2uwe - Revision history

OCA at 14:55, 13 December 2023

OCA — Wed, 13 Dec 2023 14:55:55 GMT

←Older revision		Revision as of 14:55, 13 December 2023
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	<StructureSection load='2uwe' size='340' side='right'caption='[[2uwe]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2uwe' size='340' side='right'caption='[[2uwe]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uwe]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2UWE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uwe]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UWE FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1akj\|1akj]]~~, [[~~1ao7~~\|~~1ao7~~]], [[1aqd\|1aqd]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1duy\|1duy]], [[1duz\|1duz]], [[1eey\|1eey]], [[1eez\|1eez]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1jf1\|1jf1]], [[1jht\|1jht]], [[1lp9\|1lp9]], [[1oga\|1oga]], [[1p7q\|1p7q]], [[1qew\|1qew]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1s8d\|1s8d]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1t1w\|1t1w]], [[1t1x\|1t1x]], [[1t1y\|1t1y]], [[1t1z\|1t1z]], [[1t20\|1t20]], [[1t21\|1t21]], [[1t22\|1t22]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1ur7\|1ur7]], [[2av1\|2av1]], [[2av7\|2av7]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2c7u\|2c7u]], [[2clr\|2clr]], [[2gj6\|2gj6]], [[2jcc\|2jcc]], [[3hla\|3hla]], [[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1e27\|1e27]], [[1e28\|1e28]], [[1efx\|1efx]], [[1exu\|1exu]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1im9\|1im9]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jnj\|1jnj]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1of2\|1of2]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1uqs\|1uqs]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bvq\|2bvq]], [[2cii\|2cii]], [[2cik\|2cik]], [[2d31\|2d31]], [[2esv\|2esv]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2h26\|2h26]], [[2hjk\|2hjk]], [[2hjl\|2hjl]], [[2hla\|2hla]]</div></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwe OCA], [~~http~~://pdbe.org/2uwe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2uwe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2uwe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwe OCA], [https://pdbe.org/2uwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uwe RCSB], [https://www.ebi.ac.uk/pdbsum/2uwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwe ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/HLAA_HUMAN HLAA_HUMAN] Selection of immunotherapy in solid cancer;Birdshot chorioretinopathy;Prediction of phenytoin or carbamazepine toxicity. Alleles A02:01 and A24:02 are associated with increased susceptibility to diabetes mellitus, insulin-dependent (IDDM) (PubMed:22245737, PubMed:18802479, PubMed:16731854, PubMed:22522618). In a glucose-dependent way, allele A02:01 may aberrantly present the signal peptide of preproinsulin (ALWGPDPAAA) on the surface of pancreatic beta cells to autoreactive CD8-positive T cells, potentially driving T-cell mediated cytotoxicity in pancreatic islets (PubMed:22245737, PubMed:18802479). Allele A24:02 may present the signal peptide of preproinsulin (LWMRLLPLL) and contribute to acute pancreatic beta-cell destruction and early onset of IDDM (PubMed:16731854, PubMed:22522618).<ref>PMID:16731854</ref> <ref>PMID:18802479</ref> <ref>PMID:22245737</ref> <ref>PMID:22522618</ref> Allele A03:01 is associated with increased susceptibility to multiple sclerosis (MS), an autoimmune disease of the central nervous system (PubMed:10746785). May contribute to the initiation phase of the disease by presenting myelin PLP1 self-peptide (KLIETYFSK) to autoreactive CD8-positive T cells capable of initiating the first autoimmune attacks (PubMed:18953350).<ref>PMID:10746785</ref> <ref>PMID:18953350</ref> Allele A26:01 is associated with increased susceptibility to Behcet disease (BD) in the Northeast Asian population. Especially in the HLA-B51-negative BD populations, HLA-A26 is significantly associated with the onset of BD.