2rqs - Revision history

OCA at 07:06, 1 May 2024

OCA — Wed, 01 May 2024 07:06:00 GMT

←Older revision		Revision as of 07:06, 1 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rqs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cenarchaeum_symbiosum Cenarchaeum symbiosum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rqs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cenarchaeum_symbiosum Cenarchaeum symbiosum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqs OCA], [https://pdbe.org/2rqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqs RCSB], [https://www.ebi.ac.uk/pdbsum/2rqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqs ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqs OCA], [https://pdbe.org/2rqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqs RCSB], [https://www.ebi.ac.uk/pdbsum/2rqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/O74049_CENSY O74049_CENSY]		[https://www.uniprot.org/uniprot/O74049_CENSY O74049_CENSY]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Parvulins are a group of peptidyl-prolyl isomerases (PPIases) responsible for important biological processes in all kingdoms of life. The PinA protein from the psychrophilic archaeon Cenarchaeum symbiosum is a parvulin-like PPIase. Due to its striking similarity to the human parvulins Pin1 and Par14, PinA constitutes an interesting subject for structural and functional studies. Here, we present the first high resolution NMR structure of an archaeal parvulin, PinA, based on 1798 conformational restraints. Structure calculation yields an ensemble of 20 convergent low energy structures with a backbone r.m.s.d. value of 0.6 A within the secondary structure elements. The overall fold of PinA comprises the beta-alpha(3)-beta-alpha-beta(2) fold typical for all parvulin structures known so far, but with helix III being a short 3(10)-helix. A detailed comparison of this high resolution structure of the first archaeal PinA protein with bacterial and eukaryotic parvulin PPIase structures reveals an atypically large catalytic binding site. This feature provides an explanation for cold-adapted protein function. Moreover, the residues in and around 3(10)-helix III exhibit strong intramolecular dynamics on a microsecond to millisecond timescale and display structural heterogeneity within the NMR ensemble. A putative peptide ligand was found for PinA by phage display and was used for (1)H-(15)N-HSQC titrations. Again, the flexible region around 3(10)-helix III as well as residues of the peptide binding pocket showed the strongest chemical shift perturbations upon peptide binding. The local flexibility of this region also was modulated by ligand binding. A glycine and two positively charged residues are conserved in most parvulin proteins in this flexible loop region, which may be of general functional importance for parvulin-type PPIases.
-
-	Structure and Dynamics of the First Archaeal Parvulin Reveal a New Functionally Important Loop in Parvulin-type Prolyl Isomerases.,Jaremko L, Jaremko M, Elfaki I, Mueller JW, Ejchart A, Bayer P, Zhukov I J Biol Chem. 2011 Feb 25;286(8):6554-65. Epub 2010 Dec 7. PMID:21138844<ref>PMID:21138844</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2rqs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Peptidyl-prolyl cis-trans isomerase 3D structures\|Peptidyl-prolyl cis-trans isomerase 3D structures]]		*[[Peptidyl-prolyl cis-trans isomerase 3D structures\|Peptidyl-prolyl cis-trans isomerase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:51, 12 April 2023

OCA — Wed, 12 Apr 2023 20:51:37 GMT

←Older revision		Revision as of 20:51, 12 April 2023
Line 1:		Line 1:

	==3D structure of Pin from the psychrophilic archeon Cenarcheaum symbiosum (CsPin)==		==3D structure of Pin from the psychrophilic archeon Cenarcheaum symbiosum (CsPin)==
-	<StructureSection load='2rqs' size='340' side='right'caption='[[2rqs~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2rqs' size='340' side='right'caption='[[2rqs]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rqs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"cenarchaeum_symbiosum"_delong_and_preston_1996 "cenarchaeum~~ symbiosum~~" delong and preston 1996~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rqs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cenarchaeum_symbiosum Cenarchaeum symbiosum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQS FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pinA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46770 "Cenarchaeum symbiosum" DeLong and Preston 1996])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqs OCA], [https://pdbe.org/2rqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqs RCSB], [https://www.ebi.ac.uk/pdbsum/2rqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqs ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqs OCA], [https://pdbe.org/2rqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqs RCSB], [https://www.ebi.ac.uk/pdbsum/2rqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqs ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O74049_CENSY O74049_CENSY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cenarchaeum symbiosum ~~delong and preston 1996~~]]	+	[[Category: Cenarchaeum symbiosum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Peptidylprolyl isomerase]]~~	+	[[Category: Bayer P]]
-	[[Category: Bayer, P]]	+	[[Category: Jaremko L]]
-	[[Category: Jaremko, L]]	+	[[Category: Jaremko M]]
-	[[Category: Jaremko, M]]	+	[[Category: Mueller JW]]
-	[[Category: Mueller~~, J W~~]]	+	[[Category: Zhukov I]]
-	[[Category: Zhukov, I]]	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cenarcheaum symbiosum]]~~	+
-	~~[[Category: Cis/trans isomerisation]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Low temperature]]~~	+
-	~~[[Category: Nima-kinase]]~~	+
-	~~[[Category: Parvulin]]~~	+
-	~~[[Category: Pin1~~]]	+

