2uy4 - Revision history

OCA at 14:57, 13 December 2023

OCA — Wed, 13 Dec 2023 14:57:34 GMT

←Older revision		Revision as of 14:57, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2uy4' size='340' side='right'caption='[[2uy4]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2uy4' size='340' side='right'caption='[[2uy4]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uy4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UY4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uy4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UY4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AZM:5-ACETAMIDO~~-1~~,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2uy2\|2uy2]], [[2uy3\|2uy3]], [[2uy5\|2uy5]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.2.~~1~~.14~~ 3.2~~.1.14]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy4 OCA], [https://pdbe.org/2uy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uy4 RCSB], [https://www.ebi.ac.uk/pdbsum/2uy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uy4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy4 OCA], [https://pdbe.org/2uy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uy4 RCSB], [https://www.ebi.ac.uk/pdbsum/2uy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uy4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CHIT_YEAST CHIT_YEAST]] Chitinase is required for cell separation during growth of Saccharomyces cerevisiae.	+	[https://www.uniprot.org/uniprot/CHIT_YEAST CHIT_YEAST] Chitinase is required for cell separation during growth of Saccharomyces cerevisiae.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
-	[[Category: Chitinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Aalten, D M.F van~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Hurtado-Guerrero, R]]	+	[[Category: Hurtado-Guerrero R]]
-	[[Category: ~~Carbohydrate metabolism]]~~	+	[[Category: Van Aalten DMF]]
-	~~[[Category: Cazy]]~~	+
-	~~[[Category: Cell wall]]~~	+
-	~~[[Category: Chitin degradation]]~~	+
-	~~[[Category: Chitin-binding]]~~	+
-	~~[[Category: Chitinase activity and glycoside hydrolase family 18]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Glycosidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Polysaccharide degradation~~]]	+

OCA at 12:33, 23 March 2022

OCA — Wed, 23 Mar 2022 12:33:22 GMT

←Older revision		Revision as of 12:33, 23 March 2022
Line 3:		Line 3:
	<StructureSection load='2uy4' size='340' side='right'caption='[[2uy4]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2uy4' size='340' side='right'caption='[[2uy4]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uy4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2UY4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uy4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UY4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uy2\|2uy2]], [[2uy3\|2uy3]], [[2uy5\|2uy5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2uy2\|2uy2]], [[2uy3\|2uy3]], [[2uy5\|2uy5]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2uy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy4 OCA], [~~http~~://pdbe.org/2uy4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2uy4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2uy4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2uy4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy4 OCA], [https://pdbe.org/2uy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uy4 RCSB], [https://www.ebi.ac.uk/pdbsum/2uy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uy4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CHIT_YEAST CHIT_YEAST]] Chitinase is required for cell separation during growth of Saccharomyces cerevisiae.	+	[[https://www.uniprot.org/uniprot/CHIT_YEAST CHIT_YEAST]] Chitinase is required for cell separation during growth of Saccharomyces cerevisiae.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:13, 17 June 2020

OCA — Wed, 17 Jun 2020 11:13:54 GMT

←Older revision		Revision as of 11:13, 17 June 2020
Line 1:		Line 1:

	==ScCTS1_acetazolamide crystal structure==		==ScCTS1_acetazolamide crystal structure==
-	<StructureSection load='2uy4' size='340' side='right' caption='[[2uy4]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='2uy4' size='340' side='right'caption='[[2uy4]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uy4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2UY4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uy4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2UY4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uy2\|2uy2]], [[2uy3\|2uy3]], [[2uy5\|2uy5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uy2\|2uy2]], [[2uy3\|2uy3]], [[2uy5\|2uy5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2uy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy4 OCA], [http://pdbe.org/2uy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uy4 RCSB], [http://www.ebi.ac.uk/pdbsum/2uy4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uy4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2uy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy4 OCA], [http://pdbe.org/2uy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uy4 RCSB], [http://www.ebi.ac.uk/pdbsum/2uy4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uy4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Chitinase\|Chitinase]]	+	*[[Chitinase 3D structures\|Chitinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
	[[Category: Chitinase]]		[[Category: Chitinase]]
		+	[[Category: Large Structures]]
	[[Category: Aalten, D M.F van]]		[[Category: Aalten, D M.F van]]
	[[Category: Hurtado-Guerrero, R]]		[[Category: Hurtado-Guerrero, R]]