<ref>PMID:30872678</ref> Allele A*29:02 is associated with increased susceptibility to birdshot chorioretinopathy (BSCR). May aberrantly present retinal autoantigens and induce autoimmune uveitis.<ref>PMID:1728143</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~1A02_HUMAN 1A02_HUMAN~~]~~] Involved~~ in the ~~presentation~~ of ~~foreign~~ antigens to the immune ~~system~~.	+	[https://www.uniprot.org/uniprot/HLAA_HUMAN HLAA_HUMAN] Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:2456340, PubMed:2784196, PubMed:1402688, PubMed:7504010, PubMed:9862734, PubMed:10449296, PubMed:12138174, PubMed:12393434, PubMed:15893615, PubMed:17189421, PubMed:19543285, PubMed:21498667, PubMed:24192765, PubMed:7694806, PubMed:24395804, PubMed:28250417). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728, PubMed:7679507). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17189421, PubMed:20364150, PubMed:17079320, PubMed:26929325, PubMed:27049119). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:7504010, PubMed:9862734).<ref>PMID:10449296</ref> <ref>PMID:12138174</ref> <ref>PMID:12393434</ref> <ref>PMID:12796775</ref> <ref>PMID:1402688</ref> <ref>PMID:15893615</ref> <ref>PMID:17079320</ref> <ref>PMID:17189421</ref> <ref>PMID:18275829</ref> <ref>PMID:19542454</ref> <ref>PMID:19543285</ref> <ref>PMID:20364150</ref> <ref>PMID:21498667</ref> <ref>PMID:24192765</ref> <ref>PMID:24395804</ref> <ref>PMID:2456340</ref> <ref>PMID:25880248</ref> <ref>PMID:26929325</ref> <ref>PMID:27049119</ref> <ref>PMID:2784196</ref> <ref>PMID:28250417</ref> <ref>PMID:7504010</ref> <ref>PMID:7506728</ref> <ref>PMID:7679507</ref> <ref>PMID:7694806</ref> <ref>PMID:9862734</ref> Allele A01:01: Presents a restricted peptide repertoire including viral epitopes derived from IAV NP/nucleoprotein (CTELKLSDY), IAV PB1/polymerase basic protein 1 (VSDGGPNLY), HAdV-11 capsid L3/hexon protein (LTDLGQNLLY), SARS-CoV-2 3a/ORF3a (FTSDYYQLY) as well as tumor peptide antigens including MAGE1 (EADPTGHSY), MAGEA3 (EVDPIGHLY) and WT1 (TSEKRPFMCAY), all having in common a canonical motif with a negatively charged Asp or Glu residue at position 3 and a Tyr anchor residue at the C-terminus (PubMed:1402688, PubMed:7504010, PubMed:17189421, PubMed:20364150, PubMed:25880248, PubMed:30530481, PubMed:19177349, PubMed:24395804, PubMed:26758806, PubMed:32887977). A number of HLA-A01:01-restricted peptides carry a post-translational modification with oxidation and N-terminal acetylation being the most frequent (PubMed:25880248). Fails to present highly immunogenic peptides from the EBV latent antigens (PubMed:18779413).<ref>PMID:1402688</ref> <ref>PMID:17189421</ref> <ref>PMID:18779413</ref> <ref>PMID:19177349</ref> <ref>PMID:20364150</ref> <ref>PMID:24395804</ref> <ref>PMID:25880248</ref> <ref>PMID:26758806</ref> <ref>PMID:30530481</ref> <ref>PMID:7504010</ref> Allele A02:01: A major allele in human populations, presents immunodominant viral epitopes derived from IAV M/matrix protein 1 (GILGFVFTL), HIV-1 env (TLTSCNTSV), HIV-1 gag-pol (ILKEPVHGV), HTLV-1 Tax (LLFGYPVYV), HBV C/core antigen (FLPSDFFPS), HCMV UL83/pp65 (NLVPMVATV) as well as tumor peptide antigens including MAGEA4 (GVYDGREHTV), WT1 (RMFPNAPYL) and CTAG1A/NY-ESO-1 (SLLMWITQC), all having in common hydrophobic amino acids at position 2 and at the C-terminal anchors.<ref>PMID:11502003</ref> <ref>PMID:12138174</ref> <ref>PMID:12796775</ref> <ref>PMID:17079320</ref> <ref>PMID:18275829</ref> <ref>PMID:19542454</ref> <ref>PMID:20619457</ref> <ref>PMID:22245737</ref> <ref>PMID:26929325</ref> <ref>PMID:2784196</ref> <ref>PMID:28250417</ref> <ref>PMID:7694806</ref> <ref>PMID:7935798</ref> <ref>PMID:8630735</ref> <ref>PMID:8805302</ref> <ref>PMID:8906788</ref> <ref>PMID:9177355</ref> Allele A03:01: Presents viral epitopes derived from IAV NP (ILRGSVAHK), HIV-1 nef (QVPLRPMTYK), HIV-1 gag-pol (AIFQSSMTK), SARS-CoV-2 N/nucleoprotein (KTFPPTEPK) as well as tumor peptide antigens including PMEL (LIYRRRLMK), NODAL (HAYIQSLLK), TRP-2 (RMYNMVPFF), all having in common hydrophobic amino acids at position 2 and Lys or Arg anchor residues at the C-terminus (PubMed:7504010, PubMed:7679507, PubMed:9862734, PubMed:19543285, PubMed:21943705, PubMed:2456340, PubMed:32887977). May also display spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119).