OCA at 10:35, 7 July 2021

OCA — Wed, 07 Jul 2021 10:35:35 GMT

←Older revision		Revision as of 10:35, 7 July 2021
Line 1:		Line 1:

	==3D structure of Pin from the psychrophilic archeon Cenarcheaum symbiosum (CsPin)==		==3D structure of Pin from the psychrophilic archeon Cenarcheaum symbiosum (CsPin)==
-	<StructureSection load='2rqs' size='340' side='right' caption='[[2rqs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2rqs' size='340' side='right'caption='[[2rqs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rqs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"cenarchaeum_symbiosum"_delong_and_preston_1996 "cenarchaeum symbiosum" delong and preston 1996]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rqs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"cenarchaeum_symbiosum"_delong_and_preston_1996 "cenarchaeum symbiosum" delong and preston 1996]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQS FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pinA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46770 "Cenarchaeum symbiosum" DeLong and Preston 1996])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pinA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46770 "Cenarchaeum symbiosum" DeLong and Preston 1996])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqs OCA], [~~http~~://pdbe.org/2rqs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rqs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rqs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqs OCA], [https://pdbe.org/2rqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqs RCSB], [https://www.ebi.ac.uk/pdbsum/2rqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Peptidyl-prolyl cis-trans isomerase\|Peptidyl-prolyl cis-trans isomerase]]	+	*[[Peptidyl-prolyl cis-trans isomerase 3D structures\|Peptidyl-prolyl cis-trans isomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Cenarchaeum symbiosum delong and preston 1996]]		[[Category: Cenarchaeum symbiosum delong and preston 1996]]
		+	[[Category: Large Structures]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Bayer, P]]		[[Category: Bayer, P]]

OCA at 21:09, 11 August 2016

OCA — Thu, 11 Aug 2016 21:09:14 GMT

←Older revision		Revision as of 21:09, 11 August 2016
Line 1:		Line 1:
		+
	==3D structure of Pin from the psychrophilic archeon Cenarcheaum symbiosum (CsPin)==		==3D structure of Pin from the psychrophilic archeon Cenarcheaum symbiosum (CsPin)==
	<StructureSection load='2rqs' size='340' side='right' caption='[[2rqs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rqs' size='340' side='right' caption='[[2rqs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rqs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cenarchaeum_symbiosum Cenarchaeum~~ symbiosum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rqs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"cenarchaeum_symbiosum"_delong_and_preston_1996 "cenarchaeum symbiosum" delong and preston 1996]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQS FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pinA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46770 Cenarchaeum symbiosum])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pinA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46770 "Cenarchaeum symbiosum" DeLong and Preston 1996])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rqs RCSB], [http://www.ebi.ac.uk/pdbsum/2rqs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqs OCA], [http://pdbe.org/2rqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rqs RCSB], [http://www.ebi.ac.uk/pdbsum/2rqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2rqs" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Peptidyl-prolyl cis-trans isomerase\|Peptidyl-prolyl cis-trans isomerase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cenarchaeum symbiosum]]	+	[[Category: Cenarchaeum symbiosum delong and preston 1996]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Bayer, P]]		[[Category: Bayer, P]]

