2uwh - Revision history

OCA at 14:55, 13 December 2023

OCA — Wed, 13 Dec 2023 14:55:57 GMT

←Older revision		Revision as of 14:55, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2uwh' size='340' side='right'caption='[[2uwh]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2uwh' size='340' side='right'caption='[[2uwh]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uwh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_14581 Atcc 14581~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UWH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uwh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UWH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~, ~~<scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>[[1bu7\|1bu7]], [[1bvy\|1bvy]], [[1fag\|1fag]], [[1fah\|1fah]], [[1jme\|1jme]], [[1jpz\|1jpz]], [[1p0v\|1p0v]], [[1p0w\|1p0w]], [[1p0x\|1p0x]], [[1smi\|1smi]], [[1smj\|1smj]], [[1yqo\|1yqo]], [[1yqp\|1yqp]], [[2bmh\|2bmh]], [[2hpd\|2hpd]], [[2j1m\|2j1m]], [[2j4s\|2j4s]], [[2j4v\|2j4v]], [[2j54\|2j54]]</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwh OCA], [https://pdbe.org/2uwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uwh RCSB], [https://www.ebi.ac.uk/pdbsum/2uwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwh OCA], [https://pdbe.org/2uwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uwh RCSB], [https://www.ebi.ac.uk/pdbsum/2uwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~CPXB_BACME CPXB_BACME]~~] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of ~~medium and long-chain~~ fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). ~~The~~ reductase domain ~~is required for~~ electron transfer from ~~NADP~~ to cytochrome P450.	+	[https://www.uniprot.org/uniprot/CPXB_PRIM2 CPXB_PRIM2] Functions as a fatty acid monooxygenase (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Catalyzes hydroxylation of fatty acids at omega-1, omega-2 and omega-3 positions (PubMed:1727637, PubMed:21875028). Shows activity toward medium and long-chain fatty acids, with optimum chain lengths of 12, 14 and 16 carbons (lauric, myristic, and palmitic acids). Able to metabolize some of these primary metabolites to secondary and tertiary products (PubMed:1727637). Marginal activity towards short chain lengths of 8-10 carbons (PubMed:1727637, PubMed:18619466). Hydroxylates highly branched fatty acids, which play an essential role in membrane fluidity regulation (PubMed:16566047). Also displays a NADPH-dependent reductase activity in the C-terminal domain, which allows electron transfer from NADPH to the heme iron of the cytochrome P450 N-terminal domain (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Involved in inactivation of quorum sensing signals of other competing bacteria by oxidazing efficiently acyl homoserine lactones (AHLs), molecules involved in quorum sensing signaling pathways, and their lactonolysis products acyl homoserines (AHs) (PubMed:18020460).<ref>PMID:11695892</ref> <ref>PMID:14653735</ref> <ref>PMID:16403573</ref> <ref>PMID:16566047</ref> <ref>PMID:17077084</ref> <ref>PMID:1727637</ref> <ref>PMID:17868686</ref> <ref>PMID:18004886</ref> <ref>PMID:18020460</ref> <ref>PMID:18298086</ref> <ref>PMID:18619466</ref> <ref>PMID:18721129</ref> <ref>PMID:19492389</ref> <ref>PMID:20180779</ref> <ref>PMID:21110374</ref> <ref>PMID:21875028</ref> <ref>PMID:3106359</ref> <ref>PMID:7578081</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 14581]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Unspecific monooxygenase~~]]	+	[[Category: Priestia megaterium]]
-	[[Category: Huang, W C]]	+	[[Category: Huang W-C]]
-	[[Category: Joyce~~, M G~~]]	+	[[Category: Joyce MG]]
-	[[Category: Moody~~, P C.E~~]]	+	[[Category: Moody PCE]]
-	[[Category: Roberts~~, G C.K~~]]	+	[[Category: Roberts GCK]]
-	[[Category: Westlake~~, A C.G]]~~	+	[[Category: Westlake ACG]]
-	~~[[Category: Cytochrome p450 bm3 mutant]]~~	+
-	~~[[Category: Electron transport]]~~	+
-	~~[[Category: Fad]]~~	+
-	~~[[Category: Fatty-acid binding]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Fmn]]~~	+
-	~~[[Category: Heme]]~~	+
-	~~[[Category: Hydroxylase]]~~	+
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Monooxygenase]]~~	+
-	~~[[Category: Multifunctional enzyme]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Redox]]~~	+
-	~~[[Category: Transport~~]]	+