<ref>PMID:19543285</ref> <ref>PMID:21943705</ref> <ref>PMID:2456340</ref> <ref>PMID:27049119</ref> <ref>PMID:7504010</ref> <ref>PMID:7679507</ref> <ref>PMID:9862734</ref> Allele A11:01: Presents several immunodominant epitopes derived from HIV-1 gag-pol and HHV-4 EBNA4, containing the peptide motif with Val, Ile, Thr, Leu, Tyr or Phe at position 2 and Lys anchor residue at the C-terminus. Important in the control of HIV-1, EBV and HBV infections (PubMed:10449296). Presents an immunodominant epitope derived from SARS-CoV-2 N/nucleoprotein (KTFPPTEPK) (PubMed:32887977).<ref>PMID:10449296</ref> <ref>PMID:32887977</ref> Allele A23:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response.<ref>PMID:17182537</ref> Allele A24:02: Presents viral epitopes derived from HIV-1 nef (RYPLTFGWCF), EBV lytic- and latent-cycle antigens BRLF1 (TYPVLEEMF), BMLF1 (DYNFVKQLF) and LMP2 (IYVLVMLVL), SARS-CoV nucleocapsid/N (QFKDNVILL), as well as tumor peptide antigens including PRAME (LYVDSLFFL), all sharing a common signature motif, namely an aromatic residue Tyr or Phe at position 2 and a nonhydrophobic anchor residue Phe, Leu or Iso at the C-terminus (PubMed:9047241, PubMed:12393434, PubMed:24192765, PubMed:20844028). Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response (PubMed:17182537, PubMed:18502829).<ref>PMID:12393434</ref> <ref>PMID:17182537</ref> <ref>PMID:18502829</ref> <ref>PMID:20844028</ref> <ref>PMID:24192765</ref> <ref>PMID:9047241</ref> Allele A26:01: Presents several epitopes derived from HIV-1 gag-pol (EVIPMFSAL, ETKLGKAGY) and env (LVSDGGPNLY), carrying as anchor residues preferentially Glu at position 1, Val or Thr at position 2 and Tyr at the C-terminus.<ref>PMID:15893615</ref> Allele A29:02: Presents peptides having a common motif, namely a Glu residue at position 2 and Tyr or Leu anchor residues at the C-terminus.<ref>PMID:8622959</ref> Allele A32:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response.<ref>PMID:17182537</ref> Allele A68:01: Presents viral epitopes derived from IAV NP (KTGGPIYKR) and HIV-1 tat (ITKGLGISYGR), having a common signature motif namely, Val or Thr at position 2 and positively charged residues Arg or Lys at the C-terminal anchor.<ref>PMID:1448153</ref> <ref>PMID:1448154</ref> <ref>PMID:2784196</ref> Allele A74:01: Presents immunodominant HIV-1 epitopes derived from gag-pol (GQMVHQAISPR, QIYPGIKVR) and rev (RQIHSISER), carrying an aliphatic residue at position 2 and Arg anchor residue at the C-terminus. May contribute to viral load control in chronic HIV-1 infection.<ref>PMID:21498667</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	*[[MHC 3D structures\|MHC 3D structures]]		*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Appella, E]]	+	[[Category: Appella E]]
-	[[Category: Biddison~~, W E~~]]	+	[[Category: Biddison WE]]
-	[[Category: Collins~~, E J~~]]	+	[[Category: Collins EJ]]
-	[[Category: Conti, B]]	+	[[Category: Conti B]]
-	[[Category: Miller~~, P J~~]]	+	[[Category: Miller PJ]]
-	[[Category: Pazy, Y]]	+	[[Category: Pazy Y]]
-	[[Category: Riddle, D]]	+	[[Category: Riddle D]]
-	~~[[Category: Class i mhc]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Host-virus interaction]]~~	+
-	~~[[Category: Hypothetical protein]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Mhc i]]~~	+
-	~~[[Category: Pyrrolidone carboxylic acid]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: T cell signaling]]~~	+
-	~~[[Category: Tcr-pmhc complex]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 04:57, 19 November 2020

