2v13 - Revision history

OCA at 10:40, 7 July 2021

OCA — Wed, 07 Jul 2021 10:40:42 GMT

OCA at 07:29, 3 April 2019

OCA — Wed, 03 Apr 2019 07:29:50 GMT

←Older revision		Revision as of 07:29, 3 April 2019
Line 1:		Line 1:

	==Crystal Structure of Renin with Inhibitor 7==		==Crystal Structure of Renin with Inhibitor 7==
-	<StructureSection load='2v13' size='340' side='right' caption='[[2v13]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2v13' size='340' side='right'caption='[[2v13]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v13]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V13 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V13 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C40:N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE'>C40</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C40:N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE'>C40</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bbs\|1bbs]], [[1bil\|1bil]], [[1bim\|1bim]], [[1hrn\|1hrn]], [[1pr7\|1pr7]], [[1pr8\|1pr8]], [[1rne\|1rne]], [[1uhq\|1uhq]], [[2bks\|2bks]], [[2bkt\|2bkt]], [[2g20\|2g20]], [[2ren\|2ren]], [[2v0z\|2v0z]], [[2v10\|2v10]], [[2v11\|2v11]], [[2v12\|2v12]], [[2v16\|2v16]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bbs\|1bbs]], [[1bil\|1bil]], [[1bim\|1bim]], [[1hrn\|1hrn]], [[1pr7\|1pr7]], [[1pr8\|1pr8]], [[1rne\|1rne]], [[1uhq\|1uhq]], [[2bks\|2bks]], [[2bkt\|2bkt]], [[2g20\|2g20]], [[2ren\|2ren]], [[2v0z\|2v0z]], [[2v10\|2v10]], [[2v11\|2v11]], [[2v12\|2v12]], [[2v16\|2v16]]</td></tr>
Line 17:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/2v13_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/2v13_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 2v13" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2v13" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Renin\|Renin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Renin]]		[[Category: Renin]]
	[[Category: Cohen, N C]]		[[Category: Cohen, N C]]

OCA at 11:58, 6 November 2017

OCA — Mon, 06 Nov 2017 11:58:08 GMT

←Older revision		Revision as of 11:58, 6 November 2017
Line 32:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 2v13" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2v13" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Renin\|Renin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:53, 3 August 2017

OCA — Thu, 03 Aug 2017 09:53:15 GMT

←Older revision		Revision as of 09:53, 3 August 2017
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR~~ 7==	+
		+	==Crystal Structure of Renin with Inhibitor 7==
	<StructureSection load='2v13' size='340' side='right' caption='[[2v13]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2v13' size='340' side='right' caption='[[2v13]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v13]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V13 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v13]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V13 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C40:N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE'>C40</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C40:N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE'>C40</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bbs\|1bbs]], [[1bil\|1bil]], [[1bim\|1bim]], [[1hrn\|1hrn]], [[1pr7\|1pr7]], [[1pr8\|1pr8]], [[1rne\|1rne]], [[1uhq\|1uhq]], [[2bks\|2bks]], [[2bkt\|2bkt]], [[2g20\|2g20]], [[2ren\|2ren]], [[2v0z\|2v0z]], [[2v10\|2v10]], [[2v11\|2v11]], [[2v12\|2v12]], [[2v16\|2v16]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bbs\|1bbs]], [[1bil\|1bil]], [[1bim\|1bim]], [[1hrn\|1hrn]], [[1pr7\|1pr7]], [[1pr8\|1pr8]], [[1rne\|1rne]], [[1uhq\|1uhq]], [[2bks\|2bks]], [[2bkt\|2bkt]], [[2g20\|2g20]], [[2ren\|2ren]], [[2v0z\|2v0z]], [[2v10\|2v10]], [[2v11\|2v11]], [[2v12\|2v12]], [[2v16\|2v16]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v13 OCA], [http://pdbe.org/2v13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v13 RCSB], [http://www.ebi.ac.uk/pdbsum/2v13 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v13 OCA], [http://pdbe.org/2v13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v13 RCSB], [http://www.ebi.ac.uk/pdbsum/2v13 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v13 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 38:		Line 39:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Renin]]		[[Category: Renin]]
	[[Category: Cohen, N C]]		[[Category: Cohen, N C]]
Line 51:		Line 51:
	[[Category: Stutz, S]]		[[Category: Stutz, S]]
	[[Category: Wood, J M]]		[[Category: Wood, J M]]
		+	[[Category: Alternative splicing]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]
Line 56:		Line 57:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Inhibitor-complex]]		[[Category: Inhibitor-complex]]
		+	[[Category: Polymorphism]]
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Zymogen]]		[[Category: Zymogen]]