OCA at 11:12, 25 January 2015

OCA — Sun, 25 Jan 2015 11:12:25 GMT

←Older revision		Revision as of 11:12, 25 January 2015
Line 21:		Line 21:
	[[Category: Cenarchaeum symbiosum]]		[[Category: Cenarchaeum symbiosum]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
-	[[Category: Bayer, P.]]	+	[[Category: Bayer, P]]
-	[[Category: Jaremko, L.]]	+	[[Category: Jaremko, L]]
-	[[Category: Jaremko, M.]]	+	[[Category: Jaremko, M]]
-	[[Category: Mueller, J W.]]	+	[[Category: Mueller, J W]]
-	[[Category: Zhukov, I.]]	+	[[Category: Zhukov, I]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Cenarcheaum symbiosum]]		[[Category: Cenarcheaum symbiosum]]

OCA at 09:24, 5 November 2014

OCA — Wed, 05 Nov 2014 09:24:59 GMT

←Older revision		Revision as of 09:24, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~2rqs.~~png~~\|~~left\|200px~~]]	+	==3D structure of Pin from the psychrophilic archeon Cenarcheaum symbiosum (CsPin)==
		+	<StructureSection load='2rqs' size='340' side='right' caption='[[2rqs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2rqs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cenarchaeum_symbiosum Cenarchaeum symbiosum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RQS FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pinA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46770 Cenarchaeum symbiosum])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rqs RCSB], [http://www.ebi.ac.uk/pdbsum/2rqs PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Parvulins are a group of peptidyl-prolyl isomerases (PPIases) responsible for important biological processes in all kingdoms of life. The PinA protein from the psychrophilic archaeon Cenarchaeum symbiosum is a parvulin-like PPIase. Due to its striking similarity to the human parvulins Pin1 and Par14, PinA constitutes an interesting subject for structural and functional studies. Here, we present the first high resolution NMR structure of an archaeal parvulin, PinA, based on 1798 conformational restraints. Structure calculation yields an ensemble of 20 convergent low energy structures with a backbone r.m.s.d. value of 0.6 A within the secondary structure elements. The overall fold of PinA comprises the beta-alpha(3)-beta-alpha-beta(2) fold typical for all parvulin structures known so far, but with helix III being a short 3(10)-helix. A detailed comparison of this high resolution structure of the first archaeal PinA protein with bacterial and eukaryotic parvulin PPIase structures reveals an atypically large catalytic binding site. This feature provides an explanation for cold-adapted protein function. Moreover, the residues in and around 3(10)-helix III exhibit strong intramolecular dynamics on a microsecond to millisecond timescale and display structural heterogeneity within the NMR ensemble. A putative peptide ligand was found for PinA by phage display and was used for (1)H-(15)N-HSQC titrations. Again, the flexible region around 3(10)-helix III as well as residues of the peptide binding pocket showed the strongest chemical shift perturbations upon peptide binding. The local flexibility of this region also was modulated by ligand binding. A glycine and two positively charged residues are conserved in most parvulin proteins in this flexible loop region, which may be of general functional importance for parvulin-type PPIases.

-	~~{{STRUCTURE_2rqs\| PDB=2rqs \| SCENE= }}~~	+	Structure and Dynamics of the First Archaeal Parvulin Reveal a New Functionally Important Loop in Parvulin-type Prolyl Isomerases.,Jaremko L, Jaremko M, Elfaki I, Mueller JW, Ejchart A, Bayer P, Zhukov I J Biol Chem. 2011 Feb 25;286(8):6554-65. Epub 2010 Dec 7. PMID:21138844<ref>PMID:21138844</ref>

-	~~===3D structure~~ of ~~Pin from~~ the ~~psychrophilic archeon Cenarcheaum symbiosum (CsPin)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21138844}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2rqs]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Cenarchaeum_symbiosum Cenarchaeum symbiosum]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2RQS OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021138844<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Cenarchaeum symbiosum]]		[[Category: Cenarchaeum symbiosum]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]

OCA at 13:05, 30 January 2013

OCA — Wed, 30 Jan 2013 13:05:57 GMT

←Older revision		Revision as of 13:05, 30 January 2013
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	[[Image:2rqs.png\|left\|200px]]		[[Image:2rqs.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2rqs", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2rqs\| PDB=2rqs \| SCENE= }}		{{STRUCTURE_2rqs\| PDB=2rqs \| SCENE= }}