OCA — Thu, 19 Nov 2020 04:57:35 GMT

←Older revision		Revision as of 04:57, 19 November 2020
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2uwe]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2UWE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2uwe]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2UWE FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1akj\|1akj]], [[1ao7\|1ao7]], [[1aqd\|1aqd]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1duy\|1duy]], [[1duz\|1duz]], [[1eey\|1eey]], [[1eez\|1eez]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1jf1\|1jf1]], [[1jht\|1jht]], [[1lp9\|1lp9]], [[1oga\|1oga]], [[1p7q\|1p7q]], [[1qew\|1qew]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1s8d\|1s8d]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1t1w\|1t1w]], [[1t1x\|1t1x]], [[1t1y\|1t1y]], [[1t1z\|1t1z]], [[1t20\|1t20]], [[1t21\|1t21]], [[1t22\|1t22]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1ur7\|1ur7]], [[2av1\|2av1]], [[2av7\|2av7]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2c7u\|2c7u]], [[2clr\|2clr]], [[2gj6\|2gj6]], [[2jcc\|2jcc]], [[3hla\|3hla]], [[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1e27\|1e27]], [[1e28\|1e28]], [[1efx\|1efx]], [[1exu\|1exu]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1im9\|1im9]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jnj\|1jnj]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1of2\|1of2]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1uqs\|1uqs]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bvq\|2bvq]], [[2cii\|2cii]], [[2cik\|2cik]], [[2d31\|2d31]], [[2esv\|2esv]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2h26\|2h26]], [[2hjk\|2hjk]], [[2hjl\|2hjl]], [[2hla\|2hla]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1akj\|1akj]], [[1ao7\|1ao7]], [[1aqd\|1aqd]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1duy\|1duy]], [[1duz\|1duz]], [[1eey\|1eey]], [[1eez\|1eez]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1jf1\|1jf1]], [[1jht\|1jht]], [[1lp9\|1lp9]], [[1oga\|1oga]], [[1p7q\|1p7q]], [[1qew\|1qew]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1s8d\|1s8d]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1t1w\|1t1w]], [[1t1x\|1t1x]], [[1t1y\|1t1y]], [[1t1z\|1t1z]], [[1t20\|1t20]], [[1t21\|1t21]], [[1t22\|1t22]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1ur7\|1ur7]], [[2av1\|2av1]], [[2av7\|2av7]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2c7u\|2c7u]], [[2clr\|2clr]], [[2gj6\|2gj6]], [[2jcc\|2jcc]], [[3hla\|3hla]], [[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1e27\|1e27]], [[1e28\|1e28]], [[1efx\|1efx]], [[1exu\|1exu]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1im9\|1im9]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jnj\|1jnj]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1of2\|1of2]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1uqs\|1uqs]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bvq\|2bvq]], [[2cii\|2cii]], [[2cik\|2cik]], [[2d31\|2d31]], [[2esv\|2esv]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2h26\|2h26]], [[2hjk\|2hjk]], [[2hjl\|2hjl]], [[2hla\|2hla]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwe OCA], [http://pdbe.org/2uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwe RCSB], [http://www.ebi.ac.uk/pdbsum/2uwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwe OCA], [http://pdbe.org/2uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwe RCSB], [http://www.ebi.ac.uk/pdbsum/2uwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwe ProSAT]</span></td></tr>
	</table>		</table>
Line 31:		Line 31:
	==See Also==		==See Also==
	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	*[[MHC 3D structures ~~of MHC~~\|MHC 3D structures ~~of MHC~~]]	+	*[[MHC 3D structures\|MHC 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:12, 17 June 2020

OCA — Wed, 17 Jun 2020 11:12:20 GMT

←Older revision		Revision as of 11:12, 17 June 2020
Line 1:		Line 1:

