2uza - Revision history

OCA at 14:58, 13 December 2023

OCA — Wed, 13 Dec 2023 14:58:36 GMT

←Older revision		Revision as of 14:58, 13 December 2023
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	<StructureSection load='2uza' size='340' side='right'caption='[[2uza]], [[Resolution\|resolution]] 2.42Å' scene=''>		<StructureSection load='2uza' size='340' side='right'caption='[[2uza]], [[Resolution\|resolution]] 2.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uza]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Desulfovibrio_africanus Desulfovibrio~~ africanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2UZA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfocurvibacter_africanus Desulfocurvibacter africanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UZA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=HTL:2-ACETYL-THIAMINE+DIPHOSPHATE'>HTL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.42Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b0p\|1b0p]], [[1kek\|1kek]], [[2c3m\|2c3m]], [[2c3o\|2c3o]], [[2c3p\|2c3p]], [[2c3u\|2c3u]], [[2c3y\|2c3y]], [[2c42\|2c42]], [[2pda\|2pda]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=HTL:2-ACETYL-THIAMINE+DIPHOSPHATE'>HTL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_synthase Pyruvate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.7.1 1.2.7.1] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uza OCA], [https://pdbe.org/2uza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uza RCSB], [https://www.ebi.ac.uk/pdbsum/2uza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uza ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2uza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uza OCA], [~~http~~://pdbe.org/2uza PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2uza RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2uza PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2uza ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~P94692_DESAF P94692_DESAF~~]~~] Oxidoreductase required~~ for the transfer of electrons from pyruvate to ~~flavodoxin~~ (~~By similarity~~).~~[PIRNR~~:~~PIRNR000159]~~	+	[https://www.uniprot.org/uniprot/PFOR_DESAF PFOR_DESAF] Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate. Required for the transfer of electrons from pyruvate to ferredoxin (PubMed:9294422, PubMed:7612653). Ferredoxin I and ferredoxin II, which are single 4Fe-4S cluster ferredoxins are the most effective electron carriers of POR (PubMed:7612653).<ref>PMID:7612653</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Desulfovibrio~~ africanus]]	+	[[Category: Desulfocurvibacter africanus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Pyruvate synthase]]~~	+	[[Category: Cavazza C]]
-	[[Category: Cavazza, C]]	+	[[Category: Chabriere E]]
-	[[Category: Chabriere, E]]	+	[[Category: Contreras-Martel C]]
-	[[Category: Contreras-Martel, C]]	+	[[Category: Fontecilla-Camps JC]]
-	[[Category: Fontecilla-Camps~~, J C]]~~	+
-	~~[[Category: Electron transport]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Pyruvate catabolism]]~~	+
-	~~[[Category: Tpp-dependent enzyme~~]]	+

