2rq4 - Revision history

OCA at 19:15, 29 May 2024

OCA — Wed, 29 May 2024 19:15:39 GMT

←Older revision		Revision as of 19:15, 29 May 2024
Line 1:		Line 1:

	==Refinement of RNA binding domain 3 in CUG triplet repeat RNA-binding protein 1==		==Refinement of RNA binding domain 3 in CUG triplet repeat RNA-binding protein 1==
-	<StructureSection load='2rq4' size='340' side='right'caption='[[2rq4~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2rq4' size='340' side='right'caption='[[2rq4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rq4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rq4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQ4 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2cpz\|2cpz]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq4 OCA], [https://pdbe.org/2rq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rq4 RCSB], [https://www.ebi.ac.uk/pdbsum/2rq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rq4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq4 OCA], [https://pdbe.org/2rq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rq4 RCSB], [https://www.ebi.ac.uk/pdbsum/2rq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rq4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CELF1_HUMAN CELF1_HUMAN]] RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.<ref>PMID:10536163</ref> <ref>PMID:11124939</ref> <ref>PMID:11158314</ref> <ref>PMID:12799066</ref> <ref>PMID:12649496</ref> <ref>PMID:14726956</ref> <ref>PMID:16946708</ref> <ref>PMID:16601207</ref>	+	[https://www.uniprot.org/uniprot/CELF1_HUMAN CELF1_HUMAN] RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.<ref>PMID:10536163</ref> <ref>PMID:11124939</ref> <ref>PMID:11158314</ref> <ref>PMID:12799066</ref> <ref>PMID:12649496</ref> <ref>PMID:14726956</ref> <ref>PMID:16946708</ref> <ref>PMID:16601207</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Guntert, P]]	+	[[Category: Guntert P]]
-	[[Category: Inoue, M]]	+	[[Category: Inoue M]]
-	[[Category: Kigawa, T]]	+	[[Category: Kigawa T]]
-	[[Category: Kobayashi, N]]	+	[[Category: Kobayashi N]]
-	[[Category: Kuwasako, K]]	+	[[Category: Kuwasako K]]
-	[[Category: Muto, Y]]	+	[[Category: Muto Y]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Shirouzu M]]
-	[[Category: Shirouzu, M]]	+	[[Category: Someya T]]
-	[[Category: Someya, T]]	+	[[Category: Takahashi M]]
-	[[Category: Takahashi, M]]	+	[[Category: Terada T]]
-	[[Category: Terada, T]]	+	[[Category: Tsuda K]]
-	[[Category: Tsuda, K]]	+	[[Category: Yokoyama S]]
-	[[Category: Yokoyama, S]]	+
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Mrna processing]]~~	+
-	~~[[Category: National project on protein structural and functional analyse]]~~	+
-	~~[[Category: Nppsfa]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Rbd]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Rrm domain]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 10:35, 7 July 2021

OCA — Wed, 07 Jul 2021 10:35:09 GMT

←Older revision		Revision as of 10:35, 7 July 2021
Line 1:		Line 1:

	==Refinement of RNA binding domain 3 in CUG triplet repeat RNA-binding protein 1==		==Refinement of RNA binding domain 3 in CUG triplet repeat RNA-binding protein 1==
-	<StructureSection load='2rq4' size='340' side='right' caption='[[2rq4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2rq4' size='340' side='right'caption='[[2rq4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rq4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RQ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rq4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQ4 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cpz\|2cpz]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cpz\|2cpz]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq4 OCA], [~~http~~://pdbe.org/2rq4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rq4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rq4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rq4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq4 OCA], [https://pdbe.org/2rq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rq4 RCSB], [https://www.ebi.ac.uk/pdbsum/2rq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rq4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CELF1_HUMAN CELF1_HUMAN]] RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.<ref>PMID:10536163</ref> <ref>PMID:11124939</ref> <ref>PMID:11158314</ref> <ref>PMID:12799066</ref> <ref>PMID:12649496</ref> <ref>PMID:14726956</ref> <ref>PMID:16946708</ref> <ref>PMID:16601207</ref>	+	[[https://www.uniprot.org/uniprot/CELF1_HUMAN CELF1_HUMAN]] RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.<ref>PMID:10536163</ref> <ref>PMID:11124939</ref> <ref>PMID:11158314</ref> <ref>PMID:12799066</ref> <ref>PMID:12649496</ref> <ref>PMID:14726956</ref> <ref>PMID:16946708</ref> <ref>PMID:16601207</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Guntert, P]]		[[Category: Guntert, P]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]