	==Large CDR3a loop alteration as a function of MHC mutation==		==Large CDR3a loop alteration as a function of MHC mutation==
-	<StructureSection load='2uwe' size='340' side='right' caption='[[2uwe]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2uwe' size='340' side='right'caption='[[2uwe]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uwe]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2UWE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uwe]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2UWE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1akj\|1akj]], [[1ao7\|1ao7]], [[1aqd\|1aqd]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1duy\|1duy]], [[1duz\|1duz]], [[1eey\|1eey]], [[1eez\|1eez]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1jf1\|1jf1]], [[1jht\|1jht]], [[1lp9\|1lp9]], [[1oga\|1oga]], [[1p7q\|1p7q]], [[1qew\|1qew]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1s8d\|1s8d]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1t1w\|1t1w]], [[1t1x\|1t1x]], [[1t1y\|1t1y]], [[1t1z\|1t1z]], [[1t20\|1t20]], [[1t21\|1t21]], [[1t22\|1t22]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1ur7\|1ur7]], [[2av1\|2av1]], [[2av7\|2av7]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2c7u\|2c7u]], [[2clr\|2clr]], [[2gj6\|2gj6]], [[2jcc\|2jcc]], [[3hla\|3hla]], [[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1e27\|1e27]], [[1e28\|1e28]], [[1efx\|1efx]], [[1exu\|1exu]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1im9\|1im9]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jnj\|1jnj]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1of2\|1of2]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1uqs\|1uqs]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bvq\|2bvq]], [[2cii\|2cii]], [[2cik\|2cik]], [[2d31\|2d31]], [[2esv\|2esv]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2h26\|2h26]], [[2hjk\|2hjk]], [[2hjl\|2hjl]], [[2hla\|2hla]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1akj\|1akj]], [[1ao7\|1ao7]], [[1aqd\|1aqd]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1duy\|1duy]], [[1duz\|1duz]], [[1eey\|1eey]], [[1eez\|1eez]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1jf1\|1jf1]], [[1jht\|1jht]], [[1lp9\|1lp9]], [[1oga\|1oga]], [[1p7q\|1p7q]], [[1qew\|1qew]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1s8d\|1s8d]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1t1w\|1t1w]], [[1t1x\|1t1x]], [[1t1y\|1t1y]], [[1t1z\|1t1z]], [[1t20\|1t20]], [[1t21\|1t21]], [[1t22\|1t22]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1ur7\|1ur7]], [[2av1\|2av1]], [[2av7\|2av7]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2c7u\|2c7u]], [[2clr\|2clr]], [[2gj6\|2gj6]], [[2jcc\|2jcc]], [[3hla\|3hla]], [[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1e27\|1e27]], [[1e28\|1e28]], [[1efx\|1efx]], [[1exu\|1exu]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1im9\|1im9]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jnj\|1jnj]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1of2\|1of2]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1uqs\|1uqs]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bvq\|2bvq]], [[2cii\|2cii]], [[2cik\|2cik]], [[2d31\|2d31]], [[2esv\|2esv]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2h26\|2h26]], [[2hjk\|2hjk]], [[2hjl\|2hjl]], [[2hla\|2hla]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwe OCA], [http://pdbe.org/2uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwe RCSB], [http://www.ebi.ac.uk/pdbsum/2uwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwe OCA], [http://pdbe.org/2uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwe RCSB], [http://www.ebi.ac.uk/pdbsum/2uwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]	+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	*[[~~Major histocompatibility complex~~\|~~Major histocompatibility complex~~]]	+	*[[MHC 3D structures of MHC\|MHC 3D structures of MHC]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Appella, E]]		[[Category: Appella, E]]

OCA at 08:17, 12 September 2018

OCA — Wed, 12 Sep 2018 08:17:49 GMT

←Older revision		Revision as of 08:17, 12 September 2018
Line 1:		Line 1:
-	==~~LARGE CDR3A LOOP ALTERATION AS A FUNCTION OF~~ MHC ~~MUTATION~~==	+
		+	==Large CDR3a loop alteration as a function of MHC mutation==
	<StructureSection load='2uwe' size='340' side='right' caption='[[2uwe]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2uwe' size='340' side='right' caption='[[2uwe]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2uwe]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2uwe]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1akj\|1akj]], [[1ao7\|1ao7]], [[1aqd\|1aqd]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1duy\|1duy]], [[1duz\|1duz]], [[1eey\|1eey]], [[1eez\|1eez]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1jf1\|1jf1]], [[1jht\|1jht]], [[1lp9\|1lp9]], [[1oga\|1oga]], [[1p7q\|1p7q]], [[1qew\|1qew]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1s8d\|1s8d]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1t1w\|1t1w]], [[1t1x\|1t1x]], [[1t1y\|1t1y]], [[1t1z\|1t1z]], [[1t20\|1t20]], [[1t21\|1t21]], [[1t22\|1t22]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1ur7\|1ur7]], [[2av1\|2av1]], [[2av7\|2av7]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2c7u\|2c7u]], [[2clr\|2clr]], [[2gj6\|2gj6]], [[2jcc\|2jcc]], [[3hla\|3hla]], [[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1e27\|1e27]], [[1e28\|1e28]], [[1efx\|1efx]], [[1exu\|1exu]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1im9\|1im9]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jnj\|1jnj]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1of2\|1of2]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1uqs\|1uqs]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bvq\|2bvq]], [[2cii\|2cii]], [[2cik\|2cik]], [[2d31\|2d31]], [[2esv\|2esv]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2h26\|2h26]], [[2hjk\|2hjk]], [[2hjl\|2hjl]], [[2hla\|2hla]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1akj\|1akj]], [[1ao7\|1ao7]], [[1aqd\|1aqd]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1duy\|1duy]], [[1duz\|1duz]], [[1eey\|1eey]], [[1eez\|1eez]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1jf1\|1jf1]], [[1jht\|1jht]], [[1lp9\|1lp9]], [[1oga\|1oga]], [[1p7q\|1p7q]], [[1qew\|1qew]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1s8d\|1s8d]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1t1w\|1t1w]], [[1t1x\|1t1x]], [[1t1y\|1t1y]], [[1t1z\|1t1z]], [[1t20\|1t20]], [[1t21\|1t21]], [[1t22\|1t22]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1ur7\|1ur7]], [[2av1\|2av1]], [[2av7\|2av7]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2c7u\|2c7u]], [[2clr\|2clr]], [[2gj6\|2gj6]], [[2jcc\|2jcc]], [[3hla\|3hla]], [[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1e27\|1e27]], [[1e28\|1e28]], [[1efx\|1efx]], [[1exu\|1exu]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1im9\|1im9]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jnj\|1jnj]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1of2\|1of2]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1uqs\|1uqs]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bvq\|2bvq]], [[2cii\|2cii]], [[2cik\|2cik]], [[2d31\|2d31]], [[2esv\|2esv]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2h26\|2h26]], [[2hjk\|2hjk]], [[2hjl\|2hjl]], [[2hla\|2hla]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwe OCA], [http://pdbe.org/2uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwe RCSB], [http://www.ebi.ac.uk/pdbsum/2uwe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwe OCA], [http://pdbe.org/2uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwe RCSB], [http://www.ebi.ac.uk/pdbsum/2uwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwe_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwe_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:04, 8 February 2016

