2v17 - Revision history

OCA at 15:01, 13 December 2023

OCA — Wed, 13 Dec 2023 15:01:18 GMT

←Older revision		Revision as of 15:01, 13 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v17]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V17 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v17]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V17 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v17 OCA], [https://pdbe.org/2v17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v17 RCSB], [https://www.ebi.ac.uk/pdbsum/2v17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v17 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v17 OCA], [https://pdbe.org/2v17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v17 RCSB], [https://www.ebi.ac.uk/pdbsum/2v17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v17 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 29:
	==See Also==		==See Also==
	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
-	*[[Tau protein\|Tau protein]]	+	*[[Tau protein 3D structures\|Tau protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 37:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Csokova, N]]	+	[[Category: Csokova N]]
-	[[Category: Dvorsky, R]]	+	[[Category: Dvorsky R]]
-	[[Category: Novak, M]]	+	[[Category: Novak M]]
-	[[Category: Sevcik, J]]	+	[[Category: Sevcik J]]
-	[[Category: Skrabana, R]]	+	[[Category: Skrabana R]]
-	~~[[Category: Alzheimer's disease]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Microtubule]]~~	+
-	~~[[Category: Tau protein~~]]	+

OCA at 10:40, 7 July 2021

OCA — Wed, 07 Jul 2021 10:40:46 GMT

←Older revision		Revision as of 10:40, 7 July 2021
Line 3:		Line 3:
	<StructureSection load='2v17' size='340' side='right'caption='[[2v17]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2v17' size='340' side='right'caption='[[2v17]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v17]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V17 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V17 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v17]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V17 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v17 OCA], [~~http~~://pdbe.org/2v17 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v17 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v17 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v17 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v17 OCA], [https://pdbe.org/2v17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v17 RCSB], [https://www.ebi.ac.uk/pdbsum/2v17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v17 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:
	==See Also==		==See Also==
	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
-	*[[Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau\|Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau]]
	*[[Tau protein\|Tau protein]]		*[[Tau protein\|Tau protein]]
	== References ==		== References ==

OCA at 07:37, 24 July 2019

OCA — Wed, 24 Jul 2019 07:37:11 GMT

←Older revision		Revision as of 07:37, 24 July 2019
Line 1:		Line 1:

	==Structure of the complex of antibody MN423 with a fragment of tau protein==		==Structure of the complex of antibody MN423 with a fragment of tau protein==
-	<StructureSection load='2v17' size='340' side='right' caption='[[2v17]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='2v17' size='340' side='right'caption='[[2v17]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v17]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V17 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V17 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v17]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V17 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V17 FirstGlance]. <br>
Line 29:		Line 29:
	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	*[[Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau\|Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau]]		*[[Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau\|Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau]]
		+	*[[Tau protein\|Tau protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Csokova, N]]		[[Category: Csokova, N]]

OCA at 08:33, 12 September 2018

OCA — Wed, 12 Sep 2018 08:33:00 GMT

←Older revision		Revision as of 08:33, 12 September 2018
Line 1:		Line 1:

-	==~~STRUCTURE OF THE COMPLEX OF ANTIBODY~~ MN423 ~~WITH A FRAGMENT OF TAU PROTEIN~~==	+	==Structure of the complex of antibody MN423 with a fragment of tau protein==
	<StructureSection load='2v17' size='340' side='right' caption='[[2v17]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2v17' size='340' side='right' caption='[[2v17]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 10:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/2v17_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/2v17_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 27:

	==See Also==		==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	*[[Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau\|Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau]]		*[[Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau\|Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau]]
-	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:33, 11 August 2016

OCA — Thu, 11 Aug 2016 14:33:47 GMT

←Older revision		Revision as of 14:33, 11 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF THE COMPLEX OF ANTIBODY MN423 WITH A FRAGMENT OF TAU PROTEIN==		==STRUCTURE OF THE COMPLEX OF ANTIBODY MN423 WITH A FRAGMENT OF TAU PROTEIN==
	<StructureSection load='2v17' size='340' side='right' caption='[[2v17]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2v17' size='340' side='right' caption='[[2v17]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v17]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V17 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V17 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v17]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V17 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V17 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v17 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v17 RCSB], [http://www.ebi.ac.uk/pdbsum/2v17 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v17 OCA], [http://pdbe.org/2v17 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v17 RCSB], [http://www.ebi.ac.uk/pdbsum/2v17 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v17 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v17 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2v17" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Monoclonal Antibody\|Monoclonal Antibody]]
	*[[Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau\|Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau]]		*[[Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau\|Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau]]
		+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:43, 19 January 2015

