cep-1]]
	[[Category: Oligomerization domain]]		[[Category: Oligomerization domain]]

OCA at 11:21, 20 October 2014

OCA — Mon, 20 Oct 2014 11:21:00 GMT

←Older revision		Revision as of 11:21, 20 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2rp5.~~png~~\|~~left~~\|~~200px~~]]	+	==Solution structure of the oligomerization domain in CEP-1==
		+	<StructureSection load='2rp5' size='340' side='right' caption='[[2rp5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2rp5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RP5 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rp4\|2rp4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cep-1, F52B5.5, F52B5.5a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rp5 RCSB], [http://www.ebi.ac.uk/pdbsum/2rp5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The tetrameric state of p53, p63, and p73 has been considered one of the hallmarks of this protein family. While the DNA binding domain (DBD) is highly conserved among vertebrates and invertebrates, sequences C-terminal to the DBD are highly divergent. In particular, the oligomerization domain (OD) of the p53 forms of the model organisms Caenorhabditis elegans and Drosophila cannot be identified by sequence analysis. Here, we present the solution structures of their ODs and show that they both differ significantly from each other as well as from human p53. CEP-1 contains a composite domain of an OD and a sterile alpha motif (SAM) domain, and forms dimers instead of tetramers. The Dmp53 structure is characterized by an additional N-terminal beta-strand and a C-terminal helix. Truncation analysis in both domains reveals that the additional structural elements are necessary to stabilize the structure of the OD, suggesting a new function for the SAM domain. Furthermore, these structures show a potential path of evolution from an ancestral dimeric form over a tetrameric form, with additional stabilization elements, to the tetramerization domain of mammalian p53.

-	~~{{STRUCTURE_2rp5\| PDB=2rp5 \| SCENE= }}~~	+	Structural evolution of C-terminal domains in the p53 family.,Ou HD, Lohr F, Vogel V, Mantele W, Dotsch V EMBO J. 2007 Jul 25;26(14):3463-73. Epub 2007 Jun 21. PMID:17581633<ref>PMID:17581633</ref>

-	~~===Solution structure~~ of the ~~oligomerization domain in CEP-1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17581633}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2rp5]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA].~~	+	</StructureSection>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
	[[Category: Doetsch, V.]]		[[Category: Doetsch, V.]]

OCA: Protected "2rp5" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 21:55:46 GMT

Protected "2rp5" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:55, 7 January 2013

OCA at 21:55, 7 January 2013

OCA — Mon, 07 Jan 2013 21:55:41 GMT

←Older revision		Revision as of 21:55, 7 January 2013
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-	~~{{Seed}}~~	+	[[Image:2rp5.png\|left\|200px]]
-	[[Image:2rp5.~~jpg~~\|left\|200px]]	+

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	{{STRUCTURE_2rp5\| PDB=2rp5 \| SCENE= }}		{{STRUCTURE_2rp5\| PDB=2rp5 \| SCENE= }}

	===Solution structure of the oligomerization domain in CEP-1===		===Solution structure of the oligomerization domain in CEP-1===

-
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	{{ABSTRACT_PUBMED_17581633}}		{{ABSTRACT_PUBMED_17581633}}

	==About this Structure==		==About this Structure==
-	~~2RP5 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA].	+	[[2rp5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA].
-		+
-	~~==Reference==~~	+
-	Structural evolution of C-terminal domains in the p53 family., Ou HD, Lohr F, Vogel V, Mantele W, Dotsch V, EMBO J. 2007 Jul 25;26(14):3463-73. Epub 2007 Jun 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17581633 17581633]	+
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
-	[[Category: ~~Single protein~~]]	+	[[Category: Doetsch, V.]]
		+	[[Category: Ou, H D.]]
	[[Category: Cep-1]]		[[Category: Cep-1]]
	[[Category: Oligomerization domain]]		[[Category: Oligomerization domain]]
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	[[Category: Sam domain]]		[[Category: Sam domain]]
	[[Category: Transcription]]		[[Category: Transcription]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:45:00 2008''

OCA at 15:45, 28 July 2008

OCA — Mon, 28 Jul 2008 15:45:03 GMT

←Older revision		Revision as of 15:45, 28 July 2008
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		+	{{Seed}}
	[[Image:2rp5.jpg\|left\|200px]]		[[Image:2rp5.jpg\|left\|200px]]

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	{{STRUCTURE_2rp5\| PDB=2rp5 \| SCENE= }}		{{STRUCTURE_2rp5\| PDB=2rp5 \| SCENE= }}

-	~~'''~~Solution structure of the oligomerization domain in CEP-1~~'''~~	+	===Solution structure of the oligomerization domain in CEP-1===


-	~~==Overview==~~	+	<!--
-	The ~~tetrameric state of p53~~, ~~p63~~, ~~and p73 has been considered one of~~ the ~~hallmarks of this protein family. While the DNA binding domain (DBD) is highly conserved among vertebrates and invertebrates, sequences C-terminal~~ to the ~~DBD are highly divergent. In particular, the oligomerization domain~~ (~~OD) of the p53 forms of the model organisms Caenorhabditis elegans and Drosophila cannot be identified by sequence analysis~~. ~~Here, we present the solution structures of their ODs and show that they both differ significantly from each other as well as from human p53~~. ~~CEP-1 contains a composite domain of an OD and a sterile alpha motif (SAM~~) ~~domain~~, ~~and forms dimers instead of tetramers~~. ~~The Dmp53 structure is characterized by an additional N~~-~~terminal beta~~-strand and a C-terminal helix. Truncation analysis in both domains reveals that the additional structural elements are necessary to stabilize the structure of the OD, suggesting a new function for the SAM domain. Furthermore, these structures show a potential path of evolution from an ancestral dimeric form over a tetrameric form, with additional stabilization elements, to the tetramerization domain of mammalian p53.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17581633}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17581633 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17581633}}

	==About this Structure==		==About this Structure==
-	2RP5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA].	+	2RP5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA].

	==Reference==		==Reference==
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	[[Category: Sam domain]]		[[Category: Sam domain]]
	[[Category: Transcription]]		[[Category: Transcription]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed May~~ 28 09:15:12 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:45:00 2008''