OCA — Mon, 08 Feb 2016 23:04:13 GMT

←Older revision		Revision as of 23:04, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2uwe' size='340' side='right' caption='[[2uwe]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2uwe' size='340' side='right' caption='[[2uwe]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uwe]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uwe]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1akj\|1akj]], [[1ao7\|1ao7]], [[1aqd\|1aqd]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1duy\|1duy]], [[1duz\|1duz]], [[1eey\|1eey]], [[1eez\|1eez]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1jf1\|1jf1]], [[1jht\|1jht]], [[1lp9\|1lp9]], [[1oga\|1oga]], [[1p7q\|1p7q]], [[1qew\|1qew]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1s8d\|1s8d]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1t1w\|1t1w]], [[1t1x\|1t1x]], [[1t1y\|1t1y]], [[1t1z\|1t1z]], [[1t20\|1t20]], [[1t21\|1t21]], [[1t22\|1t22]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1ur7\|1ur7]], [[2av1\|2av1]], [[2av7\|2av7]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2c7u\|2c7u]], [[2clr\|2clr]], [[2gj6\|2gj6]], [[2jcc\|2jcc]], [[3hla\|3hla]], [[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1e27\|1e27]], [[1e28\|1e28]], [[1efx\|1efx]], [[1exu\|1exu]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1im9\|1im9]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jnj\|1jnj]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1of2\|1of2]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1uqs\|1uqs]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bvq\|2bvq]], [[2cii\|2cii]], [[2cik\|2cik]], [[2d31\|2d31]], [[2esv\|2esv]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2h26\|2h26]], [[2hjk\|2hjk]], [[2hjl\|2hjl]], [[2hla\|2hla]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1akj\|1akj]], [[1ao7\|1ao7]], [[1aqd\|1aqd]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1duy\|1duy]], [[1duz\|1duz]], [[1eey\|1eey]], [[1eez\|1eez]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1jf1\|1jf1]], [[1jht\|1jht]], [[1lp9\|1lp9]], [[1oga\|1oga]], [[1p7q\|1p7q]], [[1qew\|1qew]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1s8d\|1s8d]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1t1w\|1t1w]], [[1t1x\|1t1x]], [[1t1y\|1t1y]], [[1t1z\|1t1z]], [[1t20\|1t20]], [[1t21\|1t21]], [[1t22\|1t22]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1ur7\|1ur7]], [[2av1\|2av1]], [[2av7\|2av7]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2c7u\|2c7u]], [[2clr\|2clr]], [[2gj6\|2gj6]], [[2jcc\|2jcc]], [[3hla\|3hla]], [[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1e27\|1e27]], [[1e28\|1e28]], [[1efx\|1efx]], [[1exu\|1exu]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1im9\|1im9]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jnj\|1jnj]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1of2\|1of2]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1uqs\|1uqs]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bvq\|2bvq]], [[2cii\|2cii]], [[2cik\|2cik]], [[2d31\|2d31]], [[2esv\|2esv]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2h26\|2h26]], [[2hjk\|2hjk]], [[2hjl\|2hjl]], [[2hla\|2hla]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwe RCSB], [http://www.ebi.ac.uk/pdbsum/2uwe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwe OCA], [http://pdbe.org/2uwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwe RCSB], [http://www.ebi.ac.uk/pdbsum/2uwe PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uwe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2uwe" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Appella, E]]		[[Category: Appella, E]]
	[[Category: Biddison, W E]]		[[Category: Biddison, W E]]