OCA at 08:45, 12 September 2018

OCA — Wed, 12 Sep 2018 08:45:55 GMT

←Older revision		Revision as of 08:45, 12 September 2018
Line 1:		Line 1:
		+
	==Refinement of RNA binding domain 3 in CUG triplet repeat RNA-binding protein 1==		==Refinement of RNA binding domain 3 in CUG triplet repeat RNA-binding protein 1==
	<StructureSection load='2rq4' size='340' side='right' caption='[[2rq4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rq4' size='340' side='right' caption='[[2rq4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cpz\|2cpz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cpz\|2cpz]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq4 OCA], [http://pdbe.org/2rq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rq4 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq4 OCA], [http://pdbe.org/2rq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rq4 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rq4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rq4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rq4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 47:		Line 48:
	[[Category: Yokoyama, S]]		[[Category: Yokoyama, S]]
	[[Category: Activator]]		[[Category: Activator]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cytoplasm]]
	[[Category: Mrna processing]]		[[Category: Mrna processing]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]

OCA at 19:11, 9 February 2016

OCA — Tue, 09 Feb 2016 19:11:05 GMT

←Older revision		Revision as of 19:11, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2rq4' size='340' side='right' caption='[[2rq4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rq4' size='340' side='right' caption='[[2rq4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rq4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rq4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQ4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cpz\|2cpz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cpz\|2cpz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rq4 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq4 OCA], [http://pdbe.org/2rq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rq4 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rq4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2rq4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Guntert, P]]		[[Category: Guntert, P]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]

OCA at 08:55, 25 December 2014

OCA — Thu, 25 Dec 2014 08:55:50 GMT

←Older revision		Revision as of 08:55, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rq4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQ4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rq4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQ4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cpz\|2cpz]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cpz\|2cpz]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rq4 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rq4 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CELF1_HUMAN CELF1_HUMAN]] RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.<ref>PMID:10536163</ref> <ref>PMID:11124939</ref> <ref>PMID:11158314</ref> <ref>PMID:12799066</ref> <ref>PMID:12649496</ref> <ref>PMID:14726956</ref> <ref>PMID:16946708</ref> <ref>PMID:16601207</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Guntert, P.]]	+	[[Category: Guntert, P]]
-	[[Category: Inoue, M.]]	+	[[Category: Inoue, M]]
-	[[Category: Kigawa, T.]]	+	[[Category: Kigawa, T]]
-	[[Category: Kobayashi, N.]]	+	[[Category: Kobayashi, N]]
-	[[Category: Kuwasako, K.]]	+	[[Category: Kuwasako, K]]
-	[[Category: Muto, Y.]]	+	[[Category: Muto, Y]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Shirouzu, M.]]	+	[[Category: Shirouzu, M]]
-	[[Category: Someya, T.]]	+	[[Category: Someya, T]]
-	[[Category: Takahashi, M.]]	+	[[Category: Takahashi, M]]
-	[[Category: Terada, T.]]	+	[[Category: Terada, T]]
-	[[Category: Tsuda, K.]]	+	[[Category: Tsuda, K]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Mrna processing]]		[[Category: Mrna processing]]
Line 50:		Line 52:
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Rbd]]		[[Category: Rbd]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Rrm domain]]		[[Category: Rrm domain]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 02:09, 1 October 2014

OCA — Wed, 01 Oct 2014 02:09:49 GMT

←Older revision		Revision as of 02:09, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2rq4.~~png~~\|~~left~~\|200px]]	+	==Refinement of RNA binding domain 3 in CUG triplet repeat RNA-binding protein 1==
		+	<StructureSection load='2rq4' size='340' side='right' caption='[[2rq4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2rq4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQ4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cpz\|2cpz]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rq4 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rq4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The CUG-binding protein 1 (CUG-BP1) is a member of the CUG-BP1 and ETR-like factors (CELF) family or the Bruno-like family and is involved in the control of splicing, translation and mRNA degradation. Several target RNA sequences of CUG-BP1 have been predicted, such as the CUG triplet repeat, the GU-rich sequences and the AU-rich element of nuclear pre-mRNAs and/or cytoplasmic mRNA. CUG-BP1 has three RNA-recognition motifs (RRMs), among which the third RRM (RRM3) can bind to the target RNAs on its own. In this study, we solved the solution structure of the CUG-BP1 RRM3 by hetero-nuclear NMR spectroscopy. The CUG-BP1 RRM3 exhibited a noncanonical RRM fold, with the four-stranded beta-sheet surface tightly associated with the N-terminal extension. Furthermore, we determined the solution structure of the CUG-BP1 RRM3 in the complex with (UG)(3) RNA, and discovered that the UGU trinucleotide is specifically recognized through extensive stacking interactions and hydrogen bonds within the pocket formed by the beta-sheet surface and the N-terminal extension. This study revealed the unique mechanism that enables the CUG-BP1 RRM3 to discriminate the short RNA segment from other sequences, thus providing the molecular basis for the comprehension of the role of the RRM3s in the CELF/Bruno-like family.