OCA at 08:56, 12 September 2018

OCA — Wed, 12 Sep 2018 08:56:52 GMT

←Older revision		Revision as of 08:56, 12 September 2018
Line 1:		Line 1:
-	==~~SCCTS1_ACETAZOLAMIDE CRYSTAL STRUCTURE~~==	+
		+	==ScCTS1_acetazolamide crystal structure==
	<StructureSection load='2uy4' size='340' side='right' caption='[[2uy4]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2uy4' size='340' side='right' caption='[[2uy4]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uy2\|2uy2]], [[2uy3\|2uy3]], [[2uy5\|2uy5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uy2\|2uy2]], [[2uy3\|2uy3]], [[2uy5\|2uy5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy4 OCA], [http://pdbe.org/2uy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uy4 RCSB], [http://www.ebi.ac.uk/pdbsum/2uy4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy4 OCA], [http://pdbe.org/2uy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uy4 RCSB], [http://www.ebi.ac.uk/pdbsum/2uy4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uy4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uy/2uy4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uy/2uy4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 38:		Line 39:
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
	[[Category: Chitinase]]		[[Category: Chitinase]]
-	[[Category: Aalten, D M.F ~~Van~~]]	+	[[Category: Aalten, D M.F van]]
	[[Category: Hurtado-Guerrero, R]]		[[Category: Hurtado-Guerrero, R]]
	[[Category: Carbohydrate metabolism]]		[[Category: Carbohydrate metabolism]]

OCA at 03:22, 8 February 2016

OCA — Mon, 08 Feb 2016 03:22:31 GMT

←Older revision		Revision as of 03:22, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2uy4' size='340' side='right' caption='[[2uy4]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2uy4' size='340' side='right' caption='[[2uy4]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uy4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UY4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uy4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UY4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uy2\|2uy2]], [[2uy3\|2uy3]], [[2uy5\|2uy5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uy2\|2uy2]], [[2uy3\|2uy3]], [[2uy5\|2uy5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uy4 RCSB], [http://www.ebi.ac.uk/pdbsum/2uy4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy4 OCA], [http://pdbe.org/2uy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uy4 RCSB], [http://www.ebi.ac.uk/pdbsum/2uy4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uy4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2uy4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
	[[Category: Chitinase]]		[[Category: Chitinase]]
-	[[Category: Saccharomyces cerevisiae]]
	[[Category: Aalten, D M.F Van]]		[[Category: Aalten, D M.F Van]]
	[[Category: Hurtado-Guerrero, R]]		[[Category: Hurtado-Guerrero, R]]

OCA at 20:13, 24 December 2014

OCA — Wed, 24 Dec 2014 20:13:09 GMT

←Older revision		Revision as of 20:13, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2uy4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UY4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2uy4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UY4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uy2\|2uy2]], [[2uy3\|2uy3]], [[2uy5\|2uy5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uy2\|2uy2]], [[2uy3\|2uy3]], [[2uy5\|2uy5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uy4 RCSB], [http://www.ebi.ac.uk/pdbsum/2uy4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uy4 RCSB], [http://www.ebi.ac.uk/pdbsum/2uy4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CHIT_YEAST CHIT_YEAST]] Chitinase is required for cell separation during growth of Saccharomyces cerevisiae.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Chitinase]]		[[Category: Chitinase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Aalten, D M.F Van.]]	+	[[Category: Aalten, D M.F Van]]
-	[[Category: Hurtado-Guerrero, R.]]	+	[[Category: Hurtado-Guerrero, R]]
	[[Category: Carbohydrate metabolism]]		[[Category: Carbohydrate metabolism]]
	[[Category: Cazy]]		[[Category: Cazy]]