OCA at 02:45, 25 December 2014

OCA — Thu, 25 Dec 2014 02:45:07 GMT

←Older revision		Revision as of 02:45, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2uwe]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2uwe]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1akj\|1akj]], [[1ao7\|1ao7]], [[1aqd\|1aqd]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1duy\|1duy]], [[1duz\|1duz]], [[1eey\|1eey]], [[1eez\|1eez]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1jf1\|1jf1]], [[1jht\|1jht]], [[1lp9\|1lp9]], [[1oga\|1oga]], [[1p7q\|1p7q]], [[1qew\|1qew]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1s8d\|1s8d]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1t1w\|1t1w]], [[1t1x\|1t1x]], [[1t1y\|1t1y]], [[1t1z\|1t1z]], [[1t20\|1t20]], [[1t21\|1t21]], [[1t22\|1t22]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1ur7\|1ur7]], [[2av1\|2av1]], [[2av7\|2av7]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2c7u\|2c7u]], [[2clr\|2clr]], [[2gj6\|2gj6]], [[2jcc\|2jcc]], [[3hla\|3hla]], [[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1e27\|1e27]], [[1e28\|1e28]], [[1efx\|1efx]], [[1exu\|1exu]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1im9\|1im9]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jnj\|1jnj]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1of2\|1of2]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1uqs\|1uqs]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bvq\|2bvq]], [[2cii\|2cii]], [[2cik\|2cik]], [[2d31\|2d31]], [[2esv\|2esv]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2h26\|2h26]], [[2hjk\|2hjk]], [[2hjl\|2hjl]], [[2hla\|2hla]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1akj\|1akj]], [[1ao7\|1ao7]], [[1aqd\|1aqd]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1duy\|1duy]], [[1duz\|1duz]], [[1eey\|1eey]], [[1eez\|1eez]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1jf1\|1jf1]], [[1jht\|1jht]], [[1lp9\|1lp9]], [[1oga\|1oga]], [[1p7q\|1p7q]], [[1qew\|1qew]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1s8d\|1s8d]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1t1w\|1t1w]], [[1t1x\|1t1x]], [[1t1y\|1t1y]], [[1t1z\|1t1z]], [[1t20\|1t20]], [[1t21\|1t21]], [[1t22\|1t22]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1ur7\|1ur7]], [[2av1\|2av1]], [[2av7\|2av7]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2c7u\|2c7u]], [[2clr\|2clr]], [[2gj6\|2gj6]], [[2jcc\|2jcc]], [[3hla\|3hla]], [[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1e27\|1e27]], [[1e28\|1e28]], [[1efx\|1efx]], [[1exu\|1exu]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1im9\|1im9]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jnj\|1jnj]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1of2\|1of2]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1uqs\|1uqs]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bvq\|2bvq]], [[2cii\|2cii]], [[2cik\|2cik]], [[2d31\|2d31]], [[2esv\|2esv]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2h26\|2h26]], [[2hjk\|2hjk]], [[2hjl\|2hjl]], [[2hla\|2hla]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwe RCSB], [http://www.ebi.ac.uk/pdbsum/2uwe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwe RCSB], [http://www.ebi.ac.uk/pdbsum/2uwe PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Appella, E.]]	+	[[Category: Appella, E]]
-	[[Category: Biddison, W E.]]	+	[[Category: Biddison, W E]]
-	[[Category: Collins, E J.]]	+	[[Category: Collins, E J]]
-	[[Category: Conti, B.]]	+	[[Category: Conti, B]]
-	[[Category: Miller, P J.]]	+	[[Category: Miller, P J]]
-	[[Category: Pazy, Y.]]	+	[[Category: Pazy, Y]]
-	[[Category: Riddle, D.]]	+	[[Category: Riddle, D]]
	[[Category: Class i mhc]]		[[Category: Class i mhc]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]

