2rsv - Revision history

OCA at 20:52, 12 April 2023

OCA — Wed, 12 Apr 2023 20:52:25 GMT

←Older revision		Revision as of 20:52, 12 April 2023
Line 1:		Line 1:

	==Solution structure of human full-length vaccinia related kinase 1 (VRK1)==		==Solution structure of human full-length vaccinia related kinase 1 (VRK1)==
-	<StructureSection load='2rsv' size='340' side='right'caption='[[2rsv~~]], [[NMR_Ensembles_of_Models \| 18 NMR models~~]]' scene=''>	+	<StructureSection load='2rsv' size='340' side='right'caption='[[2rsv]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rsv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RSV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rsv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RSV FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VRK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rsv OCA], [https://pdbe.org/2rsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rsv RCSB], [https://www.ebi.ac.uk/pdbsum/2rsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rsv ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rsv OCA], [https://pdbe.org/2rsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rsv RCSB], [https://www.ebi.ac.uk/pdbsum/2rsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rsv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>	+	[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>

	==See Also==		==See Also==
Line 19:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Kigawa T]]
-	[[Category: Kigawa, T]]	+	[[Category: Koshiba S]]
-	[[Category: Koshiba, S]]	+	[[Category: Tochio N]]
-	[[Category: Tochio, N]]	+	[[Category: Yokoyama J]]
-	[[Category: Yokoyama, J]]	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Vrk~~]]	+

OCA at 10:36, 7 July 2021

OCA — Wed, 07 Jul 2021 10:36:27 GMT

←Older revision		Revision as of 10:36, 7 July 2021
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Solution structure of human full-length vaccinia related kinase 1 (VRK1)==		==Solution structure of human full-length vaccinia related kinase 1 (VRK1)==
-	<StructureSection load='2rsv' size='340' side='right' caption='[[2rsv]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>	+	<StructureSection load='2rsv' size='340' side='right'caption='[[2rsv]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rsv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RSV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rsv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RSV FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VRK1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VRK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rsv OCA], [~~http~~://pdbe.org/2rsv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rsv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rsv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rsv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rsv OCA], [https://pdbe.org/2rsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rsv RCSB], [https://www.ebi.ac.uk/pdbsum/2rsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rsv ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>	+	[[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>

	==See Also==		==See Also==
-	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]	+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 11:07, 4 August 2016

OCA — Thu, 04 Aug 2016 11:07:36 GMT

←Older revision		Revision as of 11:07, 4 August 2016
Line 1:		Line 1:
		+	{{Large structure}}
	==Solution structure of human full-length vaccinia related kinase 1 (VRK1)==		==Solution structure of human full-length vaccinia related kinase 1 (VRK1)==
	<StructureSection load='2rsv' size='340' side='right' caption='[[2rsv]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>		<StructureSection load='2rsv' size='340' side='right' caption='[[2rsv]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VRK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VRK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rsv RCSB], [http://www.ebi.ac.uk/pdbsum/2rsv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rsv OCA], [http://pdbe.org/2rsv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rsv RCSB], [http://www.ebi.ac.uk/pdbsum/2rsv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rsv ProSAT]</span></td></tr>
	</table>		</table>
		+	{{Large structure}}
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.

OCA at 17:59, 21 December 2014

OCA — Sun, 21 Dec 2014 17:59:07 GMT

←Older revision		Revision as of 17:59, 21 December 2014
Line 1:		Line 1:
-	~~{{Large structure}}~~	+	==Solution structure of human full-length vaccinia related kinase 1 (VRK1)==
-	~~{{STRUCTURE_2rsv\| PDB=2rsv \| SCENE= }}~~	+	<StructureSection load='2rsv' size='340' side='right' caption='[[2rsv]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
-	===Solution structure of human full-length vaccinia related kinase 1 (VRK1)===	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2rsv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RSV FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VRK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rsv RCSB], [http://www.ebi.ac.uk/pdbsum/2rsv PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>		[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~2rsv]] is a 1 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=2RSV OCA~~].	+	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Kigawa, T.]]	+	[[Category: Kigawa, T]]
-	[[Category: Koshiba, S.]]	+	[[Category: Koshiba, S]]
-	[[Category: Tochio, N.]]	+	[[Category: Tochio, N]]
-	[[Category: Yokoyama, J.]]	+	[[Category: Yokoyama, J]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Vrk]]		[[Category: Vrk]]

OCA at 07:26, 4 December 2013

OCA — Wed, 04 Dec 2013 07:26:51 GMT

←Older revision		Revision as of 07:26, 4 December 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{Large structure}}
		+	{{STRUCTURE_2rsv\| PDB=2rsv \| SCENE= }}
		+	===Solution structure of human full-length vaccinia related kinase 1 (VRK1)===

-	The ~~entry 2rsv~~ is ~~ON HOLD until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.

-	~~Authors~~: ~~Koshiba, S~~.~~, Tochio, N~~., ~~Yokoyama, J~~., ~~Kigawa, T~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>

-	~~Description: Solution~~ structure ~~of human full~~-~~length vaccinia related~~ kinase ~~1 (VRK1)~~	+	==About this Structure==
		+	[[2rsv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSV OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Kigawa, T.]]
		+	[[Category: Koshiba, S.]]
		+	[[Category: Tochio, N.]]
		+	[[Category: Yokoyama, J.]]
		+	[[Category: Kinase]]
		+	[[Category: Transferase]]
		+	[[Category: Vrk]]

OCA at 05:15, 22 August 2012

OCA — Wed, 22 Aug 2012 05:15:50 GMT

←Older revision		Revision as of 05:15, 22 August 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2rsv is ON HOLD	+	The entry 2rsv is ON HOLD until Paper Publication

	Authors: Koshiba, S., Tochio, N., Yokoyama, J., Kigawa, T.		Authors: Koshiba, S., Tochio, N., Yokoyama, J., Kigawa, T.

	Description: Solution structure of human full-length vaccinia related kinase 1 (VRK1)		Description: Solution structure of human full-length vaccinia related kinase 1 (VRK1)

OCA: Protected "2rsv" [edit=sysop:move=sysop]

OCA — Wed, 18 Jul 2012 04:45:30 GMT

Protected "2rsv" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:45, 18 July 2012

OCA: New page: '''Unreleased structure''' The entry 2rsv is ON HOLD Authors: Koshiba, S., Tochio, N., Yokoyama, J., Kigawa, T. Description: Solution structure of human full-length vaccinia related ki...

OCA — Wed, 18 Jul 2012 04:45:29 GMT

New page: '''Unreleased structure''' The entry 2rsv is ON HOLD Authors: Koshiba, S., Tochio, N., Yokoyama, J., Kigawa, T. Description: Solution structure of human full-length vaccinia related ki...

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'''Unreleased structure'''

The entry 2rsv is ON HOLD

Authors: Koshiba, S., Tochio, N., Yokoyama, J., Kigawa, T.

Description: Solution structure of human full-length vaccinia related kinase 1 (VRK1)