2uwi - Revision history

OCA at 10:38, 7 July 2021

OCA — Wed, 07 Jul 2021 10:38:54 GMT

←Older revision		Revision as of 10:38, 7 July 2021
Line 3:		Line 3:
	<StructureSection load='2uwi' size='340' side='right'caption='[[2uwi]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2uwi' size='340' side='right'caption='[[2uwi]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uwi]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Vaccl Vaccl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2UWI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uwi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccl Vaccl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UWI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2uwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwi OCA], [~~http~~://pdbe.org/2uwi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2uwi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2uwi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwi ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwi OCA], [https://pdbe.org/2uwi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uwi RCSB], [https://www.ebi.ac.uk/pdbsum/2uwi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwi ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 12:07, 10 May 2019

OCA — Fri, 10 May 2019 12:07:46 GMT

←Older revision		Revision as of 12:07, 10 May 2019
Line 1:		Line 1:

	==Structure of CrmE, a poxvirus TNF receptor==		==Structure of CrmE, a poxvirus TNF receptor==
-	<StructureSection load='2uwi' size='340' side='right' caption='[[2uwi]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2uwi' size='340' side='right'caption='[[2uwi]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2uwi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccl Vaccl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2uwi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccl Vaccl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWI FirstGlance]. <br>
Line 29:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Vaccl]]		[[Category: Vaccl]]
	[[Category: Abrescia, N G]]		[[Category: Abrescia, N G]]

OCA at 05:36, 8 March 2018

OCA — Thu, 08 Mar 2018 05:36:28 GMT

←Older revision		Revision as of 05:36, 8 March 2018
Line 1:		Line 1:

-	==~~STRUCTURE OF CRME~~, ~~A POXVIRUS~~ TNF ~~RECEPTOR~~==	+	==Structure of CrmE, a poxvirus TNF receptor==
	<StructureSection load='2uwi' size='340' side='right' caption='[[2uwi]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2uwi' size='340' side='right' caption='[[2uwi]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 10:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwi_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwi_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:48, 11 August 2016

OCA — Thu, 11 Aug 2016 18:48:45 GMT

←Older revision		Revision as of 18:48, 11 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF CRME, A POXVIRUS TNF RECEPTOR==		==STRUCTURE OF CRME, A POXVIRUS TNF RECEPTOR==
	<StructureSection load='2uwi' size='340' side='right' caption='[[2uwi]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2uwi' size='340' side='right' caption='[[2uwi]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uwi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Vaccinia_virus Vaccinia virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uwi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccl Vaccl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwi RCSB], [http://www.ebi.ac.uk/pdbsum/2uwi PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwi OCA], [http://pdbe.org/2uwi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwi RCSB], [http://www.ebi.ac.uk/pdbsum/2uwi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwi ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uwi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2uwi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vaccinia virus~~]]	+	[[Category: Vaccl]]
	[[Category: Abrescia, N G]]		[[Category: Abrescia, N G]]
	[[Category: Bahar, M W]]		[[Category: Bahar, M W]]

OCA at 15:04, 19 January 2015

OCA — Mon, 19 Jan 2015 15:04:10 GMT

←Older revision		Revision as of 15:04, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2uwi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2uwi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwi RCSB], [http://www.ebi.ac.uk/pdbsum/2uwi PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwi RCSB], [http://www.ebi.ac.uk/pdbsum/2uwi PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Vaccinia virus]]		[[Category: Vaccinia virus]]
-	[[Category: Abrescia, N G.]]	+	[[Category: Abrescia, N G]]
-	[[Category: Bahar, M W.]]	+	[[Category: Bahar, M W]]
-	[[Category: Graham, S C.]]	+	[[Category: Graham, S C]]
-	[[Category: Grimes, J M.]]	+	[[Category: Grimes, J M]]
-	[[Category: Smith, G L.]]	+	[[Category: Smith, G L]]
-	[[Category: Stuart, D I.]]	+	[[Category: Stuart, D I]]
	[[Category: Poxvirus tnf receptor]]		[[Category: Poxvirus tnf receptor]]
	[[Category: Receptor]]		[[Category: Receptor]]
	[[Category: Receptor immunomodulator]]		[[Category: Receptor immunomodulator]]
	[[Category: Tnf alpha receptor]]		[[Category: Tnf alpha receptor]]

OCA at 01:53, 1 October 2014

OCA — Wed, 01 Oct 2014 01:53:04 GMT

←Older revision		Revision as of 01:53, 1 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2uwi.~~png\|left~~\|200px]]	+	==STRUCTURE OF CRME, A POXVIRUS TNF RECEPTOR==
		+	<StructureSection load='2uwi' size='340' side='right' caption='[[2uwi]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2uwi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwi RCSB], [http://www.ebi.ac.uk/pdbsum/2uwi PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwi_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Vaccinia virus (VACV), the smallpox vaccine, encodes many proteins that subvert the host immune response. One of these, cytokine response modifier E (CrmE), is secreted by infected cells and protects these cells from apoptotic challenge by tumour necrosis factor alpha (TNFalpha). We have expressed recombinant CrmE from VACV strain Lister in Escherichia coli, shown that the purified protein is monomeric in solution and competent to bind TNFalpha, and solved the structure to 2.0 A resolution. This is the first structure of a virus-encoded tumour necrosis factor receptor (TNFR). CrmE shares significant sequence similarity with mammalian type 2 TNF receptors (TNFSFR1B, p75; TNFR type 2). The structure confirms that CrmE adopts the canonical TNFR fold but only one of the two "ligand-binding" loops of TNFRSF1A is conserved in CrmE, suggesting a mechanism for the higher affinity of poxvirus TNFRs for TNFalpha over lymphotoxin-alpha. The roles of dimerisation and pre-ligand-assembly domains (PLADs) in poxvirus and mammalian TNFR activity are discussed.

