2rqm - Revision history

OCA at 07:05, 1 May 2024

OCA — Wed, 01 May 2024 07:05:55 GMT

←Older revision		Revision as of 07:05, 1 May 2024
Line 1:		Line 1:

	==NMR Solution Structure of Mesoderm Development (MESD) - open conformation==		==NMR Solution Structure of Mesoderm Development (MESD) - open conformation==
-	<StructureSection load='2rqm' size='340' side='right'caption='[[2rqm~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2rqm' size='340' side='right'caption='[[2rqm]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rqm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rqm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQM FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2rqk\|2rqk]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mesdc2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqm OCA], [https://pdbe.org/2rqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqm RCSB], [https://www.ebi.ac.uk/pdbsum/2rqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqm OCA], [https://pdbe.org/2rqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqm RCSB], [https://www.ebi.ac.uk/pdbsum/2rqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MESD_MOUSE MESD_MOUSE]] Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.<ref>PMID:12581525</ref> <ref>PMID:21397183</ref>	+	[https://www.uniprot.org/uniprot/MESD_MOUSE MESD_MOUSE] Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.<ref>PMID:12581525</ref> <ref>PMID:21397183</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rqm ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rqm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Mesoderm development (MESD) is a 224 amino acid mouse protein that acts as a molecular chaperone for the low-density lipoprotein receptor (LDLR) family. Here, we provide evidence that the region 45-184 of MESD is essential and sufficient for this function and suggest a model for its mode of action. NMR studies reveal a beta-alpha-beta-beta-alpha-beta core domain with an alpha-helical N-terminal extension that interacts with the beta sheet in a dynamic manner. As a result, the structural ensemble contains open (active) and closed (inactive) forms, allowing for regulation of chaperone activity through substrate binding. The mutant W61R, which is lethal in Drosophila, adopts only the open state. The receptor motif recognized by MESD was identified by in vitro-binding studies. Furthermore, in vivo functional evidence for the relevance of the identified contact sites in MESD is provided.
-
-	The Structure of MESD45-184 Brings Light into the Mechanism of LDLR Family Folding.,Kohler C, Lighthouse JK, Werther T, Andersen OM, Diehl A, Schmieder P, Du J, Holdener BC, Oschkinat H Structure. 2011 Mar 9;19(3):337-48. PMID:21397185<ref>PMID:21397185</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2rqm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Andersen~~, O M~~]]	+	[[Category: Andersen OM]]
-	[[Category: Diehl, A]]	+	[[Category: Diehl A]]
-	[[Category: Holdener~~, B C~~]]	+	[[Category: Holdener BC]]
-	[[Category: Koehler, C]]	+	[[Category: Koehler C]]
-	[[Category: Lighthouse~~, J K~~]]	+	[[Category: Lighthouse JK]]
-	[[Category: Oschkinat, H]]	+	[[Category: Oschkinat H]]
-	[[Category: Schmieder, P]]	+	[[Category: Schmieder P]]
-	[[Category: Werther, T]]	+	[[Category: Werther T]]
-	~~[[Category: Chaperone~~]]	+

OCA at 10:35, 7 July 2021

OCA — Wed, 07 Jul 2021 10:35:31 GMT

←Older revision		Revision as of 10:35, 7 July 2021
Line 1:		Line 1:

	==NMR Solution Structure of Mesoderm Development (MESD) - open conformation==		==NMR Solution Structure of Mesoderm Development (MESD) - open conformation==
-	<StructureSection load='2rqm' size='340' side='right' caption='[[2rqm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2rqm' size='340' side='right'caption='[[2rqm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rqm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RQM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rqm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQM FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rqk\|2rqk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2rqk\|2rqk]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mesdc2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mesdc2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqm OCA], [~~http~~://pdbe.org/2rqm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rqm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rqm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqm OCA], [https://pdbe.org/2rqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqm RCSB], [https://www.ebi.ac.uk/pdbsum/2rqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MESD_MOUSE MESD_MOUSE]] Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.<ref>PMID:12581525</ref> <ref>PMID:21397183</ref>	+	[[https://www.uniprot.org/uniprot/MESD_MOUSE MESD_MOUSE]] Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.<ref>PMID:12581525</ref> <ref>PMID:21397183</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Andersen, O M]]		[[Category: Andersen, O M]]

OCA at 08:07, 12 September 2018

OCA — Wed, 12 Sep 2018 08:07:48 GMT

←Older revision		Revision as of 08:07, 12 September 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rqm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rqm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:56, 5 August 2016

OCA — Fri, 05 Aug 2016 12:56:17 GMT

←Older revision		Revision as of 12:56, 5 August 2016
Line 1:		Line 1:
		+
	==NMR Solution Structure of Mesoderm Development (MESD) - open conformation==		==NMR Solution Structure of Mesoderm Development (MESD) - open conformation==
	<StructureSection load='2rqm' size='340' side='right' caption='[[2rqm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rqm' size='340' side='right' caption='[[2rqm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rqm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rqm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rqk\|2rqk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rqk\|2rqk]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mesdc2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mesdc2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rqm RCSB], [http://www.ebi.ac.uk/pdbsum/2rqm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqm OCA], [http://pdbe.org/2rqm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rqm RCSB], [http://www.ebi.ac.uk/pdbsum/2rqm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~MESD2_MOUSE MESD2_MOUSE~~]] Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.<ref>PMID:12581525</ref> <ref>PMID:21397183</ref>	+	[[http://www.uniprot.org/uniprot/MESD_MOUSE MESD_MOUSE]] Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.<ref>PMID:12581525</ref> <ref>PMID:21397183</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rqm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2rqm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Andersen, O M]]		[[Category: Andersen, O M]]
	[[Category: Diehl, A]]		[[Category: Diehl, A]]