OCA — Mon, 19 Jan 2015 13:43:41 GMT

←Older revision		Revision as of 13:43, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v17]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V17 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V17 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v17]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V17 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V17 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v17 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v17 RCSB], [http://www.ebi.ac.uk/pdbsum/2v17 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v17 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v17 RCSB], [http://www.ebi.ac.uk/pdbsum/2v17 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Csokova, N.]]	+	[[Category: Csokova, N]]
-	[[Category: Dvorsky, R.]]	+	[[Category: Dvorsky, R]]
-	[[Category: Novak, M.]]	+	[[Category: Novak, M]]
-	[[Category: Sevcik, J.]]	+	[[Category: Sevcik, J]]
-	[[Category: Skrabana, R.]]	+	[[Category: Skrabana, R]]
	[[Category: Alzheimer's disease]]		[[Category: Alzheimer's disease]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Microtubule]]		[[Category: Microtubule]]
	[[Category: Tau protein]]		[[Category: Tau protein]]

OCA at 01:28, 1 October 2014

OCA — Wed, 01 Oct 2014 01:28:50 GMT

←Older revision		Revision as of 01:28, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2v17\| PDB=2v17 \| SCENE= }}~~	+	==STRUCTURE OF THE COMPLEX OF ANTIBODY MN423 WITH A FRAGMENT OF TAU PROTEIN==
-	===STRUCTURE OF THE COMPLEX OF ANTIBODY MN423 WITH A FRAGMENT OF TAU PROTEIN===	+	<StructureSection load='2v17' size='340' side='right' caption='[[2v17]], [[Resolution\|resolution]] 1.65Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18061582}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2v17]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V17 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V17 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v17 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v17 RCSB], [http://www.ebi.ac.uk/pdbsum/2v17 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/2v17_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The major constituent of Alzheimer's disease paired helical filaments (PHF) core is intrinsically disordered protein (IDP) tau. In spite of a considerable effort, insoluble character of PHF together with inherent physical properties of IDP tau have precluded so far reconstruction of PHF 3D structure by X-ray crystallography or NMR spectroscopy. Here we present first crystallographic study of PHF core C-terminus. Using monoclonal antibody MN423 specific to the tertiary structure of the PHF core, the in vivo PHF structure was imprinted into recombinant core PHF tau. Crystallization of the complex led to determination of the structure of the core PHF tau protein fragment 386TDHGAE391 at 1.65A resolution. Structural analysis suggests important role of the core PHF C-terminus for PHF assembly. It is reasonable to expect that this approach will help to reveal the structural principles underlying the tau protein assembly into PHF and possibly will facilitate rationale drug design for inhibition of Alzheimer neurofibrillary changes.

-	~~==About this Structure==~~	+	X-ray structure of the PHF core C-terminus: insight into the folding of the intrinsically disordered protein tau in Alzheimer's disease.,Sevcik J, Skrabana R, Dvorsky R, Csokova N, Iqbal K, Novak M FEBS Lett. 2007 Dec 22;581(30):5872-8. Epub 2007 Dec 3. PMID:18061582<ref>PMID:18061582</ref>
-	~~[[2v17]] is a 3 chain~~ structure ~~with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http~~:~~//en~~.~~wikipedia.org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2V17 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Monoclonal Antibody\|Monoclonal Antibody]]		*[[Monoclonal Antibody\|Monoclonal Antibody]]
	*[[Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau\|Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau]]		*[[Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau\|Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018061582<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 09:21, 11 March 2013

OCA — Mon, 11 Mar 2013 09:21:04 GMT

←Older revision		Revision as of 09:21, 11 March 2013
Line 1:		Line 1:
-	[[Image:2v17.png\|left\|200px]]
-
	{{STRUCTURE_2v17\| PDB=2v17 \| SCENE= }}		{{STRUCTURE_2v17\| PDB=2v17 \| SCENE= }}
-
	===STRUCTURE OF THE COMPLEX OF ANTIBODY MN423 WITH A FRAGMENT OF TAU PROTEIN===		===STRUCTURE OF THE COMPLEX OF ANTIBODY MN423 WITH A FRAGMENT OF TAU PROTEIN===
-
	{{ABSTRACT_PUBMED_18061582}}		{{ABSTRACT_PUBMED_18061582}}

OCA at 20:25, 20 October 2012

OCA — Sat, 20 Oct 2012 20:25:51 GMT

←Older revision		Revision as of 20:25, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2v17]] is a 3 chain structure ~~of [[Monoclonal Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V17 OCA].	+	[[2v17]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V17 OCA].

	==See Also==		==See Also==
	*[[Monoclonal Antibody\|Monoclonal Antibody]]		*[[Monoclonal Antibody\|Monoclonal Antibody]]
		+	*[[Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau\|Structure and dynamics of the microtubule-binding hot-spots on the neuronal protein tau]]

	==Reference==		==Reference==

OCA: Protected "2v17" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 10:28:11 GMT

Protected "2v17" [edit=sysop:move=sysop]

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Revision as of 10:28, 27 July 2012