OCA at 17:33, 8 February 2016

OCA — Mon, 08 Feb 2016 17:33:45 GMT

←Older revision		Revision as of 17:33, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2v13' size='340' side='right' caption='[[2v13]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2v13' size='340' side='right' caption='[[2v13]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V13 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V13 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C40:N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE'>C40</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C40:N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE'>C40</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bbs\|1bbs]], [[1bil\|1bil]], [[1bim\|1bim]], [[1hrn\|1hrn]], [[1pr7\|1pr7]], [[1pr8\|1pr8]], [[1rne\|1rne]], [[1uhq\|1uhq]], [[2bks\|2bks]], [[2bkt\|2bkt]], [[2g20\|2g20]], [[2ren\|2ren]], [[2v0z\|2v0z]], [[2v10\|2v10]], [[2v11\|2v11]], [[2v12\|2v12]], [[2v16\|2v16]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bbs\|1bbs]], [[1bil\|1bil]], [[1bim\|1bim]], [[1hrn\|1hrn]], [[1pr7\|1pr7]], [[1pr8\|1pr8]], [[1rne\|1rne]], [[1uhq\|1uhq]], [[2bks\|2bks]], [[2bkt\|2bkt]], [[2g20\|2g20]], [[2ren\|2ren]], [[2v0z\|2v0z]], [[2v10\|2v10]], [[2v11\|2v11]], [[2v12\|2v12]], [[2v16\|2v16]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v13 RCSB], [http://www.ebi.ac.uk/pdbsum/2v13 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v13 OCA], [http://pdbe.org/2v13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v13 RCSB], [http://www.ebi.ac.uk/pdbsum/2v13 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v13 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2v13" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Renin]]		[[Category: Renin]]
	[[Category: Cohen, N C]]		[[Category: Cohen, N C]]

OCA at 14:27, 19 January 2015

OCA — Mon, 19 Jan 2015 14:27:46 GMT

←Older revision		Revision as of 14:27, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V13 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V13 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C40:N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE'>C40</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C40:N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE'>C40</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bbs\|1bbs]], [[1bil\|1bil]], [[1bim\|1bim]], [[1hrn\|1hrn]], [[1pr7\|1pr7]], [[1pr8\|1pr8]], [[1rne\|1rne]], [[1uhq\|1uhq]], [[2bks\|2bks]], [[2bkt\|2bkt]], [[2g20\|2g20]], [[2ren\|2ren]], [[2v0z\|2v0z]], [[2v10\|2v10]], [[2v11\|2v11]], [[2v12\|2v12]], [[2v16\|2v16]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bbs\|1bbs]], [[1bil\|1bil]], [[1bim\|1bim]], [[1hrn\|1hrn]], [[1pr7\|1pr7]], [[1pr8\|1pr8]], [[1rne\|1rne]], [[1uhq\|1uhq]], [[2bks\|2bks]], [[2bkt\|2bkt]], [[2g20\|2g20]], [[2ren\|2ren]], [[2v0z\|2v0z]], [[2v10\|2v10]], [[2v11\|2v11]], [[2v12\|2v12]], [[2v16\|2v16]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v13 RCSB], [http://www.ebi.ac.uk/pdbsum/2v13 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v13 RCSB], [http://www.ebi.ac.uk/pdbsum/2v13 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:[http://omim.org/entry/267430 267430]]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).<ref>PMID:16116425</ref> Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:[http://omim.org/entry/613092 613092]]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.<ref>PMID:19664745</ref>		[[http://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:[http://omim.org/entry/267430 267430]]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).<ref>PMID:16116425</ref> Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:[http://omim.org/entry/613092 613092]]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.<ref>PMID:19664745</ref>
Line 39:		Line 39:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Renin]]		[[Category: Renin]]
-	[[Category: Cohen, N C.]]	+	[[Category: Cohen, N C]]
-	[[Category: Cumin, F.]]	+	[[Category: Cumin, F]]
-	[[Category: Fuhrer, W.]]	+	[[Category: Fuhrer, W]]
-	[[Category: Goschke, R.]]	+	[[Category: Goschke, R]]
-	[[Category: Grutter, M G.]]	+	[[Category: Grutter, M G]]
-	[[Category: Maibaum, J.]]	+	[[Category: Maibaum, J]]
-	[[Category: Rahuel, J.]]	+	[[Category: Rahuel, J]]
-	[[Category: Rasetti, V.]]	+	[[Category: Rasetti, V]]
-	[[Category: Rueger, H.]]	+	[[Category: Rueger, H]]
-	[[Category: Stutz, S.]]	+	[[Category: Stutz, S]]
-	[[Category: Wood, J M.]]	+	[[Category: Wood, J M]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]