-	~~{{STRUCTURE_2rq4\| PDB=2rq4 \| SCENE= }}~~	+	Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3.,Tsuda K, Kuwasako K, Takahashi M, Someya T, Inoue M, Terada T, Kobayashi N, Shirouzu M, Kigawa T, Tanaka A, Sugano S, Guntert P, Muto Y, Yokoyama S Nucleic Acids Res. 2009 Aug;37(15):5151-66. Epub 2009 Jun 24. PMID:19553194<ref>PMID:19553194</ref>

-	~~===Refinement~~ of ~~RNA binding domain 3 in CUG triplet repeat RNA-binding protein 1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19553194}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2rq4]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ4 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019553194<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Guntert, P.]]		[[Category: Guntert, P.]]

OCA: Protected "2rq4" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:20:29 GMT

Protected "2rq4" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:20, 7 January 2013

OCA at 20:20, 7 January 2013

OCA — Mon, 07 Jan 2013 20:20:24 GMT

←Older revision		Revision as of 20:20, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2rq4.png\|left\|200px]]
-	[[Image:2rq4.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2rq4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2rq4\| PDB=2rq4 \| SCENE= }}		{{STRUCTURE_2rq4\| PDB=2rq4 \| SCENE= }}

	===Refinement of RNA binding domain 3 in CUG triplet repeat RNA-binding protein 1===		===Refinement of RNA binding domain 3 in CUG triplet repeat RNA-binding protein 1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19553194}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19553194 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19553194}}		{{ABSTRACT_PUBMED_19553194}}

	==About this Structure==		==About this Structure==
-	~~2RQ4~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ4 OCA].	+	[[2rq4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ4 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19553194~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019553194</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Guntert, P.]]		[[Category: Guntert, P.]]
Line 39:		Line 27:
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S.]]
	[[Category: Activator]]		[[Category: Activator]]
-	[[Category: Alternative splicing]]
-	[[Category: Cytoplasm]]
	[[Category: Mrna processing]]		[[Category: Mrna processing]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
Line 53:		Line 39:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Transcription]]		[[Category: Transcription]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 10:27:38 2009''

OCA at 07:27, 5 August 2009

OCA — Wed, 05 Aug 2009 07:27:42 GMT

←Older revision		Revision as of 07:27, 5 August 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2rq4.jpg\|left\|200px]]

-	The ~~entry 2rq4~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2rq4", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2rq4\| PDB=2rq4 \| SCENE= }}

-	~~Authors: Tsuda, K., Kuwasako, K., Takahashi, M., Someya, T., Inoue, M., Terada, T., Kobayashi, N., Shirouzu, M., Kigawa, T., Guntert, P., Muto, Y., Yokoyama, S.~~	+	===Refinement of RNA binding domain 3 in CUG triplet repeat RNA-binding protein 1===

-	Description:

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar~~ ~~4 14~~:28:54 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19553194}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19553194 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19553194}}
		+
		+	==About this Structure==
		+	2RQ4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19553194</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Guntert, P.]]
		+	[[Category: Inoue, M.]]
		+	[[Category: Kigawa, T.]]
		+	[[Category: Kobayashi, N.]]
		+	[[Category: Kuwasako, K.]]
		+	[[Category: Muto, Y.]]
		+	[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
		+	[[Category: Shirouzu, M.]]
		+	[[Category: Someya, T.]]
		+	[[Category: Takahashi, M.]]
		+	[[Category: Terada, T.]]
		+	[[Category: Tsuda, K.]]
		+	[[Category: Yokoyama, S.]]
		+	[[Category: Activator]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Mrna processing]]
		+	[[Category: National project on protein structural and functional analyse]]
		+	[[Category: Nppsfa]]
		+	[[Category: Nucleus]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Rbd]]
		+	[[Category: Riken structural genomics/proteomics initiative]]
		+	[[Category: Rna-binding]]
		+	[[Category: Rrm domain]]
		+	[[Category: Rsgi]]
		+	[[Category: Structural genomic]]
		+	[[Category: Transcription]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 10:27:38 2009''

OCA at 12:28, 4 March 2009

OCA — Wed, 04 Mar 2009 12:28:54 GMT

←Older revision		Revision as of 12:28, 4 March 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2rq4 is ON HOLD	+	The entry 2rq4 is ON HOLD until Paper Publication

	Authors: Tsuda, K., Kuwasako, K., Takahashi, M., Someya, T., Inoue, M., Terada, T., Kobayashi, N., Shirouzu, M., Kigawa, T., Guntert, P., Muto, Y., Yokoyama, S.		Authors: Tsuda, K., Kuwasako, K., Takahashi, M., Someya, T., Inoue, M., Terada, T., Kobayashi, N., Shirouzu, M., Kigawa, T., Guntert, P., Muto, Y., Yokoyama, S.
Line 7:		Line 7:
	Description:		Description:

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb~~ 4 11:08:15 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 4 14:28:54 2009''