OCA at 19:01, 25 December 2014

OCA — Thu, 25 Dec 2014 19:01:25 GMT

←Older revision		Revision as of 19:01, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rqm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rqm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rqk\|2rqk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rqk\|2rqk]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mesdc2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mesdc2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rqm RCSB], [http://www.ebi.ac.uk/pdbsum/2rqm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rqm RCSB], [http://www.ebi.ac.uk/pdbsum/2rqm PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MESD2_MOUSE MESD2_MOUSE]] Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.<ref>PMID:12581525</ref> <ref>PMID:21397183</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Andersen, O M.]]	+	[[Category: Andersen, O M]]
-	[[Category: Diehl, A.]]	+	[[Category: Diehl, A]]
-	[[Category: Holdener, B C.]]	+	[[Category: Holdener, B C]]
-	[[Category: Koehler, C.]]	+	[[Category: Koehler, C]]
-	[[Category: Lighthouse, J K.]]	+	[[Category: Lighthouse, J K]]
-	[[Category: Oschkinat, H.]]	+	[[Category: Oschkinat, H]]
-	[[Category: Schmieder, P.]]	+	[[Category: Schmieder, P]]
-	[[Category: Werther, T.]]	+	[[Category: Werther, T]]
	[[Category: Chaperone]]		[[Category: Chaperone]]

OCA at 01:10, 1 October 2014

OCA — Wed, 01 Oct 2014 01:10:12 GMT

←Older revision		Revision as of 01:10, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2rqm.~~png~~\|~~left~~\|200px]]	+	==NMR Solution Structure of Mesoderm Development (MESD) - open conformation==
		+	<StructureSection load='2rqm' size='340' side='right' caption='[[2rqm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2rqm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rqk\|2rqk]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mesdc2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rqm RCSB], [http://www.ebi.ac.uk/pdbsum/2rqm PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rqm_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mesoderm development (MESD) is a 224 amino acid mouse protein that acts as a molecular chaperone for the low-density lipoprotein receptor (LDLR) family. Here, we provide evidence that the region 45-184 of MESD is essential and sufficient for this function and suggest a model for its mode of action. NMR studies reveal a beta-alpha-beta-beta-alpha-beta core domain with an alpha-helical N-terminal extension that interacts with the beta sheet in a dynamic manner. As a result, the structural ensemble contains open (active) and closed (inactive) forms, allowing for regulation of chaperone activity through substrate binding. The mutant W61R, which is lethal in Drosophila, adopts only the open state. The receptor motif recognized by MESD was identified by in vitro-binding studies. Furthermore, in vivo functional evidence for the relevance of the identified contact sites in MESD is provided.

-	~~{{STRUCTURE_2rqm\| PDB=2rqm \| SCENE= }}~~	+	The Structure of MESD45-184 Brings Light into the Mechanism of LDLR Family Folding.,Kohler C, Lighthouse JK, Werther T, Andersen OM, Diehl A, Schmieder P, Du J, Holdener BC, Oschkinat H Structure. 2011 Mar 9;19(3):337-48. PMID:21397185<ref>PMID:21397185</ref>

-	~~===NMR Solution Structure~~ of ~~Mesoderm Development (MESD) - open conformation===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21397185}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2rqm]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2RQM OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021397185<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Andersen, O M.]]		[[Category: Andersen, O M.]]

OCA at 14:09, 20 February 2013

OCA — Wed, 20 Feb 2013 14:09:46 GMT

←Older revision		Revision as of 14:09, 20 February 2013
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	[[Image:2rqm.png\|left\|200px]]		[[Image:2rqm.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2rqm\| PDB=2rqm \| SCENE= }}		{{STRUCTURE_2rqm\| PDB=2rqm \| SCENE= }}

	===NMR Solution Structure of Mesoderm Development (MESD) - open conformation===		===NMR Solution Structure of Mesoderm Development (MESD) - open conformation===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21397185}}, adds the Publication Abstract to the page
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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21397185~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021397185</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Andersen, O M.]]		[[Category: Andersen, O M.]]
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	[[Category: Schmieder, P.]]		[[Category: Schmieder, P.]]
	[[Category: Werther, T.]]		[[Category: Werther, T.]]
		+	[[Category: Chaperone]]

OCA: Protected "2rqm" [edit=sysop:move=sysop]

OCA — Wed, 13 Apr 2011 04:26:57 GMT

Protected "2rqm" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:26, 13 April 2011

OCA at 04:26, 13 April 2011

OCA — Wed, 13 Apr 2011 04:26:55 GMT

←Older revision		Revision as of 04:26, 13 April 2011
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-	{{Seed}}
	[[Image:2rqm.png\|left\|200px]]		[[Image:2rqm.png\|left\|200px]]

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	===NMR Solution Structure of Mesoderm Development (MESD) - open conformation===		===NMR Solution Structure of Mesoderm Development (MESD) - open conformation===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21397185}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21397185 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21397185}}

	==About this Structure==		==About this Structure==
-	~~2RQM~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQM OCA].	+	[[2rqm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQM OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21397185</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Andersen, O M.]]		[[Category: Andersen, O M.]]
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	[[Category: Schmieder, P.]]		[[Category: Schmieder, P.]]
	[[Category: Werther, T.]]		[[Category: Werther, T.]]
-	[[Category: Chaperone]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 16:39:00 2009''

OCA: New page: {{Seed}} 200px