OCA at 01:43, 1 October 2014

OCA — Wed, 01 Oct 2014 01:43:24 GMT

←Older revision		Revision as of 01:43, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2v13~~\| ~~PDB~~=2v13 \| ~~SCENE~~= }}	+	==CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 7==
-	===~~CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 7~~===	+	<StructureSection load='2v13' size='340' side='right' caption='[[2v13]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_10903938}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2v13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V13 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C40:N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE'>C40</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bbs\|1bbs]], [[1bil\|1bil]], [[1bim\|1bim]], [[1hrn\|1hrn]], [[1pr7\|1pr7]], [[1pr8\|1pr8]], [[1rne\|1rne]], [[1uhq\|1uhq]], [[2bks\|2bks]], [[2bkt\|2bkt]], [[2g20\|2g20]], [[2ren\|2ren]], [[2v0z\|2v0z]], [[2v10\|2v10]], [[2v11\|2v11]], [[2v12\|2v12]], [[2v16\|2v16]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v13 RCSB], [http://www.ebi.ac.uk/pdbsum/2v13 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:[http://omim.org/entry/267430 267430]]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).<ref>PMID:16116425</ref> Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:[http://omim.org/entry/613092 613092]]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.<ref>PMID:19664745</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/2v13_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: The aspartic proteinase renin plays an important physiological role in the regulation of blood pressure. It catalyses the first step in the conversion of angiotensinogen to the hormone angiotensin II. In the past, potent peptide inhibitors of renin have been developed, but none of these compounds has made it to the end of clinical trials. Our primary aim was to develop novel nonpeptide inhibitors. Based on the available structural information concerning renin-substrate interactions, we synthesized inhibitors in which the peptide portion was replaced by lipophilic moieties that interact with the large hydrophobic S1/S3-binding pocket in renin. RESULTS: Crystal structure analysis of renin-inhibitor complexes combined with computational methods were employed in the medicinal-chemistry optimisation process. Structure analysis revealed that the newly designed inhibitors bind as predicted to the S1/S3 pocket. In addition, however, these compounds interact with a hitherto unrecognised large, distinct, sub-pocket of the enzyme that extends from the S3-binding site towards the hydrophobic core of the enzyme. Binding to this S3(sp) sub-pocket was essential for high binding affinity. This unprecedented binding mode guided the drug-design process in which the mostly hydrophobic interactions within subsite S3(sp) were optimised. CONCLUSIONS: Our design approach led to compounds with high in vitro affinity and specificity for renin, favourable bioavailability and excellent oral efficacy in lowering blood pressure in primates. These renin inhibitors are therefore potential therapeutic agents for the treatment of hypertension and related cardiovascular diseases.

-	~~==Disease==~~	+	Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin.,Rahuel J, Rasetti V, Maibaum J, Rueger H, Goschke R, Cohen NC, Stutz S, Cumin F, Fuhrer W, Wood JM, Grutter MG Chem Biol. 2000 Jul;7(7):493-504. PMID:10903938<ref>PMID:10903938</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot/RENI_HUMAN RENI_HUMAN]] Defects in REN are a cause of renal tubular dysgenesis~~ (~~RTD~~) ~~[MIM~~:[http://omim.org/entry/267430 267430]]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-~~onset oligohydramnios (the Potter phenotype)~~.~~<ref>~~PMID:16116425</ref> Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:[http://omim.org/entry/613092 613092]]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.<ref>PMID:~~19664745~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Renin is a highly specific endopeptidase~~, ~~whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating~~ a ~~cascade~~ of ~~reactions that produce an elevation of blood pressure and increased sodium retention by~~ the ~~kidney~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[2v13]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA].~~	+

	==See Also==		==See Also==
	*[[Renin\|Renin]]		*[[Renin\|Renin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:010903938</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Renin]]		[[Category: Renin]]