OCA at 12:32, 23 March 2022

OCA — Wed, 23 Mar 2022 12:32:02 GMT

←Older revision		Revision as of 12:32, 23 March 2022
Line 3:		Line 3:
	<StructureSection load='2uwh' size='340' side='right'caption='[[2uwh]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2uwh' size='340' side='right'caption='[[2uwh]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uwh]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_14581 Atcc 14581]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2UWH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uwh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_14581 Atcc 14581]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UWH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1bvy\|1bvy]], [[1fag\|1fag]], [[1fah\|1fah]], [[1jme\|1jme]], [[1jpz\|1jpz]], [[1p0v\|1p0v]], [[1p0w\|1p0w]], [[1p0x\|1p0x]], [[1smi\|1smi]], [[1smj\|1smj]], [[1yqo\|1yqo]], [[1yqp\|1yqp]], [[2bmh\|2bmh]], [[2hpd\|2hpd]], [[2j1m\|2j1m]], [[2j4s\|2j4s]], [[2j4v\|2j4v]], [[2j54\|2j54]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bu7\|1bu7]], [[1bvy\|1bvy]], [[1fag\|1fag]], [[1fah\|1fah]], [[1jme\|1jme]], [[1jpz\|1jpz]], [[1p0v\|1p0v]], [[1p0w\|1p0w]], [[1p0x\|1p0x]], [[1smi\|1smi]], [[1smj\|1smj]], [[1yqo\|1yqo]], [[1yqp\|1yqp]], [[2bmh\|2bmh]], [[2hpd\|2hpd]], [[2j1m\|2j1m]], [[2j4s\|2j4s]], [[2j4v\|2j4v]], [[2j54\|2j54]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwh OCA], [~~http~~://pdbe.org/2uwh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2uwh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2uwh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwh OCA], [https://pdbe.org/2uwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uwh RCSB], [https://www.ebi.ac.uk/pdbsum/2uwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CPXB_BACME CPXB_BACME]] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450.	+	[[https://www.uniprot.org/uniprot/CPXB_BACME CPXB_BACME]] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:12, 17 June 2020

OCA — Wed, 17 Jun 2020 11:12:28 GMT

←Older revision		Revision as of 11:12, 17 June 2020
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	==Cytochrome P450 BM3 mutant in complex with palmitic acid==		==Cytochrome P450 BM3 mutant in complex with palmitic acid==
-	<StructureSection load='2uwh' size='340' side='right' caption='[[2uwh]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2uwh' size='340' side='right'caption='[[2uwh]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uwh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14581 Atcc 14581]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2UWH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uwh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14581 Atcc 14581]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2UWH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1bvy\|1bvy]], [[1fag\|1fag]], [[1fah\|1fah]], [[1jme\|1jme]], [[1jpz\|1jpz]], [[1p0v\|1p0v]], [[1p0w\|1p0w]], [[1p0x\|1p0x]], [[1smi\|1smi]], [[1smj\|1smj]], [[1yqo\|1yqo]], [[1yqp\|1yqp]], [[2bmh\|2bmh]], [[2hpd\|2hpd]], [[2j1m\|2j1m]], [[2j4s\|2j4s]], [[2j4v\|2j4v]], [[2j54\|2j54]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1bvy\|1bvy]], [[1fag\|1fag]], [[1fah\|1fah]], [[1jme\|1jme]], [[1jpz\|1jpz]], [[1p0v\|1p0v]], [[1p0w\|1p0w]], [[1p0x\|1p0x]], [[1smi\|1smi]], [[1smj\|1smj]], [[1yqo\|1yqo]], [[1yqp\|1yqp]], [[2bmh\|2bmh]], [[2hpd\|2hpd]], [[2j1m\|2j1m]], [[2j4s\|2j4s]], [[2j4v\|2j4v]], [[2j54\|2j54]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwh OCA], [http://pdbe.org/2uwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwh RCSB], [http://www.ebi.ac.uk/pdbsum/2uwh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwh OCA], [http://pdbe.org/2uwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwh RCSB], [http://www.ebi.ac.uk/pdbsum/2uwh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Cytochrome P450\|Cytochrome P450]]	+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 14581]]		[[Category: Atcc 14581]]
		+	[[Category: Large Structures]]
	[[Category: Unspecific monooxygenase]]		[[Category: Unspecific monooxygenase]]
	[[Category: Huang, W C]]		[[Category: Huang, W C]]

