2rq5 - Revision history

OCA at 19:15, 29 May 2024

OCA — Wed, 29 May 2024 19:15:40 GMT

←Older revision		Revision as of 19:15, 29 May 2024
Line 1:		Line 1:

	==Solution structure of the AT-rich interaction domain (ARID) of Jumonji/JARID2==		==Solution structure of the AT-rich interaction domain (ARID) of Jumonji/JARID2==
-	<StructureSection load='2rq5' size='340' side='right'caption='[[2rq5~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2rq5' size='340' side='right'caption='[[2rq5]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rq5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rq5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQ5 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Jmj ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq5 OCA], [https://pdbe.org/2rq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rq5 RCSB], [https://www.ebi.ac.uk/pdbsum/2rq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rq5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq5 OCA], [https://pdbe.org/2rq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rq5 RCSB], [https://www.ebi.ac.uk/pdbsum/2rq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rq5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/JARD2_MOUSE JARD2_MOUSE]] Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.<ref>PMID:10913339</ref> <ref>PMID:10807864</ref> <ref>PMID:12852854</ref> <ref>PMID:12890668</ref> <ref>PMID:15542826</ref> <ref>PMID:15870077</ref> <ref>PMID:20064376</ref> <ref>PMID:20064375</ref> <ref>PMID:19010785</ref> <ref>PMID:20075857</ref>	+	[https://www.uniprot.org/uniprot/JARD2_MOUSE JARD2_MOUSE] Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.<ref>PMID:10913339</ref> <ref>PMID:10807864</ref> <ref>PMID:12852854</ref> <ref>PMID:12890668</ref> <ref>PMID:15542826</ref> <ref>PMID:15870077</ref> <ref>PMID:20064376</ref> <ref>PMID:20064375</ref> <ref>PMID:19010785</ref> <ref>PMID:20075857</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Kohno, T]]	+	[[Category: Kohno T]]
-	[[Category: Kusunoki, H]]	+	[[Category: Kusunoki H]]
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Protein]]~~	+
-	~~[[Category: Repressor]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 10:35, 7 July 2021

OCA — Wed, 07 Jul 2021 10:35:11 GMT

←Older revision		Revision as of 10:35, 7 July 2021
Line 1:		Line 1:

	==Solution structure of the AT-rich interaction domain (ARID) of Jumonji/JARID2==		==Solution structure of the AT-rich interaction domain (ARID) of Jumonji/JARID2==
-	<StructureSection load='2rq5' size='340' side='right' caption='[[2rq5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2rq5' size='340' side='right'caption='[[2rq5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rq5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RQ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rq5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQ5 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Jmj ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Jmj ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq5 OCA], [~~http~~://pdbe.org/2rq5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rq5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rq5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rq5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq5 OCA], [https://pdbe.org/2rq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rq5 RCSB], [https://www.ebi.ac.uk/pdbsum/2rq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rq5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/JARD2_MOUSE JARD2_MOUSE]] Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.<ref>PMID:10913339</ref> <ref>PMID:10807864</ref> <ref>PMID:12852854</ref> <ref>PMID:12890668</ref> <ref>PMID:15542826</ref> <ref>PMID:15870077</ref> <ref>PMID:20064376</ref> <ref>PMID:20064375</ref> <ref>PMID:19010785</ref> <ref>PMID:20075857</ref>	+	[[https://www.uniprot.org/uniprot/JARD2_MOUSE JARD2_MOUSE]] Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.<ref>PMID:10913339</ref> <ref>PMID:10807864</ref> <ref>PMID:12852854</ref> <ref>PMID:12890668</ref> <ref>PMID:15542826</ref> <ref>PMID:15870077</ref> <ref>PMID:20064376</ref> <ref>PMID:20064375</ref> <ref>PMID:19010785</ref> <ref>PMID:20075857</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Kohno, T]]		[[Category: Kohno, T]]

OCA at 08:36, 12 September 2018

OCA — Wed, 12 Sep 2018 08:36:14 GMT

←Older revision		Revision as of 08:36, 12 September 2018
Line 1:		Line 1:
		+
	==Solution structure of the AT-rich interaction domain (ARID) of Jumonji/JARID2==		==Solution structure of the AT-rich interaction domain (ARID) of Jumonji/JARID2==
	<StructureSection load='2rq5' size='340' side='right' caption='[[2rq5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rq5' size='340' side='right' caption='[[2rq5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2rq5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rq5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQ5 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Jmj ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Jmj ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq5 OCA], [http://pdbe.org/2rq5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rq5 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq5 OCA], [http://pdbe.org/2rq5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rq5 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rq5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rq5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rq5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:56, 9 February 2016