OCA at 19:09, 24 March 2013

OCA — Sun, 24 Mar 2013 19:09:23 GMT

←Older revision		Revision as of 19:09, 24 March 2013
Line 1:		Line 1:
-	[[Image:2v13.png\|left\|200px]]
-
	{{STRUCTURE_2v13\| PDB=2v13 \| SCENE= }}		{{STRUCTURE_2v13\| PDB=2v13 \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 7===		===CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 7===
		+	{{ABSTRACT_PUBMED_10903938}}

-	~~{{ABSTRACT_PUBMED_10903938}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:[http://omim.org/entry/267430 267430]]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).<ref>PMID:16116425</ref> Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:[http://omim.org/entry/613092 613092]]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.<ref>PMID:19664745</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:010903938</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010903938</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Renin]]		[[Category: Renin]]

OCA at 10:54, 20 October 2012

OCA — Sat, 20 Oct 2012 10:54:56 GMT

←Older revision		Revision as of 10:54, 20 October 2012
Line 1:		Line 1:
	[[Image:2v13.png\|left\|200px]]		[[Image:2v13.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2v13", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2v13\| PDB=2v13 \| SCENE= }}		{{STRUCTURE_2v13\| PDB=2v13 \| SCENE= }}

	===CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 7===		===CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 7===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10903938}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10903938 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10903938}}		{{ABSTRACT_PUBMED_10903938}}

	==About this Structure==		==About this Structure==
	[[2v13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA].		[[2v13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA].
		+
		+	==See Also==
		+	*[[Renin\|Renin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10903938</ref><ref group="xtra">PMID:1807356~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010903938</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Renin]]		[[Category: Renin]]
Line 36:		Line 28:
	[[Category: Stutz, S.]]		[[Category: Stutz, S.]]
	[[Category: Wood, J M.]]		[[Category: Wood, J M.]]
-	[[Category: Alternative splicing]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]
Line 42:		Line 33:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Inhibitor-complex]]		[[Category: Inhibitor-complex]]
-	[[Category: Polymorphism]]
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Zymogen]]		[[Category: Zymogen]]

OCA: Protected "2v13" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 19:20:32 GMT

Protected "2v13" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:20, 14 March 2011

←Older revision		Revision as of 10:40, 7 July 2021
Line 3:		Line 3:
	<StructureSection load='2v13' size='340' side='right'caption='[[2v13]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2v13' size='340' side='right'caption='[[2v13]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v13]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V13 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V13 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C40:N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE'>C40</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C40:N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE'>C40</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bbs\|1bbs]], [[1bil\|1bil]], [[1bim\|1bim]], [[1hrn\|1hrn]], [[1pr7\|1pr7]], [[1pr8\|1pr8]], [[1rne\|1rne]], [[1uhq\|1uhq]], [[2bks\|2bks]], [[2bkt\|2bkt]], [[2g20\|2g20]], [[2ren\|2ren]], [[2v0z\|2v0z]], [[2v10\|2v10]], [[2v11\|2v11]], [[2v12\|2v12]], [[2v16\|2v16]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bbs\|1bbs]], [[1bil\|1bil]], [[1bim\|1bim]], [[1hrn\|1hrn]], [[1pr7\|1pr7]], [[1pr8\|1pr8]], [[1rne\|1rne]], [[1uhq\|1uhq]], [[2bks\|2bks]], [[2bkt\|2bkt]], [[2g20\|2g20]], [[2ren\|2ren]], [[2v0z\|2v0z]], [[2v10\|2v10]], [[2v11\|2v11]], [[2v12\|2v12]], [[2v16\|2v16]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Renin Renin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Renin Renin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v13 OCA], [~~http~~://pdbe.org/2v13 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v13 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v13 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v13 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v13 OCA], [https://pdbe.org/2v13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v13 RCSB], [https://www.ebi.ac.uk/pdbsum/2v13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v13 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:[~~http~~://omim.org/entry/267430 267430]]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).<ref>PMID:16116425</ref> Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:[~~http~~://omim.org/entry/613092 613092]]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.<ref>PMID:19664745</ref>	+	[[https://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:[https://omim.org/entry/267430 267430]]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).<ref>PMID:16116425</ref> Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:[https://omim.org/entry/613092 613092]]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.<ref>PMID:19664745</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.	+	[[https://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]