OCA at 08:11, 12 September 2018

OCA — Wed, 12 Sep 2018 08:11:39 GMT

←Older revision		Revision as of 08:11, 12 September 2018
Line 1:		Line 1:
-	==~~CYTOCHROME~~ P450 BM3 ~~MUTANT IN COMPLEX WITH PALMITIC ACID~~==	+
		+	==Cytochrome P450 BM3 mutant in complex with palmitic acid==
	<StructureSection load='2uwh' size='340' side='right' caption='[[2uwh]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2uwh' size='340' side='right' caption='[[2uwh]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1bvy\|1bvy]], [[1fag\|1fag]], [[1fah\|1fah]], [[1jme\|1jme]], [[1jpz\|1jpz]], [[1p0v\|1p0v]], [[1p0w\|1p0w]], [[1p0x\|1p0x]], [[1smi\|1smi]], [[1smj\|1smj]], [[1yqo\|1yqo]], [[1yqp\|1yqp]], [[2bmh\|2bmh]], [[2hpd\|2hpd]], [[2j1m\|2j1m]], [[2j4s\|2j4s]], [[2j4v\|2j4v]], [[2j54\|2j54]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1bvy\|1bvy]], [[1fag\|1fag]], [[1fah\|1fah]], [[1jme\|1jme]], [[1jpz\|1jpz]], [[1p0v\|1p0v]], [[1p0w\|1p0w]], [[1p0x\|1p0x]], [[1smi\|1smi]], [[1smj\|1smj]], [[1yqo\|1yqo]], [[1yqp\|1yqp]], [[2bmh\|2bmh]], [[2hpd\|2hpd]], [[2j1m\|2j1m]], [[2j4s\|2j4s]], [[2j4v\|2j4v]], [[2j54\|2j54]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwh OCA], [http://pdbe.org/2uwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwh RCSB], [http://www.ebi.ac.uk/pdbsum/2uwh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwh OCA], [http://pdbe.org/2uwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwh RCSB], [http://www.ebi.ac.uk/pdbsum/2uwh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 33:
	==See Also==		==See Also==
	*[[Cytochrome P450\|Cytochrome P450]]		*[[Cytochrome P450\|Cytochrome P450]]
-	*[[Flavocytochrome\|Flavocytochrome]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:01, 8 February 2016

OCA — Mon, 08 Feb 2016 16:01:01 GMT

←Older revision		Revision as of 16:01, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2uwh' size='340' side='right' caption='[[2uwh]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2uwh' size='340' side='right' caption='[[2uwh]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uwh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_megaterium Bacillus megaterium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uwh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14581 Atcc 14581]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1bvy\|1bvy]], [[1fag\|1fag]], [[1fah\|1fah]], [[1jme\|1jme]], [[1jpz\|1jpz]], [[1p0v\|1p0v]], [[1p0w\|1p0w]], [[1p0x\|1p0x]], [[1smi\|1smi]], [[1smj\|1smj]], [[1yqo\|1yqo]], [[1yqp\|1yqp]], [[2bmh\|2bmh]], [[2hpd\|2hpd]], [[2j1m\|2j1m]], [[2j4s\|2j4s]], [[2j4v\|2j4v]], [[2j54\|2j54]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1bvy\|1bvy]], [[1fag\|1fag]], [[1fah\|1fah]], [[1jme\|1jme]], [[1jpz\|1jpz]], [[1p0v\|1p0v]], [[1p0w\|1p0w]], [[1p0x\|1p0x]], [[1smi\|1smi]], [[1smj\|1smj]], [[1yqo\|1yqo]], [[1yqp\|1yqp]], [[2bmh\|2bmh]], [[2hpd\|2hpd]], [[2j1m\|2j1m]], [[2j4s\|2j4s]], [[2j4v\|2j4v]], [[2j54\|2j54]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwh RCSB], [http://www.ebi.ac.uk/pdbsum/2uwh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwh OCA], [http://pdbe.org/2uwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwh RCSB], [http://www.ebi.ac.uk/pdbsum/2uwh PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uwh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2uwh" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus megaterium~~]]	+	[[Category: Atcc 14581]]
	[[Category: Unspecific monooxygenase]]		[[Category: Unspecific monooxygenase]]
	[[Category: Huang, W C]]		[[Category: Huang, W C]]