	===3D structure of Pin from the psychrophilic archeon Cenarcheaum symbiosum (CsPin)===		===3D structure of Pin from the psychrophilic archeon Cenarcheaum symbiosum (CsPin)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21138844}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21138844 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21138844}}		{{ABSTRACT_PUBMED_21138844}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21138844~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021138844</ref><references group="xtra"/>
	[[Category: Cenarchaeum symbiosum]]		[[Category: Cenarchaeum symbiosum]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
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	[[Category: Mueller, J W.]]		[[Category: Mueller, J W.]]
	[[Category: Zhukov, I.]]		[[Category: Zhukov, I.]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cenarcheaum symbiosum]]
		+	[[Category: Cis/trans isomerisation]]
		+	[[Category: Isomerase]]
		+	[[Category: Low temperature]]
		+	[[Category: Nima-kinase]]
		+	[[Category: Parvulin]]
		+	[[Category: Pin1]]

OCA: Protected "2rqs" [edit=sysop:move=sysop]

OCA — Wed, 23 Mar 2011 05:58:56 GMT

Protected "2rqs" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:58, 23 March 2011

OCA at 05:58, 23 March 2011

OCA — Wed, 23 Mar 2011 05:58:53 GMT

←Older revision		Revision as of 05:58, 23 March 2011
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-	~~{{Seed}}~~	+	[[Image:2rqs.png\|left\|200px]]
-	[[Image:2rqs.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	===3D structure of Pin from the psychrophilic archeon Cenarcheaum symbiosum (CsPin)===		===3D structure of Pin from the psychrophilic archeon Cenarcheaum symbiosum (CsPin)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21138844}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21138844 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21138844}}

	==About this Structure==		==About this Structure==
-	~~2RQS~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cenarchaeum_symbiosum Cenarchaeum symbiosum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQS OCA].	+	[[2rqs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cenarchaeum_symbiosum Cenarchaeum symbiosum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQS OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21138844</ref><references group="xtra"/>
	[[Category: Cenarchaeum symbiosum]]		[[Category: Cenarchaeum symbiosum]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
Line 20:		Line 28:
	[[Category: Jaremko, L.]]		[[Category: Jaremko, L.]]
	[[Category: Jaremko, M.]]		[[Category: Jaremko, M.]]
-	[[Category: Mueller, J.]]	+	[[Category: Mueller, J W.]]
	[[Category: Zhukov, I.]]		[[Category: Zhukov, I.]]
-	[[Category: Cell cycle]]
-	[[Category: Cenarcheaum symbiosum]]
-	[[Category: Cis/trans isomerisation]]
-	[[Category: Isomerase]]
-	[[Category: Low temperature]]
-	[[Category: Nima-kinase]]
-	[[Category: Parvulin]]
-	[[Category: Pin1]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 14:10:03 2010''

OCA at 10:58, 24 November 2010

OCA — Wed, 24 Nov 2010 10:58:32 GMT

←Older revision		Revision as of 10:58, 24 November 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2rqs.jpg\|left\|200px]]

-	The ~~entry 2rqs~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2rqs", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2rqs\| PDB=2rqs \| SCENE= }}

-	~~Authors: Zhukov, I., Jaremko, L., Jaremko, M., Mueller, J., Bayer, P.~~	+	===3D structure of Pin from the psychrophilic archeon Cenarcheaum symbiosum (CsPin)===

-	Description: 3D structure of Pin from the psychrophilic archeon Cenarcheaum symbiosum (CsPin)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 21 09~~:20:30 2010''	+	==About this Structure==
		+	2RQS is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cenarchaeum_symbiosum Cenarchaeum symbiosum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQS OCA].
		+	[[Category: Cenarchaeum symbiosum]]
		+	[[Category: Peptidylprolyl isomerase]]
		+	[[Category: Bayer, P.]]
		+	[[Category: Jaremko, L.]]
		+	[[Category: Jaremko, M.]]
		+	[[Category: Mueller, J.]]
		+	[[Category: Zhukov, I.]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cenarcheaum symbiosum]]
		+	[[Category: Cis/trans isomerisation]]
		+	[[Category: Isomerase]]
		+	[[Category: Low temperature]]
		+	[[Category: Nima-kinase]]
		+	[[Category: Parvulin]]
		+	[[Category: Pin1]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 14:10:03 2010''