OCA — Tue, 09 Feb 2016 02:56:43 GMT

←Older revision		Revision as of 02:56, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2rq5' size='340' side='right' caption='[[2rq5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rq5' size='340' side='right' caption='[[2rq5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rq5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rq5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQ5 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Jmj ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Jmj ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rq5 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq5 OCA], [http://pdbe.org/2rq5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rq5 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rq5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Kohno, T]]		[[Category: Kohno, T]]
	[[Category: Kusunoki, H]]		[[Category: Kusunoki, H]]

OCA at 03:55, 25 December 2014

OCA — Thu, 25 Dec 2014 03:55:40 GMT

←Older revision		Revision as of 03:55, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rq5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rq5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQ5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Jmj ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Jmj ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rq5 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rq5 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq5 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/JARD2_MOUSE JARD2_MOUSE]] Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.<ref>PMID:10913339</ref> <ref>PMID:10807864</ref> <ref>PMID:12852854</ref> <ref>PMID:12890668</ref> <ref>PMID:15542826</ref> <ref>PMID:15870077</ref> <ref>PMID:20064376</ref> <ref>PMID:20064375</ref> <ref>PMID:19010785</ref> <ref>PMID:20075857</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 18:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Kohno, T.]]	+	[[Category: Kohno, T]]
-	[[Category: Kusunoki, H.]]	+	[[Category: Kusunoki, H]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Nucleus]]		[[Category: Nucleus]]

OCA at 01:31, 1 October 2014

OCA — Wed, 01 Oct 2014 01:31:35 GMT

←Older revision		Revision as of 01:31, 1 October 2014
Line 1:		Line 1:
-	~~[[Image:2rq5.png\|left\|200px]]~~	+	==Solution structure of the AT-rich interaction domain (ARID) of Jumonji/JARID2==
-		+	<StructureSection load='2rq5' size='340' side='right' caption='[[2rq5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{STRUCTURE_2rq5\| PDB=2rq5 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2rq5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQ5 FirstGlance]. <br>
-	===Solution structure of the AT-rich interaction domain (ARID) of Jumonji/JARID2===	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Jmj ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rq5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rq5 RCSB], [http://www.ebi.ac.uk/pdbsum/2rq5 PDBsum]</span></td></tr>
-		+	<table>
-	==~~About this Structure~~==	+	== Evolutionary Conservation ==
-	[[2rq5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA].	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-		+	Check<jmol>
-	==~~Reference~~==	+	<jmolCheckbox>
-	<~~ref group~~="~~xtra~~">~~PMID~~:~~019455710~~</~~ref~~><~~references group~~="~~xtra~~"/>	+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rq5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Kohno, T.]]		[[Category: Kohno, T.]]

OCA: Protected "2rq5" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:31:48 GMT

Protected "2rq5" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:31, 7 January 2013

OCA at 19:31, 7 January 2013

OCA — Mon, 07 Jan 2013 19:31:46 GMT

←Older revision		Revision as of 19:31, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2rq5.png\|left\|200px]]		[[Image:2rq5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2rq5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2rq5\| PDB=2rq5 \| SCENE= }}		{{STRUCTURE_2rq5\| PDB=2rq5 \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~2RQ5~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA].	+	[[2rq5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19455710~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019455710</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Kohno, T.]]		[[Category: Kohno, T.]]
Line 27:		Line 20:
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 16:26:28 2009''

OCA at 13:26, 3 September 2009

OCA — Thu, 03 Sep 2009 13:26:30 GMT

←Older revision		Revision as of 13:26, 3 September 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2rq5.~~jpg~~\|left\|200px]]	+	[[Image:2rq5.png\|left\|200px]]

	<!--		<!--
Line 14:		Line 14:

	==About this Structure==		==About this Structure==
-	2RQ5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA].	+	2RQ5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA].

	==Reference==		==Reference==
Line 28:		Line 28:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jun 10 17~~:55:43 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 16:26:28 2009''

OCA at 14:55, 10 June 2009

OCA — Wed, 10 Jun 2009 14:55:45 GMT

←Older revision		Revision as of 14:55, 10 June 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2rq5.jpg\|left\|200px]]

-	The ~~entry 2rq5~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2rq5", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2rq5\| PDB=2rq5 \| SCENE= }}

-	~~Authors: Kusunoki, H., Takeuchi, T., Kohno, T.~~	+	===Solution structure of the AT-rich interaction domain (ARID) of Jumonji/JARID2===

-	Description: Solution structure of the AT-rich interaction domain (ARID) of Jumonji/JARID2

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 4 14:28~~:55 2009''	+	==About this Structure==
		+	2RQ5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQ5 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19455710</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Kohno, T.]]
		+	[[Category: Kusunoki, H.]]
		+	[[Category: Developmental protein]]
		+	[[Category: Nucleus]]
		+	[[Category: Protein]]
		+	[[Category: Repressor]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 17:55:43 2009''