OCA at 00:30, 25 December 2014

OCA — Thu, 25 Dec 2014 00:30:19 GMT

←Older revision		Revision as of 00:30, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2uwh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2uwh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1bvy\|1bvy]], [[1fag\|1fag]], [[1fah\|1fah]], [[1jme\|1jme]], [[1jpz\|1jpz]], [[1p0v\|1p0v]], [[1p0w\|1p0w]], [[1p0x\|1p0x]], [[1smi\|1smi]], [[1smj\|1smj]], [[1yqo\|1yqo]], [[1yqp\|1yqp]], [[2bmh\|2bmh]], [[2hpd\|2hpd]], [[2j1m\|2j1m]], [[2j4s\|2j4s]], [[2j4v\|2j4v]], [[2j54\|2j54]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1bvy\|1bvy]], [[1fag\|1fag]], [[1fah\|1fah]], [[1jme\|1jme]], [[1jpz\|1jpz]], [[1p0v\|1p0v]], [[1p0w\|1p0w]], [[1p0x\|1p0x]], [[1smi\|1smi]], [[1smj\|1smj]], [[1yqo\|1yqo]], [[1yqp\|1yqp]], [[2bmh\|2bmh]], [[2hpd\|2hpd]], [[2j1m\|2j1m]], [[2j4s\|2j4s]], [[2j4v\|2j4v]], [[2j54\|2j54]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwh RCSB], [http://www.ebi.ac.uk/pdbsum/2uwh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwh RCSB], [http://www.ebi.ac.uk/pdbsum/2uwh PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CPXB_BACME CPXB_BACME]] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Bacillus megaterium]]		[[Category: Bacillus megaterium]]
	[[Category: Unspecific monooxygenase]]		[[Category: Unspecific monooxygenase]]
-	[[Category: Huang, W C.]]	+	[[Category: Huang, W C]]
-	[[Category: Joyce, M G.]]	+	[[Category: Joyce, M G]]
-	[[Category: Moody, P C.E.]]	+	[[Category: Moody, P C.E]]
-	[[Category: Roberts, G C.K.]]	+	[[Category: Roberts, G C.K]]
-	[[Category: Westlake, A C.G.]]	+	[[Category: Westlake, A C.G]]
	[[Category: Cytochrome p450 bm3 mutant]]		[[Category: Cytochrome p450 bm3 mutant]]
	[[Category: Electron transport]]		[[Category: Electron transport]]

OCA at 06:18, 29 September 2014

OCA — Mon, 29 Sep 2014 06:18:09 GMT

←Older revision		Revision as of 06:18, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2uwh.~~png~~\|~~left~~\|200px]]	+	==CYTOCHROME P450 BM3 MUTANT IN COMPLEX WITH PALMITIC ACID==
		+	<StructureSection load='2uwh' size='340' side='right' caption='[[2uwh]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2uwh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1bvy\|1bvy]], [[1fag\|1fag]], [[1fah\|1fah]], [[1jme\|1jme]], [[1jpz\|1jpz]], [[1p0v\|1p0v]], [[1p0w\|1p0w]], [[1p0x\|1p0x]], [[1smi\|1smi]], [[1smj\|1smj]], [[1yqo\|1yqo]], [[1yqp\|1yqp]], [[2bmh\|2bmh]], [[2hpd\|2hpd]], [[2j1m\|2j1m]], [[2j4s\|2j4s]], [[2j4v\|2j4v]], [[2j54\|2j54]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwh RCSB], [http://www.ebi.ac.uk/pdbsum/2uwh PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytochrome P450BM3 (CYP102A1) from Bacillus megaterium, a fatty acid hydroxylase, is a member of a very large superfamily of monooxygenase enzymes. The available crystal structures of the enzyme show non-productive binding of substrates with their omega-end distant from the iron in a hydrophobic pocket at one side of the active site. We have constructed and characterised mutants in which this pocket is filled by large hydrophobic side-chains replacing alanine at position 82. The mutants having phenylalanine or tryptophan at this position have very much (approximately 800-fold) greater affinity for substrate, with a greater conversion of the haem iron to the high-spin state, and similarly increased catalytic efficiency. The enzyme as isolated contains bound palmitate, reflecting this much higher affinity. We have determined the crystal structure of the haem domain of the Ala82Phe mutant with bound palmitate; this shows that the substrate is binding differently from the wild-type enzyme but still distant from the haem iron. Detailed analysis of the structure indicates that the tighter binding in the mutant reflects a shift in the conformational equilibrium of the substrate-free enzyme towards the conformation seen in the substrate complex rather than differences in the enzyme-substrate interactions. On this basis, we outline a sequence of events for the initial stages of the catalytic cycle. The Ala82Phe and Ala82Trp mutants are also very much more effective catalysts of indole hydroxylation than the wild-type enzyme, suggesting that they will be valuable starting points for the design of mutants to catalyse synthetically useful hydroxylation reactions.