-	~~{{STRUCTURE_2uwi\| PDB=2uwi \| SCENE= }}~~	+	Structure of CrmE, a virus-encoded tumour necrosis factor receptor.,Graham SC, Bahar MW, Abrescia NG, Smith GL, Stuart DI, Grimes JM J Mol Biol. 2007 Sep 21;372(3):660-71. Epub 2007 Jul 3. PMID:17681535<ref>PMID:17681535</ref>

-	~~===STRUCTURE OF CRME~~, ~~A POXVIRUS TNF RECEPTOR===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17681535}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2uwi]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Vaccinia_virus Vaccinia virus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017681535<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Vaccinia virus]]		[[Category: Vaccinia virus]]
	[[Category: Abrescia, N G.]]		[[Category: Abrescia, N G.]]

OCA: Protected "2uwi" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 21:19:49 GMT

Protected "2uwi" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:19, 7 January 2013

OCA at 21:19, 7 January 2013

OCA — Mon, 07 Jan 2013 21:19:47 GMT

←Older revision		Revision as of 21:19, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2uwi.png\|left\|200px]]		[[Image:2uwi.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2uwi", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2uwi\| PDB=2uwi \| SCENE= }}		{{STRUCTURE_2uwi\| PDB=2uwi \| SCENE= }}

	===STRUCTURE OF CRME, A POXVIRUS TNF RECEPTOR===		===STRUCTURE OF CRME, A POXVIRUS TNF RECEPTOR===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17681535}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17681535 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17681535}}		{{ABSTRACT_PUBMED_17681535}}

	==About this Structure==		==About this Structure==
-	~~2UWI~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA].	+	[[2uwi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17681535~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017681535</ref><references group="xtra"/>
	[[Category: Vaccinia virus]]		[[Category: Vaccinia virus]]
	[[Category: Abrescia, N G.]]		[[Category: Abrescia, N G.]]
Line 32:		Line 20:
	[[Category: Stuart, D I.]]		[[Category: Stuart, D I.]]
	[[Category: Poxvirus tnf receptor]]		[[Category: Poxvirus tnf receptor]]
		+	[[Category: Receptor]]
	[[Category: Receptor immunomodulator]]		[[Category: Receptor immunomodulator]]
	[[Category: Tnf alpha receptor]]		[[Category: Tnf alpha receptor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:05:36 2009''

OCA at 06:05, 18 February 2009

OCA — Wed, 18 Feb 2009 06:05:37 GMT

←Older revision		Revision as of 06:05, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2UWI is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA].	+	2UWI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWI OCA].

	==Reference==		==Reference==
-	~~Structure of CrmE, a virus-encoded tumour necrosis factor receptor., Graham SC, Bahar MW, Abrescia NG, Smith GL, Stuart DI, Grimes JM, J Mol Biol. 2007 Sep 21;372(3):660-71. Epub 2007 Jul 3.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17681535 17681535]~~	+	<ref group="xtra">PMID:17681535</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Vaccinia virus]]		[[Category: Vaccinia virus]]
	[[Category: Abrescia, N G.]]		[[Category: Abrescia, N G.]]
Line 36:		Line 35:
	[[Category: Tnf alpha receptor]]		[[Category: Tnf alpha receptor]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 14~~:33:~~31 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:05:36 2009''

OCA at 11:33, 29 July 2008

OCA — Tue, 29 Jul 2008 11:33:35 GMT

←Older revision		Revision as of 11:33, 29 July 2008
Line 1:		Line 1:
-	[[Image:2uwi.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2uwi.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2uwi\| PDB=2uwi \| SCENE= }}		{{STRUCTURE_2uwi\| PDB=2uwi \| SCENE= }}

-	~~'''~~STRUCTURE OF CRME, A POXVIRUS TNF RECEPTOR~~'''~~	+	===STRUCTURE OF CRME, A POXVIRUS TNF RECEPTOR===


-	~~==Overview==~~	+	<!--
-	~~Vaccinia virus (VACV)~~, ~~the smallpox vaccine~~, ~~encodes many proteins that subvert~~ the host immune response. One of these, cytokine response modifier E (CrmE), is secreted by infected cells and protects these cells from apoptotic challenge by tumour necrosis factor alpha (TNFalpha). We have expressed recombinant CrmE from VACV strain Lister in Escherichia coli, shown that the purified protein is monomeric in solution and competent to ~~bind TNFalpha, and solved~~ the ~~structure to 2~~.~~0 A resolution~~. ~~This is the first structure of a virus-encoded tumour necrosis factor receptor (TNFR~~)~~. CrmE shares significant sequence similarity with mammalian type 2 TNF receptors (TNFSFR1B~~, ~~p75; TNFR type 2). The structure confirms that CrmE adopts the canonical TNFR fold but only one of the two "ligand-binding" loops of TNFRSF1A~~ is ~~conserved in CrmE, suggesting a mechanism for~~ the ~~higher affinity of poxvirus TNFRs for TNFalpha over lymphotoxin-alpha~~. ~~The roles of dimerisation and pre~~-~~ligand~~-~~assembly domains (PLADs) in poxvirus and mammalian TNFR activity are discussed.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17681535}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17681535 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17681535}}

	==About this Structure==		==About this Structure==
Line 31:		Line 35:
	[[Category: Receptor immunomodulator]]		[[Category: Receptor immunomodulator]]
	[[Category: Tnf alpha receptor]]		[[Category: Tnf alpha receptor]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 17~~:39:52 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:33:31 2008''