OCA at 06:54, 19 August 2020

OCA — Wed, 19 Aug 2020 06:54:52 GMT

←Older revision		Revision as of 06:54, 19 August 2020
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	==CRYSTAL STRUCTURE OF THE FREE RADICAL INTERMEDIATE OF PYRUVATE:FERREDOXIN OXIDOREDUCTASE FROM DESULFOVIBRIO AFRICANUS==		==CRYSTAL STRUCTURE OF THE FREE RADICAL INTERMEDIATE OF PYRUVATE:FERREDOXIN OXIDOREDUCTASE FROM DESULFOVIBRIO AFRICANUS==
-	<StructureSection load='2uza' size='340' side='right' caption='[[2uza]], [[Resolution\|resolution]] 2.42Å' scene=''>	+	<StructureSection load='2uza' size='340' side='right'caption='[[2uza]], [[Resolution\|resolution]] 2.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_africanus Desulfovibrio africanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2UZA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_africanus Desulfovibrio africanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2UZA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=HTL:2-ACETYL-THIAMINE+DIPHOSPHATE'>HTL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=HTL:2-ACETYL-THIAMINE+DIPHOSPHATE'>HTL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b0p\|1b0p]], [[1kek\|1kek]], [[2c3m\|2c3m]], [[2c3o\|2c3o]], [[2c3p\|2c3p]], [[2c3u\|2c3u]], [[2c3y\|2c3y]], [[2c42\|2c42]], [[2pda\|2pda]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b0p\|1b0p]], [[1kek\|1kek]], [[2c3m\|2c3m]], [[2c3o\|2c3o]], [[2c3p\|2c3p]], [[2c3u\|2c3u]], [[2c3y\|2c3y]], [[2c42\|2c42]], [[2pda\|2pda]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_synthase Pyruvate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.7.1 1.2.7.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_synthase Pyruvate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.7.1 1.2.7.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2uza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uza OCA], [http://pdbe.org/2uza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uza RCSB], [http://www.ebi.ac.uk/pdbsum/2uza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uza ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2uza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uza OCA], [http://pdbe.org/2uza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uza RCSB], [http://www.ebi.ac.uk/pdbsum/2uza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: Desulfovibrio africanus]]		[[Category: Desulfovibrio africanus]]
		+	[[Category: Large Structures]]
	[[Category: Pyruvate synthase]]		[[Category: Pyruvate synthase]]
	[[Category: Cavazza, C]]		[[Category: Cavazza, C]]

OCA at 08:37, 12 September 2018

OCA — Wed, 12 Sep 2018 08:37:23 GMT

←Older revision		Revision as of 08:37, 12 September 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uza_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uza_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:37, 5 August 2016

OCA — Fri, 05 Aug 2016 04:37:18 GMT

←Older revision		Revision as of 04:37, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE FREE RADICAL INTERMEDIATE OF PYRUVATE:FERREDOXIN OXIDOREDUCTASE FROM DESULFOVIBRIO AFRICANUS==		==CRYSTAL STRUCTURE OF THE FREE RADICAL INTERMEDIATE OF PYRUVATE:FERREDOXIN OXIDOREDUCTASE FROM DESULFOVIBRIO AFRICANUS==
	<StructureSection load='2uza' size='340' side='right' caption='[[2uza]], [[Resolution\|resolution]] 2.42Å' scene=''>		<StructureSection load='2uza' size='340' side='right' caption='[[2uza]], [[Resolution\|resolution]] 2.42Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b0p\|1b0p]], [[1kek\|1kek]], [[2c3m\|2c3m]], [[2c3o\|2c3o]], [[2c3p\|2c3p]], [[2c3u\|2c3u]], [[2c3y\|2c3y]], [[2c42\|2c42]], [[2pda\|2pda]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b0p\|1b0p]], [[1kek\|1kek]], [[2c3m\|2c3m]], [[2c3o\|2c3o]], [[2c3p\|2c3p]], [[2c3u\|2c3u]], [[2c3y\|2c3y]], [[2c42\|2c42]], [[2pda\|2pda]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_synthase Pyruvate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.7.1 1.2.7.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_synthase Pyruvate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.7.1 1.2.7.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uza RCSB], [http://www.ebi.ac.uk/pdbsum/2uza PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uza OCA], [http://pdbe.org/2uza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uza RCSB], [http://www.ebi.ac.uk/pdbsum/2uza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uza ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2uza" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:51, 25 December 2014

OCA — Thu, 25 Dec 2014 15:51:05 GMT

←Older revision		Revision as of 15:51, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uza RCSB], [http://www.ebi.ac.uk/pdbsum/2uza PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uza RCSB], [http://www.ebi.ac.uk/pdbsum/2uza PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/P94692_DESAF P94692_DESAF]] Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity).[PIRNR:PIRNR000159]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Desulfovibrio africanus]]		[[Category: Desulfovibrio africanus]]
	[[Category: Pyruvate synthase]]		[[Category: Pyruvate synthase]]
-	[[Category: Cavazza, C.]]	+	[[Category: Cavazza, C]]
-	[[Category: Chabriere, E.]]	+	[[Category: Chabriere, E]]
-	[[Category: Contreras-Martel, C.]]	+	[[Category: Contreras-Martel, C]]
-	[[Category: Fontecilla-Camps, J C.]]	+	[[Category: Fontecilla-Camps, J C]]
	[[Category: Electron transport]]		[[Category: Electron transport]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Pyruvate catabolism]]		[[Category: Pyruvate catabolism]]
	[[Category: Tpp-dependent enzyme]]		[[Category: Tpp-dependent enzyme]]