-	~~{{STRUCTURE_2uwh\| PDB=2uwh \| SCENE= }}~~	+	Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency.,Huang WC, Westlake AC, Marechal JD, Joyce MG, Moody PC, Roberts GC J Mol Biol. 2007 Oct 26;373(3):633-51. Epub 2007 Aug 21. PMID:17868686<ref>PMID:17868686</ref>

-	~~===CYTOCHROME P450 BM3 MUTANT IN COMPLEX WITH PALMITIC ACID===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17868686}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2uwh]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_megaterium Bacillus megaterium]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA].~~	+

	==See Also==		==See Also==
	*[[Cytochrome P450\|Cytochrome P450]]		*[[Cytochrome P450\|Cytochrome P450]]
	*[[Flavocytochrome\|Flavocytochrome]]		*[[Flavocytochrome\|Flavocytochrome]]
-	*[[NADPH-Cytochrome P450 Reductase\|NADPH-Cytochrome P450 Reductase]]	+	== References ==
-		+	<references/>
-	==~~Reference~~==	+	__TOC__
-	<~~ref group="xtra">PMID:017868686<~~/~~ref~~><~~references group="xtra"~~/>	+	</StructureSection>
	[[Category: Bacillus megaterium]]		[[Category: Bacillus megaterium]]
	[[Category: Unspecific monooxygenase]]		[[Category: Unspecific monooxygenase]]

OCA at 10:41, 20 October 2012

OCA — Sat, 20 Oct 2012 10:41:21 GMT

←Older revision		Revision as of 10:41, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2uwh]] is a 6 chain structure ~~of [[Cytochrome P450]], [[Flavocytochrome]] and [[NADPH-Cytochrome P450 Reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA].	+	[[2uwh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA].

	==See Also==		==See Also==

OCA at 02:57, 26 July 2012

OCA — Thu, 26 Jul 2012 02:57:02 GMT

←Older revision		Revision as of 02:57, 26 July 2012
Line 1:		Line 1:
	[[Image:2uwh.png\|left\|200px]]		[[Image:2uwh.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2uwh", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2uwh\| PDB=2uwh \| SCENE= }}		{{STRUCTURE_2uwh\| PDB=2uwh \| SCENE= }}

	===CYTOCHROME P450 BM3 MUTANT IN COMPLEX WITH PALMITIC ACID===		===CYTOCHROME P450 BM3 MUTANT IN COMPLEX WITH PALMITIC ACID===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17868686}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17868686 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17868686}}		{{ABSTRACT_PUBMED_17868686}}

	==About this Structure==		==About this Structure==
-	[[2uwh]] is a 6 chain structure of [[Cytochrome P450]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA].	+	[[2uwh]] is a 6 chain structure of [[Cytochrome P450]], [[Flavocytochrome]] and [[NADPH-Cytochrome P450 Reductase]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWH OCA].

	==See Also==		==See Also==
-	*[[Cytochrome P450]]	+	*[[Cytochrome P450\|Cytochrome P450]]
		+	*[[Flavocytochrome\|Flavocytochrome]]
		+	*[[NADPH-Cytochrome P450 Reductase\|NADPH-Cytochrome P450 Reductase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17868686~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017868686</ref><references group="xtra"/>
	[[Category: Bacillus megaterium]]		[[Category: Bacillus megaterium]]
	[[Category: Unspecific monooxygenase]]		[[Category: Unspecific monooxygenase]]

OCA: Protected "2uwh" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 23:35:23 GMT

Protected "2uwh" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:35, 26 December 2010