OCA at 07:08, 29 September 2014

OCA — Mon, 29 Sep 2014 07:08:29 GMT

←Older revision		Revision as of 07:08, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2uy4.~~png~~\|~~left~~\|200px]]	+	==SCCTS1_ACETAZOLAMIDE CRYSTAL STRUCTURE==
		+	<StructureSection load='2uy4' size='340' side='right' caption='[[2uy4]], [[Resolution\|resolution]] 1.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2uy4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UY4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uy2\|2uy2]], [[2uy3\|2uy3]], [[2uy5\|2uy5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uy4 RCSB], [http://www.ebi.ac.uk/pdbsum/2uy4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uy/2uy4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chitinases hydrolyse the beta(1,4)-glycosidic bonds of chitin, an essential fungal cell wall component. Genetic data on a subclass of fungal family 18 chitinases have suggested a role in cell wall morphology. Specific inhibitors of these enzymes would be useful as tools to study their role in cell wall morphogenesis and could possess antifungal properties. Here, we describe the crystallographic structure of a fungal "plant-type" family 18 chitinase, that of Saccharomyces cerevisiae CTS1. The enzyme is active against 4-methylumbelliferyl chitooligosaccharides and displays an unusually low pH optimum for activity. A library screen against ScCTS1 yielded hits with Ki 's as low as 3.2 microM. Crystal structures of ScCTS1 in complex with inhibitors from three series reveal striking mimicry of carbohydrate substrate by small aromatic moieties and a pocket that could be further exploited in optimization of these inhibitors.

-	~~{{STRUCTURE_2uy4\| PDB=2uy4 \| SCENE= }}~~	+	Structure of Saccharomyces cerevisiae chitinase 1 and screening-based discovery of potent inhibitors.,Hurtado-Guerrero R, van Aalten DM Chem Biol. 2007 May;14(5):589-99. PMID:17524989<ref>PMID:17524989</ref>

-	~~===SCCTS1_ACETAZOLAMIDE CRYSTAL STRUCTURE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17524989}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2uy4]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA].~~	+

	==See Also==		==See Also==
	*[[Chitinase\|Chitinase]]		*[[Chitinase\|Chitinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017524989<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Chitinase]]		[[Category: Chitinase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]

OCA at 08:44, 20 October 2012

OCA — Sat, 20 Oct 2012 08:44:30 GMT

←Older revision		Revision as of 08:44, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2uy4]] is a 1 chain structure ~~of [[Chitinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA].	+	[[2uy4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA].

	==See Also==		==See Also==

OCA: Protected "2uy4" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 20:37:00 GMT

Protected "2uy4" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:37, 25 July 2012

OCA at 20:36, 25 July 2012

OCA — Wed, 25 Jul 2012 20:36:58 GMT

←Older revision		Revision as of 20:36, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2uy4.png\|left\|200px]]		[[Image:2uy4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2uy4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2uy4\| PDB=2uy4 \| SCENE= }}		{{STRUCTURE_2uy4\| PDB=2uy4 \| SCENE= }}

	===SCCTS1_ACETAZOLAMIDE CRYSTAL STRUCTURE===		===SCCTS1_ACETAZOLAMIDE CRYSTAL STRUCTURE===

		+	{{ABSTRACT_PUBMED_17524989}}

	==About this Structure==		==About this Structure==
-	~~2UY4~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA].	+	[[2uy4]] is a 1 chain structure of [[Chitinase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY4 OCA].
		+
		+	==See Also==
		+	*[[Chitinase\|Chitinase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:017524989</ref><references group="xtra"/>
	[[Category: Chitinase]]		[[Category: Chitinase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
Line 29:		Line 29:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Polysaccharide degradation]]		[[Category: Polysaccharide degradation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:26:37 2009''