OCA at 06:39, 10 October 2014

OCA — Fri, 10 Oct 2014 06:39:03 GMT

←Older revision		Revision as of 06:39, 10 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2uza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_africanus Desulfovibrio africanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2uza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_africanus Desulfovibrio africanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UZA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=HTL:2-ACETYL-THIAMINE+DIPHOSPHATE'>HTL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=HTL:2-ACETYL-THIAMINE+DIPHOSPHATE'>HTL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b0p\|1b0p]], [[1kek\|1kek]], [[2c3m\|2c3m]], [[2c3o\|2c3o]], [[2c3p\|2c3p]], [[2c3u\|2c3u]], [[2c3y\|2c3y]], [[2c42\|2c42]], [[2pda\|2pda]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b0p\|1b0p]], [[1kek\|1kek]], [[2c3m\|2c3m]], [[2c3o\|2c3o]], [[2c3p\|2c3p]], [[2c3u\|2c3u]], [[2c3y\|2c3y]], [[2c42\|2c42]], [[2pda\|2pda]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_synthase Pyruvate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.7.1 1.2.7.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_synthase Pyruvate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.7.1 1.2.7.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uza RCSB], [http://www.ebi.ac.uk/pdbsum/2uza PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uza RCSB], [http://www.ebi.ac.uk/pdbsum/2uza PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 02:22, 7 August 2014

OCA — Thu, 07 Aug 2014 02:22:40 GMT

←Older revision		Revision as of 02:22, 7 August 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2uza\| PDB=2uza \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF THE FREE RADICAL INTERMEDIATE OF PYRUVATE:FERREDOXIN OXIDOREDUCTASE FROM DESULFOVIBRIO AFRICANUS==
-	===CRYSTAL STRUCTURE OF THE FREE RADICAL INTERMEDIATE OF PYRUVATE:FERREDOXIN OXIDOREDUCTASE FROM DESULFOVIBRIO AFRICANUS===	+	<StructureSection load='2uza' size='340' side='right' caption='[[2uza]], [[Resolution\|resolution]] 2.42Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16472741}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2uza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_africanus Desulfovibrio africanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UZA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=HTL:2-ACETYL-THIAMINE+DIPHOSPHATE'>HTL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b0p\|1b0p]], [[1kek\|1kek]], [[2c3m\|2c3m]], [[2c3o\|2c3o]], [[2c3p\|2c3p]], [[2c3u\|2c3u]], [[2c3y\|2c3y]], [[2c42\|2c42]], [[2pda\|2pda]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_synthase Pyruvate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.7.1 1.2.7.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uza RCSB], [http://www.ebi.ac.uk/pdbsum/2uza PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uza_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pyruvate-ferredoxin oxidoreductases (PFOR) are unique among thiamine pyrophosphate (ThDP)-containing enzymes in giving rise to a rather stable cofactor-based free-radical species upon the decarboxylation of their first substrate, pyruvate. We have obtained snapshots of unreacted and partially reacted (probably as a tetrahedral intermediate) pyruvate-PFOR complexes at different time intervals. We conclude that pyruvate decarboxylation involves very limited substrate-to-product movements but a significant displacement of the thiazolium moiety of ThDP. In this respect, PFOR seems to differ substantially from other ThDP-containing enzymes, such as transketolase and pyruvate decarboxylase. In addition, exposure of PFOR to oxygen in the presence of pyruvate results in significant inhibition of catalytic activity, both in solution and in the crystals. Examination of the crystal structure of inhibited PFOR suggests that the loss of activity results from oxime formation at the 4' amino substituent of the pyrimidine moiety of ThDP.