OCA at 01:18, 1 October 2014

OCA — Wed, 01 Oct 2014 01:18:08 GMT

←Older revision		Revision as of 01:18, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2uwe\| PDB=2uwe \| SCENE= }}~~	+	==LARGE CDR3A LOOP ALTERATION AS A FUNCTION OF MHC MUTATION==
-	===LARGE CDR3A LOOP ALTERATION AS A FUNCTION OF MHC MUTATION===	+	<StructureSection load='2uwe' size='340' side='right' caption='[[2uwe]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17825839}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2uwe]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1akj\|1akj]], [[1ao7\|1ao7]], [[1aqd\|1aqd]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1duy\|1duy]], [[1duz\|1duz]], [[1eey\|1eey]], [[1eez\|1eez]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1jf1\|1jf1]], [[1jht\|1jht]], [[1lp9\|1lp9]], [[1oga\|1oga]], [[1p7q\|1p7q]], [[1qew\|1qew]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1s8d\|1s8d]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1t1w\|1t1w]], [[1t1x\|1t1x]], [[1t1y\|1t1y]], [[1t1z\|1t1z]], [[1t20\|1t20]], [[1t21\|1t21]], [[1t22\|1t22]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1ur7\|1ur7]], [[2av1\|2av1]], [[2av7\|2av7]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2c7u\|2c7u]], [[2clr\|2clr]], [[2gj6\|2gj6]], [[2jcc\|2jcc]], [[3hla\|3hla]], [[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1e27\|1e27]], [[1e28\|1e28]], [[1efx\|1efx]], [[1exu\|1exu]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1im9\|1im9]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jnj\|1jnj]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1of2\|1of2]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1uqs\|1uqs]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bvq\|2bvq]], [[2cii\|2cii]], [[2cik\|2cik]], [[2d31\|2d31]], [[2esv\|2esv]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2h26\|2h26]], [[2hjk\|2hjk]], [[2hjl\|2hjl]], [[2hla\|2hla]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwe RCSB], [http://www.ebi.ac.uk/pdbsum/2uwe PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwe_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The keystone of the adaptive immune response is T cell receptor (TCR) recognition of peptide presented by major histocompatibility complex (pMHC) molecules. The crystal structure of AHIII TCR bound to MHC, HLA-A2, showed a large interface with an atypical binding orientation. MHC mutations in the interface of the proteins were tested for changes in TCR recognition. From the range of responses observed, three representative HLA-A2 mutants, T163A, W167A, and K66A, were selected for further study. Binding constants and co-crystal structures of the AHIII TCR and the three mutants were determined. K66 in HLA-A2 makes contacts with both peptide and TCR, and has been identified as a critical residue for recognition by numerous TCR. The K66A mutation resulted in the lowest AHIII T cell response and the lowest binding affinity, which suggests that the T cell response may correlate with affinity. Importantly, the K66A mutation does not affect the conformation of the peptide. The change in affinity appears to be due to a loss in hydrogen bonds in the interface as a result of a conformational change in the TCR complementarity-determining region 3 (CDR3) loop. Isothermal titration calorimetry confirmed the loss of hydrogen bonding by a large loss in enthalpy. Our findings are inconsistent with the notion that the CDR1 and CDR2 loops of the TCR are responsible for MHC restriction, while the CDR3 loops interact solely with the peptide. Instead, we present here an MHC mutation that does not change the conformation of the peptide, yet results in an altered conformation of a CDR3.

-	~~==Function==~~	+	Single MHC mutation eliminates enthalpy associated with T cell receptor binding.,Miller PJ, Pazy Y, Conti B, Riddle D, Appella E, Collins EJ J Mol Biol. 2007 Oct 19;373(2):315-27. Epub 2007 Jul 26. PMID:17825839<ref>PMID:17825839</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system.~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2uwe]] is~~ a ~~10 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
	*[[Major histocompatibility complex\|Major histocompatibility complex]]		*[[Major histocompatibility complex\|Major histocompatibility complex]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:017825839</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 22:54, 24 March 2013

OCA — Sun, 24 Mar 2013 22:54:53 GMT

←Older revision		Revision as of 22:54, 24 March 2013
Line 1:		Line 1:
-	[[Image:2uwe.png\|left\|200px]]
-
	{{STRUCTURE_2uwe\| PDB=2uwe \| SCENE= }}		{{STRUCTURE_2uwe\| PDB=2uwe \| SCENE= }}
-
	===LARGE CDR3A LOOP ALTERATION AS A FUNCTION OF MHC MUTATION===		===LARGE CDR3A LOOP ALTERATION AS A FUNCTION OF MHC MUTATION===
		+	{{ABSTRACT_PUBMED_17825839}}

-	~~{{ABSTRACT_PUBMED_17825839}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system.

	==About this Structure==		==About this Structure==
Line 15:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:017825839</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017825839</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 11:47, 20 October 2012

OCA — Sat, 20 Oct 2012 11:47:00 GMT

←Older revision		Revision as of 11:47, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2uwe]] is a 10 chain structure ~~of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA].	+	[[2uwe]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWE OCA].

	==See Also==		==See Also==

OCA: Protected "2uwe" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 06:35:29 GMT

Protected "2uwe" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:35, 26 July 2012