-	~~==Function==~~	+	Flexibility of thiamine diphosphate revealed by kinetic crystallographic studies of the reaction of pyruvate-ferredoxin oxidoreductase with pyruvate.,Cavazza C, Contreras-Martel C, Pieulle L, Chabriere E, Hatchikian EC, Fontecilla-Camps JC Structure. 2006 Feb;14(2):217-24. PMID:16472741<ref>PMID:16472741</ref>
-	~~[[http://www.uniprot.org/uniprot/P94692_DESAF P94692_DESAF]] Oxidoreductase required for~~ the ~~transfer~~ of ~~electrons from~~ pyruvate ~~to flavodoxin~~ (~~By similarity~~).~~[PIRNR~~:~~PIRNR000159]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2uza]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Desulfovibrio_africanus Desulfovibrio africanus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2UZA OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Pyruvate-ferredoxin oxidoreductase\|Pyruvate-ferredoxin oxidoreductase]]		*[[Pyruvate-ferredoxin oxidoreductase\|Pyruvate-ferredoxin oxidoreductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:016472741</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Desulfovibrio africanus]]		[[Category: Desulfovibrio africanus]]
	[[Category: Pyruvate synthase]]		[[Category: Pyruvate synthase]]

OCA at 19:15, 17 April 2013

OCA — Wed, 17 Apr 2013 19:15:27 GMT

←Older revision		Revision as of 19:15, 17 April 2013
Line 1:		Line 1:
-	[[Image:2uza.png\|left\|200px]]
-
	{{STRUCTURE_2uza\| PDB=2uza \| SCENE= }}		{{STRUCTURE_2uza\| PDB=2uza \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF THE FREE RADICAL INTERMEDIATE OF PYRUVATE:FERREDOXIN OXIDOREDUCTASE FROM DESULFOVIBRIO AFRICANUS===		===CRYSTAL STRUCTURE OF THE FREE RADICAL INTERMEDIATE OF PYRUVATE:FERREDOXIN OXIDOREDUCTASE FROM DESULFOVIBRIO AFRICANUS===
		+	{{ABSTRACT_PUBMED_16472741}}

-	~~{{ABSTRACT_PUBMED_16472741}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/P94692_DESAF P94692_DESAF]] Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity).[PIRNR:PIRNR000159]

	==About this Structure==		==About this Structure==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016472741</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016472741</ref><references group="xtra"/><references/>
	[[Category: Desulfovibrio africanus]]		[[Category: Desulfovibrio africanus]]
	[[Category: Pyruvate synthase]]		[[Category: Pyruvate synthase]]
Line 22:		Line 21:
	[[Category: Fontecilla-Camps, J C.]]		[[Category: Fontecilla-Camps, J C.]]
	[[Category: Electron transport]]		[[Category: Electron transport]]
-	[[Category: Iron]]
-	[[Category: Iron-sulfur]]
-	[[Category: Iron-sulfur cluster]]
-	[[Category: Metal-binding]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: Pyruvate]]
	[[Category: Pyruvate catabolism]]		[[Category: Pyruvate catabolism]]
	[[Category: Tpp-dependent enzyme]]		[[Category: Tpp-dependent enzyme]]
-	[[Category: Transport]]

OCA at 18:33, 20 October 2012

OCA — Sat, 20 Oct 2012 18:33:31 GMT

←Older revision		Revision as of 18:33, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2uza]] is a 2 chain structure ~~of [[Pyruvate-ferredoxin oxidoreductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_africanus Desulfovibrio africanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZA OCA].	+	[[2uza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_africanus Desulfovibrio africanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZA OCA].

	==See Also==		==See Also==

OCA: Protected "2uza" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 04:27:58 GMT

Protected "2uza" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:27, 27 July 2012